He aha kāu e ʻike ai e pili ana i ka MTHFR Gene

Anter

• Nā ʻano o ka hoʻololi MTHFR
• Nā ʻōuli o ka hoʻololi MTHFR
• Ke hoʻāʻo nei no nā hoʻololi MTHFR
• Ka lapaʻau ʻana no nā hopohopo olakino pili
• Nā pilikia i ka hāpai ʻana
• Hoʻohui kūpono
• Nā manaʻo papaʻai
• ʻO ka lawe lawe ʻana

Hoʻopili mākou i nā huahana a mākou e manaʻo nei he pono no kā mākou poʻe heluhelu. Inā kūʻai ʻoe ma o nā loulou i kēia ʻaoʻao, loaʻa iā mākou kahi kōmike liʻiliʻi. Eia kā mākou hana.

He aha ka MTHFR?

Ua ʻike paha ʻoe i ka pōkole ʻo "MTHFR" i kū i nā nūhou olakino hou. E like paha ia me kahi huaʻōlelo hōʻino i ka nānā mua ʻana, akā pili maoli ia i kahi hoʻololi kūʻē maʻamau.

Kū ʻo MTHFR methylenetetrahydrofolate hōʻemi. Ke kiʻi nei i ka nānā ʻana ma muli o ka mutation genetic e alakaʻi i nā kiʻekiʻe kiʻekiʻe o ka homocysteine ​​i ke koko a me nā pae haʻahaʻa o folate a me nā huaora ʻē aʻe.

Aia kekahi hopohopo e pili ana kekahi mau pilikia olakino me nā hoʻololi MTHFR, no laila ua lilo ka hoʻāʻo i mea nui i nā makahiki.

Nā ʻano o ka hoʻololi MTHFR

Hiki iā ʻoe ke hana i hoʻokahi a i ʻole ʻelua mau hoʻololi - a i ʻole - ma ka ʻāpana MTHFR. Kāhea pinepine ʻia kēia mau hoʻololi ʻana he mau ʻano. ʻO kahi ʻano ʻē aʻe kahi ʻāpana o kā DNA gen e ʻokoʻa mau ai, a ʻokoʻa paha, mai kēlā me kēia kanaka.

Loaʻa i kahi ʻano ʻokoʻa - heterozygous - he mea liʻiliʻi ia e hāʻawi i nā pilikia olakino. Manaʻo kekahi poʻe i ka loaʻa ʻana o ʻelua mau hoʻololi - homozygous - hiki ke alakaʻi i nā pilikia koʻikoʻi. ʻElua mau ʻano, a i ʻole nā ​​ʻano o nā hoʻololi i hiki ke hana ʻia ma ka ʻaoʻao MTHFR.

ʻO nā ʻano kikoʻī:

• C677T. Ma kahi o 30 a 40 pākēneka o ko ʻAmelika mau heluna e loaʻa i kahi mutation ma ke kūlana gen C677T. Ma kahi o 25 pākēneka o ka poʻe Hispanic, a 10 a 15 pākēneka o ko Caucasian moʻomeheu, homozygous no kēia ʻano ʻokoʻa.
• A1298C. Aia ka palena o ka noiʻi e pili ana i kēia ʻano. Loaʻa nā noiʻi i loaʻa ʻia ma nā ʻāina a me nā lāhui. ʻO kahi laʻana, kahi noiʻi 2004 i kia i 120 mau mea hāʻawi koko o ka hoʻoilina Irish. ʻO nā mea hāʻawi, 56, a i ʻole 46.7 pakeneka, heterozygous no kēia ʻano, a 11, a i ʻole 14.2 pakeneka, he homozygous.
• Hiki nō hoʻi ke kiʻi i nā hoʻololi C677T a me A1298C, kahi kope o kēlā me kēia.

Ua hoʻoilina ʻia ka hoʻololi ʻana o nā keiki, ʻo ia hoʻi ke kiʻi ʻia mai nā mākua. I ka hapai ʻana, loaʻa iā ʻoe hoʻokahi kope o ka moʻokūʻauhau MTHFR mai kēlā me kēia makua. Inā loaʻa nā hoʻololi o nā mea ʻelua, ʻoi aku ka nui o kāu makaʻu i ka loaʻa ʻana o kahi mutation homozygous.

Nā ʻōuli o ka hoʻololi MTHFR

Hoʻololi nā ʻōuli i kēlā me kēia kanaka a mai kekahi ʻano i kahi ʻano ʻē. Inā ʻoe e huli wikiwiki i ka pūnaewele, ʻike paha ʻoe i nā pūnaewele he nui e koi nei i ka MTHFR ke kumu pololei o kekahi mau ʻano.

E hoʻomanaʻo i ka noiʻi ʻana e pili ana iā MTHFR a me nā hopena e ulu mau nei. ʻO nā hōʻike e hoʻopili nei i ka hapa nui o kēia mau kūlana olakino i MTHFR e nele nei a i ʻole hōʻole ʻia.

ʻOi aku paha ma mua o ka hopena, inā ʻaʻole he pilikia a i ʻole he hoʻokolohua i hana ʻia, ʻaʻole ʻoe e hoʻomaopopo i kou kūlana mutation MTHFR.

Nā kūlana i noi ʻia e pili me MTHFR e komo pū me:

• nā maʻi maʻi maʻi a me nā maʻi thromboembolic (kikoʻī ke koko, hahau, embolism, a me nā puʻuwai puʻuwai)
• kaumaha
• hopohopo
• bipolar kāna hana
• schizophrenia
• maʻi ʻaʻai kolone
• maʻi leukemia
• ʻeha mau a luhi hoʻi
• ʻeha nerve
• neʻe hele
• hana hewa hou ʻole i nā wahine o nā makahiki hānau keiki
• nā hāpai hāpai me nā kīnā neural tube, e like me ka spina bifida a me ka anencephaly

E aʻo hou aʻe e pili ana i ka hāpai hāpai ʻana me MTHFR.

Hoʻonui ʻia paha ka makaʻi inā loaʻa i kekahi kanaka ʻelua ʻano ʻokoʻa a i ʻole homozygous no ka hoʻololi MTHFR.

Ke hoʻāʻo nei no nā hoʻololi MTHFR

ʻO nā hui olakino like ʻole - me ke Kulanui ʻAmelika o nā Obstetricians a me nā Gynecologists, College of American Pathologists, American College of Medical Genetics, a me American Heart Association - mai paipai i ka hoʻāʻo ʻana no nā mea ʻokoʻa ke ʻole ke kiʻekiʻe kiʻekiʻe o nā homosistine kiʻekiʻe a i ʻole nā ​​hōʻike olakino ʻē aʻe.

Eia nō naʻe, pīhoihoi paha ʻoe e ʻike i kāu kūlana MTHFR pākahi. E noʻonoʻo e kipa i kāu kauka a kūkākūkā i nā maikaʻi a me nā maikaʻi ʻole o ka hoʻāʻo ʻana.

E hoʻomanaʻo i ʻole e uhi ʻia ka hoʻāʻo genetika e kāu ʻinikua. Kāhea i kāu mea lawe inā e noʻonoʻo ana ʻoe e hoʻāʻo ʻia e nīnau e pili ana i nā kumukūʻai.

Hāʻawi kekahi mau ʻōkuhi hoʻāʻo genetika ma ka home i ka kānana no MTHFR pū kekahi. ʻO nā laʻana me:

• ʻO 23andMe kahi koho nui e hāʻawi i nā kūpuna kūpuna a me ka ʻike olakino. He mea kumukūʻai hoʻi ($ 200). I mea e hana ai i kēia hoʻokolohua, waiho ʻoe i ka huha i loko o kahi paipu a hoʻouna iā ia ma o ka leka uila i kahi keʻena. ʻEono a ʻewalu pule paha nā hopena.
• ʻO kaʻu Home MTHFR ($ 150) kahi koho ʻē aʻe e pili kikoʻī i ka hoʻololi. Hana ʻia ka hoʻāʻo e ka hōʻiliʻili ʻana iā DNA mai loko o kou pāpālina me nā swabs. Ma hope o ka hoʻouna ʻana i ka hoʻokalakupua, hoʻokahi a ʻelua pule paha ka hopena.

Ka lapaʻau ʻana no nā hopohopo olakino pili

Loaʻa ka loaʻa ʻana o kahi ʻano MTHFR ʻaʻole pono ʻoe i ka lāʻau lapaʻau. ʻO ka manaʻo paha he pono ʻoe e lawe i kahi huaora B.

Koi ʻia ka lāʻau lapaʻau ke loaʻa iā ʻoe nā pae homocysteine ​​kiʻekiʻe loa, kokoke i luna mau o ka pae i hāʻawi ʻia i ka nui o nā ʻano MTHFR. Pono kāu kauka e kāpae i nā kumu kūpono ʻē aʻe o ka hoʻonui ʻia o ka homocysteine, i hiki ke hana ʻia me ka ʻole a me ka ʻole o nā ʻano MTHFR.

ʻO nā kumu ʻē aʻe o ka homocysteine ​​kiʻekiʻe:

• hypothyroidism
• nā kūlana e like me ka maʻi diabetes, kiʻekiʻe kōkōlō, a me ke koko kiʻekiʻe
• momona a me ka hana ʻole
• kekahi mau lāʻau, e like me atorvastatin, fenofibrate, methotrexate, a me nicotinic acid

Mai laila mai, pili ka lāʻau i ke kumu a ʻaʻole pono e noʻonoʻo i ka MTHFR. ʻO ka ʻokoʻa ke ʻike ʻia ʻoe me nā ʻano aʻe āpau i ka manawa like:

• kiʻekiʻe pae homocysteine
• kahi hoʻololi MTHFR i hōʻoia
• nā hemahema o ka wikamina ma folate, choline, a i ʻole nā ​​wikamina B-12, B-6, a i ʻole riboflavin

I kēia mau hihia, hiki i kāu kauka ke ʻōlelo i ka supplementation e hoʻoponopono i nā hemahema me nā lāʻau a i ʻole nā ​​lāʻau e hoʻoponopono ai i ke ʻano olakino kikoʻī.

Makemake paha ka poʻe me ka mutation MTHFR e hana i nā hana pale e hoʻohaʻahaʻa ai i kā lākou pae homocysteine. Hoʻololi kahi ana ʻohana i nā koho nohona, hiki ke kōkua me ka hoʻohana ʻole ʻia o nā lāʻau. ʻO nā laʻana me:

• ke kū nei i ka puhi ʻana, ke puhi ʻoe
• ka lawa ʻana o ka hoʻoikaika kino
• ʻai ana i ka papaʻai olakino, kaulike

Nā pilikia i ka hāpai ʻana

Hoʻohui pū ʻia nā miscarriages hou a me nā kīnā neural tube me MTHFR. Wahi a ka Genetic and Rare Diseases Information Center ke hōʻike nei nā noiʻi i nā wahine i ʻelua mau ʻano C677T i ka nui o ka makaʻu o ka loaʻa ʻana o kahi keiki me kahi kīnā neural tube.

Ua nānā kahi noiʻi 2006 i nā wahine me ka mōʻaukala o ka hana hewa hou ʻole ʻana. Ua ʻike ʻia he 59 pākēneka o lākou i loaʻa he mau homozygous gene mutation, e like me MTHFR, e pili pū ana me ke kāpili ʻana o ke koko, ma kahi o 10 pākēneka wale nō o nā wahine ma ka papa hoʻonohonoho

E kamaʻilio me kāu kauka e pili ana i ka hoʻāʻo inā pili kekahi o nā ʻano aʻe iā ʻoe.

• Ua ʻike ʻoe i kekahi mau miscarriages i hōʻike ʻole ʻia.
• Loaʻa iā ʻoe kahi keiki me kahi kīnā neural tube.
• ʻIke ʻoe aia iā ʻoe ka hoʻololi MTHFR, a hāpai ʻoe.

ʻOiai heʻuʻuku nā hōʻike e kākoʻo iā ia, manaʻo kekahi mau kauka e lawe i nā lāʻau hōʻuluʻulu koko. Hoʻohui pū kekahi me ka supplementation folate keu.

Hoʻohui kūpono

Hoʻopili ka MTHFR gene mutation i ke ʻano o ke kino e hana ai i ka waikawa folic a me nā huaʻai B ʻē aʻe. Ke hoʻololi nei i ka supplementation o kēia nutrient kahi mea hiki ke nānā i ka pale ʻana i kāna hopena.

ʻO ka Folic acid kahi mana i hana ʻia e ke kanaka no ka folate, kahi mea pono maoli i loaʻa i nā meaʻai. Lawe i ke ʻano bioavailable o folate - methylated folate - hiki ke kōkua i kou kino e omo me ka mākaukau.

Paipai ʻia ka hapa nui o ka poʻe e lawe i ka multivitamin e loaʻa ana ma kahi o 0.4 milligrams o ka folic acid i kēlā me kēia lā.

Paipai ʻole ʻia nā wahine hāpai e hoʻololi i nā wikamina prenatal a i ʻole mālama mālama e pili ana i kā lākou kūlana MTHFR wale nō. ʻO kēia ka lawe ʻana i ka mahele maʻamau o 0.6 milligrams o folic acid i kēlā me kēia lā.

ʻO nā wahine me ka mōʻaukala o nā neural tube defect pono e kamaʻilio me kā lākou kauka no nā ʻōlelo kikoʻī.

ʻO nā multivitamins me ka folh methylated e komo pū me:

• ʻO Thorne Basic Nutrients 2 / Lā
• Pants makua akamai
• ʻO nā Manuʻa Prenatal Mama Manu

E kamaʻilio me kāu kauka ma mua o ka loli ʻana i nā wikamina a me nā mea hoʻohui. Hoʻopilikia paha kekahi i nā lāʻau a lāʻau ʻē aʻe āu e loaʻa nei.

E kuhi paha kāu kauka i nā huaora i kuhikuhi ʻia i loko o folate me folic acid. Kaukaʻi ʻia i kāu ʻinikua, ʻokoʻa paha nā kumukūʻai o kēia mau koho i ka hoʻohālikelike ʻana i nā ʻano over-the-counter.

Nā manaʻo papaʻai

ʻO kaʻai ʻana i nā meaʻai i loko o ka folate e kōkua i ke kākoʻo kūlohelohe i kāu mau pae o kēia wikamina koʻikoʻi. Eia naʻe, pono nō paha ka supplementation.

ʻO nā koho meaʻai maikaʻi nā:

• nā polokina e like me nā pi i kuke ʻia, ka pi, a me ka lihi
• ʻo nā mea ʻai e like me ka milo, asparagus, lettuce, beets, broccoli, corn, Brussels sprouts, a me bok choy
• nā hua e like me ka cantaloupe, ka meli, ka maiʻa, nā huaʻalaki, ka huaʻakai, a me nā strawberry
• nā wai e like me ka ʻalani, ka paina kēkē, ka pākaʻi, ke kōmato, a i ʻole ka wai mea kanu ʻē aʻe
• pata pīnī
• nā hua pua lā

Makemake paha ka poʻe me ka mutation MTHFR e hōʻalo i nā meaʻai i loaʻa i ke ʻano synthetic o folate, folic acid - ʻoiai ʻaʻole maopopo ka hōʻike he pono a he pono paha.

E nānā pono i nā lepili, no ka mea ua hoʻohui ʻia kēia huaola i nā hua hua nui i waiwai ʻia, e like me ka pasta, nā palaoa, nā berena, a me nā palaoa i hana ʻia ma ke ʻano pāʻoihana.

E aʻo hou aʻe e pili ana i ka ʻokoʻa ma waena o folate a me folic acid.

ʻO ka lawe lawe ʻana

ʻAʻole paha e pili ana kāu kūlana MTHFR i kāu olakino. Pono nā noiʻi hou e hoʻoholo i ka hopena maoli, inā loaʻa, e pili ana i nā ʻano.

Eia hou, nui ʻole nā ​​ʻoihana olakino mahalo ʻole e hōʻoia i ka hoʻāʻo ʻana no kēia hoʻololi ʻana, keu hoʻi me ka ʻole o nā hōʻailona olakino ʻē aʻe. E kamaʻilio me kāu kauka e pili ana i nā pono a me nā pilikia o ka hoʻāʻo ʻana, a me nā hopohopo ʻē aʻe āu e loaʻa ai.

E hoʻomau i ka ʻai maikaʻi, hoʻoikaika kino, a hoʻomaʻamaʻa i nā ʻano nohona olakino e kākoʻo i kou olakino holoʻokoʻa.