Hōʻike BCR ABL Genetic Test

Anter

• He aha ka hoʻokolohua kūlohelohe BCR-ABL?
• No ke aha ia e hoʻohana ai?
• No ke aha wau e pono ai i kahi hoʻokolohua kūlohelohe BCR-ABL?
• He aha ka hana i ka wā o ka hoʻokolohua kūlohelohe BCR-ABL?
• Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?
• Aia kekahi mau pilikia i ka hoʻāʻo?
• He aha ke ʻano o nā hopena?
• Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i kahi hoʻokolohua kūlohelohe BCR-ABL?
• Nā kūmole

He aha ka hoʻokolohua kūlohelohe BCR-ABL?

Nānā kahi hoʻokolohua kūlohelohe BCR-ABL no ka hoʻololi gen (hoʻololi) ma kahi chromosome kikoʻī.

ʻO nā Chromosome nā ʻāpana o kāu mau pūnaewele i loaʻa i kāu mau ʻāpana. ʻO nā ʻāpana nā ʻāpana o ka DNA i hoʻoili ʻia mai kou makuahine a me kou makuakāne. Hāpai lākou i ka ʻike e hoʻoholo ai i kāu ʻano kū hoʻokahi, e like me ke kiʻekiʻe a me ke kala o ka maka.

Loaʻa i nā kānaka he 46 chromosome, i mahele ʻia i 23 mau pālua, i kēlā me kēia cell. ʻO kekahi o kēlā me kēia pālua chromosome mai kou makuahine, a ʻo kekahi mau mea ʻelua mai kou makuakāne mai.

ʻO BCR-ABL kahi hoʻololi i hana ʻia e ka hui ʻana o ʻelua mau ʻaoʻao, i kapa ʻia ʻo BCR a me ABL. Kapa ʻia ia i kekahi manawa he fusion gene.

• ʻO ka gen BCR ma ka helu chromosome 22 maʻamau.
• ʻO ka ʻāpana ABL ma ka helu chromosome 9 maʻamau.
• Hana ka hoʻololi BCR-ABL ke haki nā ʻāpana o BCR a me ABL a hoʻololi i nā wahi.
• Hōʻike ka mutation ma chromosome 22, kahi o ka ʻāpana o chromosome 9 i hoʻopili ai iā ia iho.
• Ua kapa ʻia ka chromosome 22 mutated ʻo ka chromosome Philadelphia no ka mea ʻo ia ke kūlanakauhale kahi i ʻike mua ai ka poʻe noiʻi.
• ʻAʻole ka ʻāpana BCR-ABL ke ʻano o ka hoʻololi ʻana i hoʻoilina ʻia mai kou mau mākua mai. ʻO ia kahi ʻano o ka hoʻololi somatic, ʻo ia hoʻi ʻaʻole ʻoe i hānau ʻia me ia. Loaʻa iā ʻoe ma hope ma ke ola.

Hōʻike ʻia ka ʻāpana BCR-ABL i nā mea maʻi me kekahi ʻano leukemia, kahi maʻi ʻaʻai o ka iwi iwi a me nā aʻa koko keʻokeʻo. Loaʻa ʻo BCR-ABL ma kahi o nā mea maʻi āpau me kahi ʻano leukemia i kapa ʻia ʻo myeloid leukemia (CML) mau. ʻO kekahi inoa no CML ka lōʻihi myelogenous maʻi leukemia ʻO nā inoa ʻelua i ka maʻi like.

Loaʻa ka ʻāpana BCR-ABL i kekahi mau maʻi me kahi ʻano o ka leukemia lymphoblastic nui (ALL) a kākaʻikahi ka poʻe maʻi me ka leukemia myelogenous koʻikoʻi (AML).

ʻO kekahi o nā lāʻau lapaʻau maʻi ʻaʻai e maikaʻi loa i ka mālama ʻana i nā mea maʻi leukemia me ka mutation gene BCR-ABL. ʻOi aku ka liʻiliʻi o nā hopena o kēia mau lāʻau ma mua o nā ʻano maʻi ʻaʻai ʻē aʻe. ʻAʻole maikaʻi nā lāʻau like i ka mālama ʻana i nā ʻano maʻi leukemia a i ʻole nā ​​maʻi ʻino ʻē aʻe.

Nā inoa ʻē aʻe: BCR-ABL1, BCR-ABL1 fusion, Philadelphia chromosome

No ke aha ia e hoʻohana ai?

Hoʻohana pinepine ʻia kahi hoʻokolohua BCR-ABL e kuhikuhi a hōʻole paha i ka leukemia myeloid mau (CML) a i ʻole kahi ʻano kikoʻī o ka leukemia lymphoblastic nui (ALL) i kapa ʻia ʻo Ph-positive ALL. ʻO Ph-positive ke kumu i loaʻa ai kahi chromosome Philadelphia. ʻAʻole hoʻohana ʻia ka hōʻike e ʻike ai i nā ʻano maʻi leukemia ʻē aʻe.

E hoʻohana ʻia ka hōʻike i:

• E ʻike inā maikaʻi ka mālama ʻana i ka maʻi ʻaʻai.
• E ʻike inā ua hoʻomohala ka mea maʻi i kekahi kūpaʻa i kekahi lāʻau. ʻO ia hoʻi, ʻaʻole hana hou kahi lāʻau i hoʻohana ʻia ma mua.

No ke aha wau e pono ai i kahi hoʻokolohua kūlohelohe BCR-ABL?

Pono paha ʻoe i kahi hōʻike BCR-ABL inā loaʻa iā ʻoe nā ʻōuli o ka maʻi myeloid leukemia (CML) a i ʻole Ph-positive leukemia lymphoblastic (ALL). Pākuʻi ʻia kēia mau mea:

• Ka luhi
• Fiva
• Kaumaha emi
• Pāleo ka pō (sweating nui i ka hiamoe ʻana)
• ʻEha puʻupuʻu a i ʻole ʻeha iwi

ʻO kekahi poʻe me CML a i ʻole Ph-positive ALL ʻaʻohe hōʻailona, ​​a i ʻole nā ​​hōʻailona akahai loa, keu hoʻi i nā pae mua o ka maʻi. No laila hiki i kāu kauka olakino ke kauoha i kēia hoʻokolohua inā kahi helu piha o ke koko a i ʻole hōʻike hōʻike koko ʻē aʻe i hōʻike i nā hopena ʻaʻole maʻamau. E hoʻomaopopo pū ʻoe i kāu mea hāʻawi inā loaʻa iā ʻoe nā hōʻailona e hopohopo iā ʻoe. Maʻalahi ʻo CML a me Ph-positive ALL e mālama ke loaʻa ke kakahiaka.

Pono paha ʻoe i kēia hōʻike inā mālama ʻia ʻoe i kēia manawa no CML a i ʻole Ph-positive ALL. Hiki i ka hōʻoia ke kōkua i kāu mea lawelawe e ʻike inā ke holo nei kāu lāʻau.

He aha ka hana i ka wā o ka hoʻokolohua kūlohelohe BCR-ABL?

ʻO kahi ho'āʻo BCR-ABL he maʻa mau i ka hoʻāʻo koko a i ʻole kahi hana i kapa ʻia ʻo ka ʻono iwi a me ka biopsy.

Inā ʻoe e hōʻoia i ke koko, e lawe kahi loea mālama ola i kahi laʻana koko mai kahi aa i loko o kou lima, e hoʻohana ana i kahi nila liʻiliʻi. Ma hope o ka hoʻokomo ʻia ʻana o ka nila, e hōʻiliʻili ʻia kahi koko liʻiliʻi i loko o kahi pahu hoʻāʻo a ipu paha. Hiki paha iā ʻoe ke ʻoni iki i ka wā e hele ai a kuʻi paha ka nila. Lōʻihi kēia ma mua o ʻelima mau minuke.

Inā ʻoe e kiʻi i ka ʻiʻiwi iwi a me ka biopsy, hiki i kāu kaʻina hana ke hoʻopili i nā kaʻina hana penei:

• E moe ʻoe i kou ʻaoʻao a i ʻole kou ʻōpū, e hilinaʻi ana i ka iwi hea e hoʻohana ai no ka hoʻāʻo ʻana. Lawe ʻia ka hapa nui o nā hoʻā o ka iwi iwi mai ka iwi iwi.
• E uhi ʻia kou kino i ka lole, i hōʻike wale ʻia nā wahi a puni ka pūnaewele hoʻāʻo.
• E hoʻomaʻemaʻe ka pūnaewele me kahi antiseptic.
• E loaʻa ʻoe i ka ʻoki o kahi hopena numbing. ʻEwehi paha ia.
• Ke pulu ka ʻāpana, e lawe ka mea mālama ola i kahi laʻana. Pono ʻoe e moe mālie i ka wā o nā hoʻokolohua.
  • No ka makemake o ka iwi iwi, ka mea e hana mau ʻia ma mua, e hoʻokomo ka mea mālama ola i kahi nila ma o ka iwi a huki i ka wai iwi momona a me nā hunaola. Hiki paha iā ʻoe ke ʻeha a ʻeha pōkole hoʻi ke hoʻokomo ʻia ka nila.
  • No kahi biopsy iwi pū, e hoʻohana ka mea mālama ola i kahi pono hana e wili i loko o ka iwi e lawe i kahi hāpana o ka iwi pūpū iwi. ʻIke paha ʻoe i kekahi kaomi ma ka pūnaewele ʻoiai e lawe ʻia nei kahi laʻana.
• Ma kahi o 10 mau minuke e hana ai i nā hōʻike ʻelua.
• Ma hope o ka hoʻāʻo, e uhi ka mea mālama ola i ka pūnaewele me kahi bandage.
• E hoʻolālā e hoʻokele iā ʻoe i kahi home, no ka mea hiki ke hāʻawi ʻia iā ʻoe kahi mea hōʻoluʻolu ma mua o nā hoʻokolohua, e hiamoe ai paha ʻoe.

Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?

ʻAʻole pono ʻoe i kahi hoʻomākaukau kūikawā no ka hoʻāʻo ʻana o ke koko a iwi paha.

Aia kekahi mau pilikia i ka hoʻāʻo?

ʻAʻohe liʻiliʻi loa i ka hōʻoia ʻana o ke koko. Loaʻa paha iā ʻoe ka ʻeha a ʻeha paha ma kahi o ka nila i hoʻokomo ʻia ai, akā ʻo ka hapa nui o nā ʻōuli e hele wikiwiki aku.

Ma hope o ka hoʻāʻo ʻana o ka iwi iwi, ʻāʻī paha ʻoe a ʻeha paha ma ka pūnaewele injection. Hele maʻamau kēia i kekahi mau lā. Koi aku kāu kauka olakino iā ʻoe a kauoha paha i kahi mea kōkua ʻeha e kōkua.

He aha ke ʻano o nā hopena?

Inā hōʻike kāu hopena ua loaʻa iā ʻoe ka moʻokūʻauhau BCR-ABL, a me kahi nui o nā kiko keʻokeʻo keʻokeʻo, e ʻike ʻia paha ʻoe me ka leukemia myeloid maʻi (CML) a i ʻole Ph-positive, leukemia lymphoblastic koʻikoʻi (ALL).

Inā mālama ʻia ʻoe i kēia manawa no CML a i ʻole Ph-positive ALL, e hōʻike paha kāu mau hopena.

• Ke piʻi nei ka nui o BCR-ABL i kou koko a i ʻole ka iwi iwi. ʻO kēia paha ka hana ʻole o kāu lāʻau a / a i ʻole ua kūʻē ʻoe i kekahi ʻano lāʻau.
• Ke emi nei ka nui o BCR-ABL i kou koko a i ʻole ka iwi iwi. ʻO kēia paha ke hana nei kāu lāʻau.
• ʻAʻole hoʻonui a hoʻemi ʻia ka nui o BCR-ABL i kou koko a i ʻole ka iwi iwi. ʻO kēia paha he kūpaʻa kou maʻi.

Inā he mau nīnau kāu e pili ana i kāu hopena, e kamaʻilio me kāu kauka olakino.

E aʻo hou aʻe e pili ana i nā hoʻokolohua hoʻokolohua, nā pae kuhikuhi, a me ka hoʻomaopopo ʻana i nā hopena.

Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i kahi hoʻokolohua kūlohelohe BCR-ABL?

ʻO nā mālama ʻana no ka maʻi myeloid leukemia (CML) a me Ph-positive, leukemia lymphoblastic maha (ALL) i kūleʻa i nā maʻi me kēia ʻano leukemia. He mea nui ia e ʻike pinepine i kāu mea mālama ola e hōʻoia i ka hoʻomau ʻana o ka mālama ʻana i kāu mau mālama. Inā kūpaʻa ʻoe i ka mālama ʻana, hiki i kāu mea hāʻawi ke paipai i nā ʻano ʻano ʻē aʻe o ka maʻi ʻaʻai.

Nā kūmole

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ʻAʻole pono e hoʻohana i ka ʻike ma kēia pūnaewele i pani no ka mālama olakino ʻoihana a ʻōlelo aʻoaʻo paha. Kāhea aku i ka mea mālama ola inā he nīnau kāu e pili ana i kou olakino.