Axicabtagene Ciloleucel Injection

Anter

• Ma mua o ka loaʻa ʻana o ka injection axicabtagene ciloleucel,
• Hiki i nā Axicabtagene ciloleucel ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻ sectionlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka:

Hoʻokumu paha ka pīhoihoi o Axicabtagene ciloleucel i kahi hopena koʻikoʻi a weliweli paha i kapa ʻia ʻo cytokine hoʻokuʻu syndrome (CRS). E nānā pono kahi kauka a kahu hānai paha iā ʻoe i kāu infusion a no 4 mau pule ma hope. E haʻi i kāu kauka inā loaʻa ʻoe i kahi maʻi hōʻeha a i ʻole inā manaʻo a manaʻo paha ʻoe he ʻano maʻi paha kāu i kēia manawa. Hāʻawi ʻia ʻoe i nā lāʻau i 60 mau minuke ma mua o kou hoʻokomo ʻana e kōkua i ka pale ʻana i nā hopena i ka axicabtagene ciloleucel. Inā ʻoe e ʻike i kekahi o nā ʻōuli ma hope a ma hope o kou infusion, e haʻi koke aku i kāu kauka: ke kuni, ka haʻalulu, ka wikiwiki o ka puʻuwai a i ʻole kūleʻa, haʻalulu, ka maʻi luhi, nāwaliwali, nāwaliwali, nā pilikia e hanu ai, ka hanu ʻana o ka hanu, ka huikau, ka pīhoihoi, ka luaʻi, ka luhi , a i ʻole lightheadedness.

Hoʻokumu paha ka pīhoihoi axicabtagene ciloleucel i ke ʻano o ka hopena o ka ʻōnaehana ʻōnaehana koʻikoʻi a hoʻoweliweli paha. Hiki ke hana i kēia mau hopena ma hope o ka mālama ʻana me ka axicabtagene ciloleucel. E haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha i nā kuʻi ʻana, ka hahau, a me ka nalo ʻana o ka hoʻomanaʻo. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e haʻi koke aku i kāu kauka: ʻeha ke poʻo, ʻūpē, paʻakikī e hiamoe a hiamoe paha, hoʻomaha ʻole, huikau, hopohopo, haʻalulu ʻole o kahi ʻāpana o ke kino, nalowale o ka ʻike, hoʻonāukiuki, hopu ʻana, nalo ʻana o kaulike, paʻakikī ʻike, a paʻakikī ʻōlelo paha.

Loaʻa wale ka pīhoihoi Axicabtagene ciloleucel ma o kahi papahana hoʻokaʻawale kūikawā no ka makaʻu o ka CRS a me nā mea ʻona neurological. Hiki iā ʻoe ke loaʻa nā lāʻau mai ke kauka a me nā lawelawe mālama ola e komo i ka papahana. E nīnau i kāu kauka inā he nīnau kāu e pili ana i kēia polokalamu.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me ka axicabtagene ciloleucel. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Hoʻohana ʻia ka injection Axicabtagene ciloleucel e mālama ai i kekahi ʻano lymphoma non-Hodgkin (maʻi ʻaʻai e hoʻomaka i nā hunaola keokeo e hakakā maʻamau i ka maʻi) i hoʻi a pane ʻole paha i nā ʻano lāʻau ʻē aʻe i ka poʻe i mālama mua ʻia me ka liʻiliʻi. ʻelua mau lāʻau chemotherapy ʻē aʻe. Aia ka injection Axicabtagene ciloleucel i loko o ka papa o nā lāʻau i kapa ʻia autotherapy cellular immunotherapy, kahi ʻano o ka lāʻau i hoʻomākaukau ʻia e hoʻohana ana i nā hunaola mai ke koko ponoʻī o ka mea maʻi. Hana ia e ke kumu o ke kino o ke kino (kahi hui o nā hunaola, nāʻaʻaʻa, a me nā mea i pale i ke kino mai ka hoʻouka ʻia ʻana e nā koʻohune, nā mea ʻino, nā hunaola maʻi ʻaʻai, a me nā mea like ʻē aʻe e hōʻeha i nā maʻi) e hakakā me nā hunaola maʻi ʻaʻai.

Hele mai ka injection Axicabtagene ciloleucel ma ke ʻano he wehe (wai) e ʻimi ʻino ʻia (i loko o kahi aa) e ke kauka a kahu wahine paha i ke keʻena o ke kauka a infusion kikowaena paha. Hāʻawi pinepine ʻia ia ma kahi o 30 mau minuke ma ke ʻano he mahele manawa hoʻokahi. Ma mua o ka loaʻa ʻana o kāu lāʻau axicabtagene ciloleucel, na kāu kauka a kahu wahine paha e lawelawe i nā lāʻau chemotherapy ʻē aʻe e hoʻomākaukau ai i kou kino no ka axicabtagene ciloleucel.

Ma mua o ka hāʻawi ʻia ʻana o ka lāʻau axicabtagene ciloleucel injection, e lawe ʻia kahi laʻana o kou mau keʻokeʻo keʻokeʻo ma kahi kikowaena ohi cell e hoʻohana ana i kahi hana i kapa ʻia ʻo leukapheresis (kahi hana e lawe i nā hunaola keokeo mai ke kino). Ma muli o ka hana ʻia ʻana o kēia lāʻau i kou mau huna ponoʻī, pono e hāʻawi ʻia iā ʻoe wale nō. He mea nui ia ma ka manawa kūpono a mai haʻalele i kāu koho ʻana i ka ʻohiʻohi a hoʻonohonoho ʻia a i ʻole e loaʻa i kāu mahele lāʻau. Pono ʻoe e hoʻolālā e noho kokoke i kahi i loaʻa ai iā ʻoe kāu axicabtagene ciloleucel lapaʻau no 4 mau pule ma hope o kāu kau lāʻau. E nānā kāu mea olakino e ʻike inā e hana ana kāu lāʻau a nānā iā ʻoe no nā hopena ʻē aʻe. E kamaʻilio me kāu kauka e pili ana pehea e hoʻomākaukau ai no ka leukapheresis a me ka mea e kali ai i ka wā a ma hope o ke kaʻina hana.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka loaʻa ʻana o ka injection axicabtagene ciloleucel,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka axicabtagene ciloleucel, gentamicin, i nā lāʻau ʻē aʻe, dimethyl sulokside (DMSO), a i ʻole nā ​​mea hana ʻē aʻe i ka injection axicabtagene ciloleucel. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻōlelo pono i kekahi o kēia mau mea: nā steroid e like me dexamethasone, methylprednisolone (Medrol), prednisolone, a me prednisone (Rayos). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a loaʻa paha iā ʻoe kahi pilikia hanu a i ʻole ka mumū, hakuʻala, puʻuwai, a i ʻole nā ​​maʻi ate.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Pono ʻoe e loaʻa kahi hōʻike hāpai keiki ma mua o kou hoʻomaka ʻana i ka lāʻau axicabtagene ciloleucel. Inā hāpai ʻoe i ka loaʻa ʻana o ka pahu axicabtagene ciloleucel, e kelepona koke i kāu kauka.
• pono ʻoe e ʻike ʻo ka pīpī axicabtagene ciloleucel e hiamoe ai ʻoe a hoʻonāukiuki i ka nāwaliwali, nāwaliwali, nāwaliwali, nā hopu ʻana, a me nā pilikia hoʻohui. Mai hoʻokele i kahi kaʻa a hana i nā mīkini ma kahi o 8 mau pule ma hope o kāu lāʻau axicabtagene ciloleucel.
• mai hāʻawi manawaleʻa i ke koko, nā lālā, nā aʻa, a i ʻole nā ​​hunaola no ke kanu ʻana ma hope o kou loaʻa ʻana i kāu injection axicabtagene ciloleucel.
• nānā me kāu kauka e ʻike inā pono ʻoe e loaʻa i nā lāʻau āpau. Mai loaʻa i nā lāʻau āpau me ke kamaʻilio ʻole ʻana me kāu kauka no 6 mau pule ma mua o ka hoʻomaka ʻana o ka chemotherapy, i ka manawa o kāu lāʻau axicabtagene ciloleucel, a hiki i ka haʻi ʻana o kāu kauka iā ʻoe ua ola kāu ʻōnaehana pale.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā haʻalele ʻoe i ka manawa e hōʻiliʻili ai i kāu mau hunaola, pono ʻoe e kāhea koke i kāu kauka a me ke kikowaena hōʻiliʻili. Inā haʻalele ʻoe i ka manawa e loaʻa ai kāu lāʻau axicabtagene ciloleucel, pono ʻoe e kelepona koke i kāu kauka.

Hiki i nā Axicabtagene ciloleucel ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• kōpaʻa
• ʻeha ka ʻōpū
• ʻeha kua
• ʻeha hui a ʻeha ʻeha paha
• waha maloo
• nalo ʻai ʻole
• Kaumaha emi

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻ sectionlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka:

• koko i ka mimi
• ʻoi aku ka maʻalahi o ke kahe ʻana ma mua o ka maʻamau
• fiva, ʻeha ka ʻāʻī, haʻalulu, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• hoʻemi i ke alapine urination a i ʻole ka nui
• ʻili mae
• luhi
• ka pehu o nā maka, ka maka, ka lehelehe, ka elelo, ka ʻāʻī, ka lima, ka lima, ka wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
• paʻakikī i ka ale ʻana
• hūwī
• hives
• ʻūlili

Hiki paha i ka axicabtagene ciloleucel injection ke hoʻonui i kou makaʻu i ka hoʻomohala ʻana i kekahi mau maʻi maʻi maʻi. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka loaʻa ʻana o kēia lāʻau.

Hoʻokumu paha ʻo Axicabtagene ciloleucel i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i nā manawa a pau me kāu kauka, ke kikowaena ohi cell, a me ka hale hana. Hiki i kāu kauka ke kauoha i kekahi mau hoʻokolohua hoʻokolohua ma mua, i ka wā, a ma hope o kāu mālama ʻana e nānā i ka pane o kou kino i ka injection axicabtagene ciloleucel.

Ma mua o ka hoʻāʻo ʻana i kahi lumi hoʻokolohua, e haʻi i kāu kauka a me nā limahana o ke keʻena hoʻokolohua ke loaʻa nei iā ʻoe ka ʻume axicabtagene ciloleucel. Hiki i kēia lāʻau ke hoʻololi i nā hopena o kekahi mau hoʻokolohua hoʻokolohua.

E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka injection axicabtagene ciloleucel.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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