ʻO Lumacaftor lāua ʻo Ivacaftor

Anter

• Ma mua o ka lawe ʻana i ka lumacaftor a me ka ivacaftor,
• Hiki i ka Lumacaftor a me ka ivacaftor ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:
• Pākuʻi ʻia paha nā ʻōuli o ka overdose:

Hoʻohana ʻia ʻo Lumacaftor a me ivacaftor e mālama i kekahi ʻano o ka cystic fibrosis (kahi maʻi hānau i hoʻopuka ʻia nā pilikia me ka hanu ʻana, digestion, a me ka reproduction) i nā mākua a me nā keiki ʻo 2 mau makahiki a ʻoi paha. Aia ʻo Lumacaftor i kahi papa o nā lāʻau i kapa ʻia he cystic fibrosis transmembrane conductance regulator (CFTR) hoʻoponopono. Aia ʻo Ivacaftor i kahi papa o nā lāʻau i kapa ʻia he cystic fibrosis transmembrane conductance regulator (CFTR) potentiators.Hana kēia mau lāʻau ʻelua ma o ka hoʻomaikaʻi ʻana i ka hana o kahi protein i ke kino e hōʻemi i ke kūkulu ʻia ʻana o nā mucus mānoanoa i nā akemāmā a me ka hoʻomaikaʻi ʻana i nā ʻōuli ʻē aʻe o ka cystic fibrosis.

ʻO ka hui pū ʻana o lumacaftor a me ivacaftor e hele mai ma ke ʻano he papa a me nā granula e lawe ʻia e ka waha. Lawe pinepine ʻia me nā meaʻai momona i ʻelua mau manawa i ka lā, 12 mau hola ke kaʻawale. Lawe i ka lumacaftor a me ka ivacaftor ma nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka lumacaftor a me ka ivacaftor e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E hoʻomākaukau i kahi mahele o lumacaftor a me ivacaftor granules, e kāwili i ka piha piha o nā granula i 1 teaspoon (5 ml) o kahi meaʻai palupalu a wai paha (anuanu a i ʻole ke ana wela o ka lumi) e like me ka yogurt, applesauce, pudding, waiū, a wai wai paha. Lawe i ka hui holoʻokoʻa ma waena o 1 mau hola o ka hoʻohuihui ʻana i nā granula me ka meaʻai a i ʻole kahi wai.

E lawe i ka lumacaftor a me ka ivacaftor me nā meaʻai momona e like me nā hua manu, nā avocados, nā nati, ka bata, ka pīni pīni, ka waiū tī, ka waiū piha a me nā huahana waiū holoʻokoʻa e like me ka tī a me ka yogurt momona piha. E kamaʻilio me kāu kauka e pili ana i nā meaʻai momona ʻē aʻe e ʻai me ka lumacaftor a me ka ivacaftor.

Mālama ʻo Lumacaftor a me ivacaftor i ka cystic fibrosis akā ʻaʻole ia e hoʻōla. E hoʻomau i ka lawe lumacaftor a me ivacaftor ʻoiai inā ʻoe e manaʻo maikaʻi. Mai hōʻoki i ka lawe ʻana i ka lumacaftor a me ka ivacaftor me ka walaʻau ʻole ʻana me kāu kauka.

Inā ʻaʻole ʻoe e lawe i ka lumacaftor a me ka ivacaftor no 7 mau lā a ʻoi aku paha, mai hoʻomaka hou e lawe me ka ʻole e kamaʻilio pū me kāu kauka. Pono paha kāu kauka e hoʻololi i kāu lāʻau o kēia lāʻau a i ʻole nā ​​lāʻau ʻē aʻe āu e lawe nei.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka lumacaftor a me ka ivacaftor,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka lumacaftor a me ka ivacaftor, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i lumacaftor a me nā papa ivacaftor a i ʻole nā ​​granule. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, a me nā mea hoʻopihaʻaiʻai āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: kekahi antifungals e like me itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), a me voriconazole (Vfend); kekahi mau lāʻauʻalopelo e like me clarithromycin (Biaxin, in Prevpac), erythromycin (E.E.S., Erythrocin, Eryped, kekahi), rifabutin (Mycobutin) a me rifampin (Rifadin, Rifamate, Rifater, Rimactane); kekahi mau lāʻau no ka maʻi diabetes e like me chlorpropamide (Diabinese), glimepiride (Amaryl, in Duetact), glipizide (Glucotrol), glyburide (Diabeta, Glynase, in Glucovance), repaglinide (Prandin), tolazamide a me tolbutamide; digoxin (Lanoxin); ibuprofen (Advil, Motrin, i Vicoprofen); kekahi mau immunosuppressants e like me cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune) a me tacrolimus (Astagraf, Prograf); midazolam; montelukast (Singulair); methylprednisolone (Medrol); prednisone (Rayos); kekahi protitors pump proton (PPI) e like me esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), a me omeprazole (Prilosec, i Zegerid); ranitidine (Zantac); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, a me phenytoin (Dilantin, Phenytek); kekahi o nā mea hoʻoliʻiliʻi hou i nā serotonin reuptake (SSRI) e like me citalopram (Celexa), escitalopram (Lexapro), a me sertraline (Zoloft); triazolam (Halcion); a me warfarin (Coumadin, Jantoven). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Hiki paha i nā lāʻau ʻē aʻe ke launa pū me ka lumacaftor a me ka ivacaftor, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka wort a St. John ʻoiai e lawe ana i ka lumacaftor a me ka ivacaftor.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha nā pilikia hanu a i ʻole nā ​​kūlana, kahi transplant organ, a i ʻole ate a i ʻole nā ​​maʻi puʻupaʻa.
• pono ʻoe e ʻike i ka lumacaftor a me ka ivacaftor e hoʻoliʻiliʻi i ka pono o nā pale hormonal (nā lāʻau kaohi hānau, nā pā, nā apo, nā inikū, nā implant, a i ʻole nā ​​polokalamu intrauterine). E kamaʻilio me kāu kauka e pili ana i nā ʻano hana ʻē aʻe o ka kaohi hānau e holo pono nāu iā ʻoe ke lawe ʻoe i ka lumacaftor a me ka ivacaftor.
• e haʻi i kāu kauka inā hāpai ʻoe, hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i lumacaftor a me ivacaftor, e kāhea i kāu kauka.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā hoʻomanaʻo ʻoe i ka lāʻau i hala ʻole i loko o 6 mau hola o ka manawa āu i hoʻonohonoho ʻia ai e lawe, lawe koke i ka lāʻau i nalo ʻia. Eia nō naʻe, inā ua hala ma mua o 6 mau hola mai ka manawa āu e lawe mau ai i ka lumacaftor a me ka ivacaftor, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i ka Lumacaftor a me ka ivacaftor ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• pokole o ka hanu
• ka paʻa o ka umauma a ʻeha paha
• nā pilikia hanu
• pāhoehoe
• ʻenekini
• luhi nui loa
• hūwī
• kūleʻa, hala, kaumaha a ʻeha hoʻi nā manawa o ka menstrual, keu hoʻi i nā wahine e lawe ana i nā mea pale hormonal
• ihu ihu, ʻūlū, uā, ʻāʻī, a i ʻole nā ​​hōʻailona like flu
• eha ka 'ā'ī
• ihu peʻa a holo paha
• ʻeha poʻo

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

• nausea
• ka luaʻi
• nalo ʻai ʻole
• ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū
• mimi ʻeleʻele
• huikau
• melemele o ka ʻili a me nā maka

Hiki i ka Lumacaftor a me ka ivacaftor ke kumu o ka cataract (ke ao ʻana o nā aniani o ka maka e hoʻopilikia i ka ʻike maka) i nā keiki a me nā ʻōpio. ʻO nā keiki a me nā ʻōpio e lawe ana i ka lumacaftor a me ivacaftor e ʻike i ke kauka maka ma mua a i ka wā o kā lākou mālama ʻia. E kamaʻilio me kāu kauka o kāu keiki e pili ana i nā pilikia o ka hāʻawi ʻana i ka lumacaftor a me ka ivacaftor i kāu keiki.

Hiki i ka Lumacaftor a me ka ivacaftor ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Pākuʻi ʻia paha nā ʻōuli o ka overdose:

• ʻeha poʻo
• hūwī

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kahi hoʻokolohua hoʻokolohua ma mua o kou hoʻomaka ʻana i kāu lāʻau e ʻike ai hiki ke mālama ʻia i kou ʻano me ka lumacaftor a me ivacaftor e like me ka mea e hoʻohana wale ʻia ai i ka poʻe me kahi make-up. E kauoha kāu kauka i kahi hoʻokolohua maka a me kekahi mau hoʻokolohua lab ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino i ka lumacaftor a me ka ivacaftor. Pono e nānā pinepine ʻia kou kaomi koko ke lawe ʻoe i kēia lāʻau.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Orkambi^®