Mea Kākau: Marcus Baldwin
Lā O Ka Hana: 18 Iune 2021
HōʻAno Hou I Ka Lā: 16 Nowemapa 2024
Anonim
How does Dapagliflozin work? Understanding SGLT2 inhibitors.
Wikiō: How does Dapagliflozin work? Understanding SGLT2 inhibitors.

Anter

Hoʻohana ʻia ʻo Dapagliflozin me ka papaʻai a me ka hoʻoikaika kino, a i kekahi manawa me nā lāʻau ʻē aʻe, e hoʻohaʻahaʻa i nā pae kō kō i nā mākua me ka maʻi diabetes 2 (ke ʻano kiʻekiʻe ke kō kō no ka mea ʻaʻole hana a hoʻohana ʻole ke kino i ka insulin maʻamau). Hoʻohana ʻia ʻo Dapagliflozin e hōʻemi i ka makaʻu o ka pono i ka haukapila no ka ʻole o ka puʻuwai i nā mākua i loaʻa ka ʻano diabetes 2 me ka maʻi puʻuwai a me nā kīʻaha koko a i ʻole nā ​​mea pilikia no ka hoʻomohala ʻana i ka maʻi puʻuwai a me ke kīʻaha koko. Hoʻohana ʻia ʻo Dapagliflozin i nā mākua me ka puʻuwai puʻuwai e hōʻemi i ka makaʻu o ka pono i ka haukapila a me ka make ma muli o ka maʻi puʻuwai a me nā kīʻaha koko. Aia ʻo Dapagliflozin i kahi papa o nā lāʻau i kapa ʻia he sodium-glucose co-transporter 2 (SGLT2) nā mea kāohi. Hoʻoiho ia i ke kō i ke kō ma o ke kuhi ʻana i nā puʻupaʻa i ka nui o nā glucose i ka mimi. ʻAʻole hoʻohana ʻia ʻo Dapagliflozin e mālama ai i ka maʻi maʻamau ʻo 1 (ʻano ʻaʻohe e hana ke kino i ka insulin a, no laila, ʻaʻole hiki ke kaohi i ka nui o ke kō i ke koko) a i ʻole ka ketoacidosis diabetic (kahi ʻano koʻikoʻi e ulu inā ʻaʻole mālama ʻia ke kō kiʻekiʻe o ke kō. ).


I ka hala ʻana o ka manawa, hiki i ka poʻe i loaʻa i ka maʻi diabetes a me ke kō kō ke kiʻekiʻe ke hoʻomohala i nā pilikia koʻikoʻi a i ʻole hoʻoweliweli i ke ola, e like me ka maʻi puʻuwai, ka hahau, nā pilikia o ka puʻupaʻa, nā ʻeha o ke aʻa, a me nā pilikia o ka maka. Lawe iā dapagliflozin, hana i nā loli nohona (e laʻa me, ʻai, hoʻoikaika kino, haʻalele i ka puhipaka), a me ka nānā pinepine ʻana i kāu kō kō e kōkua paha i ka mālama ʻana i kāu maʻi diabetes a hoʻomaikaʻi i kou olakino. Hoʻoemi paha kēia hoʻomaʻamaʻa i kou manawa e loaʻa ai ka puʻuwai puʻuwai, hahau ʻana, a i ʻole nā ​​pilikia e pili ana i ka maʻi diabetes e like me ka hōʻino ʻana o ka puʻuwai, nā ʻāʻī nerve (numb, nā wāwae anu a i ʻole nā ​​wāwae; hoʻemi i ka hiki i ka wahine i nā kāne a me nā wahine), nā pilikia o ka maka, me nā loli. a i ʻole ka nalo ʻana o ka ʻike, a i ʻole ka maʻi gum. E kamaʻilio pū kāu kauka a me nā mea lawelawe ʻē aʻe iā ʻoe e pili ana i ke ala maikaʻi loa e mālama ai i kāu maʻi diabetes.

Hele mai ʻo Dapagliflozin ma ke ʻano he papa e lawe ma ka waha. Lawe ʻia ia me ka ʻai ʻole aʻai ʻole hoʻokahi manawa i ka lā o ke kakahiaka. Lawe iā dapagliflozin ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono iā dapagliflozin e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.


E hoʻomaka paha kāu kauka iā ʻoe ma kahi lāʻau haʻahaʻa o dapagliflozin a hoʻonui i kāu lāʻau inā pono.

Mālama ʻo Dapagliflozin i ka maʻi diabetes ʻano 2 akā ʻaʻole ia e hoʻōla iā ia. E hoʻomau i ka lawe iā dapagliflozin ʻoiai inā maikaʻi ʻoe. Mai hoʻōki i ka lawe ʻana i ka dapagliflozin me ka walaʻau ʻole ʻana me kāu kauka.

E hāʻawi aku kāu kauka a mea kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Ke alakaʻi alakaʻi) ke hoʻomaka ʻoe i ka lāʻau me dapagliflozin a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) e kiʻi i ke alakaʻi Medication.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana iā dapagliflozin,

  • e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka dapagliflozin, i nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o ka papa dapagliflozin. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E hōʻike pono i kekahi o kēia mau mea: angiotensin-hoʻololi i ka enzyme (ACE) mea kāohi e like me benazepril (Lotensin, ma Lotrel), captopril, enalapril (Vasotec, i Vaseretic), fosinopril, lisinopril (i Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon, ma Prestalia), ramipril (Altace), a me trandolapril (Mavik, ma Tarka); angiotensin receptor blockers (ARB) e like me azilsartan (Edarbi, ma Edarbyclor), candesartan (Atacand, ma Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, ma Avalide), losartan (Cozaar, ma Hyzaar), olmesartan (Benicar, ma Azor, ma Benicar HCT, ma Tribenzor), telmisartan (Micardis, ma Micardis HCT, ma Twynsta); aspirin a me nā lāʻau anti-inflammatory nonsteroidal (NSAID) e like me ibuprofen (Advil, Motrin) a me naproxen (Aleve, Naprosyn); nā lāʻau lapaʻau diabetes e like me glimepiride (Amaryl, i Duetact), glipizide (Glucotrol), glyburide (DiaBeta, Glynase), repaglinide (Prandin, i Prandimet), a me tolbutamide; diuretics ('pills wai'); a me ka insulin.
  • e haʻi i kāu kauka inā ʻoe e pili ana i ka dialysis a inā ua loaʻa a i ʻole loaʻa iā ʻoe ka maʻi ʻaʻai. E haʻi paha kāu kauka iā ʻoe mai lawe i dapagliflozin.
  • e haʻi i kāu kauka inā inu pinepine ʻoe i ka waiʻona a i kekahi manawa inu i ka nui o ka waiʻona i loko o kahi manawa pōkole (inu inu inu) a i ʻole inā aia ʻoe ma kahi papa sodium liʻiliʻi. E haʻi pū aku i kāu kauka inā loaʻa a i ʻole loaʻa paha iā ʻoe ka puʻuwai puʻuwai, ka maʻi pancreatic me ka pancreatitis (ka pehu ʻana o ka pancreas) a i ʻole ua ʻoki ʻia kāu maʻi pancreas, nā maʻi maʻi urinary a i ʻole nā ​​pilikia urencing, ke koko kiʻekiʻe, nā maʻi hū i ka wahi genital, ʻōpū a i ʻole maʻi ate. Inā he kāne ʻoe, e haʻi i kāu kauka inā ʻaʻole ʻoe i ʻoki poepoe ʻia. E haʻi aku i kāu kauka, inā ʻoe e ʻai liʻiliʻi ma muli o ka maʻi, ʻoki kino a i ʻole ka loli o kāu papaʻai, a i ʻole iho nei ua loaʻa ka palahī, ka luaʻi, ʻaʻole inu i ka nui o ka wai, ua lōʻihi loa i ka lā, a ua nui ka hou, i hiki ke kumu i ka make wai (nalo o kahi nui o nā kino wai).
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Mai hānai i ka wā e lawe ana ʻoe i dapagliflozin. Inā hāpai ʻoe i ka lawe ʻana iā dapagliflozin, e kāhea i kāu kauka.
  • inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o ka niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe ana ʻoe i dapagliflozin. E haʻi paha kāu kauka iā ʻoe e hōʻoki i ka lawe ʻana i ka dapagliflozin ma kahi o 3 mau lā ma mua o ke kahakaha ʻana.
  • hiki i ka wai ʻona ke hoʻololi i ke kō kō. E noi i kāu kauka e pili ana i ka hoʻohana palekana o nā inu waiʻona ʻoiai ʻoe e lawe nei i dapagliflozin.
  • pono ʻoe e ʻike ʻo dapagliflozin ke kumu o ka puʻupuʻu, ka uila, a me ka maʻule ke ala koke ʻoe mai kahi kūlana wahaheʻe. Inā loaʻa kēia pilikia iā ʻoe, e kāhea i kāu kauka. ʻOi aku ka maʻamau o kēia pilikia ke hoʻomaka mua ʻoe e lawe i dapagliflozin. I mea e hōʻalo ai i kēia pilikia, e hele mālie i waho o kahi moe, e hoʻomaha ana i kou mau wāwae i ka papahele no kekahi mau minuke ma mua o ke kū ʻana i luna.
  • e noi i kāu kauka i ka mea e hana ai inā loaʻa ʻoe i ka maʻi, hoʻomohala i kahi maʻi a i ʻole fiva, ʻike i ke koʻikoʻi koʻikoʻi ʻole, a ʻeha ʻia paha. Hiki i kēia mau kūlana ke hoʻololi i kāu kō kō a me ka nui o dapagliflozin āu e pono ai.

E mālama pono i nā hana hoʻoikaika kino a me nā papa kuhikuhi papaʻai i hana ʻia e kāu kauka a i ʻole dietitian. He mea nui ka ʻai ʻana i ka papaʻai olakino a hoʻoikaika mau.


E hāhai i nā ʻōkuhi a kāu kauka e pili ana i ka inu ʻana i nā wai i loko o ka lā a ʻoiai ʻoe ma kēia lāʻau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i kēia lāʻau ke hoʻololi i kāu kō kō. Pono ʻoe e ʻike i nā ʻōuli o ke kō a me ke kō i kō a me nā mea e hana inā loaʻa kēia mau hōʻailona iā ʻoe.

Hoʻokumu paha ʻo Dapagliflozin i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • mimiki nui loa, me ka pō hoʻi
  • hoʻonui ka make wai

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

  • pinepine, wikiwiki, wela, a i ʻole ka mimino ʻeha
  • ʻehu ke ao, ʻulaʻula, ʻulaʻula, a ʻeleʻele paha
  • mimi ikaika loa
  • hoʻemi i ka nui o ka mimi
  • ʻeha pelvic a i ʻole rectal pain
  • (i nā wahine) pilau a keʻokeʻo, keʻokeʻo a melemele paha i ka hemo (hiki i ka lumpy a i ʻole ke nānā aku e like me ka tī liʻiliʻi), a i ʻole ka huehue wahine
  • (i nā kāne) ʻulaʻula, aniani, a pehu paha o ka peni; lapuwale ma ka peni; hoʻokuʻu kīnā ʻole mai ka peni; aiʻole kaʻeha ma kaʻili a puni ka peni
  • luhi, nāwaliwali, a ʻoluʻolu ʻole paha; me ke kuni a me ka ʻeha, palupalu, ʻulaʻula, a me ka pehu ʻana o nā genital a i ʻole ka wahi ma waena o nā genital a me ka pololei.
  • pehu o nā wāwae a me nā wāwae paha

Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e hōʻoki i ka lawe ʻana i dapagliflozin a kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • hūwī
  • hives
  • ʻūlili
  • pilikia i ka hanu ʻana a i ʻole ke ale ʻana
  • pehu o ka maka, ʻāʻī, elelo, lehelehe, waha, a i ʻole nā ​​maka
  • hulahula

Inā ʻoe e ʻike i kekahi o nā ʻōuli o ketoacidosis, e hoʻōki i ka lawe ʻana i dapagliflozin a kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino. Inā hiki, e nānā i nā ketona i loko o kou mimi inā loaʻa kēia mau ʻōuli, ʻoiai inā ʻoi aku ka emi o kāu kō kō i mua o 250 mg / dL:

  • nausea
  • ka luaʻi
  • ʻeha ʻeha o ka ʻōpū
  • luhi
  • paʻakikī i ka hanu ʻana

Hoʻokumu paha ʻo Dapagliflozin i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua hoʻokolohua ma mua a i kāu wā e mālama ai e nānā i ka pane o kou kino iā dapagliflozin.

Pono e nānā pinepine i kāu mau kō kō kō e hoʻoholo ai i kāu pane iā dapagliflozin. E kauoha kāu kauka i nā hoʻokolohua lab e ae, e like me glycosylated hemoglobin (HbA1c), e nānā i kāu pane iā dapagliflozin. E haʻi aku kāu kauka iā ʻoe pehea e nānā ai i kāu pane i kēia lāʻau ma ke ana ʻana i kou kiʻekiʻe o ke kō i ka home. E hāhai pono i kēia mau ʻōkuhi.

Ma mua o ka hoʻāʻo ʻana i kahi keʻena hoʻokolohua, e haʻi i kāu kauka a me nā limahana o ke keʻena hoʻokolohua āu e lawe nei iā dapagliflozin. Ma muli o ke ʻano o ka hana ʻana o kēia lāʻau, hōʻoia paha ka mimi i ka maikaʻi o ka glucose.

Pono ʻoe e ʻaʻa mau i ke kūpeʻe kuhi diabetic e ʻike pono i ka loaʻa ʻana o kahi lāʻau kūpono i kahi ulia pōpilikia.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • Farxiga®
  • Qtern® (me ka loaʻa ʻo Dapagliflozin, Sākagliptin)
  • ʻO Qternmet® XR (loaʻa iā Dapagliflozin, Metformin, Sachagliptin)
  • Xigduo® XR (loaʻa ʻo Dapagliflozin, Metformin)
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