Ovarian overproduction o androgens

ʻO ka ovarian overproduction o androgens kahi kūlana kahi e nui ai ka testosterone i nā ovaries. Ke alakaʻi nei kēia i ka hoʻomohala ʻana o nā ʻano kāne i ka wahine. Hiki i nā Androgens mai nā ʻāpana ʻē aʻe o ke kino ke hoʻomohala i nā ʻano kāne kāne i nā wahine.

I nā wahine olakino, hana nā ovaries a me nā adrenal glands ma kahi o 40% a 50% o ka testosterone o ke kino. Hiki i nā tumors o nā ovaries a me ka polycystic ovary syndrome (PCOS) ke hana i nā androgen he nui.

ʻO ka maʻi Cushing kahi pilikia me ka pituitary gland e alakaʻi i ka nui o nā corticosteroids. Hoʻokumu ʻo Corticosteroids i ke kino o ke kāne kāne i nā wahine. Hiki i nā tumors i nā adrenal glands ke kumu i ka hana nui o androgens a hiki i ke ʻano o ke kino kāne i nā wahine.

Hiki i nā pae kiʻekiʻe o androgens i ka wahine ke kumu:

• Huehue
• Hoʻololi i ke ʻano o ke kino wahine
• Hoʻoemi i ka nui o ka umauma
• Hoʻonui i ka lauoho o ke kino i kahi ʻano kāne, e like me ka maka, ka auwae, a me ka ʻōpū
• Ka nele o nā menstrual period (amenorrhea)
• ʻIli ʻaila

E loli paha kēia mau hoʻololi:

• Hoʻonui i ka nui o ka clitoris
• Hoʻoneʻe ʻana i ka leo
• Hoʻonui i ka nui o nā mākala
• ʻO ka lauoho lahilahi a me ka nalo ʻana o ka lauoho i mua o ka maʻi poʻo ma nā ʻaoʻao ʻelua o ke poʻo

E hana i kāu mea mālama ola i kahi hoʻokolohua kino. ʻO kēlā me kēia hōʻoia o ke koko a me nā kiʻi kiʻi e kau ʻia ma kāu mau ʻōuli, akā hiki ke hoʻopili ʻia:

• 17-hydroxyprogesterone hoʻāʻo
• Hoʻoikaika ACTH (ʻokoʻa)
• Hōʻike koko Cholesterol
• CT scan
• Hōʻike koko DHEA
• Hōʻike Glucose
• Hōʻike insulina
• Pelvic ultrasound
• Hōʻike Prolactin (inā hele pinepine mai nā manawa a ʻaʻole paha)
• Hōʻike testosterone (ʻo nā testosterone manuahi a manuahi hoʻi)
• Hōʻike TSH (inā loaʻa ka lauoho)

Pili ka mālama ʻana i ka pilikia e hoʻonui ai i ka hana androgen. Hiki ke hāʻawi ʻia i nā lāʻau e hōʻemi i ka hana lauoho i nā wahine me ka lauoho o ke kino, a i ʻole e hoʻoponopono i nā pōʻai menstrual. I kekahi mau hihia, pono paha ke ʻoki e wehe i kahi tumo ovarian a adrenal paha.

ʻO ka kūleʻa hoʻomaʻamaʻa e pili ana i ke kumu o ka hana androgene nui aʻe. Inā hopena ʻia ke ʻano e kahi tumo ovarian, hiki i ke ʻoki ʻana e hemo i ka tumo ke hoʻoponopono i ka pilikia. ʻAʻole ka maʻi ʻaʻai (benign) ka hapa nui o nā puʻupuʻu ovarian a ʻaʻole e hoʻi hou ma hope o ka hemo ʻana.

I ka polycystic ovary syndrome, hiki i nā ana aʻe ke hōʻemi i nā hōʻailona i hoʻokumu ʻia e nā pae androgen kiʻekiʻe:

• Ka mālama pono ʻana
• Kaumaha emi
• Hoʻololi nā meaʻai
• Nā Lapaʻau
• ʻO ka hoʻoikaika kino ikaika

Hiki ke hānau ʻole a me nā pilikia i ka wā hāpai.

Hiki paha i nā wahine me ka polycystic ovary syndrome ke hoʻonui i ka makaʻu no:

• Diabetes
• Piʻi koko kiʻekiʻe
• Kolesterol kiʻekiʻe
• Ka momona
• Maʻi ʻaʻai Uterine

Hiki i nā wahine i loaʻa i ka polycystic ovary syndrome ke hōʻemi i kā lākou hoʻololi o nā pilikia lōʻihi ma ka mālama ʻana i kahi kaupaona maʻamau ma o ka papaʻai olakino a me ka hoʻoikaika mau.

• Nā ovaries overproductive
• Hoʻolālā Follicle

Bulun SE Physiology a me nā pathology o ka wahine hānau axis. I: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. ʻO Williams Textbook of Endocrinology. 14th ed. Piladelapia, PA: Elsevier; 2020: chap 17.

ʻO Huddleston HG, Quinn M, Gibson M. Polycystic ovary maʻi a me hirsutism. I: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. ʻO Puka Textbook of Pediatrics ʻo Nelson. 21st ed. Piladelapia, PA: Elsevier; 2020: chap 567.

Lobo RA. ʻO Hyperandrogenism a me androgen ʻoi aku: physiology, etiology, ʻike ʻano ʻokoʻa, hoʻokele. I: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Gynecology Comprehensive. ʻEpekema 7 Piladelapia, PA: Elsevier; 2017: chap 40.

ʻO Rosenfield RL, Barnes RB, Ehrmann DA. ʻO Hyperandrogenism, hirsutism, a me polycystic ovary syndrome. I: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Makua a Pediatric. ʻEpekema 7 Piladelapia, PA: Elsevier Saunders; 2016: chap 133.