He aha ka maʻi Vogt-Koyanagi-Harada

Anter

• He aha ke kumu
• Nā hōʻailona kūpono
• Pehea e hana ai i ka lāʻau

ʻO Vogt-Koyanagi-Harada Syndrome kahi maʻi maʻi laha ʻole e hoʻopili i nāʻiʻo i piha i nā melanocytes, e like me ka maka, ke kikowaena pūnaewele, ka pepeiao a me ka ʻili, e hoʻoulu ai i ka retina o ka maka, pili pinepine ʻia me nā pilikia dermatological a me ka hoʻolohe ʻana.

Kū pinepine kēia maʻi maʻi i nā ʻōpio ʻōpio ma waena o nā makahiki 20 a 40, me nā wahine ka nui o ka hopena. ʻO ka mālama ʻana i ka lawelawe ʻana o corticosteroids a me nā immunomodulator.

He aha ke kumu

ʻAʻole i ʻike ʻia ke kumu o ka maʻi, akā manaʻo ʻia he maʻi autoimmune ia, kahi e ulu ai ka huhū ma ka ʻili o nā melanocytes, e paipai ana i ka hopena inflammatory me ka nui o nā lymphocytes T.

Nā hōʻailona kūpono

Pili nā ʻōuli o kēia maʻi i ke kahua āu i loko:

Pae Prodromal

I kēia wā, ʻike ʻia nā ʻōuli ʻōnaehana e like me nā ʻōuli like ʻole o ka flu, a hele pū ʻia me nā ʻōuli neurological i hala i kekahi mau lā. ʻO nā ʻōuli maʻamau ka fever, headache, meningism, nausea, dizziness, ʻeha a puni nā maka, tinnitus, nāwaliwali o nā mākala āpau, paralysis hapa ma kekahi ʻaoʻao o ke kino, paʻakikī e haʻi pololei i nā huaʻōlelo a ʻike paha i ka ʻōlelo, photophobia, haehae, ʻili a me ke poʻo. hypersensitivity.

Pae Uveitis

I kēia manawa, predominate nā hiʻohiʻona ocular, e like me ka mumū o ka retina, hoʻemi i ka hihiʻo a i ka hopena hemo ka retina. E ʻike paha kekahi poʻe i nā ʻōuli lohe e like me tinnitus, ʻeha a me ka hōʻoluʻolu ʻole o nā pepeiao.

Pae anuʻu

I kēia wā, hōʻike ʻia nā ʻōuli a me nā dermatological, e like me vitiligo, depigmentation o nā maka maka, nā kuʻemaka, i hiki ke hala i mau mahina i mau makahiki. Mālama ʻia ʻo Vitiligo i ka symmetrically mahele ma luna o ke poʻo, ke alo a me ke kumu, a hiki ke mau.

Pae hou ʻana

I kēia manawa hiki i ka poʻe ke hoʻomohala i ka mumū mau o ka retina, cataract, glaucoma, chovidal neovascularization a me subretinal fibrosis.

Pehea e hana ai i ka lāʻau

Hoʻomaʻamaʻa ʻia ka lawelawe ʻana o nā kiʻekiʻena o nā corticosteroids e like me prednisone a i ʻole prednisolone, keu hoʻi i ka ʻāpana koʻikoʻi o ka maʻi, no 6 mau mahina. Hiki i kēia lapaʻau ke kumu i ke kūpaʻa a me ke kīnā ʻole o ke ake a ma kēia mau hihia hiki ke koho i ka hoʻohana ʻana o betamethasone a i ʻole dexamethasone.

I ka poʻe i loko o lākou nā hopena ʻino o nā corticosteroids e hoʻohana ai i nā kaha minimally kūpono ʻole unsustainable, nā immunomodulator e like me cyclosporine A, methotrexate, azathioprine, tacrolimus a i ʻole adalimumab hiki ke hoʻohana ʻia, i hoʻohana ʻia me nā hopena maikaʻi.

I nā hihia kūpaʻa i nā corticosteroids a i ka poʻe pane ʻole i ka lāʻau immunomodulatory, hiki ke hoʻohana ʻia ka immunoglobulin intravenous.