9 Nā nīnau e pili ana iā Waldenstrom Macroglobulinemia

Anter

• 1. Hiki ke mālama ʻia ʻo Waldenstrom macroglobulinemia?
• 2. Hiki iā Waldenstrom macroglobulinemia ke hele i ke kala?
• 3. Pehea ka maʻamau o Waldenstrom macroglobulinemia?
• 4. Pehea e holomua ai ʻo Waldenstrom macroglobulinemia?
• 5. Holo anei ʻo Waldenstrom macroglobulinemia i loko o nā ʻohana?
• 6. He aha ke kumu o Waldenstrom macroglobulinemia?
• 7. Pehea ka lōʻihi e hiki ai iā ʻoe ke ola me Waldenstrom macroglobulinemia?
• 8. Hiki iā Waldenstrom macroglobulinemia metastasize?
• 9. Pehea e mālama ʻia ai ʻo Waldenstrom macroglobulinemia?
• ʻO ka lawe lawe ʻana

ʻO Waldenstrom macroglobulinemia (WM) kahi ʻano laha ʻole o ka lymphoma non-Hodgkin i hōʻike ʻia e kahi overproduction o nā hunaola keʻokeʻo maʻamau.

ʻO ia kahi ʻano lohi o ka ulu ʻana o ka maʻi ʻaʻai koko e pili ana i 3 o kēlā me kēia miliona miliona i ʻAmelika Hui Pū ʻIa i kēlā me kēia makahiki, e like me ka American Cancer Society.

Kāhea ʻia ʻo WM i kekahi manawa:

• Maʻi ʻo Waldenstrom
• lymphoplasmacytic lymphoma
• macroglobulinemia kumu

Inā ua hōʻoia ʻia ʻoe me WM, he nui paha kāu mau nīnau e pili ana i kēia maʻi. Ke aʻo ʻana e like me ka hiki iā ʻoe e pili ana i ka maʻi ʻaʻai a me ka ʻimi ʻana i nā koho lapaʻau hiki ke kōkua iā ʻoe e kū me ke ʻano.

Eia nā pane i nā nīnau ʻeiwa i hiki ke kōkua iā ʻoe e hoʻomaopopo pono iā WM.

1. Hiki ke mālama ʻia ʻo Waldenstrom macroglobulinemia?

ʻAʻole i ʻike ʻia ʻo WM i kahi lā hoʻōla. Eia nō naʻe, loaʻa nā ʻano lapaʻau like ʻole e kōkua iā ʻoe e hoʻokele i kāu mau ʻōuli.

ʻO ka kuanaʻike no ka poʻe i ʻike ʻia me WM ua hoʻomaikaʻi i nā makahiki. Ke ʻimi pū nei nā kānaka ʻepekema i nā lāʻau lapaʻau e kōkua ai i ka hoʻoikaika ʻana i ka ʻōnaehana pale e hōʻole i kēia ʻano maʻi ʻaʻai a hoʻomohala i nā koho lapaʻau hou.

2. Hiki iā Waldenstrom macroglobulinemia ke hele i ke kala?

Aia kahi manawa liʻiliʻi e hiki ai iā WM ke hele i ke kala kala, akā ʻaʻole ia he ʻano maʻamau. Ua ʻike wale nā ​​kauka i ke kala piha ʻana o ka maʻi i kekahi mau poʻe. ʻAʻole hiki i nā mālama o kēia wā ke pale i ka hoʻi hou.

ʻOiai ʻaʻohe nui o ka ʻikepili e pili ana i nā uku kala, ua loaʻa i hoʻokahi haʻawina liʻiliʻi mai ka 2016 me ka WM i loko o ke kala piha loa ma hope o ka mālama ʻia ʻana me ka "R-CHOP regimen."

Ua komo i loko o ka R-CHOP regimen ka hoʻohana ʻana o:

• rituximab
• cyclophosphamide
• vincristine
• doxorubicin
• prednisone

Ua loaʻa i nā mea komo 31 kahi kala hou.

E kamaʻilio me kāu kauka e ʻike inā kūpono kēia lapaʻau iā ʻoe, a i ʻole kahi regimen ʻē aʻe.

3. Pehea ka maʻamau o Waldenstrom macroglobulinemia?

Hoʻomaopopo nā kauka he 1000 i ka 1,500 poʻe ma ʻAmelika Hui Pū ʻIa me WM i kēlā me kēia makahiki, e like me ka American Cancer Society. Manaʻo ka National Organization of Rare Disorder he ʻano maʻamau loa ia.

Hoʻololi ʻo WM i ka pālua o ka nui o nā kāne e like me ka wahine. ʻAʻole liʻiliʻi ka maʻi i waena o nā poʻe ʻeleʻele ma mua o ka poʻe keʻokeʻo.

4. Pehea e holomua ai ʻo Waldenstrom macroglobulinemia?

Hoʻolālā mālie ʻo WM i ka holomua. Hoʻokumu ia i kahi keu o kekahi ʻano o nā hunaola keokeo i kapa ʻia ʻo B lymphocytes.

Hoʻokumu kēia mau pūnaewele i kahi overabundance o kahi antibody i kapa ʻia immunoglobulin M (IgM), i kumu i ke ʻano mānoanoa o ke koko i kapa ʻia ʻo hyperviscosity. He mea paʻakikī kēia no kāu mau ʻōpala a me nā ʻaʻa e hana pono.

Hiki i kahi mea ʻoi aku o ka lymphocytes B ke waiho i kahi keʻena liʻiliʻi ma ka iwi o ka iwi no nā hunaola koko maikaʻi. Hiki paha iā ʻoe ke hoʻomohala i ka anemia inā heleleʻi haʻahaʻa ka helu o kou koko ʻulaʻula.

Hiki i ka nele o nā keokeo keokeo paʻakikī ke paʻakikī i kou kino e hakakā aku i nā ʻano maʻi ʻē aʻe. E heleleʻi paha kāu mau platelet, i hiki ai ke alakaʻi i ke kahe a me ka ʻeha.

ʻAʻole ʻike kekahi poʻe i nā hōʻailona no kekahi mau makahiki ma hope o ka hōʻoia ʻana.

ʻO nā ʻōuli mua e pili ana i ka luhi a me ka ikehu haʻahaʻa ma muli o ke anemia. Hiki paha iā ʻoe ke kani i kou mau manamana lima a me kou manamana wāwae a hoʻokahe ke koko i kou ihu a me nā ʻāʻī.

Hiki i ka WM ke hoʻopili i nā ʻōpū, e alakaʻi ana i ka pehu ʻana i ke ake, nā mānoanoa, a me nā pūnana lymph. Hiki i ka Hyperviscosity mai ka maʻi ke alakaʻi i ka ʻike maka ʻole a i ʻole nā ​​pilikia me ke kahe o ke koko i ka retina.

Hiki i ke kanesa ke hōʻeha i nā ʻōuli e like me nā ʻōuli ma muli o ke kahe o ke koko i ka lolo, a me nā pilikia puʻuwai a me nā puʻupaʻa.

5. Holo anei ʻo Waldenstrom macroglobulinemia i loko o nā ʻohana?

Ke aʻo nei nā ʻepekema iā WM, akā manaʻo lākou hiki i nā gen hoʻoilina ke hoʻonui i ka manawa o kekahi poʻe i ka maʻi.

Ma kahi o 20 pākēneka o ka poʻe me kēia ʻano maʻi ʻaʻai e pili pili loa i kekahi me WM a i ʻole kekahi maʻi ʻē aʻe e kumu i nā hunaola B maʻamau.

ʻO ka hapa nui o ka poʻe i ʻike ʻia me WM ʻaʻohe moʻolelo ʻohana o kēia maʻi. Hana ʻia ia ma ke ʻano he hopena o ka hoʻololi ʻana o ke kelepona, ʻaʻole hoʻoilina, i loko o ke ola o ke kanaka.

6. He aha ke kumu o Waldenstrom macroglobulinemia?

ʻAʻole i kuhi nā ʻepekema i ke kumu o WM. Hōʻike nā hōʻike i kahi hui o nā genetical, environment, a me nā mea viral i loko o ke ola o kekahi e alakaʻi i ka ulu ʻana o ka maʻi.

Loaʻa kahi hoʻololi o ka gen MYD88 ma kahi o 90 ka pākēneka o ka poʻe me Waldenstrom macroglobulinemia, e like me ka International Waldenstrom's Macroglobulinemia Foundation (IWMF).

Ua loaʻa kekahi mau noiʻi i ka pilina ma waena o ka maʻi hepatitis C a me WM mau loa i kekahi (akā ʻaʻole ka poʻe a pau) me ka maʻi.

ʻO ka hōʻike ʻana i nā mea i loko o ka ʻili, kāpala, nā mea hoʻoheheʻe, nā kala, a me nā mea pena i kumu paha i kekahi mau hihia o WM. Ke hoʻomau nei ka noiʻi ʻana i ke kumu o WM.

7. Pehea ka lōʻihi e hiki ai iā ʻoe ke ola me Waldenstrom macroglobulinemia?

Hōʻike nā noiʻi hou e ola ana ka hapalua o ka poʻe me WM no 14 a 16 mau makahiki ma hope o kā lākou ʻike ʻana, e like me ka IWMF.

E loli paha kāu kuanaʻike pilikino e pili ana i:

• kou mau makahiki
• olakino holoʻokoʻa
• pehea ka wikiwiki e holo ai ka maʻi

ʻAʻole like me nā ʻano maʻi ʻaʻai ʻē aʻe, ʻaʻole ʻike ʻia ʻo WM i nā pae. Ma ka hakahaka, hoʻohana nā kauka i ka ʻōnaehana scognostic scoring pūnaewele no Waldenstrom Macroglobulinemia (ISSWM) e loiloi i kāu kuana.

Lawe kēia ʻōnaehana i nā ʻano like ʻole, me kāu:

• makahiki
• pae hemoglobin koko
• helu pāpālua
• pae beta-2 microglobulin pae
• pae IgM monoclonal

Ma muli o kāu mau helu no kēia mau kumu pilikia, hiki i kāu kauka ke hoʻokau iā ʻoe i kahi hui haʻahaʻa, waena, a i ʻole pilikia kiʻekiʻe, hiki ke kōkua iā ʻoe e hoʻomaopopo pono i kāu kuana.

ʻO ka helu ola 5 mau makahiki no ka poʻe i ka pūʻulu haʻahaʻa haʻahaʻa he 87 pākēneka, ʻo ka hui waena o ka pōpilikia he 68 pākēneka, a ʻo ka pūʻulu kūlana kiʻekiʻe he 36 pākēneka, e like me ka American Cancer Society.

Hoʻokumu ʻia kēia mau helu helu i ka ʻikepili mai ka poʻe 600 i ʻike ʻia me WM a mālama ʻia ma mua o Ianuali 2002.

Hāʻawi paha nā mālama hou i kahi kuʻina ʻoi loa ka maikaʻi.

8. Hiki iā Waldenstrom macroglobulinemia metastasize?

Ae. Hoʻopili ʻo WM i kaʻiʻo lymphatic, i loaʻa ma nā ʻāpana he nui o ke kino. I ka manawa e ʻike ʻia ke kanaka me ka maʻi, hiki ke loaʻa i loko o ke koko a me ka iwi o ka iwi.

Hiki iā ia ke pālahalaha i nā lymph node, ke ake, a me ka palu. I nā hihia kakaikahi, hiki i ka WM ke metastasize i loko o ka ʻōpū, kelepaʻi thyroid, ʻili, akemāmā, a me nā ʻōpū.

9. Pehea e mālama ʻia ai ʻo Waldenstrom macroglobulinemia?

Hoʻololi ka hoʻomaʻamaʻa no WM mai kēlā me kēia kanaka a ʻaʻole hoʻomaka ka nui a ʻike ʻoe i nā ʻōuli mai ka maʻi. ʻAʻole pono kekahi poʻe i ka lāʻau lapaʻau a hiki i kekahi mau makahiki ma hope o kā lākou ʻike ʻana.

Hiki i kāu kauka ke koi aku e hoʻomaka i ka lāʻau ke loaʻa kekahi mau hopena ma muli o ke kanesa.

• maʻi maʻi hyperviscosity
• anemia
• pōʻino nerve
• pilikia o ke kino
• amyloidosis
• cryoglobulins

Loaʻa nā ʻano lapaʻau like ʻole e kōkua iā ʻoe e hoʻokele i nā ʻōuli. ʻO nā mālama maʻamau no WM e:

• plasmapheresis
• chemotherapy
• hoʻomālama mākaukau
• immunotherapy

I nā hihia kakaikahi, hiki i kāu kauka ke koi aku i nā lapaʻau maʻamau, e like me:

• ka hoʻoneʻe ʻana o ka lūlū
• transplant cell paʻa
• lāʻau pāhawewe

ʻO ka lawe lawe ʻana

Ke ʻike ʻia nei me kahi maʻi ʻaʻai laha ʻole e like me WM hiki ke lilo i ʻike nui loa.

Eia nō naʻe, ke kiʻi ʻana i ka ʻike e kōkua iā ʻoe e hoʻomaopopo pono i kāu ʻano a me nā koho lapaʻau, hiki ke kōkua iā ʻoe i ka hilinaʻi hou ʻana e pili ana i kāu kuana.