Mea Kākau: Randy Alexander
Lā O Ka Hana: 28 Apelila 2021
HōʻAno Hou I Ka Lā: 22 Iune 2024
Anonim
Further Prescribing Considerations for Glecaprevir/Pibrentasvir (Mavyret (G/P))
Wikiō: Further Prescribing Considerations for Glecaprevir/Pibrentasvir (Mavyret (G/P))

Anter

He aha ka Mavyret?

ʻO Mavyret kahi lāʻau lapaʻau inoa inoa inoa inoa e hoʻohana ʻia e mālama i ka maʻi hepatitis C maʻi mau (HCV). Hoʻopili kēia virus i kou akepaʻa a hoʻomaka i ka puhū.

Hiki ke hoʻohana ʻia ʻo Mavyret e kekahi poʻe me kekahi o nā ʻano ʻeono o ka HCV i loaʻa ʻole i ka cirrhosis (scarring ate) a i ʻole ka poʻe i uku i ka cirrhosis. Hiki nō ke hoʻohana i ka Mavyret e mālama i ka ʻano HCV 1 i ka poʻe i mālama mua ʻia (akā ʻaʻole i hoʻōla ʻia) me kahi ʻano lāʻau like ʻole.

ʻAe ʻia ʻo Mavyret no ka hoʻohana i nā mākua. Ua ʻae ʻia no ka hoʻohana ʻana i nā keiki he 12 mau makahiki a ʻoi paha, a i ʻole nā ​​mea kaupaona ma kahi o 45 kilokilo (ma kahi o 99 paona).

Hele mai ʻo Mavyret ma ke ʻano he papa hoʻokahi i loaʻa nā lāʻau antiviral ʻelua: glecaprevir (100 mg) a me pibrentasvir (40 mg). Lawe ʻia e ka waha hoʻokahi i kēlā me kēia lā.

Ka hoʻokō ʻana

I nā hoʻokolohua hoʻokolohua, nā mākua me ka HCV (ʻano 1, 2, 3, 4, 5, a me 6) i mālama ʻole ʻia no ka maʻi virus i hāʻawi ʻia iā Mavyret. ʻO kēia poʻe, 98% a 100% i hoʻōla ʻia ma hope o 8 a 12 mau pule o ka mālama ʻana. I kēia mau noiʻi ʻana, ua hoʻōla ʻia ka manaʻo o nā hōʻike koko o ka poʻe, i hana ʻia ʻekolu mau mahina ma hope o ka lapaʻau ʻana, ʻaʻole i hōʻike ʻia kahi hōʻailona o ka maʻi HCV i ko lākou kino.


No ka ʻike hou aku e pili ana i ka pono, e ʻike i ka ʻāpana ʻo "Effectiveness" ma lalo o "Mavyret for hepatitis C" ma lalo.

ʻAe ʻia e FDA

Ua ʻae ʻia ʻo Mavyret e ka Food and Drug Administration (FDA) i ʻApelila 2017 e mālama i ka maʻi hepatitis C mau loa (ʻano 1, 2, 3, 4, 5, a me 6) i nā mākua.

I ʻApelila 2019, ua hoʻonui ka FDA i ka ʻae o ka lāʻau e hoʻopili i kāna hoʻohana i nā keiki. Ua ʻae ʻia no ka hoʻohana ʻana i nā keiki he 12 mau makahiki a ʻoi paha, a i ʻole nā ​​mea kaupaona ma ka liʻiliʻi 45 kg (ma kahi o 99 lbs.).

Mavyret generic

Loaʻa ʻo Mavyret ma ke ʻano he lāʻau lapaʻau inoa. ʻAʻole i loaʻa i kēia manawa i ka palapala generic.

Loaʻa i loko o Mavyret nā lāʻau lapaʻau ʻeleu ʻeleu: glecaprevir a me pibrentasvir.

ʻO ke kumu kūʻai ʻo Mavyret

E like me nā lāʻau āpau, hiki ke hoʻololi ke kumukūʻai o Mavyret. No ka loaʻa ʻana o nā kumukūʻai o Mavyret i kēia wahi i kāu wahi, e nānā iā GoodRx.com.

ʻO ke kumukūʻai āu e ʻike ai ma GoodRx.com ka mea āu e uku ai me ka ʻole o ka ʻinikua. ʻO ke kumukūʻai maoli āu e uku ai ma muli o kāu hoʻolālā ʻinikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.


Kōkua kālā a me nā ʻinikua

Inā makemake ʻoe i kākoʻo kālā e uku no Mavyret, a inā ʻoe e kōkua i ka hoʻomaopopo ʻana i kāu ʻinikua uhi, loaʻa ke kōkua.

Hāʻawi ʻo Abbvie, ka mea hana a Mavyret i kahi papahana i kapa ʻia ʻo Mavyret Patient Support, a hāʻawi paha i ke kōkua e hoʻohaʻahaʻa i kāu kumukūʻai o ka lāʻau. No ka ʻike hou aku a e ʻike inā he kūpono ʻoe no ke kākoʻo, kāhea iā 877-628-9738 a i ʻole kipa i ka pūnaewele pūnaewele.

Nā hopena ʻaoʻao Mavyret

Hiki i ka Mavyret ke hana i nā hopena ʻoluʻolu a koʻikoʻi paha. Loaʻa i nā papa inoa aʻe kekahi o nā hopena ʻaoʻao nui i hiki ke hana ʻia i ka lawe ʻana iā Mavyret. ʻAʻole pili kēia mau papa inoa i nā hopena ʻaoʻao āpau.

No ka ʻike hou aku e pili ana i nā hopena ʻē aʻe o Mavyret, e kamaʻilio me kāu kauka a kauka paha. Hiki iā lākou ke hāʻawi iā ʻoe i nā ʻōlelo aʻoaʻo e pili ana i ka hana me nā hopena ʻē aʻe e hoʻonāukiuki paha.

Nā hopena ʻaoʻao hou aʻe

Hiki i nā hopena ʻaoʻao maʻamau o Mavyret ke hoʻopili pū:

  • ʻeha poʻo
  • luhi nei
  • nausea
  • pāhoehoe
  • pae bilirubin kiʻekiʻe (kahi hōʻike lab e nānā i kāu hana ate)

E hala paha ka hapa nui o kēia mau hopena i loko o kekahi mau lā a i ʻole ʻelua mau pule. Inā ʻoi aku ke koʻikoʻi a i ʻole hele aku, e kamaʻilio me kāu kauka a kauka paha.


Nā hopena hopena koʻikoʻi

ʻAʻole maʻamau nā hopena koʻikoʻi mai Mavyret, akā hiki iā lākou ke hana. Kāhea koke i kāu kauka inā loaʻa nā hopena koʻikoʻi. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Nā hopena ʻino, e kūkākūkā ʻia ma lalo nei ma "Nā kikoʻī o ka ʻaoʻao," e hoʻopili me kēia:

  • hepatitis B mea hoʻomaʻi reactivation (kahi lapalapa o ka maʻi, inā ʻo ia i loko o kou kino) *
  • hopena hopena maʻi ʻino

Nā kikoʻī hopena ʻaoʻao

Mahalo paha ʻoe i ka hopena o kekahi mau hopena ʻē aʻe me kēia lāʻau, a i ʻole pili paha kekahi mau ʻaoʻao iā ia. Eia kekahi mau kikoʻī e pili ana i kekahi o nā hopena i hiki ʻole ai i kēia lāʻau.

Ka hopena hoʻowali

E like me ka nui o nā lāʻau, hiki i kekahi poʻe ke loaʻa i kahi hopena maʻi ma hope o ka lawe ʻana iā Mavyret. ʻAʻole maopopo ia i ka manawa pinepine e lawe ai ka poʻe i kēia lāʻau i kahi hopena maʻi. Hiki i nā ʻōuli o ke ʻano ʻāpiki mālie ke hoʻopili pū i:

  • ʻāwīwī o ka ʻili
  • ʻumeʻume
  • flushing (hoʻomehana a ʻulaʻula i kou ʻili)

Kākaʻikahi ka hopena maʻi ʻino ʻoi aku ka paʻakikī akā hiki. Hiki i nā ʻōuli o ke kūpilikiʻi ʻāpiki loa ke hoʻopili pū me

  • ʻōhū ma lalo o kou ʻili, maʻamau i kou lihilihi, lehelehe, lima, a mau wāwae paha
  • pehu o kou alelo, waha, a ʻāʻī paha
  • pilikia i ka hanu ʻana a i ʻole ka ʻōlelo ʻana

Kāhea koke i kāu kauka inā loaʻa iā ʻoe kahi maʻi maʻi ʻino iā Mavyret. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Kāwili

ʻIke paha ʻoe i ka ʻūlū ʻoiai ʻoe e hoʻohana ana iā Mavyret.I nā hoʻokolohua hoʻokolohua, ua ʻili kekahi poʻe i ka lawe ʻana i kēia lāʻau. ʻIke pinepine ʻia ka ʻūlū wale i ka poʻe e lawe ana i ka lāʻau i loaʻa i nā maʻi puʻuwai mau a me ka maʻi hepitis C (HCV). I kēia hui, ma kahi o 17% o ka poʻe i hōʻike i ka aniani ma ke ʻano he hopena.

ʻO ka makaʻu kekahi manawa kahi hōʻailona e HCV. Kū ka ʻūlū ma kahi o 20% o ka poʻe me HCV. Ma muli paha o ke kūkulu ʻia ʻana o kahi kemika i kapa ʻia bilirubin i loko o kou kino. ʻO ka makaʻu e ka HCV ma kahi wahi a i ʻole ma kou kino holoʻokoʻa.

Inā he hopohopo kou e pili ana i ka loaʻa ʻana o ka ʻili makaʻu ʻoiai ʻoe e lawe nei iā Mavyret, e kamaʻilio me kāu kauka. Hiki iā lākou ke koi i nā ala e kōkua ai e hōʻemi i kēia hopena a ke hoʻohana nei ʻoe i ka lāʻau.

Hepatitis B reactivation

Hiki paha iā ʻoe ke hoʻonui i ka makaʻu o ka maʻi hepatitis B (HBV) reactivation (flare-up) ʻoiai ʻoe e lawe nei iā Mavyret.

Hoʻonui ka mālama Mavyret i ka makaʻu o ka HBV reactivation i ka poʻe me ka HBV a me ka HCV. I nā hihia koʻikoʻi, hiki i ka reactivation o HBV ke kumu i ka holo ʻole o ka ate a i ʻole ka make.

Hiki i nā ʻōuli o ka HBV reactivation ke hoʻopili pū:

  • ʻeha ma ka ʻaoʻao ʻākau o kou ʻōpū
  • pahu noho kukui
  • luhi nei
  • melemele o kou ʻili a i ʻole nā ​​keʻokeʻo o kou mau maka

Ma mua o ka hoʻomaka ʻana iā Mavyret, e hoʻāʻo kāu kauka iā ʻoe no HBV. Inā loaʻa iā HBV, pono ʻoe e mālama ʻia ma mua o kou hoʻomaka ʻana e lawe iā Mavyret. A i ʻole hiki i kāu kauka ke koi aku i ka hoʻāʻo ʻana i ka wā o kāu mālama Mavyret e nānā ai no ka hoʻohou hou ʻana o ka HBV a mālama i ke ʻano inā pono.

Hoʻololi ke kaupaona (ʻaʻole kahi hopena)

ʻAʻole i hōʻike ʻia ka pohō kaumaha a me ka loaʻa kaumaha ma ke ʻano he hopena o Mavyret i ka wā o nā hoʻokolohua hoʻokolohua. Eia nō naʻe, hiki i ka Mavyret ke kumu i ka nausea, i hiki ai ke alakaʻi i ka pohō kaumaha i kekahi poʻe. Inā huhū ʻoe i ka lawe ʻana i kēia lāʻau, ʻai paha ʻoe i ka liʻiliʻi o ka meaʻai, a ʻo ia ka hopena o ka pohō kaumaha.

Inā he hopohopo kāu e pili ana i ka loaʻa ʻana o ke kaumaha a i ʻole ka pohō kaumaha ʻoiai ʻoe e lawe nei iā Mavyret, e kamaʻilio me kāu kauka. Hiki iā lākou ke kōkua iā ʻoe e hoʻolālā i kahi papaʻai olakino i kou wā lapaʻau.

ʻ Skinhū ʻili (ʻaʻole kahi hopena)

ʻAʻole i hōʻike ʻia ka ʻili o ka ʻili ma ke ʻano he hopena o Mavyret i ka wā o nā hoʻokolohua hoʻokolohua. Eia nō naʻe, hiki i ka HCV ponoʻī ke hoʻonā i ka ʻili i kekahi manawa. Kuhihewa paha kēia no ka hopena o ka lāʻau. ʻO ka ʻōpala i hoʻokumu ʻia e HCV hiki ma nā wahi āpau o kou kino, me kou alo, umauma, a me nā lima. Hoʻonani paha ʻoe iā ʻoe.

Inā he ʻeha kou i ka wā e hoʻohana ana iā Mavyret, e kamaʻilio me kāu kauka. Hiki iā lākou ke ʻōlelo i nā ala e hōʻemi ai i kāu mau ʻōuli a koi i ka mālama inā pono.

Nā hopena ʻē aʻe i nā keiki

I ka wā o nā noiʻi maʻi ʻana, ʻike ʻia nā hopena i nā keiki (nā makahiki 12 a 17) e lawe ana iā Mavyret e like me nā hopena i ʻike ʻia i nā mākua e lawe nei i ka lāʻau. I kēia mau haʻawina, ʻaʻohe keiki i hōʻoki i ka mālama ʻana ma muli o nā hopena ʻaoʻao.

ʻO nā hopena ʻē aʻe i ʻike ʻia i nā keiki e komo pū ana:

  • luhi nei
  • nausea
  • ʻeha poʻo
  • pae bilirubin kiʻekiʻe (kahi hōʻike lab e nānā i kāu hana ate)

Inā ʻoe hopohopo e pili ana i nā hopena i loaʻa i kahi keiki e hoʻohana ana iā Mavyret, e kamaʻilio me kāu kauka. Hiki paha iā lākou ke ʻōlelo i nā ala e hōʻemi ai i kēia mau hopena i ka wā o ka mālama ʻana.

Mākaha Mavyret

Hōʻike ka ʻikepili aʻe i nā lāʻau i hoʻohana pinepine ʻia a koi ʻia paha. Eia nō naʻe, e mālama pono i nā lāʻau a ke kauka i kuhikuhi ai nāu. E hoʻoholo kāu kauka i ke ana ʻoi loa e kūpono i kāu mau pono.

Nā ʻano lāʻau a me nā ikaika

Hele mai ʻo Mavyret ma ke ʻano he papa i lawe ʻia e ka waha. Loaʻa i kēlā me kēia papa ka 100 mg o glecaprevir a me 40 mg o pibrentasvir.

Nā hana no ka maʻi hepitis C

ʻO nā mahele o Mavyret no ka maʻi hepitis C maʻi mau (HCV) ʻekolu papa i lawe ʻia e ka waha hoʻokahi i kēlā me kēia lā. Lawe ʻia kēia lāʻau i ka meaʻai. Lawe ʻia ia ma kahi o ka manawa like i kēlā me kēia lā.

E hoʻoholo kāu kauka i ka lōʻihi e pono ai ʻoe e lawe iā Mavyret. Pili kēia hoʻoholo i nā mālama ʻana o ka HCV ma mua āu i hoʻohana ai.

Hiki ke ʻokoʻa ka lōʻihi o ka hoʻomaʻamaʻa ʻana o kēlā me kēia kanaka, akā lawe ka hapa nui o ka poʻe iā Mavyret ma kahi o 8 mau pule a 16 mau pule. ʻO ka lōʻihi maʻamau o Mavyret lapaʻau penei:

  • Inā ʻaʻole ʻoe i mālama ʻia no HCV, a ʻaʻohe ou cirrhosis (scarring ate), e mālama ʻia paha ʻoe no 8 mau pule.
  • Inā ʻaʻole ʻoe i mālama ʻia no HCV, a ua uku ʻia ʻoe (cirrhosis) (akahai), e mālama ʻia paha ʻoe no 12 mau pule.
  • Inā ua mālama mua ʻia ʻoe no HCV, a ʻaʻole maikaʻi kāu mālama ʻana (ʻaʻole hoʻōla i kāu maʻi), hiki ke loli kou lōʻihi o ka mālama ʻana me Mavyret. E mau paha ma kahi o 8 mau pule a 16 mau pule. ʻO ka lōʻihi pololei o kāu mālama ʻana e kaukaʻi ʻia i nā ʻano lawelawe HCV āu i hoʻohana ai i ka wā i hala.

Inā he nīnau kāu e pili ana i ka lōʻihi e pono ai ʻoe e lawe iā Mavyret, e kamaʻilio me kāu kauka. Hiki iā lākou ke paipai i ka hoʻolālā lapaʻau maikaʻi loa nāu.

ʻĀpana pēpē

ʻO ke ana pediatric o Mavyret ka mea like me ia no nā mākua: ʻekolu papa i lawe ʻia e ka waha (me ka meaʻai) hoʻokahi i kēlā me kēia lā. Pili ka lāʻau pediatric i nā keiki:

  • nā makahiki 12 a 17 mau makahiki, a i ʻole
  • nā mea kaupaona ma ka liʻiliʻi 45 kg (ma kahi o 99 paona)

ʻAʻole ʻae ʻia ʻo Mavyret i kēia manawa no ka hoʻohana ʻana i nā keiki ma mua o 12 mau makahiki a i ʻole i nā mea kaupaona ʻo 45 kg.

He aha inā e haʻo wau i kahi lāʻau?

Inā ʻike ʻoe i kahi mahele lāʻau o Mavyret, eia ka mea āu e hana ai:

  • Inā he emi ma lalo o 18 mau hola mai ka wā āu e lawe ai iā Mavyret, hele i mua a lawe i kāu lāʻau i kou wā e hoʻomanaʻo ai. A laila, e lawe i kāu kau ma hope aʻe i ka manawa maʻamau.
  • Inā ʻoi aku ma mua o 18 mau hola mai ka wā pono ʻoe e lawe iā Mavyret, e lele wale i kēlā lāʻau. Hiki iā ʻoe ke lawe i kāu lāʻau aʻe ma ka manawa maʻamau.

I mea e ʻike pono ʻaʻole ʻoe e haʻalele i kahi lāʻau, e hoʻāʻo e kau i kahi hoʻomanaʻo ma kāu kelepona. He mea pono nō hoʻi ka wati lāʻau.

Pono wau e hoʻohana i kēia lāʻau lōʻihi?

ʻO ka lōʻihi o ka manawa āu e pono ai e lawe iā Mavyret e pili ana i nā mea ʻelua. Hoʻopili kēia inā ua mālama mua ʻia ʻoe no ka HCV ma mua, a inā loaʻa iā ʻoe kekahi scarring ate (cirrhosis).

ʻO ka maʻamau, ʻo ka mālama ʻana me Mavyret ma kahi o 8 a 16 mau pule. ʻAʻole lōʻihi ka lōʻihi ma mua o 16 mau pule.

Mavyret a me ka waiʻona

ʻAʻohe o Mavyret i ʻike i ka launa pū me ka ʻalekohola. Eia nō naʻe, ʻaʻole pono ʻoe e inu i ka waiʻona inā loaʻa ʻoe i ka maʻi hepitis C (HCV). Hoʻonui ka waiʻona i ka HCV, a hiki i ka scarring nui (cirrhosis) i kou ake.

Inā inu ʻoe i ka waiʻona, a hopohopo ʻoe e pili ana i ka hoʻōki ʻana i ka inu, e kamaʻilio me kāu kauka.

Nā koho ʻē aʻe iā Mavyret

Loaʻa nā lāʻau ʻē aʻe i hiki ke mālama i ka maʻi hepatitis C maʻi mau (HCV). Kūpono paha kekahi iā ʻoe ma mua o nā poʻe ʻē aʻe. Inā makemake ʻoe i ka ʻimi ʻana i kahi ʻē aʻe i Mavyret, e kamaʻilio me kāu kauka. Hiki iā lākou ke haʻi iā ʻoe e pili ana i nā lāʻau ʻē aʻe i hana maikaʻi iā ʻoe.

ʻO nā lāʻau lapaʻau ʻē aʻe, i piha i ka hui pū ʻia o nā lāʻau antiviral e mālama iā HCV, me nā mea aʻe:

  • ledipasvir and sofosbuvir (Harvoni)
  • sofosbuvir a me velpatasvir (Epclusa)
  • velpatasvir, sofosbuvir, a me voxilaprevir (Vosevi)
  • elbasvir and grazoprevir (Zepatier)
  • simeprevir (Olysio) a me sofosbuvir (Sovaldi)

ʻOiai ʻaʻole lākou i hele mai ma ke ʻano he lāʻau hoʻohuihui, Simeprevir (Olysio) a me sofosbuvir (Sovaldi) i lawe pū ʻia e mālama iā HCV.

Mavyret vs. Harvoni

Mahalo paha ʻoe pehea e hoʻohālikelike ai ʻo Mavyret i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai i ka like a like ʻole o Mavyret lāua ʻo Harvoni.

E pili ana i

Aia ʻo Mavyret i nā lāʻau glecaprevir a me pibrentasvir. Loaʻa iā Harvoni nā lāʻau ledipasvir a me sofosbuvir. Loaʻa i loko o Mavyret a me Harvoni kahi hui pū o nā antivirals, a pili lākou i ka papa like o nā lāʻau.

Hoʻohana

ʻAe ʻia ʻo Mavyret e mālama i ka maʻi hepatitis C maʻi mau (HCV) i nā mākua. Ua ʻae ʻia no ka hoʻohana ʻana i nā keiki he 12 mau makahiki a ʻoi paha, a i ʻole nā ​​mea kaupaona ma ka liʻiliʻi 45 kg, ma kahi o 99 lbs.

Hoʻohana ʻia ʻo Mavyret e mālama i nā ʻano āpau (1, 2, 3, 4, 5, a me 6) o ka HCV i ka poʻe:

  • me ka scarring ate (cirrhosis), a i ʻole i ka poʻe i loaʻa i ka cirrhosis me ka ʻole o nā ʻōuli o ke ʻano
  • ka poʻe i loaʻa i ke ake a i ʻole ke kuʻina kōpaʻa
  • i loaʻa ka maʻi HIV

Hiki nō ke hoʻohana i ka Mavyret e mālama i ka ʻano HCV 1 i ka poʻe i mālama mua ʻia (akā ʻaʻole i hoʻōla ʻia) me kahi ʻano lāʻau like ʻole.

Ua ʻae ʻia ʻo Harvoni e mālama iā HCV i nā mākua. Hiki ke hoʻohana ʻia e mālama i nā ʻano o ka HCV:

  • ʻano 1, 2, 5, a i ʻole 6 i ka poʻe me ka ʻaʻa ʻole o ka ake (cirrhosis), a i ʻole i ka poʻe i loaʻa ka cirrhosis me ka ʻole o nā ʻōuli o ke ʻano.
  • ʻano 1 i ka poʻe i loaʻa i ka cirrhosis me nā ʻōuli o ke ʻano (i kēia mau kānaka, e hui pū ʻia ʻo Harvoni me ka ribavirin)
  • kikokiko 1 a i ʻole 4 i nā poʻe i loaʻa i ka hoʻoliʻiliʻi o ke ake, a ʻaʻohe paha ʻehaʻeha o ke ake, a i ʻole nā ​​scarring ate me ka ʻole o nā ʻōuli (i kēia mau poʻe, e hui pū ʻia ʻo Harvoni me ribavirin

Ua ʻae ʻia ʻo Harvoni no ka hoʻohana ʻana i nā keiki he 12 mau makahiki a ʻoi paha, a i ʻole nā ​​mea kaupaona ma kahi o 35 kg, ma kahi o 77 lbs. Hiki ke hoʻohana ʻia i nā keiki aʻe:

  • nā mea me nā ʻano HCV 1, 4, 5, a i ʻole 6
  • nā keiki me ka ʻili ʻole o ke ake (cirrhosis), a i ʻole nā ​​mea me ka cirrhosis akā ʻaʻohe o lākou ʻōuli o ke ʻano

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Mavyret ma ke ʻano he papa, i lawe ʻia e ka waha (me ka meaʻai) hoʻokahi i kēlā me kēia lā. Hāʻawi pinepine ʻia ia no ka manawa o 8, 12, a i ʻole 16 mau pule e pili ana i kāu mōʻaukala lapaʻau a me ke koʻikoʻi o kou maʻi ate.

Hele mai ʻo Harvoni e like me nā papa, i lawe ʻia e ka waha (me ka ʻole o ka meaʻai) hoʻokahi i kēlā me kēia lā. Hāʻawi pinepine ʻia ma kahi o 8, 12, a i ʻole 24 mau pule e pili ana i kāu mōʻaukala lapaʻau a me ke ʻano o kou ake.

Nā hopena a me nā pilikia

ʻAʻole loaʻa iā Mavyret lāua ʻo Harvoni nā lāʻau like, akā he ʻāpana ia o ka papa like o nā lāʻau. Hiki i kēia mau lāʻau lapaʻau ke kumu i nā hopena ʻaoʻao like a me nā ʻano ʻaoʻao ʻokoʻa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Mavyret, me Harvoni, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Mavyret:
    • pāhoehoe
    • pae bilirubin kiʻekiʻe (kahi hōʻike lab e nānā i kāu hana ate)
  • Hiki iā Harvoni ke hana:
    • nawaliwali ana
    • hiamoe (pilikia hiamoe)
    • ʻūhā
    • huhū
  • Hiki ke hana me Mavyret lāua ʻo Harvoni:
    • ʻeha poʻo
    • luhi nei
    • nausea

Nā hopena hopena koʻikoʻi

Nā hopena ʻē aʻe hiki ke kū ʻia me Mavyret a me Harvoni (ke lawe ʻokoʻa ʻia) me nā mea aʻe:

  • hepatitis B mea hoʻomaʻi reactivation (kahi lapalapa o ka maʻi, inā ʻo ia i loko o kou kino) *
  • hopena hopena maʻi ʻino

Ka hoʻokō ʻana

Ua ʻae ʻia ʻo Mavyret lāua ʻo Harvoni e mālama i ka maʻi hepatitis C mau loa (HCV). Eia nō naʻe, ʻoi aku paha ka hopena o kekahi lāʻau lapaʻau ma mua o nā mea ʻē aʻe, kaukaʻi ʻia i ke ʻano o ka HCV āu a inā paha he scarring ate (cirrhosis) kāu.

ʻAʻole i hoʻohālikelike pololei ʻia kēia mau lāʻau i nā noiʻi maʻi. Akā ua loaʻa i kahi ʻimi noiʻi ʻokoʻa ka maikaʻi o ka Mavyret a me Harvoni i ka mālama ʻana iā HCV.

Nā kumukūʻai

ʻO Mavyret lāua ʻo Harvoni nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe ʻano generic o nā lāʻau āpau i kēia manawa. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma GoodRx.com, ʻo Mavyret lāua ʻo Harvoni ke kumu kūʻai like e pili ana. ʻO ke kumukūʻai maoli āu e uku ai no kēlā me kēia lāʻau e pili ana i kāu hoʻolālā ʻinikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.

Mavyret vs. Epclusa

Mahalo paha ʻoe pehea e hoʻohālikelike ai ʻo Mavyret i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai i ka like a like ʻole o Mavyret lāua ʻo Epclusa.

E pili ana i

Aia ʻo Mavyret i nā lāʻau glecaprevir a me pibrentasvir. Loaʻa iā Epclusa nā lāʻau velpatasvir a me sofosbuvir. Loaʻa i loko o Mavyret a me Epclusa kahi hui pū ʻana o nā lāʻau antiviral, a pili like lāua i ka papa like o nā lāʻau.

Hoʻohana

ʻAe ʻia ʻo Mavyret e mālama i ka maʻi hepatitis C maʻi mau (HCV) i nā mākua. Ua ʻae ʻia no ka hoʻohana ʻana i nā keiki he 12 mau makahiki a ʻoi paha, a i ʻole nā ​​mea kaupaona ma ka liʻiliʻi 45 kg, ma kahi o 99 lbs.

Hoʻohana ʻia ʻo Mavyret e mālama i nā ʻano āpau (1, 2, 3, 4, 5, a me 6) o ka HCV i ka poʻe:

  • me ka scarring ate (cirrhosis), a i ʻole i ka poʻe i loaʻa i ka cirrhosis me ka ʻole o nā ʻōuli o ke ʻano
  • ka poʻe i loaʻa i ke ake a i ʻole ke kuʻina kōpaʻa
  • i loaʻa ka maʻi HIV

Hiki nō ke hoʻohana i ka Mavyret e mālama i ka ʻano HCV 1 i ka poʻe i mālama mua ʻia (akā ʻaʻole i hoʻōla ʻia) me kahi ʻano lāʻau like ʻole.

E like me Mavyret, ʻae ʻia ʻo Epclusa e mālama i ka HCV mau loa i hoʻokumu ʻia e nā ʻano maʻi āpau (ʻano 1, 2, 3, 4, 5, a me 6). Hoʻohana ʻia ia i nā mākua ʻaʻohe ona ʻili ate (cirrhosis), a i ʻole me nā maʻi ʻōpaʻa o ke akepaʻa ʻaʻohe o nā ʻōuli o ke ʻano.

Hiki ke hoʻohana ʻia ʻo Epclusa i nā mākua me ka cirrhosis i loaʻa nā ʻōuli o ke ʻano.

ʻAʻole ʻae ʻia ʻo Epclusa e hoʻohana i nā keiki.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Mavyret ma ke ʻano he papa, i lawe ʻia e ka waha (me ka meaʻai) hoʻokahi i kēlā me kēia lā. Hāʻawi pinepine ʻia ia no ka manawa o 8, 12, a i ʻole 16 mau pule e pili ana i kāu mōʻaukala lapaʻau a me ke koʻikoʻi o kou maʻi ate.

Hele mai ʻo Epclusa ma ke ʻano he papa, i lawe ʻia e ka waha i hoʻokahi manawa i kēlā me kēia lā. Hiki ke lawe ʻia ʻo Epclusa me ka ʻole o ka meaʻai. Hāʻawi pinepine ʻia ia no 12 mau pule.

Nā hopena a me nā pilikia

ʻAʻohe lāʻau like ʻo Mavyret lāua ʻo Epclusa i loko o lāua. Eia nō naʻe, pili lākou i ka papa like o nā lāʻau. No laila, hiki i nā lāʻau ʻelua ke hana i nā hopena ʻaoʻao like. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Mavyret, me Epclusa, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Mavyret:
    • pāhoehoe
    • pae bilirubin kiʻekiʻe (kahi hōʻike lab e nānā i kāu hana ate)
  • Hiki ke hana me Epclusa:
    • nawaliwali ana
    • hiamoe (pilikia hiamoe)
  • Hiki ke hana me Mavyret a me Epclusa:
    • ʻeha poʻo
    • luhi nei
    • nausea

Nā hopena hopena koʻikoʻi

Nā hopena ʻē aʻe hiki ke kū ʻia me Mavyret a me Epclusa (ke lawe ʻia i hoʻokahi) me kēia mau mea:

  • hepatitis B mea hoʻomaʻi reactivation (kahi lapalapa o ka maʻi, inā ʻo ia i loko o kou kino) *
  • hopena hopena maʻi ʻino

Ka hoʻokō ʻana

Hoʻohana ʻia ʻo Mavyret lāua ʻo Epclusa e mālama i nā ʻano ʻono o ka HCV mau. Koi paha kāu kauka iā ʻoe e lawe iā Epclusa a i ʻole Mavyret ma muli o ke ʻano o ka HCV āu i loaʻa ai a me ke ʻano o kou ake.

ʻAʻole i hoʻohālikelike pololei ʻia kēia mau lāʻau i nā noiʻi maʻi. Akā ua loaʻa i kahi ʻimi noiʻi ʻokoʻa ka maikaʻi o ka Mavyret a me Epclusa i ka mālama ʻana iā HCV.

Nā kumukūʻai

ʻO Mavyret lāua ʻo Epclusa nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe ʻano generic o nā lāʻau āpau i kēia manawa. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma GoodRx.com, ʻo Mavyret lāua ʻo Epclusa ke kumu kūʻai like. ʻO ke kumukūʻai maoli āu e uku ai no kēlā me kēia lāʻau e pili ana i kāu hoʻolālā ʻinikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.

ʻO Mavyret no ka maʻi hepa C

Ua ʻae ka Food and Drug Administration (FDA) i nā lāʻau i kuhikuhi ʻia e like me Mavyret e mālama i kekahi mau ʻano.

Ua ʻae ʻia ʻo Mavyret e mālama i nā maʻi kūlohelohe i hoʻokumu ʻia e ka maʻi hepatitis C (HCV). Hoʻopili kēia virus i kou akepaʻa a hoʻokumu i ka mumū, a hiki i kekahi manawa ke alakaʻi i ka scarring ate (i kapa ʻia ʻo cirrhosis). Hiki i ka HCV ke hana i nā hōʻailona e like me:

  • melemele o kou ʻili a keʻokeʻo o kou mau maka
  • wai kahe i loko o kou ʻōpū
  • fiva
  • nā pilikia lōʻihi, e like me ke kō ʻole o ke ake

Hoʻolahalaha ʻia ʻo HCV ma o ke koko i pā ʻia i ka maʻi. Lawe (hoʻolaha) hana pinepine ʻia ma o ka poʻe e kaʻana like ana i nā nila kuʻikuʻi me kekahi. Wahi a nā Centers for Disease Control and Prevention (CDC), i ka makahiki 2016 ma kahi o 2.4 miliona mau kānaka ma ʻAmelika Hui Pū ʻIa i loaʻa he hepatitis C. mau.

Ua ʻae ʻia ʻo Mavyret e mālama iā HCV i nā mākua. Ua ʻae ʻia no ka hoʻohana ʻana i nā keiki he 12 mau makahiki a ʻoi paha, a i ʻole nā ​​mea kaupaona ma ka liʻiliʻi 45 kg, ma kahi o 99 lbs. Hoʻohana ʻia e mālama i nā ʻano HCV āpau (1, 2, 3, 4, 5, a me 6) i nā kānaka:

  • me ka scarring ate (cirrhosis), a i ʻole i ka poʻe i loaʻa ka cirrhosis me ka ʻole o nā ʻōuli o ke ʻano (i kapa ʻia ʻo cirrhosis compensated)
  • ka poʻe i loaʻa i ke ake a i ʻole ke kuʻina kōpaʻa
  • i loaʻa ka maʻi HIV

Hiki nō ke hoʻohana i ka Mavyret e mālama i ka ʻano HCV 1 i ka poʻe i mālama mua ʻia (akā ʻaʻole i hoʻōla ʻia) me kahi ʻano lāʻau like ʻole.

Ka hoʻokō ʻana

I nā hoʻokolohua hoʻokolohua, nā mākua me ka HCV (ʻano 1, 2, 3, 4, 5, a me 6) i mālama ʻole ʻia no ka maʻi virus i hāʻawi ʻia iā Mavyret. ʻO kēia poʻe, 98% a 100% i hoʻōla ʻia ma waena o 8 a 12 mau pule o ka mālama. I kēia mau noiʻi ʻana, ua hoʻōla ʻia ka manaʻo o nā hōʻike koko o ka poʻe, i hana ʻia ʻekolu mau mahina ma hope o ka lapaʻau ʻana, ʻaʻole i hōʻike ʻia kahi hōʻailona o ka maʻi HCV i ko lākou kino.

ʻO nā poʻe āpau i ke aʻo ʻana (ʻo ka poʻe i mālama mua ʻia no ka HCV a me ka poʻe ʻaʻole i mālama ʻia), ma waena o 92% a me 100% i hoʻōla ʻia e ka HCV. Ua loli nā hopena ma muli o ka mālama ʻia ʻana o ka poʻe ma mua a me ke ʻano o ka HCV i loaʻa iā lākou.

Hoʻohālikelike nā hoʻokolohua hoʻokolohua iā Mavyret i ka hui pū ʻana o nā lāʻau antiviral ʻelua i kapa ʻia sofosbuvir (Sovaldi) a me daclatasvir (Daklinza). Nānā hoʻokahi haʻawina i ka poʻe me ka HCV ʻano 3, ʻaʻole lākou i mālama ʻia ma mua. ʻAʻole i loaʻa i kēia poʻe ka makaʻu o ka ate (cirrhosis).

Ma hope o 12 mau hebedoma, 95.3% o ka poʻe e lawe ana iā Mavyret i manaʻo ʻia ua hoʻōla ʻia (ʻaʻohe o lākou virus HCV i kā lākou hōʻike koko). ʻO kēlā mau mea e lawe nei i ka sofosbuvir a me daclatasvir, he 96.5% ka hopena like.

Mavyret no nā keiki

ʻAe ʻia ʻo Mavyret e mālama iā HCV i nā keiki he 12 mau makahiki a ʻoi paha, a i ʻole nā ​​mea kaupaona ma kahi o 45 kg, ma kahi o 99 lbs.

Nā pilina Mavyret

Hiki i ka Mavyret ke launa pū me nā lāʻau ʻē aʻe. Hiki iā ia ke launa pū me kekahi mau mea hoʻohui.

Hiki i nā launa like ʻole ke kumu i nā hopena like ʻole. ʻO kahi laʻana, hiki i kekahi mau pilina ke hoʻopilikia me ka maikaʻi o ka hana ʻana o ka lāʻau. Hiki i nā pilina ʻē aʻe ke hoʻonui i nā hopena a i ʻole e hoʻonui i ke koʻikoʻi.

Mavyret a me nā lāʻau ʻē aʻe

Ma lalo nā papa inoa o nā lāʻau i hiki ke launa pū me Mavyret. ʻAʻole i loko o kēia mau papa inoa nā lāʻau āpau e launa pū me Mavyret.

Ma mua o ka lawe ʻana iā Mavyret, e kamaʻilio me kāu kauka a me kāu kauka lāʻau. E haʻi iā lākou e pili ana i nā kuhikuhi āpau, nā mea kūʻai aku, a me nā lāʻau ʻē aʻe āu e lawe ai. E haʻi pū iā lākou e pili ana i nā wikamina, nā mea kanu, a me nā mea hoʻopiha āu e hoʻohana ai. Hiki ke kōkua i ka hāʻawi ʻana i kēia ʻike iā ʻoe e hōʻalo i nā launa ʻole.

Inā he mau nīnau kāu e pili ana i nā launa lāʻau e hoʻopili iā ʻoe, e nīnau i kāu kauka a kauka paha.

Mavyret a me ka carbamazepine (Tegretol)

Lawe i ka carbamazepine me Mavyret hiki ke hoʻemi i ka nui o Mavyret i kou kino. Hiki iā ia ke kumu i ka hana ʻole o ka lāʻau, i alakaʻi ʻia ai i kāu maʻi maʻi hepatitis C (HCV) i mālama ʻole ʻia. He mea nui e hōʻole ʻole i ka lawe pū ʻana i ka carbamazepine a me Mavyret.

Mavyret a me warfarin (Coumadin)

Lawe i ka warfarin me Mavyret hiki ke hoʻololi i ka pae o warfarin i kou kino. Hiki i kēia ke alakaʻi i nā loli i ka mānoanoa o kou koko, e lilo i lahilahi a mānoanoa paha. Inā kū kēia, e makaʻu paha ʻoe no kekahi mau pilikia, e like me ke kahe ʻana o ke koko a i ʻole ke loaʻa ʻana o ke koko.

Inā lawe ʻoe iā Mavyret me warfarin, he mea nui ia e hana pinepine i nā hoʻokolohua koko e nānā i ka mānoanoa o kou koko. Inā pono ʻoe e lawe pū i kēia mau lāʻau, e paipai kāu kauka i nā ala e kōkua ai e hōʻoia i kou palekana i ka wā o ka lapaʻau.

Mavyret a me digoxin (Lanoxin)

Lawe iā Mavyret me digoxin hiki ke hoʻonui i nā pae o ka digoxin i kou kino. Hiki i kēia ke kumu i nā hōʻailona e like me:

  • nausea
  • ka luaʻi
  • pāhoehoe
  • pā kōlewa puʻuwai

Inā lawe ʻoe i ka digoxin ke hoʻohana nei ʻoe iā Mavyret, pono paha i kāu kauka e hoʻohaʻahaʻa i kāu mahele o digoxin. E kōkua kēia i ka pale ʻana i kāu pae digoxin mai ke kiʻekiʻe a hoʻonā i nā hopena ʻaoʻao. Hiki i kāu kauka ke nānā i kāu mau pae digoxin ma nā hoʻāʻo ʻana i ke koko ma mua o ka maʻamau i ka wā e lawe ana iā Mavyret.

ʻO Mavyret a me dabigatran (Pradaxa)

ʻO ka lawe ʻana iā Mavyret me dabigatran e hoʻonui ai i nā kiʻekiʻe o dabigatran i kou kino. Inā piʻi kiʻekiʻe loa kēia pae, loaʻa iā ʻoe ka nui o ka makaʻu o ke kahe ʻana a i ʻole ka palapū. E nāwaliwali paha ʻoe. Hiki ke koʻikoʻi kēia mau ʻōuli i kekahi manawa.

Inā ʻoe e lawe ana i ka dabigatran ʻoiai ʻoe e hoʻohana ana iā Mavyret, pono paha i kāu kauka e hoʻohaʻahaʻa i kāu lāʻau o dabigatran. E kōkua kēia i mea e pale ʻole ai i kēia mau ʻōuli.

Mavyret a me rifampin (Rifadin)

ʻO ka lawe ʻana iā Mavyret me ka rifampin e hoʻohaʻahaʻa i nā pae o Mavyret i kou kino. Inā hoʻohaʻahaʻa ʻia ke kiʻekiʻe o Mavyret i kou kino, ʻaʻole holo pono paha ka lāʻau e mālama iā HCV. Pono ʻoe e hōʻalo i ka lawe ʻana iā Mavyret a me Rifampin i ka manawa like.

ʻO Mavyret a me kekahi mau lāʻau hoʻomalu hānau

Loaʻa i kekahi mau lāʻau lapaʻau hoʻomalu hānau kahi lāʻau i kapa ʻia ʻo ethinyl estradiol. ʻO ka lawe ʻana i kēia lāʻau i hui pū ʻia me Mavyret hiki ke hoʻonui i nā pae o kou kino o kekahi enzyme ate i kapa ʻia ʻo alanine aminotransferase (ALT). Hiki i nā pae ALT ke hoʻonui ʻia e hōʻeha i kāu mau maʻi hepatitis.

Paipai ʻia ʻaʻole ʻoe e hoʻohana i ka kaohi hānau i loaʻa ka ethinyl estradiol ʻoiai ʻoe e lawe nei iā Mavyret.

ʻO nā laʻana o nā pilina kaohi hānau i loaʻa ka ethinyl estradiol me:

  • levonorgestrel a me ka ethinyl estradiol (Lessina, Levora, Seasonique)
  • desogestrel and ethinyl estradiol (Apri, Kariva)
  • norethindrone a me ethinyl estradiol (Balziva, Junel, Loestrin / Loestrin Fe, Microgestin / Microgestin Fe)
  • norgestrel a me ethinyl estradiol (Cryselle, Lo / Ovral)
  • drospirenone a me ethinyl estradiol (Loryna, Yaz)
  • norgestimate a me ethinyl estradiol (Ortho Tri-Cyclen / Ortho Tri-Cyclen Lo, Sprintec, Tri-Sprintec, TriNessa)

ʻAʻole kēia kahi papa inoa piha o nā pilina mālama hānau i loaʻa ka ethinyl estradiol. Inā ʻaʻole ʻoe e maopopo inā he ethinyl estradiol kāu kaohi hānau ma loko, e nīnau pono i kāu kauka a kauka paha.

ʻO kekahi mau ʻano hana ʻē aʻe o ka kaohi hānau ma waho o nā huaʻai pū kekahi me ethinyl estradiol. Hoʻopili kēia mau hana i ka patch contraceptive (Ortho Evra) a me ke apo o ka wahine (NuvaRing).

Inā ʻoe e hoʻohana nei i ka kaohi hānau i loaʻa ka ethinyl estradiol, e kamaʻilio me kāu kauka e pili ana i nā koho ʻē aʻe e pale i ka hāpai ʻana ʻoiai ʻoe e lawe nei iā Mavyret.

ʻO Mavyret a me kekahi mau lāʻau antiviral HIV

Hiki i kekahi mau lāʻau HIV (i kapa ʻia nā antivirals) ke hoʻopili i ka nui o Mavyret i kou kino. ʻO nā laʻana o nā lāʻau antiviral i hiki ke hoʻololi i ka nui o Mavyret i kou kino e:

  • atazanavir (Reyataz)
  • darunavir (Prezista)
  • lopinavir and ritonavir (Kaletra)
  • ritonavir (Norvir)
  • efavirenz (Sustiva)

ʻAʻole pono e lawe ʻia ʻo Atazanavir me Mavyret. ʻO ka lawe pū ʻana i kēia mau lāʻau e hoʻonui ai i ka pae o kou kino o kekahi enzyme ate i kapa ʻia ʻo alanine aminotransferase (ALT). Hiki i nā pae ALT ke hoʻonui ʻia e hōʻeha i kāu mau maʻi hepatitis.

Lawe ʻole ʻia ʻo Mavyret me darunavir, lopinavir, a i ʻole ritonavir. ʻO kēia no ka mea hiki i kēia mau lāʻau antiviral ke hoʻonui i nā kiʻekiʻe o Mavyret i kou kino. Hiki i kēia ke alakaʻi i ka hoʻonui i nā hopena mai Mavyret.

ʻO ka lawe ʻana iā Mavyret me efavirenz e hoʻemi ana i nā kiʻekiʻe o Mavyret i kou kino. ʻO kēia paha ka mea e hana ʻole ai ʻo Mavyret. Pono ʻoe e hōʻalo i ka hoʻohana ʻana iā efavirenz ʻoiai e lawe ana iā Mavyret.

ʻO Mavyret a me kekahi mau lāʻau kolesterol

ʻO ka lawe ʻana iā Mavyret me kekahi mau lāʻau kolesterol i kapa ʻia he statins hiki ke hoʻonui i ka pae o ka statin i kou kino. ʻO ka loaʻa ʻana o nā pae statins e hoʻonui i kou makaʻi i nā hopena ʻaoʻao (e like me ka ʻeha o nā mākala) mai ka statin.

Eia kekahi laʻana o nā statins:

  • atorvastatin (Lipitor)
  • lovastatin (Mevacor)
  • simvastatin (Zocor)
  • pravastatin (Pravachol)
  • rosuvastatin (Crestor)
  • fluvastatin (Lescol)
  • pitavastatin (Livalo)

Paipai ʻia ʻaʻole ʻoe e lawe iā Mavyret i ka hui pū ʻia me atorvastatin, lovastatin, a i ʻole simvastatin. Loaʻa i kēia mau statins ka makaʻu kiʻekiʻe loa o ka hoʻonui ʻana i nā hopena ke lawe ʻia me Mavyret.

Hiki ke lawe ʻia ʻo Pravastatin me Mavyret inā paipai kāu kauka e pono ʻoe i kahi lāʻau kolesterol. Pono e hoʻohaʻahaʻa ʻia kāu ana o pravastatin ma mua o kou hoʻomaka ʻana e lawe iā Mavyret. E kōkua kēia e hōʻemi i kou makaʻi i nā hopena ʻaoʻao mai ka statin.

Inā lawe ʻia ka fluvastatin a me ka pitavastatin me Mavyret, pono e hāʻawi ʻia ia ma nā mea hiki ke haʻahaʻa. Kōkua kēia i ka hōʻemi i kou makaʻu i ka hoʻonui ʻana i nā hopena ʻaoʻao mai nā statins.

Mavyret a me cyclosporine (Sandimmune)

ʻAʻole koi ʻia ʻo Mavyret e hoʻohana i ka poʻe e lawe nei ma mua o 100 mg i kēlā me kēia lā o ka cyclosporine. Hoʻonui kēia lāʻau i nā pae o Mavyret i kou kino, i hiki ke hoʻonui i kou makaʻi i nā hopena ʻaoʻao mai Mavyret.

Inā lawe ʻoe i ka cyclosporine, e kamaʻilio me kāu kauka e pili ana i ke ʻano o ka cyclosporine e palekana ai iā ʻoe.

ʻO Mavyret a me omeprazole (ʻaʻole pili)

ʻAʻole i ʻike ʻia nā pilina ma waena o omeprazole a me Mavyret. Hāʻawi ʻia ʻo Omeprazole i kekahi manawa i ka poʻe e lawe ana iā Mavyret inā loaʻa ka nausea i ka wā o ka lapaʻau. I kekahi manawa, hoʻokumu ʻia ka nausea e ka acid acid buildup i kou ʻōpū. ʻO ka lawe ʻana i ka omeprazole e kōkua i ka hoʻohaʻahaʻa ʻana i ka nui o ka waikawa i loko o kou ʻōpū, a hiki ke kōkua i ka hōʻemi ʻana i kēia hopena ʻaoʻao.

ʻO Mavyret a me ibuprofen (ʻaʻole pili)

ʻAʻohe mea i ʻike ʻia ma waena o ka ibuprofen a me Mavyret. Hiki ke hoʻohana ʻia ʻo Ibuprofen e mālama i ka maʻi poʻo i ka poʻe e lawe ana iā Mavyret. ʻO nā poʻo hina kahi hopena hopena maʻamau e hiki ke hana ʻia ke lawe ʻoe iā Mavyret. Hiki i ka Ibuprofen ke kōkua i ka hōʻemi ʻana i ka ʻeha a me ka hōʻoluʻolu ʻole o kahi ʻeha poʻo.

ʻO Mavyret a me nā mea kanu a me nā mea hoʻopili

Hiki i ka Mavyret ke launa pū me kekahi mau mea kanu a me nā mea hoʻohui, e like me ka St. John's wort (i kikoʻī ʻia ma lalo). Hiki i kēia mau pilina ke hoʻololi i ka hana a Mavyret i kou kino.

Pono ʻoe e loiloi i nā lāʻau a pau āu e lawe ai (me nā mea kanu a me nā mea hoʻopili) me kāu kauka a kauka paha ma mua o kou hoʻomaka ʻana e lawe iā Mavyret.

ʻO Mavyret lāua ʻo St. John's wort

ʻO ka lawe ʻana iā St. John's wort me Mavyret hiki ke hōʻemi nui i nā pae o Mavyret i kou kino. Hiki i kēia ke kumu iā Mavyret e hana pū ʻole i ka mālama ʻana i kāu maʻi hepatitis C. Paipai ʻia ʻaʻole ʻoe e lawe i ka wort a St. John ke hoʻohana nei ʻoe iā Mavyret.

ʻO Mavyret a me ka hāpai keiki

ʻAʻole i loaʻa nā noiʻi i loko o nā kānaka e nānā ana inā paha ʻaʻole palekana ʻo Mavyret e lawe i ka wā hāpai.

I loko o nā noiʻi holoholona, ​​ʻaʻohe mea ʻino i ʻike ʻia i nā fetus nona nā makuwahine i hāʻawi ʻia iā Mavyret i ka wā hāpai. Eia naʻe, ʻaʻole e wānana mau nā hopena o nā noiʻi holoholona i nā mea e hiki i nā kānaka.

Inā hāpai ʻoe a hāpai paha ʻoe i ka hoʻohana ʻana iā Mavyret, e kamaʻilio me kāu kauka. Hiki iā lākou ke kūkākūkā me ʻoe i nā pilikia a me nā pono o ka hoʻohana ʻana i kēia lāʻau i ka wā hāpai.

Mavyret a me ka waiū hānai

ʻAʻole i loaʻa nā noiʻi i loko o nā kānaka e ʻike inā ʻaʻole hele ʻo Mavyret i ka waiū umauma, a i ʻole inā he hopena paha ia i kahi keiki hānai.

I nā noiʻi holoholona, ​​ua hala ʻo Mavyret i ka waiū o nā ʻiole lactating. Eia naʻe, ʻaʻole hana kēia waiū i mea ʻino i nā holoholona nāna i hoʻopau. E hoʻomanaʻo he ʻokoʻa paha kēia mau hopena i nā kānaka.

Inā hānai ʻoe i ka waiū, a i ʻole ke hoʻolālā nei i ka hānai ʻana i ka wā e lawe ana iā Mavyret, e kamaʻilio me kāu kauka inā he koho palekana kēia. Paipai paha lākou i nā ala olakino ʻē aʻe e hānai ai i kāu keiki.

Pehea e lawe ai iā Mavyret

Pono ʻoe e lawe iā Mavyret e like me kāu kauka a i ʻole nā ​​ʻōlelo aʻoaʻo mālama ola.

I ka manawa hea e lawe ai

ʻAʻole ia he mea nui i ka manawa o ke lā āu e koho ai e lawe iā Mavyret, akā pono ʻoe e lawe ma kahi o ka manawa like i kēlā me kēia lā. Kōkua kēia i ka lāʻau e hana i ke ala kūpono i loko o kou kino.

I mea e ʻike pono ʻaʻole ʻoe e haʻalele i kahi lāʻau, e hoʻāʻo e kau i kahi hoʻomanaʻo ma kāu kelepona. He mea pono nō hoʻi ka wati lāʻau.

Lawe iā Mavyret me ka meaʻai

Pono e lawe ʻia ʻo Mavyret me ka meaʻai. Kōkua kēia i kou kino e omo maikaʻi i ka lāʻau.

Hiki iā Mavyret ke haki, wāwahi ʻia, a nau ʻia paha.

ʻAʻole, ʻaʻole pono e māhele ʻia ʻo Mavyret, haki, a nauʻu paha. ʻO nā papa e pono e ale wale ʻia. ʻO ka hoʻokaʻawale ʻana, ʻānai ʻana a i ʻole ka nau ʻana iā lākou hiki ke hōʻemi i ka nui o nā lāʻau i loko o kou kino. Hiki i kēia ke kumu iā Mavyret e hana pū ʻole i ka mālama ʻana i kāu maʻi hepatitis C.

Pehea e hana ai ʻo Mavyret

ʻAe ʻia ʻo Mavyret e mālama i ka maʻi hepatitis C maʻi mau (HCV). Hoʻokumu kēia virus i kahi maʻi i kou kino e pili ana i kou ake. Hiki i ka HCV ke alakaʻi i ka hōʻino nui o ke ake inā ʻaʻole e mālama ʻia i ke ala kūpono.

Loaʻa i loko o Mavyret nā lāʻau ʻelua: glecaprevir a me pibrentasvir. Hana ia ma ka hoʻōki ʻana i ka maʻi hepatitis C mai ka hoʻonui ʻana (hana ʻana i nā mea hou aku i loko o kou kino). Ma muli o ka hiki ʻole o ka virus ke hoʻomāhuahua, e make nō ia.

I ka manawa i make ai nā maʻi āpau, a ʻaʻole ia i loko o kou kino, hiki i kou ake ke hoʻomaka e hoʻōla. Hana ʻo Mavyret e mālama i nā ʻano ʻeono (1, 2, 3, 4, 5, a me 6) o ka HCV.

Pehea ka lōʻihi o ka hana?

I ka wā o nā noiʻi maʻi ʻana, ua hoʻōla ʻia ka 92% a i ka 100% poʻe me ka HCV ma hope o ka lawe ʻana iā Mavyret no kā lākou lōʻihi i kuhikuhi ʻia. ʻO kēia lōʻihi o ka lōʻihi mai 8 a 16 mau pule.

I kēia mau noiʻi ʻana, ua hoʻōla ʻia ka manaʻo o nā hōʻike koko o ka poʻe, i hana ʻia ʻekolu mau mahina ma hope o ka lapaʻau ʻana, ʻaʻole i hōʻike ʻia kahi hōʻailona o ka maʻi HCV i ko lākou kino.

Nā nīnau maʻamau e pili ana iā Mavyret

Eia nā pane i kekahi o nā nīnau e nīnau pinepine ʻia e pili ana iā Mavyret.

Hiki iaʻu ke lawe iā Mavyret inā he maʻi koʻu a me ka maʻi hepitis C?

ʻAe, hiki iā ʻoe ke lawe iā Mavyret inā loaʻa iā ʻoe i ka maʻi HIV a me ka maʻi hepitis C (HCV). ʻAʻole loaʻa ka loaʻa ʻana o ka maʻi HIV i ke ʻano o ka hana ʻana a Mavyret i kou kino e mālama iā HCV.

Pehea ka maikaʻi o Mavyret i ka hoʻōla ʻana i ka maʻi hepatitis C?

Ua hōʻike ʻia ka maikaʻi loa o Mavyret i ka hoʻōla ʻana i nā maʻi maʻi hepatitis C (HCV). I nā hoʻokolohua hoʻokolohua, ma waena o 98% a me 100% o ka poʻe e lawe ana iā Mavyret i hoʻōla ʻia e ka HCV.

I kēia mau noiʻi ʻana, ua hoʻōla ʻia ka manaʻo o nā hōʻike koko o ka poʻe, i hana ʻia ʻekolu mau mahina ma hope o ka lapaʻau ʻana, ʻaʻole i hōʻike ʻia kahi hōʻailona o ka maʻi HCV. ʻO ka pākēneka o ka poʻe i hoʻōla ʻia e pili ana i ke ʻano o ka HCV i loaʻa iā lākou, a me ke ʻano o nā ʻano maʻi a lākou e hoʻohana ai i ka wā i hala.

Inā ua lawe wau i nā lāʻau hepitis C ʻē aʻe, hiki iaʻu ke hoʻohana iā Mavyret?

Inā ua hoʻāʻo ʻoe i nā lāʻau ʻē aʻe no kāu hepatitis C i hana ʻole (hoola i kou maʻi), hiki nō paha iā ʻoe ke hoʻohana iā Mavyret. Kaukaʻi ʻia i nā lāʻau āu i hoʻohana ai i ka wā ma mua, kou lōʻihi lapaʻau me Mavyret hiki i kēlā me kēia wahi mai 8 a 16 mau pule.

Inā he nīnau kāu e pili ana inā hiki iā ʻoe ke hoʻohana iā Mavyret, e kamaʻilio me kāu kauka.

E pono paha iaʻu i nā hoʻokolohua ma mua a i ʻole ma Motherret lapaʻau.

Ma mua o kou hoʻomaka ʻana i ka lāʻau me Mavyret, e hoʻāʻo kāu kauka i kou koko no ka maʻi hepitis B (HBV). Inā loaʻa iā HBV, hiki iā ia ke hoʻouluulu hou (flare) i ka wā o Mavyret lapaʻau. Hoʻomaʻamaʻa hou i ka HBV hiki i nā pilikia o ke ake nui, e like me ka pau ʻole o ka ate a me ka make.

Inā loaʻa iā HBV, e paipai kāu kauka i nā hoʻokolohua koko i ka wā o kāu mālama Mavyret e nānā ai no ka hoʻohou hou ʻana o ka HBV. Pono ʻoe e mālama ʻia no HBV ma mua o kou hoʻomaka ʻana e lawe iā Mavyret.

Hiki iaʻu ke hoʻohana iā Mavyret inā he cirrhosis koʻu?

Hiki paha iā ʻoe, akā pili ia i ke koʻikoʻi o kāu cirrhosis (scarring ate).

Hiki ke hoʻohana ʻia ʻo Mavyret inā ua uku ʻoe i ka cirrhosis. Me kēia kūlana, loaʻa i kou ake ka scarring, akā ʻaʻohe ou ʻōuli o ke ʻano a ke hana mau nei kou ate.

ʻAʻole ʻae ʻia ʻo Mavyret no ka hoʻohana ʻana i ka poʻe me ka cirrhosis decompensated. Me kēia kūlana, loaʻa i kou ake ka scarring a loaʻa iā ʻoe nā ʻōuli o ke ʻano. Hiki i nā ʻōuli ke hoʻohui pū:

  • melemele o kou ʻili a i ʻole nā ​​keʻokeʻo o kou mau maka
  • keu ka wai i loko o kou ʻōpū
  • hoʻonui ʻia nā kīʻaha koko i kou ʻāʻī, i kumu e kahe ai ke kahe

Inā loaʻa ʻoe i ka cirrhosis akā ʻaʻole maopopo iā ʻoe ke ʻano, e kamaʻilio me kāu kauka.

Nā hana palekana Mavyret

Hele mai kēia lāʻau lapaʻau me kekahi mau akahele.

Ka ʻōlelo aʻoaʻo a FDA: he maʻi hoʻomaʻi hepitis B

Aia kēia lāʻau i ka ʻōlelo aʻoaʻo a ka pahu. ʻO kēia ka ʻōlelo aʻo koʻikoʻi loa mai ka Food and Drug Administration (FDA). ʻO ka leka hoʻomaopopo e hōʻike i nā kauka a me nā mea maʻi e pili ana i nā hopena lāʻau e weliweli paha.

Hoʻonui ka mālama Mavyret i ka makaʻu o ka maʻi hepatitis B (HBV) reactivation (flare-up) i ka poʻe me nā HBV a me ka maʻi hepitis C (HCV). I nā hihia koʻikoʻi, hiki i ka reactivation o HBV ke kumu i ka holo ʻole o ka ate a i ʻole ka make.

Ma mua o ka hoʻomaka ʻana iā Mavyret, e hoʻāʻo kāu kauka iā ʻoe no HBV. Inā loaʻa iā HBV, pono ʻoe e mālama ʻia ma mua o kou hoʻomaka ʻana e lawe iā Mavyret. A i ʻole hiki i kāu kauka ke koi aku i ka hoʻāʻo ʻana i kāu mālama ʻana iā Mavyret e nānā ai no ka hoʻohou hou ʻana o ka HBV.

Nā ʻōlelo aʻoaʻo ʻē aʻe

Ma mua o ka lawe ʻana iā Mavyret, e kamaʻilio me kāu kauka e pili ana i kāu mōʻaukala olakino. ʻAʻole kūpono paha ʻo Mavyret iā ʻoe inā loaʻa iā ʻoe kekahi ʻano olakino. Pākuʻi ʻia kēia mau mea:

  • Hoka kōpaʻa. Inā loaʻa ʻole ʻoe i ke ake, ʻo ka lawe ʻana iā Mavyret e hoʻomāhuahua i kou ʻano. E kamaʻilio me kāu kauka inā loaʻa iā ʻoe kahi mōʻaukala o ka maʻi ate a i ʻole ke ahulau ma mua o ka hoʻomaka ʻana i ka lāʻau me Mavyret.
  • Hoʻohana o atazanavir a rifampin paha i kēia manawa. ʻAʻole pono e hoʻohana ʻia ʻo Mavyret i ka poʻe e lawe ana i atazanavir a i ʻole rifampin. ʻO ka lawe ʻana iā Mavyret a me ka rifampin e hōʻemi paha i nā pae Mavyret i kou kino. Hiki i kēia ke hōʻemi iā Mavyret ma mua iā ʻoe. Lawe i ka atazanavir me Mavyret hiki ke hoʻonui i ka nui o Mavyret i kou kino. Hiki i kēia ke hoʻonui i nā pae o ka ʻenema ate (i kapa ʻia ʻo alanine aminotransferase), hiki ke lilo i mea weliweli. E ʻike i ka ʻāpana "Mavyret interactions" no ka ʻike hou aku. E kamaʻilio mau i kāu kauka e pili ana i nā lāʻau āu e lawe nei ma mua o kou hoʻomaka ʻana iā Mavyret.
  • Hapai keiki. ʻAʻole maopopo inā hiki iā Mavyret ke hoʻopili i kahi hāpai hāpai. I nā noiʻi holoholona, ​​ʻaʻole i loaʻa iā Mavyret ka pōʻino ke hoʻohana ʻia i ka wā hāpai. Eia nō naʻe he ʻokoʻa kēia hopena i nā kānaka. No ka ʻike hou aku, e ʻoluʻolu e ʻike i ka ʻāpana ʻo "Mavyret and hāpai" ma luna.
  • Hānai umauma. ʻAʻole maopopo inā hele ʻo Mavyret i ka waiū umauma kanaka, a i ʻole inā e hōʻeha ia i kahi keiki hānai. I loko o nā noiʻi holoholona, ​​ua komo ʻo Mavyret i ka waiū umauma, akā ʻaʻole ia he mea e hōʻeha ai i nā holoholona i hoʻopau i ka waiū umauma. Eia nō naʻe, ʻokoʻa paha kēia hopena i nā kānaka. No ka ʻike hou aku, e ʻoluʻolu e ʻike i ka ʻāpana ʻo "Mavyret a me ka waiū hānai" ma luna.

Kaha: No ka ʻike hou aku e pili ana i nā hopena maikaʻi ʻole o Mavyret, e ʻike i ka ʻāpana "Mavyret effects" ma luna.

Hoʻokō nui ʻo Mavyret

ʻO ka hoʻohana ʻana ma mua o ke ana i koi ʻia o Mavyret hiki ke alakaʻi i nā hopena ʻino. Mai lawe i nā mea hou aʻe ma mua o ke ana i kuhikuhi ʻia e kāu kauka.

He aha e hana ai inā he overdose

Inā manaʻo ʻoe ua lawe nui ʻoe i kēia lāʻau, e kāhea i kāu kauka. Hiki iā ʻoe ke kāhea i ka ʻAmelika Hui Pū ʻIa o nā Poison Control ma 800-222-1222 a i ʻole hoʻohana i kā lākou mea hana pūnaewele. Akā inā koʻikoʻi kāu mau ʻōuli, e kāhea iā 911 a i ʻole e hele koke i kahi lumi pilikia kokoke.

Pau ʻo Mavyret, mālama, a hoʻolei

Ke kiʻi ʻoe iā Mavyret mai ka hale kūʻai lāʻau, e hoʻohui ka kauka i kahi lā palena pau i ka lepili ma ka ʻōmole. ʻO kēia lā maʻamau hoʻokahi makahiki mai ka lā a lākou i hāʻawi ai i ka lāʻau.

Kōkua ka lā palena i ka hōʻoia ʻana i ka maikaʻi o nā lāʻau i kēia manawa. ʻO ke kūlana o ka Food and Drug Administration (FDA) i kēia manawa e hōʻalo i ka hoʻohana ʻana i nā lāʻau i make. Inā loaʻa iā ʻoe kahi lāʻau i hoʻohana ʻole ʻia i hala i ka lā palena pau, e kamaʻilio me kāu kauka lāʻau e pili ana inā hiki paha iā ʻoe ke hoʻohana.

Waihona

Pehea ka lōʻihi o ka maikaʻi o ka lāʻau e hiki ai ke hilinaʻi i nā kumu he nui, e like me pehea a ma hea ʻoe e mālama ai i ka lāʻau.

Pono e mālama ʻia nā papa Mavyret ma ke ana wela o ka lumi (ma lalo o 86 ° F / 30 ° C) i loko o kahi ipu paʻa paʻa, mai ka mālamalama. Hōʻalo i ka mālama ʻana i kēia lāʻau i nā wahi e hiki ke maʻū a pulu paha, e like me ka lua.

Hoʻolei

Inā ʻaʻole ʻoe e pono hou e lawe iā Mavyret a loaʻa nā lāʻau i koe, he mea nui ia e hoʻolei aku me ka palekana. Kōkua kēia i ka pale aku i nā poʻe ʻē aʻe, e like me nā keiki a me nā holoholona, ​​mai ka lawe lāʻau ʻana ʻole. Mālama pū kekahi ia i ka lāʻau mai hōʻino i ke kaiapuni.

Hāʻawi ka pūnaewele FDA i nā ʻōlelo aʻoaʻo e pili ana i ka hoʻolāʻau lāʻau. Hiki iā ʻoe ke nīnau i kāu kauka lāʻau no ka ʻike e pili ana i ka hoʻolilo ʻana i kāu lāʻau.

ʻO ka ʻike ʻoihana no Mavyret

Hāʻawi ʻia ka ʻike aʻe no nā kauka lapaʻau a me nā ʻoihana ola.

Nā Hōʻike

Hōʻike ʻia ʻo Mavyret no ka mālama ʻana i nā genotypes hepatitis C mau loa (HCV) genotypes 1, 2, 3, 4, 5, a me 6. Ua ʻae ʻia ʻo Mavyret no ka hoʻohana ʻana i nā mākua a me nā keiki mai ka makahiki 12 a ʻoi paha, a i ʻole nā ​​mea kaupaona ma ka liʻiliʻi 45 kg.

Hoʻohana wale ʻia ia i nā mea maʻi me ka ʻole cirrhosis, a i ʻole me nā cirrhosis uku.

Hōʻike ʻia ʻo Mavyret e mālama i ka genotype 1 hepatitis C maʻi maʻi virus i ka poʻe i kūleʻa ʻole nā ​​mālama mua. Pono e hoʻopili i kēia mau mālama ʻana ma mua i kahi mea kāohi ʻo HCV NS5A a i ʻole mea kūpikia protease NS3 / 4A.

ʻAʻole hōʻike ʻia ʻo Mavyret no ka hoʻohana ʻana i nā mea maʻi i kūleʻa ʻole ka mālama ʻana ma mua i ka hoʻohana ʻana i ka mea kāohi iā HCV NS5A a me kahi mea kūpili protease NS3 / 4A

Mekanism o ka hana

Aia i loko o Mavyret ka glecaprevir a me ka pibrentasvir. ʻO kēia mau lāʻau lapaʻau he lāʻau lapaʻau antiviral hana pololei ia e hakakā me HCV.

ʻO Glecaprevir kahi mea hoʻopilikia protease NS3 / 4A. Hana ia ma ke kālailai ʻana iā NS3 / 4A protease, kahi mea e pono ai ka ulu ʻana o ka maʻi hepitis C.

ʻO Pibrentasvir kahi mea kāohi iā NS5A. Ma ka pale ʻana iā NS5A, hoʻopau ka pibrentasvir i ka hoʻomaʻi hou ʻana i ka maʻi hepatitis C.

Kūpono ʻo Mavyret e kūʻē i nā genotypes hepatitis C 1, 2, 3, 4, 5, a me 6.

Pharmacokinetics a me ka metabolism

I loko o kahi noiʻi e pili ana i ka poʻe maʻi ʻole i ka HCV i manaʻo ʻia he olakino, ua loli nui ʻia ka omo ʻana o Mavyret i ka loaʻa ʻana o ka meaʻai. Ke lawe ʻia me kahi ʻai, hoʻonui ʻia ka omo glecaprevir e 83% a i ka 163%. Ua hoʻonui ʻia ka omo o pibrentasvir e 40% i ka 53%. No laila, koi ʻia ʻo Mavyret e lawe ʻia me ka meaʻai e hoʻonui ai i ka lawe.

Hana ʻia ka mika plasma mika o Mavyret ma kahi o 5 mau hola ma hope o ka hopena. ʻO ka hapalua o ke ola o glecaprevir he 6 mau hola, ʻoiai ka hapalua o ke ola o pibrentasvir he 13 mau hola.

Hoʻopau ʻia ʻo Mavyret ma o ke ala biliary-fecal. ʻO ka hapa nui o nā glecaprevir a me pibrentasvir ka protein protein plasma i hoʻopaʻa ʻia.

Nā Kūʻai Kūʻai

Hoʻopiʻi ʻia ʻo Mavyret i nā maʻi me ka maʻi hepatic koʻikoʻi, i wehewehe ʻia e like me ka helu ʻo Child-Pugh C.

Hoʻokomo pū ʻia ʻo Mavyret i nā mea maʻi e lawe ana i atazanavir a i ʻole rifampin. Hoʻoemi nui ʻia ka manaʻo nui o Mavyret e rifampin, kahi e hōʻemi a pale paha i ka hopena therapeutic o Mavyret. ʻAʻole pono e lawe ʻia ʻo Mavyret me atazanavir no ka mea hiki i ka hui ʻana o nā lāʻau ke hoʻonui i nā pae alanine aminotransferase (ALT), e ulu ana i ka nui o ka hopena o ke ake ʻana o ke ake.

Waihona

Pono e mālama ʻia ʻo Mavyret ma lalo a i ʻole ma lalo o 86 ° F (30 ° C) i loko o kahi ipu paʻa a maloʻo.

Hoʻolaha: Ua hana ʻo Nūhou Lapaʻau i kēia mau lā e hōʻoia i ka pololei, ka laulā, a me ka lā hou o nā ʻike āpau. Eia nō naʻe, ʻaʻole pono e hoʻohana i kēia ʻatikala i pani no ka ʻike a me ka mākaukau o kahi loea mālama ola laikini. E nīnau mau ʻoe i kāu kauka a i ʻole ʻoihana olakino ʻē aʻe ma mua o ka lawe ʻana i nā lāʻau. Hiki ke loli i ka ʻike o ka lāʻau i loko a ʻaʻole i manaʻo ʻia e uhi i nā hoʻohana a pau, nā kuhikuhi, ka mālama ʻana, nā ʻōlelo aʻoaʻo, nā launa lāʻau, nā hopena maʻi ʻaʻai, a me nā hopena maikaʻi ʻole. ʻO ka loaʻa ʻole o nā ʻōlelo aʻoaʻo a i ʻole nā ​​ʻike ʻē aʻe no kahi lāʻau i hāʻawi ʻia ʻaʻole ia e hōʻike i ka palekana o ka lāʻau a lāʻau paha i kūpono no nā mea maʻi āpau a i ʻole nā ​​hoʻohana kikoʻī āpau.

E HōʻOia E Heluhelu

ʻO Peripheral Artery Angioplasty a me Stent kau
Ola Kino

ʻO Peripheral Artery Angioplasty a me Stent kau

He aha ka Angiopla ty a me ka tent?ʻO Angiopla ty me ke kau tent kahi hana inva ive minimally i hoʻohana ʻia e wehe i nā aʻa kuiki a i ʻole nā ​​poloka. Hoʻohana ʻia kēia kaʻina hana i nā ʻāpana like...
He aha ke ʻano o ka loaʻa ʻana o ka IUD
Ola Kino

He aha ke ʻano o ka loaʻa ʻana o ka IUD

Inā ʻoe e noʻonoʻo ana i ka loaʻa ʻana o kahi hāmeʻa intrauterine (IUD), makaʻu paha ʻoe e ʻeha paha ia. Ma hope o nā mea āpau, pono ʻeha ke loaʻa i kahi mea i hoʻokomo ʻia ma o kou cervix a i loko o ...