Mea Kākau: Gregory Harris
Lā O Ka Hana: 11 Apelila 2021
HōʻAno Hou I Ka Lā: 18 Nowemapa 2024
Anonim
How Donepezil works in Alzheimer’s disease | Mechanism and side effects
Wikiō: How Donepezil works in Alzheimer’s disease | Mechanism and side effects

Anter

Hoʻohana ʻia ʻo Donepezil e mālama i ka dementia (kahi maʻi lolo e pili ana i ka hiki ke hoʻomanaʻo, noʻonoʻo pono, kamaʻilio, a hana i nā hana o kēlā me kēia lā a hiki ke hoʻololi i ka naʻau a me ke ʻano) i ka poʻe i loaʻa ka maʻi ʻo Alzheimer (AD; kahi maʻi lolo e luku mālie. ka hoʻomanaʻo a me ka hiki ke noʻonoʻo, aʻo, kamaʻilio a lawelawe i nā hana o kēlā me kēia lā). Aia ʻo Donepezil i kahi papa o nā lāʻau i kapa ʻia ʻo nā mea kāohi iā cholinesterase. Hoʻomaikaʻi i ka hana noʻonoʻo (e like me ka hoʻomanaʻo, ka noʻonoʻo, ka hiki ke launa pū me nā poʻe ʻē aʻe, ʻōlelo, noʻonoʻo pono, a hana i nā hana maʻamau o kēlā me kēia lā) e ka hoʻonui ʻana i ka nui o kekahi mea kūlohelohe i ka lolo. Hiki paha iā Donepezil ke hoʻomaikaʻi i ka hiki ke noʻonoʻo a hoʻomanaʻo a hoʻolohi paha i ka nalo ʻana o kēia mau hiki i ka poʻe i loaʻa iā AD. Eia nō naʻe, ʻaʻole e hoʻōla ʻo donepezil iā AD a pale paha i ka nalo ʻana o ka hiki i ka noʻonoʻo i kekahi manawa i ka wā e hiki mai ana.

Hele mai ʻo Donepezil ma ke ʻano he papaha a me kahi papa hoʻohaunaele waha (papa e hoʻonā koke i ka waha) e lawe i ka waha. Lawe ʻia ia i hoʻokahi manawa i ka lā me ka ʻai ʻole, i ke ahiahi ma mua o ka hiamoe. Lawe iā donepezil ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka donepezil e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.


Kōkua ʻo Donepezil i ka mālama ʻana i nā ʻōuli o ka maʻi o Alzheimer akā ʻaʻole ia e hoʻōla iā ia. E hoʻomau i ka lawe donepezil ʻoiai inā maikaʻi ʻoe. Mai hōʻoki i ka lawe ʻana i ka donepezil me ke kamaʻilio ʻole ʻana me kāu kauka.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi haʻahaʻa o ka donepezil a hoʻonui i kāu lāʻau ma hope o 4 a 6 mau pule. E hoʻonui hou paha kāu kauka i kāu lāʻau ma hope o 3 a ʻoi paha mau mahina ma hope.

E ale i ka papa 23-mg holoʻokoʻa; mai wāwahi, ʻānai a nau hoʻi. E haʻi i kāu kauka inā ʻaʻole hiki iā ʻoe ke ale i ka papa holoʻokoʻa.

E lawe i ka papa hoʻohaunaele waha, e kau i ka papa ma kou alelo a kali iā ia e hemo. Inu i kahi wai ma hope o ka hemo ʻana o ka papa.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe donepezil,

  • e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka donepezil, nā lāʻau piperidine, nā lāʻau ʻē aʻe, nā mea hoʻohui i nā papa donepezil a i ʻole nā ​​papa hoʻohaʻahaʻa waha. E noi i kāu kauka a kauka paha inā ʻaʻole ʻoe e ʻike inā he lāʻau piperidine kāu e maʻi ai iā ʻoe. E noi i kāu kauka lāʻau a nānā paha i ka ʻike hoʻomanawanui o ka mea hana no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻai, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe E hōʻoia e haʻi i kekahi o kēia: antihistamines; aspirin a me nā lāʻau anti-inflammatory nonsteroidal (NSAIDs) e like me ibuprofen (Advil, Motrin) a me naproxen (Aleve, Naprosyn); bethanechol (Duvoid, Urecholine); carbamazepine (Tegretol); dexamethasone (Decadron, Dexone); ipratropium (Atrovent); ketoconazole (Nizoral); nā lāʻau no ka glaucoma, ka maʻi huhū o ka ʻōpū, ka neʻe ʻana o ka maʻi, myasthenia gravis, ka maʻi ʻo Parkinson, nā maʻi palapū, a me nā pilikia urinary; phenobarbital (Luminal, Solfoton); phenytoin (Dilantin); quinidine (Quinidex); a me rifampin (Rifadin, Rimactane). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi i kāu kauka inā kau kaupaona ma lalo o 120 lb (55 kg) a inā he kahe kou i loko o kou ʻōpū a i ʻole nā ​​ʻōpū. he ulcer; kūleʻa, lohi, a wikiwiki paha ka puʻuwai, ka hopu ʻana; pilikia i ka urino; hānō; maʻi pulmonary ākea ākea (kahi hui o ka maʻi pūpū e like me ka maʻi bronchitis a i ʻole empysema); aiʻole ka puʻupaʻa, ka ate, a i ʻole ka maʻi puʻuwai.
  • e haʻi i kāu kauka inā hāpai ʻoe, hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka donepezil, e kāhea i kāu kauka.
  • inā ke ʻoki ʻia ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha ʻoe e lawe nei i ka donepezil.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


Inā hoʻopoina ʻoe i ka lawe ʻana i kahi lāʻau o donepezil, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala. Inā ʻaʻole ʻoe e lawe i ka donepezil, no 1 pule a ʻoi aku paha, pono ʻoe e kāhea i kāu kauka ma mua o ka hoʻomaka ʻana e lawe hou i kēia lāʻau.

Hoʻokumu paha ʻo Donepezil i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • nausea
  • ka luaʻi
  • pāhoehoe
  • nalo ʻai ʻole
  • Kaumaha emi
  • urination pinepine
  • pilikia e kaohi ana i ka urination
  • ʻūpē mākala
  • ʻeha puʻupuʻu, pehu, a ʻoʻoleʻa
  • ʻeha
  • luhi nui loa
  • paʻakikī e hiamoe a hiamoe paha
  • ʻeha poʻo
  • ʻūpā
  • hopohopo
  • kaumaha
  • huikau
  • nā hoʻololi i ka lawena a i ʻole ke ʻano
  • hallucination (ke ʻike nei i nā mea a i ʻole ka lohe ʻana i nā leo i ʻole ola)
  • moeʻuhane ʻino
  • ʻulaʻula, hoʻonui ʻana, ʻili ʻili

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • maule ana
  • ʻūlū puʻuwai
  • ʻeha ka umauma
  • nā pilikia hanu hou a ʻino hoʻi paha
  • ʻeha a ʻeha hou paha i ka ʻeha a i ʻole ka ʻehaʻeha o ka puʻuwai
  • ʻūlū ʻeleʻele a i ʻole hoʻolohi
  • koko ʻulaʻula i nā noho
  • luaʻi koko
  • ka luaʻi e like me nā pā kope
  • pilikia i ka mimi ʻana a ʻeha paha i ka wā e mimi ai
  • ʻeha ʻeha o lalo
  • fiva
  • ka hopu ʻana
  • ka hoʻoliʻiliʻi a i ka ʻeha o ka ʻili

Hoʻokumu paha ʻo Donepezil i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau ke lawe nei ʻoe i kēia lāʻau.


E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

  • nausea
  • ka luaʻi
  • paheʻe
  • ka houʻu ʻana
  • ʻūlū puʻuwai
  • paʻakikī i ka hanu ʻana
  • nāwaliwali o nā mākala
  • maule ana
  • ka hopu ʻana

Mālama i nā manawa āpau me kāu kauka.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • Aricept®
  • Aricept® ODT
  • Namzaric®(ma ke ʻano he huahana hoʻohui me Donepezil, Memantine)
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