Alemtuzumab injection (Multiple Sclerosis)

Anter

• Hoʻohana ʻia ka hoʻopili ʻana ʻo Alemtuzumab e mālama i nā mākua me nā ʻano like ʻole o ka sclerosis maha (MS; kahi maʻi kahi e holo pono ʻole ai nā ʻalalā a ʻike paha ka poʻe i ka nāwaliwali, numbness, nalo ʻana o ka coordination o nā mākala, a me nā pilikia me ka hihi, kamaʻilio, a me ka mālama ʻana i ka maʻi ʻaʻa) ʻaʻole i hoʻomaikaʻi me ka liʻiliʻi he ʻelua a ʻoi paha mau lāʻau MS me:
• Ma mua o ka loaʻa ʻana o ka piʻo alemtuzumab,
• Hoʻokomo paha ka hopena Alemtuzumab i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.
• I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa pū ka ʻike ma ka pūnaewele. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i ke kīpē Alemtuzumab ke kumu i nā maʻi autoimmune koʻikoʻi a hoʻoweliweli paha (nā kūlana kahi e hoʻouka ai ka ʻōnaehana pale i nā ʻaoʻao olakino o ke kino a hōʻeha i ka ʻeha, pehu, a me nā hōʻino), e like me thrombositopenia (kahi helu haʻahaʻa o nā platelet [kahi ʻano o nā aʻa koko e pono ai kāpili koko]) a me nā pilikia ʻōpū. E haʻi i kāu kauka inā loaʻa iā ʻoe nā pilikia kahe o ke kahe a i ʻole nā ​​maʻi puʻupaʻa. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: kahe ʻole ke kahe ʻana, ka pehu ʻana o kou mau wāwae a me kou mau wāwae, e kahe ana i ke koko, ke kahe ʻana o ke kahe mai kahi ʻoki paʻakikī e kū, kahe a me ke kahe ʻole o ke kahe o ka menstrual, nā kiko ma kou ʻili. ʻulaʻula, ʻulaʻula, a poni paha, e kahe ana ke kaomi o ka ihu a i ʻole ka ihu, ke koko i ka mimi, ka ʻeha o ka umauma, ka hoʻemi ʻana i ka nui o ka mimi, a me ka luhi.

Hiki iā ʻoe ke ʻike i kahi hopena infusion koʻikoʻi a hoʻoweliweli paha ke loaʻa iā ʻoe kahi lāʻau o ka alemtuzumab injection a i ʻole 3 mau lā ma hope. E loaʻa iā ʻoe kēlā me kēia mahele lāʻau o ka lāʻau i loko o kahi keʻena lapaʻau, a e nānā pono kāu kauka iā ʻoe i ka wā o ka infusion a ma hope o ka loaʻa ʻana o ka lāʻau. He mea nui e noho ʻoe ma ke kikowaena infusion no 2 mau hola ma hope o ka pau ʻana o kāu hoʻopili. Inā ʻoe e ʻike i kekahi o nā ʻōuli ma hope a i ʻole ma hope o kāu infusion, e haʻi koke i kāu kauka: fiva; haʻalulu; nausea; ʻeha poʻo; ka luaʻi; hives; ʻehu; ʻumeʻume; pāheʻe; puʻuwai puʻuwai; ʻūpā; pokole o ka hanu; pilikia i ka hanu ʻana a i ʻole ke ale ʻana; hanu i ka hanu ʻana; hoʻopaʻa i ka ʻāʻī; pehu o nā maka, maka, waha, lehelehe, alelo a puʻu paha; hoarseness; ʻūpā; ʻālohilohi; maule ana; wikiwiki a i ʻole kōkō puʻuwai puʻuwai; a ʻehaʻeha paha.

Hoʻokumu paha ka pahu Alemtuzumab i kahi hahau a i ʻole nā ​​waimaka i loko o kou mau aʻa e hāʻawi i ke koko i kou lolo, keu hoʻi i loko o nā lā 3 mua ma hope o ka lapaʻau. Inā ʻoe e ʻike i kekahi o nā ʻōuli ma hope a i ʻole a ma hope o kāu infusion, e haʻi koke i kāu kauka: hāʻule ma kekahi ʻaoʻao o ka maka, ʻeha ke poʻo, ʻeha ʻāʻī, nāwaliwali koke a i ʻole ka helu ʻana o ka lima a me ka wāwae, ʻo ia hoʻi ma kekahi ʻaoʻao o ke kino. , a i ʻole paʻakikī i ka ʻōlelo ʻana, a i ʻole ka hoʻomaopopo ʻana.

Hiki i ka hoʻopili ʻana iā Alemtuzumab ke hoʻonui i ka makaʻu e hoʻomohala ʻoe i kekahi mau maʻi maʻi maʻi, e like me ka maʻi ʻaʻai thyroid, melanoma (kahi ʻano maʻi ʻaʻai ʻili), a me kekahi maʻi ʻaʻai koko. Pono ʻoe e nānā i kou ʻili e ke kauka no nā hōʻailona o ka maʻi ʻaʻai ma mua o kou hoʻomaka ʻana i ka lāʻau a me ka makahiki ma hope. Kāhea i kāu kauka inā loaʻa iā ʻoe kēia mau ʻōuli e lilo i hōʻailona o ka maʻi ʻaʻai thyroid: puʻupuʻu hou a huʻā paha i kou ʻāʻī. ʻeha i mua o ka ʻāʻī; ka wehewehe kaumaha i wehewehe ʻole ʻia; ʻehaʻeha a iwi paha; puʻupuʻu a huʻi paha i kou ʻili, ʻāʻī, poʻo, ʻūhū a ʻōpū paha. nā hoʻololi i ke ʻano mole, ka nui, a me ke kala a i ʻole ke kahe ʻana o ke koko. lesion liʻiliʻi me ka palena kaulike ʻole a me nā ʻāpana e ʻikea ʻulaʻula, keʻokeʻo, uliuli a uliuli-ʻeleʻele hoʻi; loli a ʻano hoʻololi leo ʻē aʻe paha i hele ʻole aku; pilikia i ka ale ʻana a me ka hanu ʻana; aiʻole ka hano.

Ma muli o nā pilikia o kēia lāʻau, loaʻa wale ke kīnā alemtuzumab ma o kahi papahana hoʻokaʻawale palena kūikawā wale nō. Kāhea ʻia kahi papahana He papahana i kapa ʻia ʻo Lemtrada Risk Evaluation and Mitigation Strategy (REMS) Program. E nīnau i kāu kauka inā he nīnau kāu e pili ana pehea e loaʻa ai kāu lāʻau.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua e nānā i ka pane o kou kino i ka hoʻopiʻi alemtuzumab ma mua a i ka wā o kāu lapaʻau a no 4 mau makahiki ma hope o kou loaʻa ʻana i kāu hopena hope loa.

E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka loaʻa ʻana o ka injection alemtuzumab.

Hoʻohana ʻia ka hoʻopili ʻana ʻo Alemtuzumab e mālama i nā mākua me nā ʻano like ʻole o ka sclerosis maha (MS; kahi maʻi kahi e holo pono ʻole ai nā ʻalalā a ʻike paha ka poʻe i ka nāwaliwali, numbness, nalo ʻana o ka coordination o nā mākala, a me nā pilikia me ka hihi, kamaʻilio, a me ka mālama ʻana i ka maʻi ʻaʻa) ʻaʻole i hoʻomaikaʻi me ka liʻiliʻi he ʻelua a ʻoi paha mau lāʻau MS me:

• relapsing-remitting forms (papa o ka maʻi kahi e ʻō ai nā ʻōuli mai kēlā me kēia manawa) a i ʻole
• nā papa holomua holomua (papa o ka maʻi kahi e hoʻi pinepine ai ka hoʻi ʻana).

Aia ʻo Alemtuzumab i ka papa o nā lāʻau i kapa ʻia he monoclonal antibodies. Hana ia ma ka hoʻemi ʻana i ka hana o nā hunaola ʻino e hiki ai ke hōʻino i nā nerve.

Loaʻa ʻo Alemtuzumab ma ke ʻano he injection (Campath) i hoʻohana ʻia e mālama i ka leukemia lymphocytic mau (kahi maʻi e hoʻomoe mālie i kahi o nā ʻano keokeo o ke koko keʻokeʻo e hōʻiliʻili ʻia i loko o ke kino). Hāʻawi wale kēia monograp i ka ʻike e pili ana i ka hoʻopili ʻana o alemtuzumab (Lemtrada) no nā sclerosis he nui. Inā ʻoe e loaʻa ana i ka alemtuzumab no ka leukemia lymphocytic mau, e heluhelu i ka monograph i kapa ʻia ʻo Alemtuzumab Injection (Chronic Lymphocytic Leukemia).

Hele mai ʻo Alemtuzumab injection ma ke ʻano he hopena (wai) e ʻākoʻi ʻia i loko o ke aniani (i kahi aa) ma mua o 4 mau hola e ke kauka a kahu hānai paha i ka haukapila a i ʻole ke keʻena lapaʻau. Hāʻawi pinepine ʻia ia i kēlā me kēia lā no 5 mau lā no ka pōʻai hoʻomaʻamaʻa mua. Hāʻawi pinepine ʻia kahi kekona lapaʻau ʻelua i kēlā me kēia lā no 3 mau lā, 12 mau mahina ma hope o ke kaapuni lapaʻau mua. Kauoha paha kāu kauka i kahi pōʻai hoʻoponopono hou aʻe no 3 mau lā ma ka liʻiliʻi he 12 mau mahina ma hope o ka mālama mua.

Kōkua ka hoʻopili ʻana ʻo Alemtuzumab i ka mālama ʻana i nā sclerosis he nui, akā ʻaʻole ia e hoʻōla iā ia.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka loaʻa ʻana o ka piʻo alemtuzumab,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka alemtuzumab, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka inikū alemtuzumab. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, lawe ʻoe a hoʻolālā paha e lawe. E ʻike pono i ka mea aʻe: alemtuzumab (Campath; inoa inoa o ka huahana i hoʻohana ʻia e mālama ai i ka leukemia); lāʻau lapaʻau maʻi ʻaʻai; a i ʻole nā ​​lāʻau hoʻomalu immunosuppressive e like me cyclosporine (Gengraf, Neoral, Sandimmune), mycophenolate (Cellcept), prednisone, a me tacrolimus (Astagraf, Envarsus, Prograf). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā loaʻa ʻoe i ka maʻi a i ʻole ke kanaka maʻi maʻi (HIV). E haʻi paha kāu kauka iā ʻoe ʻaʻole e loaʻa ka inikū alemtuzumab.
• e haʻi i kāu kauka inā loaʻa paha iā ʻoe ka maʻi puʻupuʻu (TB; kahi maʻi nui e pili ana i nā akemāmā a i kekahi manawa nā ʻāpana ʻē aʻe o ke kino), herpes zoster (shingles; kahi ʻūlū e hiki ke hana ʻia i ka poʻe i loaʻa i ka paukū i ka wā i hala) , genpes herpes (kahi maʻi maʻi virus herpes e kumu ai e hana a ʻeha a puni ka genital a me ke kīhā mai kēlā manawa kēia manawa), varicella (chickenpox), maʻi ate e like me ka hepatitis B a i ʻole he hepatitis C, a i ʻole thyroid, puʻuwai, akemāmā, a i ʻole ka maʻi gallbladder.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau a hoʻohana i ka kaohi hānau i kāu wā e mālama ai a no 4 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano o ka kaohi hānau hiki iā ʻoe ke hoʻohana e pale i ka hāpai ʻana i kēia manawa. Inā hāpai ʻoe i ka wā e loaʻa ana iā ʻoe kahi alemtuzumab injection, e kelepona koke i kāu kauka. Hiki paha iā Alemtuzumab ke hōʻeha i ka fetus.
• e hoʻopaʻa me kāu kauka e ʻike inā pono ʻoe e loaʻa i nā lāʻau āpau ma mua o ka loaʻa ʻana o ka alemtuzumab. E haʻi i kāu kauka inā ua loaʻa iā ʻoe kahi lāʻau lapaʻau i loko o nā 6 mau pule i hala. ʻAʻohe o nā lāʻau āpau me ke kamaʻilio ʻole ʻana me kāu kauka i kou wā e mālama ai.

Hōʻalo i nā meaʻai aʻe e hiki ai ke hōʻeha i ka mahina ma mua o 1 mau mahina ma mua o kou hoʻomaka ʻana i ka loaʻa ʻana o ka alemtuzumab a i kāu wā e mālama ai: ka ʻiʻo ʻāpana, nā huahana waiū i hana ʻia me ka waiū waiū ʻole, nā pākī palupalu, a i ʻole ka moa i hoʻomoʻa ʻole ʻia, nā iʻa iʻa, a me nā moa.

Hoʻokomo paha ka hopena Alemtuzumab i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• paʻakikī i ka hiamoe a hiamoe paha
• ʻeha ma nā wāwae, nā lima, nā manamana wāwae, a me nā lima
• ʻeha ke kua, hui, a ʻāʻī paha
• ʻūlū ʻana, ʻoniʻoni ʻana, aniani ʻana, puhi ʻana, a i ʻole numb sensation ma ka ʻili
• ʻulaʻula, ʻili, a ʻili ʻili paha
• puʻuwai puʻuwai
• pehu o ka ihu a me ka puʻu

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• ka pōkole o ka hanu, ʻeha o ka umauma a i ʻole ke kūiki, ka ʻū, ka ʻū ʻana i ke koko, a i ʻole ke kani ʻana
• fever, chills, diarrhea, nausea, luaʻi, headache, ami or muscle muscle, ʻāʻī ʻoʻoleʻa, paʻakikī i ka hele ʻana, a i ʻole hoʻololi i ke ʻano noʻonoʻo.
• ʻūpū a hoʻokahe wale paha, ke koko i ka mimi a i ʻole ka noho, ka ihu e kahe ana, ka luaʻi koko, a ʻeha a me / a i ʻole nā ​​pehu i hui ʻia.
• ka sweating nui, ka pehu ʻana o ka maka, ka pohō kaumaha, ka makaʻu, a me ka puʻuwai wikiwiki
• ʻAʻole hiki ke wehewehe ʻia ke kaupaona, luhi, manaʻo anuanu, a i ʻole ka constipation
• kaumaha
• ke noʻonoʻo nei e pili ana i ka hōʻino a pepehi paha iā ʻoe iho a i ʻole ke hoʻolālā ʻana a hoʻāʻo ʻana paha e hana pēlā
• nā ʻeha ʻeha, nā manaʻo o nā kui a me nā nila, a i ʻole nā ​​ʻūlū ma luna o ka peni a i ʻole nā ​​wahi āpau
• ʻeha ʻeha a i ʻole huehue wela a i ʻole a puni paha ka waha
• ʻeha ka ʻeha ma kekahi ʻaoʻao o ke alo a i ʻole ke kino, me ka pehu, ka ʻeha, ka ʻū ʻana, a me ke kani ʻana i ka wahi ʻāhiki
• (i nā wahine) pilau a keʻokeʻo, keʻokeʻo a melemele paha i ka hemo (hiki i ka lumpy a i ʻole ke nānā aku e like me ka tī liʻiliʻi), a i ʻole ka huehue wahine
• lesion keʻokeʻo ma ke alelo a i ʻole nā ​​papalina o loko
• ʻeha o ka ʻōpū a palupalu paha, kuni, nausea, a i ʻole ka luaʻi
• nausea, luaʻi, ʻeha o ka ʻōpū, māluhiluhi nui, nalo o ka makemake ʻole, maka melemele a i ʻole ʻili, luhi nui loa, mimi ʻeleʻele, a i ʻole ke kahe ʻana a i ʻole ka palu maʻalahi ma mua o ka maʻamau.
• nāwaliwali ma kekahi ʻaoʻao o ke kino e ʻino ana i ka hala ʻana o ka manawa; clumsiness o nā lima a mau wāwae paha; nā hoʻololi i kou noʻonoʻo, hoʻomanaʻo, hele wāwae, kaulike, ʻōlelo, ʻike maka, a i ʻole ikaika i hala i mau lā; ʻeha poʻo poʻo; ka hopu ʻana; huikau; a i ʻole hoʻololi i ke ʻano
• fiva, pehu nā gland, pehu, hopu ʻia, hoʻololi i ka noʻonoʻo a makaʻala paha, a i ʻole hou a ʻoi aku paha ke kūmau ʻole a paʻakikī i ka hele wāwae

Hiki i nā kīʻaha Alemtuzumab ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa pū ka ʻike ma ka pūnaewele. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

• ʻeha poʻo
• hūwī
• ʻūpā

E noi i kāu kauka lāʻau i nā nīnau āu e pili ana i ka injection alemtuzumab.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Lemtrada^®