Hōʻike koko Cortisol

Hoʻopili ke kolo koko i ka pae o ka cortisol i ke koko. ʻO Cortisol kahi steroid (glucocorticoid a i ʻole Corticosteroid) hormone i hana ʻia e ka adrenal gland.

Hiki ke ana ʻia ʻo Cortisol me ka hoʻohana ʻana i ka mimi a i ʻole ka lawaiʻa hōʻike.

Pono kahi laʻana koko.

E hoʻokau paha kāu kauka iā ʻoe e hana i ka hōʻike ma ke kakahiaka. He mea nui kēia, no ka mea, ʻokoʻa ka pae o cortisol i ka lā holoʻokoʻa.

E noi paha ʻoe ʻaʻole e hana i ka hoʻoikaika kino i ka lā ma mua o ka hoʻāʻo.

Hiki paha iā ʻoe ke haʻi ʻia e hōʻoki i ka lawe ʻana i nā lāʻau i hiki ke hoʻololi i ka hōʻike, e like me:

• Nā lāʻau lapaʻau kūpale
• Estrogen
• ʻO nā glucocorticoids i hana ʻia e ke kanaka (synthetic), e like me hydrocortisone, prednisone a me prednisolone
• Androgens

Ke hoʻokomo ʻia ke kui kele e huki i ke koko, manaʻo kekahi poʻe i ka ʻeha kaulike. ʻIke wale kekahi i kahi ʻōniʻu a i ʻole kui. Ma hope, loaʻa paha i kahi kūpikipiki a i ʻole ʻeha iki. Hele koke kēia.

Hana ʻia ka hoʻāʻo e nānā no ka hoʻonui a hoʻemi ʻia paha o ka hana cortisol. ʻO Cortisol kahi glucocorticoid (steroid) hormone i hoʻokuʻu ʻia mai ka adrenal gland i ka pane ʻana i ka adrenocorticotropic hormone (ACTH). ʻO ACTH kahi homone i hoʻokuʻu ʻia mai ka pituitary gland i ka lolo.

Hoʻopili ʻo Cortisol i nā ʻōnaehana kino ʻokoʻa. He mea nui ia i:

• Ulu iwi
• Kaohi kaomi koko
• Hana ʻōnaehana paleʻāina
• ʻO ka Metabolism o nā momona, nā paʻakai, a me nā protein
• Hana ʻōnaehana hopohopo
• Pane i ke koʻikoʻi

ʻO nā maʻi ʻokoʻa, e like me Cushing syndrome a me Addison maʻi, hiki ke alakaʻi i ka nui a i ʻole ka liʻiliʻi o ka hana ʻana o cortisol. Hiki i ke ana ʻana i ke kiʻekiʻe o ke kortisol ke kōkua i ke koho ʻana i kēia mau ʻano. Ua ana ʻia e loiloi i ka maikaʻi o ka hana o ka pituitary a me ka adrenal glands.

Hana pinepine ʻia ka hoʻāʻo ma mua a me 1 mau hola ma hope o ka hoʻopili ʻana o kahi lāʻau i kapa ʻia ʻo ACTH (cosyntropin). Kapa ʻia kēia ʻāpana o ka hoʻāʻo he hōʻike hoʻoweliweli ACTH. He hōʻike nui ia e kōkua i ka nānā ʻana i ka hana o ka pituitary a me nā adrenal glands.

ʻO nā kūlana ʻē aʻe e kauoha ʻia ai ka hōʻike me:

• ʻO ka pilikia adrenal koʻikoʻi, kahi kūlana hoʻoweliweli i ke ola inā ʻaʻole lawa ka nui o ka cortisol
• ʻO Sepsis, kahi maʻi kahi e pane nui ai ke kino i nā bacteria a i ʻole nā ​​mikrobia ʻē aʻe
• Kaomi haʻahaʻa

ʻO nā kumukūʻai maʻamau no kahi hāpana koko i lawe ʻia ma 8 i ke kakahiaka he 5 a 25 mcg / dL a i ʻole 140 a 690 nmol / L.

Aia nā waiwai maʻamau i ka manawa o ka lā a me ka pōʻaiapili. Hiki ke loli iki nā laulā maʻamau i waena o nā hale hana ʻokoʻa. Hoʻohana kekahi mau labs i nā ana like ʻole a i ʻole hoʻokolohua i nā hoʻohālikelike like ʻole. E kamaʻilio me kāu kauka e pili ana i ke ʻano o kāu mau hopena hōʻike kikoʻī.

E hōʻike paha kahi kiʻekiʻe ma mua o ka pae maʻamau:

• ʻO ka maʻi cushing, kahi a ka pituitary gland e hana ai i ka nui o ka ACTH ma muli o ka ulu nui ʻana o ka pituitary gland a i ʻole kahi tumo i ka pituitary gland.
• ʻO ka Ectopic Cushing syndrome, kahi o kahi tumo ma waho o ka pituitary a i ʻole ke adrenal glands e hana ai i ka nui o ka ACTH
• Tumor o ka adrenal gland e hana nei i ka nui o ka cortisol
• Kaumaha
• Maʻi maʻi koʻikoʻi

Hōʻike kahi haʻahaʻa ma mua o ka pae maʻamau:

• ʻO ka maʻi Addison, kahi a nā adrenal glands e hana ʻole ai i ka nui o ka cortisol
• Hypopituitarism, kahi a ka pituitary gland e hōʻike ʻole ai i ka adrenal gland e hoʻohua i ka nui o ka cortisol
• Kaohi ʻana i ka pituitary a i ʻole ka adrenal kuleana e nā lāʻau glucocorticoid e like me nā huaale, nā ʻili, nā kuʻemaka, nā inhalers, nā injection pū, chemotherapy

ʻAʻohe pilikia iki i ka lawe ʻia ʻana o kou koko. ʻOkoʻa nā aʻa a me nā aʻa i ka nui mai kekahi kanaka a i kekahi ʻē aʻe a mai kekahi ʻaoʻao o ke kino i kekahi. ʻOi aku ka paʻakikī o ka lawe ʻana i ke koko mai kekahi poʻe ma mua o nā poʻe ʻē aʻe.

ʻO nā pilikia ʻē aʻe e pili ana i ke kau ʻana o ke koko he liʻiliʻi, akā hiki ke hoʻopili ʻia:

• Kahe nui ke koko
• Pāleʻale a ʻoluʻolu paha
• Nā punctures he nui e ʻimi i nā uaua
• Hematoma (hōʻiliʻili koko ma lalo o ka ʻili)
• Maʻiʻaʻai (i iki kamepiula i kēlā me kēia manawa ka ʻili i haki)

Serum cortisol

Chernecky CC, Berger BJ. Cortisol - plasma a serum paha. I: Chernecky CC, Berger BJ, hua. Nā Hoʻokolohua Laboratory a me nā kaʻina hana Diagnostic. ʻElua huaʻōlelo St Louis, MO: Elsevier Saunders; 2013: 388-389.

ʻO Stewart PM, Newell-Kumukūʻai JDC. ʻO ka Cortex adrenal. I: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. ʻO Williams Textbook of Endocrinology. 13th ed. Piladelapia, PA: Elsevier; 2016: chap 15.