ʻO nā mea āpau āu e makemake ai e ʻike e pili ana i nā Inhibitors SGLT2

Anter

• He aha nā ʻano ʻokoʻa o nā mea kūpale SGLT2?
• Pehea e lawe ai i kēia lāʻau?
• He aha nā pōmaikaʻi kūpono o ka lawe ʻana i kahi mea kāohi iā SGLT2?
• He aha nā hopena a me nā hopena ʻē aʻe o ka lawe ʻana i kēia lāʻau?
• He palekana anei ka hoʻohui ʻana i kēia ʻano lāʻau me nā lāʻau ʻē aʻe?
• ʻO ka lawe lawe ʻana

Hōʻike Overview

SGLT2 mea pāpā he papa o nā lāʻau i hoʻohana ʻia e mālama ai i ka maʻi kō ʻelua. Kāhea ʻia lākou he sodium-glucose transport protein 2 mea hōʻemi a i ʻole gliflozins.

Pale aku nā mea kāohi SGLT2 i ka reabsorption o glucose mai ke koko i kānana ʻia ma o kou mau puʻupaʻa, no laila e kōkua ana i ka lawe ʻana o ka glucose i ka mimi. Kōkua kēia i ka hōʻemi i kou kiʻekiʻe kō kō.

E heluhelu aʻe e aʻo hou aʻe e pili ana i nā ʻano mea like ʻole o nā mea kāohi SGLT2, a me nā pōmaikaʻi kūpono a me nā pilikia o ka hoʻohui ʻana i kēia ʻano lāʻau i kāu papa hana lapaʻau.

He aha nā ʻano ʻokoʻa o nā mea kūpale SGLT2?

I kēia lā, ua ʻae ʻo ka U.S. Food and Drug Administration (FDA) ʻehā mau ʻano o nā mea kūpale SGLT2 e mālama i ka maʻi diabetes type 2:

• canagliflozin (Invokana)
• dapagliflozin (Farxiga)
• empagliflozin (Jardiance)
• ertugliflozin (Steglatro)

Ke hoʻomohala ʻia a ʻano hoʻāʻo ʻia nā ʻano mea kūpale SGLT2 i nā hoʻokolohua hoʻokolohua.

Pehea e lawe ai i kēia lāʻau?

SGLT2 mea pāpālina he lāʻau lapaʻau waha. Loaʻa lākou i ka palapala pila.

Inā hoʻohui kāu kauka i kahi mea kāohi SGLT2 i kāu papa hana hoʻomaʻamaʻa, aʻoaʻo lākou iā ʻoe e lawe i hoʻokahi a i ʻole ʻelua mau manawa i ka lā.

I kekahi mau hihia, kauoha paha kāu kauka i kahi mea kāohi SGLT2 me nā lāʻau maʻi diabetes ʻē aʻe. ʻO kahi laʻana, hiki ke hoʻohui ʻia kēia papa lāʻau me metformin.

Hiki i kahi hui pū ʻana o nā lāʻau diabetes ke kōkua iā ʻoe e mālama i ka pae kō kō i loko o ka pae i hoʻopaʻa ʻia. He mea nui e lawe i ka mahele lāʻau kūpono o kēlā me kēia lāʻau e hōʻoki i kāu pae kō kō mai ke iho haʻahaʻa loa.

He aha nā pōmaikaʻi kūpono o ka lawe ʻana i kahi mea kāohi iā SGLT2?

Ke lawe hoʻokahi a i ʻole me nā lāʻau maʻi diabetic ʻē aʻe, hiki i nā mea kāohi SGLT2 ke kōkua i ka hoʻohaʻahaʻa ʻana i kāu pae kō kō Hoʻoemi kēia i kou manawa o ka hoʻomohala ʻana i nā pilikia mai ka maʻi diabetes type 2.

Wahi a kahi noiʻi 2018 i paʻi ʻia i loko o ka puke pai Ka Manaʻo Diabetes, hōʻike nā ʻepekema i nā mea kāohi ʻo SGLT2 hiki i ka hoʻoliʻiliʻi kaumaha a me nā hoʻomaikaʻi haʻahaʻa i kou kahe koko a me nā pae kolesterol.

Ua ʻike ʻia kahi loiloi 2019 e pili ana nā mea kūpale SGLT2 i ka hoʻohaʻahaʻa haʻahaʻa o ka hahau, ka puʻuwai puʻuwai ʻana, a me ka make mai ka maʻi maʻi maʻi i nā poʻe me ka maʻi diabetes type 2 a me nā aʻa paʻakikī.

Ua ʻike ʻia ka loiloi like e lohi paha ka mea pāpā ʻo SGLT2 i ka holomua o ka maʻi puʻupaʻa.

E hoʻomanaʻo, ʻo nā pōmaikaʻi kūpono o nā mea kāohi SGLT2 ʻokoʻa i kēlā me kēia kanaka i kekahi, e like me kā lākou mōʻaukala olakino.

E aʻo hou aʻe e pili ana i kēia ʻano lāʻau, a inā he kūpono kūpono no kāu papa hana hoʻomaʻamaʻa, e kamaʻilio me kāu kauka.

He aha nā hopena a me nā hopena ʻē aʻe o ka lawe ʻana i kēia lāʻau?

Manaʻo ʻia ʻo nā mea kāohi SGLT2 he palekana, akā i kekahi mau hihia, hiki iā lākou ke kumu i nā hopena ʻaoʻao.

ʻO kahi laʻana, hiki i ka lawe ʻana i kēia ʻano lāʻau ke hāpai i kou makaʻu i ka hoʻomohala ʻana:

• maʻi maʻi urinary tract
• ʻo nā maʻi genital hoʻoili ʻole pili moekolohe, e like me nā maʻi hū
• ketoacidosis diabetic, ka mea e lilo ai kou koko i acidic
• hypoglycemia, a i ʻole ke kō kō

I nā hihia maʻamau, loaʻa i nā maʻi genital koʻikoʻi i ka poʻe i lawe i nā mea kūpale SGLT2. ʻIke ʻia kēia ʻano maʻi ʻo ka necrotizing fasciitis a i ʻole ʻo Fournier’s gangrene.

Hōʻike kekahi mau noiʻi e hiki i ka canagliflozin ke hoʻonui i ka makaʻu o ka haʻi iwi. ʻAʻole i hoʻopili ʻia kēia mau hopena maikaʻi ʻole i nā mea hoʻopaʻa i nā SGLT2 ʻē aʻe.

Hiki i kāu kauka ke hoʻomaopopo iā ʻoe hou e pili ana i nā makaʻi o ka lawe ʻana i nā mea kūpale SGLT2. Hiki iā lākou ke kōkua iā ʻoe e aʻo pehea e ʻike ai a mālama ai i nā hopena ʻē aʻe e hiki ai.

Inā manaʻo ʻoe e loaʻa ana iā ʻoe nā hopena ʻē aʻe mai ka lāʻau, e hoʻopili koke aku i kāu kauka.

He palekana anei ka hoʻohui ʻana i kēia ʻano lāʻau me nā lāʻau ʻē aʻe?

Ke hoʻohui ʻoe i kahi lāʻau hou i kāu papa hana, he mea nui e noʻonoʻo pehea e launa pū ai me nā lāʻau i lawe mua ʻia.

Inā lawe ʻoe i nā lāʻau maʻi diabet ʻē aʻe e hoʻohaʻahaʻa i kāu kiʻekiʻe o ke kō i ke kō, me ka hoʻohui ʻana i kahi mea kāohi SGLT2 e hoʻonui ai i kou makaʻu i ka hoʻomohala ʻana i ke kō kō.

Eia hou, inā e lawe ana ʻoe i kekahi mau ʻano diuretics, hiki i nā mea kūpale SGLT2 ke hoʻonui i ka hopena diuretic o kēlā mau lāʻau, e hoʻomaʻemaʻe pinepine ai iā ʻoe. Hiki iā ia ke hāpai i kou makaʻu i ka make wai a me ke koko haʻahaʻa.

Ma mua o kou hoʻomaka ʻana e lawe i kahi lāʻau hou a i ʻole mea kōkua, e nīnau i kāu kauka inā hiki ke launa me kekahi mea i kāu papa hana e kū nei.

I kekahi mau hihia, hiki i kāu kauka ke hoʻololi i kāu lāʻau i kuhikuhi ʻia e hoʻohaʻahaʻa i kou makaʻu i nā launa lāʻau maikaʻi ʻole.

ʻO ka lawe lawe ʻana

Hoʻolālā ʻia nā mea kāohi SGLT2 e kōkua i ka mālama ʻana i ke kō kō i nā poʻe e noho nei me ka maʻi diabetes type 2.

Ma waho aʻe o ka hōʻemi ʻana i nā pae kō kō, ua ʻike ʻia kēia papa o ka lāʻau i loaʻa i nā pono o ka maʻi me ka puʻuwai. ʻOiai manaʻo ʻia he palekana lākou, SGLT2 mea kāohi i kekahi manawa ke kumu i nā hopena a i ʻole nā ​​pilina maikaʻi ʻole me kekahi mau lāʻau.

Hiki i kāu kauka ke haʻi hou aku iā ʻoe e pili ana i nā pono kūpono a me nā pilikia o ka hoʻohui ʻana i kēia ʻano lāʻau i kāu hoʻolālā mālama.