Rituxan no MS

Anter

• E pili ana i ka hoʻohana lāʻau lāʻau hōʻailona
• Palekana a palekana ʻo Rituxan no ka mālama ʻana iā MS?
• He maikaʻi paha ia?
• Palekana anei?
• He aha ka ʻokoʻa ma waena o Rituxan a me Ocrevus?
• ʻO ka lawe lawe ʻana

Hōʻike Overview

ʻO Rituxan (inoa generic rituximab) kahi lāʻau lapaʻau e kuhikuhi i kahi protein i kapa ʻia ʻo CD20 i nā pūnaewele immune B. Ua ʻae ʻia e ka U.S. Food and Drug Administration (FDA) no ka mālama ʻana i nā maʻi e like me Non-Hodgkin's lymphoma a me ka rheumatoid arthritis (RA).

Kauoha nā kauka iā Rituxan i kekahi manawa no ka mālama ʻana i nā sclerosis he nui (MS), ʻoiai ʻaʻole i ʻae ka FDA iā ia no kēia hoʻohana. Kapa ʻia kēia ma ke ʻano he lāʻau hoʻohana "off-label".

E pili ana i ka hoʻohana lāʻau lāʻau hōʻailona

ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau i hōʻailona ʻia ʻo ia ka lāʻau i ʻae ʻia e ka FDA no hoʻokahi kumu i hoʻohana ʻia no kahi kumu ʻē aʻe i ʻae ʻole ʻia.

Eia nō naʻe, hiki i ke kauka ke hoʻohana i ka lāʻau no ia kumu. ʻO kēia no ka mea hoʻoponopono ka FDA i ka hoʻāʻo a me ka ʻae ʻana o nā lāʻau, akā ʻaʻole pehea e hoʻohana ai nā kauka i nā lāʻau e mālama ai i kā lākou mau maʻi. No laila hiki i kāu kauka ke kuhikuhi i kahi lāʻau akā manaʻo lākou ʻoi aku ka maikaʻi no kāu mālama. E aʻo hou aʻe e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau i waho o ka lepili.

Inā kuhikuhi kāu kauka i lāʻau lāʻau no ʻoe no ka hoʻohana inoa inoa ʻole, pono ʻoe e noʻonoʻo e nīnau i kāu nīnau. He kuleana kou e komo i loko o nā hoʻoholo e pili ana i kāu mālama.

ʻO nā laʻana o nā nīnau āu e nīnau ai:

• No ke aha ʻoe i kauoha aku ai i kahi hoʻohana inoa ʻole o kēia lāʻau?
• Loaʻa i nā lāʻau ʻē aʻe i ʻae ʻia hiki ke hana i ka mea like?
• E uhi paha kaʻu ʻinikua olakino i kēia hoʻohana lāʻau lapaʻau i waho?
• ʻIke paha ʻoe i nā hopena ʻē aʻe e loaʻa iaʻu i kēia lāʻau?

Palekana a palekana ʻo Rituxan no ka mālama ʻana iā MS?

ʻAʻohe manaʻo kūkākūkā e pili ana i ka palekana a me ka maikaʻi o Rituxan no ka mālama ʻana iā MS, akā hōʻike nā noiʻi e hōʻike ana i ka hoʻohiki.

He maikaʻi paha ia?

ʻOiai ʻaʻole i lawa ka hoʻohālikelike ʻana i nā aʻo ʻana o ka honua maoli e hoʻokolokolo pono iā Rituxan ma ke ʻano he lapaʻau kūpono no MS, nā hōʻailona maikaʻi paha e hōʻike.

Ua hoʻohālikelike kahi noiʻi o kahi kākau inoa Suetena MS iā Rituxan me ka maʻi kuʻuna e hoʻololi i nā koho lapaʻau e like me

• Tecfidera (dimethyl fumarate)
• Gilenya (fingolimod)
• ʻO Tysabri (natalizumab)

Ma nā ʻōlelo no ka hoʻopau ʻana i ka lāʻau a me ka pono o ka lāʻau i ka relapsing-remitting multiple sclerosis (RRMS), ʻaʻole ʻo Rituxan wale nō ke koho alakaʻi no ka lapaʻau mua, akā hōʻike pū i nā hopena maikaʻi loa.

Palekana anei?

Hana ʻo Rituxan ma ke ʻano he agena hoʻopau B-cell. Wahi a, lōʻihi o ka hoʻopau ʻia ʻana o nā hunaola B ākea ma o Rituxan ʻike ʻia he palekana, akā pono ka ʻike hou aku.

Hiki i nā hopena ʻaoʻao o Rituxan ke hoʻopili pū i:

• nā hopena infusion e like me ka ʻōhū, ka makaʻu, a me ka pehu ʻana
• nā pilikia puʻuwai e like me nā puʻuwai kūlohelohe ʻole
• nā pilikia ʻōpū
• gums kahe
• ʻeha ka ʻōpū
• fiva
• haʻalulu
• nā maʻi maʻi
• ʻeha ke kino
• nausea
• hūwī
• luhi
• haʻahaʻa keena koko keʻokeʻo
• pilikia hiamoe
• palahu ke alelo

ʻO nā moʻolelo palekana o nā ʻano lāʻau ʻē aʻe e like me Gilenya a me Tysabri no nā poʻe me MS he mau palapala ʻoi aku ka nui ma mua o Rituxan.

He aha ka ʻokoʻa ma waena o Rituxan a me Ocrevus?

ʻO Ocrevus (ocrelizumab) kahi lāʻau i ʻae ʻia e ka FDA i hoʻohana ʻia no ka mālama ʻana o RRMS a me sclerosis mua nui (PPMS).

Manaʻo kekahi poʻe he mana hou wale ʻo Ocrevus ʻo Rituxan. Hana pū lāua ʻelua ma ke kālele ʻana i nā hunaola B me nā mole o CD20 ma ko lākou ʻili.

ʻO Genentech - ka mea hoʻomohala i nā lāʻau ʻelua - ʻōlelo ʻia aia he mau ʻokoʻa mole a pili ʻokoʻa nā lāʻau i kēlā me kēia me nā ʻōnaehana paleʻāina.

ʻO kahi ʻokoʻa nui ka ʻoi aku o nā hoʻolālā ʻinikua olakino uhi iā Ocrevus no ka mālama ʻana ma MS ma mua o Rituxan.

ʻO ka lawe lawe ʻana

Inā ʻoe - a i ʻole kekahi mea kokoke iā ʻoe - loaʻa iā MS a manaʻo ʻoe ʻo Rituxan kahi koho lapaʻau ʻokoʻa, e kūkā kamaʻilio me kāu kauka. Hiki i kāu kauka ke hāʻawi i ka ʻike i loko o nā ʻano hana like ʻole a pehea e hana ai no kāu kūlana kikoʻī.