Mea Kākau: Marcus Baldwin
Lā O Ka Hana: 18 Iune 2021
HōʻAno Hou I Ka Lā: 16 Nowemapa 2024
Anonim
RACE: evaluating eltrombopag in severe aplastic anemia
Wikiō: RACE: evaluating eltrombopag in severe aplastic anemia

Anter

Inā loaʻa iā ʻoe ka maʻi he hepatitis C mau (kahi maʻi maʻi e hoʻomau nei e hōʻino paha i ke ake) a lawe ʻoe i eltrombopag me nā lāʻau no ka hepatitis C i kapa ʻia ʻo interferon (Peginterferon, Pegintron, a me nā mea ʻē aʻe) a me ribavirin (Copegus, Rebetol, Ribasphere, a me nā mea ʻē aʻe), aia kekahi hoʻonui i ka makaʻu e hoʻomohala ʻoe i nā hōʻino nā ake nui. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: melemele o ka ʻili a i ʻole nā ​​maka, mimi ʻeleʻele, luhi nui, ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū, pehu o ka ʻōpū a i ʻole huikau.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha aku kāu kauka i kekahi mau hoʻokolohua hale loiloi ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino i ka eltrombopag.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka ʻikepili ʻike hoʻomanawanui o ka mea hana (Ke alakaʻi alakaʻi) ke hoʻomaka ʻoe i ka lāʻau me eltrombopag a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.


E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana iā eltrombopag.

Hoʻohana ʻia ʻo Eltrombopag e hoʻonui i ka helu o nā platelet (nā hunaola e kōkua ai i ke kōkuʻu koko) e hoʻēmi i ka makaʻu o ke kahe ʻana o ke koko i nā mākua a me nā keiki ʻo 1 mau makahiki a ʻoi paha ka makahiki i loaʻa ka thrombositopenia immune mau loa (ITP; kahi ʻano hoʻomau i hiki ke kumu i ka ʻehaʻeha maʻamau a i ʻole ka kahe kahe ma muli o ka helu haʻahaʻa o nā platelet i loko o ke koko) a ʻaʻole i kōkua ʻia a i ʻole hiki ʻole ke mālama ʻia me nā ʻano lāʻau ʻē aʻe, e like me nā lāʻau a i ʻole ke ʻoki e hemo ai ka iwi maha. Hoʻohana ʻia ʻo Eltrombopag e hoʻonui i ka helu o nā platelet i ka poʻe i loaʻa i ka maʻi hepitis C (kahi maʻi viral e hōʻino paha i ke ake) i hiki iā lākou ke hoʻomaka a hoʻomau i ka mālama ʻana me interferon (Peginterferon, Pegintron, a me nā mea ʻē aʻe) a me ribavirin (Rebetol) Hoʻohana pū ʻia ʻo Eltrombopag me ka hoʻohui me nā lāʻau ʻē aʻe e mālama ai i ka anemia aplastic (kahi e lawa ʻole ai ke kino o nā kino hou) i nā mākua a me nā keiki ʻo 2 mau makahiki a ʻoi paha. Hoʻohana ʻia ia e mālama i ka anemia aplastic i nā mākua i kōkua ʻole ʻia me nā lāʻau ʻē aʻe. Hoʻohana ʻia ʻo Eltrombopag e hoʻonui i ka helu o nā platelet i lawa e hoʻemi i ka makaʻu o ke kahe ʻana i ka poʻe me ITP a i ʻole aplastic anemia, a i ʻole e ʻae ʻia me ka interferon a me ribavirin i ka poʻe me ka maʻi hepitis C. Akā ʻaʻole ia e hoʻohana ʻia e hoʻonui i ka helu o nā platelet i kahi pae maʻamau. ʻAʻole pono e hoʻohana ʻia ʻo Eltrombopag e mālama ai i ka poʻe i loaʻa nā helu haʻahaʻa o ka platelet ma muli o nā kūlana ʻē aʻe ma mua o ITP, hepatitis C, a i ʻole anemia aplastic. Aia ʻo Eltrombopag i kahi papa o nā lāʻau i kapa ʻia nā agonists receptor thrombopoietin. Hana ia ma ke kumu ʻana i nā hunaola i loko o ka iwi iwi e hana i nā pā hou aʻe.


Hele mai ʻo Eltrombopag ma ke ʻano he papa ʻaukā a me he pauka no ka hoʻomaha waha (wai) e lawe ʻia e ka waha. Lawe ʻia ia i hoʻokahi manawa i ka lā ma ka ʻōpū hakahaka, ma ka liʻiliʻi he 1 hola ma mua a i ʻole 2 mau hola ma hope o ka ʻai ʻana. Lawe iā eltrombopag ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pololei i eltrombopag e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E lawe i ka eltrombopag ma kahi o 2 mau hola ma mua a i ʻole 4 mau hola ma hope o kou ʻai ʻana a inu paha i nā meaʻai i piha i ka nui o ka calcium, e like me nā huahana waiū, nā wai momona i hana ʻia i ka calcium, nā cereal, nā oatmeal, a me nā berena; trout; pāpaʻi; nā lau lau ʻōmaʻomaʻo e like me ka spinach a me nā collard greens; a me ka tofu a me nā huahana soy ʻē aʻe. E noi i kāu kauka inā ʻaʻole ʻoe e maopopo inā loaʻa i ka meaʻai ka nui o ka puna. Hiki paha iā ʻoe ke kōkua he lawe eltrombopag kokoke i ka hoʻomaka a i ʻole hopena o kou lā i hiki ai iā ʻoe ke ʻai i kēia mau meaʻai i ka hapa nui o kou mau ala ala.


E ale i nā papa holoʻokoʻa. Mai hoʻokaʻawale, ʻai, a hū paha iā lākou a kāwili ʻia i meaʻai a me nā wai.

Inā ʻoe e lawe ana i ka pauka no ka hoʻomaha waha, e heluhelu pono i nā ʻōkuhi a ka mea hana no ka hoʻohana ʻana me ka lāʻau. Hōʻike kēia mau ʻōkuhi pehea e hoʻomākaukau ai a ana i kāu kau. Hoʻohui i ka pauka me ka wai anuanu a anuanu paha ma mua o ka hoʻohana. Mai hoʻopili i ka pauka me ka wai wela. Ma hope koke o ka hoʻomākaukau ʻana, moni i ka lāʻau. Inā ʻaʻole lawe ʻia i loko o 30 mau minuke a i ʻole ke koe wai, hoʻolei i ka hoʻohuihui i ka ʻōpala (mai ninini i lalo i ka poho.)

Mai ʻae i ka pauka e hoʻopā i kou ʻili. Inā ninini ʻoe i ka pauka i kou ʻili, holoi koke ʻia me ke kopa a me ka wai. Kāhea i kāu kauka inā loaʻa iā ʻoe kahi hopena o ka ʻili a i ʻole he nīnau kāu.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi haʻahaʻa o eltrombopag a hoʻomaʻamaʻa i kāu lāʻau ma muli o kāu pane i ka lāʻau. I ka hoʻomaka o kāu lapaʻau ʻana, e kauoha kāu kauka i kahi hoʻokolohua koko e nānā i kāu pae platelet hoʻokahi i kēlā me kēia pule. E hoʻonui paha kāu kauka i kāu lāʻau inā he haʻahaʻa loa kāu pae platelet. Inā kiʻekiʻe loa kāu pae platelet, hiki i kāu kauka ke hōʻemi i kāu lāʻau a hāʻawi ʻole iā ʻoe iā eltrombopag no kekahi manawa. Ma hope o ka hoʻomau ʻana o kāu lapaʻau ʻana no kekahi manawa a loaʻa i kāu kauka ka hopena o eltrombopag e pono ai nāu, e nānā pinepine ʻia kāu pae platelet. E nānā pū ʻia kāu pae platelet i kēlā me kēia pule no 4 mau pule ma hope o kou hoʻōki ʻana i ka lawe ʻana i ka eltrombopag.

Inā loaʻa iā ʻoe ka ITP mau, loaʻa paha iā ʻoe nā lāʻau ʻē aʻe e mālama ai i kou ʻano me eltrombopag. Hiki i kāu kauka ke hōʻemi i kāu lāʻau o kēia mau lāʻau inā hana maikaʻi ʻo eltrombopag nou.

ʻAʻole holo ʻo Eltrombopag no nā mea āpau. Inā ʻaʻole hoʻonui kou pae platelet ma hope o kou lawe ʻana i ka eltrombopag no kekahi manawa, hiki i kāu kauka ke ʻōlelo iā ʻoe e haʻalele i ka lawe ʻana iā eltrombopag.

Hiki paha iā Eltrombopag ke kōkua i ka mālama ʻana i kou ʻano akā ʻaʻole e hoʻōla iā ia. E hoʻomau i ka lawe eltrombopag ʻoiai ʻoe e manaʻo maikaʻi. Mai hooki i ka lawe ʻana i ka eltrombopag me ka walaʻau ʻole ʻana me kāu kauka.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i eltrombopag,

  • e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka eltrombopag, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa eltrombopag. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻai, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe E haʻi pono i kekahi o kēia mau mea: anticoagulants (nā mea lahilahi o ke koko) e like me warfarin (Coumadin, Jantoven); bosentan (Tracleer); nā lāʻau hoʻohaʻahaʻa kolesterol (statins) e like me atorvastatin (Lipitor, ma Caduet), fluvastatin (Lescol), pitavastatin (Livalo, Zypitamag), pravastatin (Pravachol), rosuvastatin (Crestor), a me simvastatin (Zocor, Flolopid, i Vytorin); ezetimibe (Zetia, i Vytorin); glyburide (Diabeta, Glynase); imatinib (Gleevec); irinotecan (Camptosar, Onivyde); olmesartan (Benicar, ma Azor, ma Tribenzor); lapatinib (Tykerb); methotrexate (Rasuvo, Trexall, nā mea ʻē aʻe); mitoxantrone; repaglinide (Prandin): rifampin (Rimactane, Rifadin, ma Rifamate, Rifater); sulfasalazine (Azulfidine); topotecan (Hycamtin), a me valsartan (Diovan, ma Byvalson, ma Entresto, ma Exforge). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.Nui paha nā lāʻau ʻē aʻe e launa pū paha me eltrombopag, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
  • inā ʻoe e lawe i nā antacids i loko o ka calcium, aluminika, a me ka magnesium (Maalox, Mylanta, Tums) a i ʻole nā ​​huaora a i ʻole mineral i loko o ka calcium, hao, zinc a selenium paha, e lawe i nā eltrombopag 2 mau hola ma mua a i ʻole 4 mau hola ma hope o kou lawe ʻana iā lākou.
  • e haʻi i kāu kauka inā no ka Hikina Hikina ʻoe (Kina, Iāpana, Taiwanese, a i ʻole Kōlea) a inā he cataract kāu (e ʻāwī ʻana i nā aniani o ka maka e hoʻopilikia i ka ʻike maka), nā huʻa koko, nā ʻano like ʻole. e hoʻonui i ka makaʻu e hoʻomohala ʻoe i kahi kōkō o ke koko, nā pilikia kahe ʻana o ke koko, myelodysplastic syndrome (MDS; kahi maʻi koko e hiki ai i ka maʻi ʻaʻai), a i ʻole nā ​​maʻi ate. E haʻi pū aku i kāu kauka inā ua loaʻa iā ʻoe kahi ʻoki e wehe i kāu spleen.
  • e haʻi i kāu kauka inā hāpai ʻoe, a i ʻole hoʻolālā e hāpai. ʻAʻole ʻoe e hāpai i ka wā o kāu mālama ʻana me eltrombopag. E hoʻohana i ka kaohi hānau pono ke loaʻa ʻoe i ka lāʻau lapaʻau a no 7 mau lā ma hope o kāu hopena hope loa. Inā hāpai ʻoe i ka lawe ʻana i eltrombopag, e kāhea i kāu kauka.
  • e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana ʻoe i ka eltrombopag.
  • e hoʻomau i ka pale ʻana i nā hana e hōʻeha a hōʻeha paha i kou wā e mālama ai me eltrombopag. Hāʻawi ʻia ʻo Eltrombopag e hōʻemi i ka makaʻu āu e ʻike ai i ke kahe nui, akā aia nō paha kahi pilikia e hiki i ke kahe ʻana o ke kahe.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala. Mai lawe ma mua o hoʻokahi mahele o eltrombopag i ka lā hoʻokahi.

Hoʻokumu paha ʻo Eltrombopag i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • ʻeha kua
  • ʻeha nā mākala a i ʻole nā ​​spasms
  • ʻeha poʻo
  • nā ʻōuli o ka maʻi palū e like me ka fiva, ʻeha ke poʻo, ʻāʻī puʻupuʻu, ʻū, luhi, haʻalulu, a me nā ʻeha o ke kino
  • nāwaliwali
  • luhi loa
  • hoʻēmi ʻai
  • ʻeha a pehu paha i ka waha a i ʻole ka puʻu
  • poho lauoho
  • hūwī
  • loli ke kala o ka ʻili
  • ʻili ka ʻili, ʻili, a mau ʻole paha
  • ka pehu ʻana o nā kuʻekuʻe wāwae, nā wāwae, a me nā wāwae lalo
  • ʻehaʻeha (i nā keiki)

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • pehu, ʻeha, palupalu, mehana a ʻulaʻula paha i hoʻokahi wāwae
  • ka pōkole o ka hanu, kahe ʻana i ke koko, ka puʻuwai wikiwiki, ka hanu wikiwiki ʻana, ka ʻeha ke hanu nui
  • ʻeha ma ka umauma, lima, kua, ʻāʻī, ʻāʻī, a ʻōpū paha, e haki ana i ka hou anu, ʻūlū māmā
  • lohi a paʻakikī paha i ka ʻōlelo, nāwaliwali koke a i ʻole numbness o ka maka, ka lima a me ka wāwae, ʻeha ke poʻo hina, nā pilikia ʻike hikiwawe, paʻakikī hele wāwae
  • ʻeha o ka ʻōpū, nausea, luaʻi, diarrhea
  • ʻōpua, ʻike hihi, a i ʻole nā ​​loli ʻike ʻē aʻe

Hoʻokumu paha ʻo Eltrombopag i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua. Inā hele mai kāu lāʻau lapaʻau me kahi ʻeke desiccant (ʻāpana liʻiliʻi i loaʻa kahi mea e omo ai i ka wai e hoʻomau i ka maloʻo o ka lāʻau), e waiho i ka pūʻolo i loko o ka hue akā e akahele ʻoe i ka moni ʻole iā ia.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

  • hūwī
  • lohi kuʻi ka naʻau
  • luhi nui loa

E kauoha kāu kauka i kahi loiloi maka ma mua a i kou wā e mālama ai me eltrombopag.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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Nānā Hou - 02/15/2019

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