Mea Kākau: Clyde Lopez
Lā O Ka Hana: 24 Iulai 2021
HōʻAno Hou I Ka Lā: 19 Nowemapa 2024
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Nā Hōʻaia Pharmacogenetic - Kino PaʻA
Nā Hōʻaia Pharmacogenetic - Kino PaʻA

Anter

He aha ka hoʻokolohua pharmacogenetic?

ʻO ka Pharmacogenetics, i kapa ʻia hoʻi ʻo pharmacogenomics, ke aʻo ʻana i ka hopena o nā gen i ka pane o ke kino i kekahi mau lāʻau. ʻO nā ʻāpana nā ʻāpana o ka DNA i hoʻoili ʻia mai kou makuahine a me kou makuakāne. Hāpai lākou i ka ʻike e hoʻoholo ai i kāu ʻano kū hoʻokahi, e like me ke kiʻekiʻe a me ke kala o ka maka. Hiki i kāu genes ke hoʻopili i ke ʻano o ka palekana a me ka maikaʻi o kekahi lāʻau iā ʻoe.

Hiki i nā Genes ke kumu o ka lāʻau like i ka mahele like e hoʻopili i ka poʻe ma nā ʻano like ʻole. ʻO Genes paha ke kumu o ka hopena maikaʻi ʻole o kekahi poʻe i ka lāʻau, ʻo ka loaʻa ʻole o kekahi.

Nānā ka hoʻāʻo ʻana ʻo Pharmacogenetic i nā gen kikoʻī e kōkua e ʻike i nā ʻano o nā lāʻau a me nā lāʻau e kūpono paha iā ʻoe.

Nā inoa ʻē aʻe: pharmacogenomics, hoʻokolohua pharmacogenomic

No ke aha ia e hoʻohana ai?

Hiki ke hoʻohana ʻia ka hoʻāʻo ʻana ʻo Pharmacogenetic i:

  • E ʻike inā he lāʻau pono paha kāu
  • E ʻike he aha nā mea ʻoi loa nāu
  • Wanana inā loaʻa iā ʻoe kahi hopena koʻikoʻi mai kahi lāʻau

No ke aha wau e pono ai i ka hoʻokolohua pharmacogenetic?

E kauoha paha kāu mea mālama ola i kēia mau hoʻokolohua ma mua o kou hoʻomaka ʻana i kekahi lāʻau, a i ʻole inā e lawe ʻoe i ka lāʻau i hana ʻole a / a i ʻole e hopena i nā hopena maikaʻi ʻole.


Loaʻa nā hoʻāʻo Pharmacogenetic no kahi palena o nā lāʻau lapaʻau. Ma lalo iho nei kekahi o nā lāʻau a me nā gen e hiki ai ke hoʻāʻo. (Hāʻawi pinepine ʻia nā inoa Gene i nā leka a me nā helu.)

LapaʻauʻO Genes
Warfarin: he lahilahi kokoCYP2C9 a me VKORC1
Plavix, he lahilahi kokoCYP2C19
Nā lāʻau Antidepressants, nā lāʻau epilepsyCYP2D6, CYPD6 CYP2C9, CYP1A2, SLC6A4, HTR2A / C
ʻO Tamoxifen, kahi lapaʻau no ka maʻi ʻaʻai umaumaCYPD6
Nā AntipsychoticsDRD3, CYP2D6, CYP2C19, CYP1A2
Nā mālama ʻana no ka maʻi deficit attentionE4D4
ʻO Carbamazepine, kahi lapaʻau no ka maʻi epilepsyHLA-B * 1502
ʻO Abacavir, kahi lapaʻau no ka maʻi HIVHLA-B * 5701
OpioidsOPRM1
Statins, nā lāʻau e mālama i ke kiʻekiʻe o ke kōSLCO1B1
Nā mālama no ka leukemia kamaliʻi a me kekahi mau maʻi autoimmuneTMPT


He aha ka hana i ka wā o ka hoʻokolohua pharmacogenetic?

Hana pinepine ʻia ka hoʻāʻo ʻana ma ke koko a i ka lawai paha.


No kahi hōʻike koko, e lawe kahi loea mālama ola i kahi laʻana koko mai kahi aa i loko o kou lima, e hoʻohana ana i kahi nila liʻiliʻi. Ma hope o ka hoʻokomo ʻia ʻana o ka nila, e hōʻiliʻili ʻia kahi koko liʻiliʻi i loko o kahi pahu hoʻāʻo a ipu paha. Hiki paha iā ʻoe ke ʻoni iki i ka wā e hele ai a kuʻi paha ka nila. Lōʻihi kēia ma mua o ʻelima mau minuke.

No kahi hōʻike lawai, e noi i kāu mea mālama ola no nā ʻōkuhi pehea e hāʻawi ai i kāu hāpana.

Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?

ʻAʻole pono ʻoe i kahi hoʻomākaukau kūikawā no ka hōʻoia koko. Inā ʻoe e loaʻa ana i kahi hōʻike lawaiʻa, ʻaʻole pono ʻoe e ʻai, inu, a puhi paha no 30 mau minuke ma mua o ka hoʻāʻo.

Aia kekahi mau pilikia i ka hoʻāʻo?

ʻAʻohe liʻiliʻi loa i ka hōʻoia ʻana o ke koko. Loaʻa paha iā ʻoe ka ʻeha a ʻeha paha ma kahi o ka nila i hoʻokomo ʻia ai, akā ʻo ka hapa nui o nā ʻōuli e hele wikiwiki aku.

ʻAʻohe makaʻu i ka loaʻa ʻana o kahi hoʻāʻo kuha.

He aha ke ʻano o nā hopena?

Inā ua hoʻāʻo ʻia ʻoe ma mua o ka hoʻomaka ʻana i kahi lāʻau, hiki i ka hōʻike ke hōʻike inā paha e maikaʻi kahi lāʻau a / a inā ʻoe e makaʻu no nā hopena ʻino. ʻO kekahi mau hoʻokolohua, e like me nā mea no kekahi mau lāʻau e mālama ai i ka maʻi epilepsy a me ka HIV, hiki ke hōʻike inā pilikia ʻoe i nā hopena ʻino e hoʻoweliweli nei i ke ola. Inā pēlā, e hoʻāʻo kāu mea lawelawe e loaʻa kahi lāʻau ʻē aʻe.


Hiki i nā hoʻokolohua ke hana ma mua a ʻoiai ʻoe ma ka mālama ʻana hiki ke kōkua i kāu kauka olakino e ʻike i ka lāʻau kūpono.

Inā he mau nīnau kāu e pili ana i kāu hopena, e kamaʻilio me kāu kauka olakino.

E aʻo hou aʻe e pili ana i nā hoʻokolohua hoʻokolohua, nā pae kuhikuhi, a me ka hoʻomaopopo ʻana i nā hopena.

Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i ka hoʻokolohua pharmacogenetic?

Hoʻohana wale ʻia ka hoʻokolohua Pharmacogenetic e ʻike i ka pane a ke kanaka i kekahi lāʻau lapaʻau kikoʻī. ʻAʻole ia ka mea like me ka hoʻāʻo genetic. Hoʻohana ʻia ka hapa nui o nā hoʻokolohua kūlohelohe e kōkua i ka hōʻoia ʻana i nā maʻi a i ʻole ka hopena o ka maʻi, ʻike i ka pilina ʻohana, a i ʻole ʻike i kekahi i kahi hoʻokolokolo lawehala.

Nā kūmole

  1. Hefti E, Blanco J. Ke kākau nei i nā hōʻike ʻo Pharmacogenomic me nā Codes Terminology (CPT) o kēia manawa, kahi loiloi o nā hana i hala a me kēia manawa. J AHIMA [Pūnaewele]. 2016 Ian [helu ʻia 2018 Jun 1]; 87 (1): 56-9. Loaʻa mai: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998735
  2. Nā Hoʻokolohua Lab ma ka Pūnaewele [Pūnaewele]. Wakinekona D.C: ʻAmelika Hui Pū ʻIa no ka Chemical Clinical; c2001–2018. Nā Hōʻaia Pharmacogenetic; [hōʻano hou ʻia 2018 Jun 1; i helu ʻia 2018 Jun 1]; [ma kahi o 2 pale]. Loaʻa mai: https://labtestsonline.org/tests/pharmacogenetic-tests
  3. Nā Hoʻokolohua Lab ma ka Pūnaewele [Pūnaewele]. Wakinekona D.C: ʻAmelika Hui Pū ʻIa no ka Chemical Clinical; c2001–2018. ʻO ke ao o ka hoʻāʻo genetic; [hōʻano 2017 2017 6; i helu ʻia 2018 Jun 1]; [ma kahi o 2 pale]. Loaʻa mai: https://labtestsonline.org/articles/genetic-testing?start=4
  4. Mayo Clinic: Center for Individualized Medicine [Pūnaewele]. Mayo Foundation no ka Hoʻomaʻamaʻa Lapaʻau a me ka noiʻi; c1998–2018. Ke hoʻāʻo ʻana ʻo Lapaʻau-Gene; [i helu ʻia 2018 Jun 1]; [ma kahi o 3 pale]. Loaʻa mai: http://mayoresearch.mayo.edu/center-for-individualized-medicine/drug-gene-testing.asp
  5. Mayo Clinic: Center for Individualized Medicine [Pūnaewele]. Mayo Foundation no ka Hoʻomaʻamaʻa Lapaʻau a me ka noiʻi; c1998–2018. CYP2D6 / Tamoxifen Pharmacogenomic Lab Hōʻike; [i helu ʻia 2018 Jun 1]; [ma kahi o 5 pale].Loaʻa mai: http://mayoresearch.mayo.edu/center-for-individualized-medicine/cyp2d6-tamoxifen.asp
  6. Mayo Clinic: Center for Individualized Medicine [Pūnaewele]. Mayo Foundation no ka Hoʻomaʻamaʻa Lapaʻau a me ka noiʻi; c1998–2018. HLA-B * 1502 / Carbamazepine Pharmacogenomic Lab Hōʻike; [i helu ʻia 2018 Jun 1]; [ma kahi o 4 pale]. Loaʻa mai: http://mayoresearch.mayo.edu/center-for-individualual-medicine/hlab1502-carbamazephine.asp
  7. Mayo Clinic: Center for Individualized Medicine [Pūnaewele]. Mayo Foundation no ka Hoʻomaʻamaʻa Lapaʻau a me ka noiʻi; c1998–2018. HLA-B * 5701 / Hōʻikeʻike Labacacomoma Labic Abacavir; [i helu ʻia 2018 Jun 1]; [ma kahi o 4 pale]. Loaʻa mai: http://mayoresearch.mayo.edu/center-for-individualual-medicine/hlab5701-abacavir.asp
  8. Kalinika Mayo: Laboratories Lapaʻau ʻo Mayo [Pūnaewele]. Mayo Foundation no ka Hoʻomaʻamaʻa Lapaʻau a me ka noiʻi; c1995–2018. Hōʻike Hōʻike: PGXFP: Pākuʻi ʻo Pharmacogenomics i kia ʻia: Keʻano; [i helu ʻia 2018 Jun 1]; [ma kahi o 3 pale]. Loaʻa mai: https://www.mayomedicallaboratories.com/test-catalog/Specimen/65566
  9. Ka Papa ʻInikena Kanaka Makahiki [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Papa Kuhikuhi NCI o nā ʻōlelo maʻi ʻaʻai: gen; [i helu ʻia 2018 Jun 1]; [ma kahi o 3 pale]. Loaʻa mai: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q;=gene
  10. National Heart, Lung, and Blood Institute [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Nā ho'āʻo koko; [i helu ʻia 2018 Jun 1]; [ma kahi o 3 pale]. Loaʻa mai: https://www.nhlbi.nih.gov/health-topics/blood-tests
  11. NIH National Institute of General Medical Science [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Pharmacogenomics; [hōʻano 2017 ʻOkakopa; i helu ʻia 2018 Jun 1]; [ma kahi o 4 pale]. Loaʻa mai: https://www.nigms.nih.gov/education/Pages/factsheet-pharmacogenomics.aspx
  12. NIH U.S. National Library of Medicine: Genetics Home Reference [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; He aha nā pharmacogenomics ?; 2018 Mei 29 [helu ʻia 2018 Jun 1]; [ma kahi o 4 pale]. Loaʻa mai: https://ghr.nlm.nih.gov/primer/genomicresearch/pharmacogenomics
  13. UF Health: Ke Kulanui o Florida Health [Pūnaewele]. Kulanui o Florida; c2018. Pehea kāu genes e hoʻohuli ai i nā lāʻau e kūpono iā ʻoe; 2016 Jan 11 [hōʻano hou ʻia 2018 Jun 1; i helu ʻia 2018 Jun 1]; [ma kahi o 2 pale]. Loaʻa mai: https://ufhealth.org/blog/how-your-genes-influence-what-medicines-are- Right-you
  14. Ka Halemai Kamaliʻi ʻohana ʻAmelika Hui Pū ʻIa UW [Pūnaewele]. Madison (WI): Ke Kulanui o Wisconsin Nā Haukapila a me nā Mana Haukino; c2018. Ke olakino kamaliʻi: Pharmacogenomics; [i helu ʻia 2018 Jun 1]; [ma kahi o 4 pale]. Loaʻa mai: https://www.uwhealthkids.org/kidshealth/en/father/pharmacogenomics.html/

ʻAʻole pono e hoʻohana i ka ʻike ma kēia pūnaewele i pani no ka mālama olakino ʻoihana a ʻōlelo aʻoaʻo paha. Kāhea aku i ka mea mālama ola inā he nīnau kāu e pili ana i kou olakino.

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