He aha ke ʻano Phage Therapy?

Anter

• ʻO kahi ala ʻokoʻa i ka hakakā ʻana i nā bacteria
• Pehea e hana ai ka phage therapy
• Phage therapy vs. antibiotic
• 1. Hoʻopiʻi nā Antibiotics ma mua o hoʻokahi ʻano bacteria
• 2. Hiki i nā Antibiotics ke alakaʻi iā “superbugs”
• Nā pōmaikaʻi Phage therapy
• Nā maikaʻi ʻole Phage therapy
• Hoʻohana pae ma ʻAmelika Hui Pū ʻIa
• I ka ʻoihana meaʻai
• Nā kūlana e pōmaikaʻi ai mai ka phage therapy
• ʻO ka lawe lawe ʻana

ʻO kahi ala ʻokoʻa i ka hakakā ʻana i nā bacteria

Kāhea ʻia ʻo Phage therapy (PT) ʻo bacteriophage therapy. Hoʻohana ia i nā mea hoʻomaʻi e mālama i nā maʻi bacteria. Kapa ʻia nā mea hoʻomaʻi koʻohune nā phages a i ʻole bacteriophages. Hoʻouka wale lākou i ka bacteria; pelu ʻole nā ​​phages i nā kānaka, nā holoholona, ​​a me nā mea kanu.

ʻO nā bacteriophages nā ʻenemi kūlohelohe o nā bacteria. ʻO ka manaʻo o ka huaʻōlelo bacteriophage ʻo "bacteria eater." Loaʻa lākou i ka lepo, ka hoʻohaumia, ka wai, a me nā wahi ʻē aʻe e noho nei nā bacteria. Kōkua kēia mau mea hoʻomaʻemaʻe i ka mālama ʻana i nā koʻohune i ke ʻano maoli.

He mea hou paha ke ʻano ʻo Phage therapy, akā ua hoʻohana ʻia no nā makahiki. Eia naʻe, ʻaʻole kaulana ka lapaʻau ʻana. Pono nā noiʻi hou aʻe e pili ana i nā bacteriophages. Kēia therapy no ka maʻi koʻohune-maʻa koʻohune paha ia i kahi pono koho i antibiotics.

Pehea e hana ai ka phage therapy

Pepehi kanaka bacteriophages i nā koʻohune ma o ka hana ʻana iā lākou e haki a lyse paha. Hana ʻia kēia ke hoʻopaʻa ka maʻi i ka bacteria. Hoʻopili kahi virus i nā bacteria ma ke komo ʻana i kāna mau gen (DNA a i ʻole RNA).

Ke kope nei ka virus phage iā ia iho (kope) i loko o ka bacteria. Hiki i kēia ke hana i nā virus hou i kēlā me kēia bacteria. ʻO ka hope, haki ka maʻi i ka bacteria, hoʻokuʻu i nā bacteriophages hou.

Hiki i nā bacteriophages ke hoʻonui a ulu wale i loko o kahi bacteria.Ke lysed (make) nā koʻohune āpau, e pau lākou i ka hoʻonui ʻana. E like me nā mea ʻino ʻē aʻe, hiki i nā phages ke moe i ka hiamoe (i ka hibernation) a hiki i ka hōʻike ʻana o nā bacteria.

Phage therapy vs. antibiotic

Kāhea ʻia nā lāʻau ʻona he anti-bacterial. ʻO lākou ka ʻano maʻamau o ka mālama ʻana i nā maʻi bacteria. ʻO nā Antibiotics he kemika a lāʻau paha e luku i nā bacteria i kou kino.

Mālama ʻo Antibiotics i nā ola a pale i ka maʻi mai ka laha ʻana. Eia nō naʻe, hiki iā lākou ke kumu i nā pilikia nui ʻelua:

1. Hoʻopiʻi nā Antibiotics ma mua o hoʻokahi ʻano bacteria

ʻO kēia ke hiki iā lākou ke pepehi i nā bacteria maikaʻi a maikaʻi ʻole i kou kino. Pono kou kino i kekahi ʻano bacteria e kōkua iā ʻoe e ʻeli i ka meaʻai, hana i kekahi mea momona, a mālama i kou olakino.

Kōkua pū ka bacteria maikaʻi i ka hōʻoki ʻana i nā maʻi koʻohune, viral, a me nā maʻi fungal mai ka ulu ʻana i kou kino. ʻO kēia ke kumu e hiki ai i nā antibiotic ke kumu i nā hopena ʻē aʻe e like me:

• hoʻohuhū ʻōpū
• nausea a me ka luaʻi
• cramping
• bloating a me ka gassiness
• pāhoehoe
• nā maʻi hū

2. Hiki i nā Antibiotics ke alakaʻi iā “superbugs”

ʻO ke kumu o kēia ma kahi o ke kū ʻana, lilo kekahi mau koʻohune i pale a pale aku paha i ka lāʻau antibiotic. Kū ke kūpale ke loli a loli paha ka ikaika ma mua o nā antibiotics.

Hiki iā lākou ke hoʻolaha i kēia "superpower" i nā bacteria ʻē aʻe. Hiki i kēia ke hoʻonāukiuki i nā maʻi weliweli i hiki ʻole ke mālama ʻia. Hiki ke make i nā koʻohune hiki ʻole ke mālama ʻia.

E hoʻohana pono i nā antibiotic e kōkua pale aku i nā koʻohune kūpale. O kahi laʻana:

• E hoʻohana wale i nā antibiotic no nā maʻi bacteria. ʻAʻole mālama nā Antibiotics i nā maʻi viral e like me nā anu, flus, a me bronchitis.
• Mai hoʻohana i nā antibiotic inā ʻaʻole pono ʻoe iā lākou.
• Mai kaomi i kāu kauka e kuhikuhi i nā lāʻau ʻalopika na ʻoe a me kāu keiki.
• Lawe i nā antibiotic āpau e like me ke kuhikuhi.
• Hoʻopiha i ke ana piha o nā antibiotic, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi.
• Mai lawe i nā lāʻau ʻaloʻalo pau.
• Kiola i nā antibiotic make ʻole a hoʻohana ʻole ʻia paha.

Nā pōmaikaʻi Phage therapy

ʻO nā pōmaikaʻi o ka phage therapy e hoʻoponopono i nā hemahema o nā lāʻau ʻaloʻalo.

E like me ka nui o nā ʻano bacteria, aia kekahi mau ʻano bacteriophages. Akā e hoʻouka wale kēlā me kēia ʻano phage i kekahi bacteria. ʻAʻole ia e hoʻopili i nā ʻano bacteria ʻē aʻe.

ʻO kēia ka mea i hiki ke hoʻohana ʻia i kahi phage e māka pono ai i ka maʻi bacteria. ʻO kahi laʻana, ʻo kahi strep bacteriophage e pepehi wale i nā koʻohune e kumu ai i nā maʻi puʻu strep.

Ua hoʻopaʻa inoa kahi noiʻi 2011 i kekahi mau pros o bacteriophages:

• Hana nā pae kūʻē i nā koʻohune hiki ke mālama ʻia a me nā lāʻau kūpona.
• Hoʻohana wale ʻia lākou a i ʻole me nā lāʻau ʻaloʻalo a me nā lāʻau ʻē aʻe.
• Hoʻonui a hoʻonui nā helu iā lākou iho i ka wā o ka mālama ʻana (pono wale nō kahi mahele lāʻau).
• Hoʻoluhi wale lākou i nā bacteria "maikaʻi" maʻamau i ke kino.
• Kūlohelohe nā mahele a maʻalahi hoʻi e loaʻa.
• ʻAʻole lākou ʻino (ʻino) i ke kino.
• ʻAʻole lākou ʻona i nā holoholona, ​​nā mea kanu, a me ke kaiapuni.

Nā maikaʻi ʻole Phage therapy

ʻAʻole hoʻohana ākea ʻia nā bacteriophages. Pono kēia lāʻau e noiʻi hou e ʻike i ka maikaʻi o ka hana. ʻAʻole ʻike ʻia inā hiki i nā phages ke hōʻeha i ka poʻe a i ʻole nā ​​holoholona i nā ala i pili ʻole e kuhikuhi i ka hoʻoweliweli.

Hoʻohui ʻia, ʻaʻole ʻike ʻia inā hoʻōla ka phage therapy i ka bacteria e lilo i mea ikaika ma mua o ka bacteriophage, e hopena ai i ka phage resistence.

ʻO nā cons of phage therapy me kēia:

• Kū paʻakikī nā paepae i kēia manawa no ka hoʻomākaukau no ka hoʻohana ʻana i nā kānaka a me nā holoholona.
• ʻAʻole maopopo ia he aha ka mahele lāʻau a i ʻole ka nui o nā phages e pono ai e hoʻohana.
• ʻAʻole maopopo pehea ka lōʻihi o ka hana ʻana o ka phage therapy.
• He paʻakikī paha e ʻike i ka phage kikoʻī e pono ai e mālama i kahi maʻi.
• Hiki i nā ʻāpana ke hoʻoulu i ka ʻōnaehana pale e hoʻokahuli a hana i kahi kaulike ʻole.
• ʻAʻole holo kekahi mau ʻano phages e like me nā ʻano ʻē aʻe e mālama ai i nā maʻi bacteria.
• ʻAʻole lawa paha nā ʻano phages e mālama ai i nā maʻi bacteria a pau.
• Hiki i kekahi mau phages ke lilo i mea kūpale.

Hoʻohana pae ma ʻAmelika Hui Pū ʻIa

ʻAʻole ʻae ʻia ʻo Phage therapy no ka poʻe ma ʻAmelika Hui Pū ʻIa a i ʻole i ʻEulopa. Ua hoʻohana ʻia kahi phage hoʻokolohua i kekahi mau hanana kakaikahi wale nō.

ʻO kekahi kumu o kēia no ka loaʻa maʻalahi o nā antibiotic a ua manaʻo ʻia he ʻoi aku ka palekana o ka hoʻohana ʻana. Ke hoʻomau nei ka noiʻi ʻana i ke ala ʻoi loa e hoʻohana ai i nā bacteriophages i nā kānaka a me nā holoholona. Pono ka palekana o ka phage therapy i kahi noiʻi hou aku.

I ka ʻoihana meaʻai

Hoʻohana ʻia ka phage therapy i ka ʻoihana meaʻai. Ua ʻae ʻo ka US Food and Drug Administration (FDA) i kekahi o nā hui phage e kōkua ai e hōʻoki i nā bacteria mai ka ulu ʻana i nā meaʻai. Phage therapy i ka meaʻai pale i nā bacteria e hiki ai ke hoʻoweliweli i ka meaʻai, e like me:

• Salmonella
• Listeria
• E. coli
• Mycobacterium tuberculosis
• Campylobacter
• Pseudomonas

Hoʻohui ʻia nā phages i kekahi mau meaʻai i hana ʻia e kōkua ai i ka pale ʻana i ka ulu ʻana o ka maʻi.

ʻO kahi hoʻohana ʻē aʻe no ka phage therapy e hoʻāʻo ʻia nei e pili ana i ka hoʻohui ʻana i nā bacteriophages i ka hoʻomaʻemaʻe ʻana i nā huahana e luku ai i nā bacteria ma nā ʻili He mea maikaʻi paha kēia ma nā haukapila, nā hale ʻaina, a me nā wahi ʻē aʻe.

Nā kūlana e pōmaikaʻi ai mai ka phage therapy

He mea nui paha ka Phage therapy i ka mālama ʻana i nā maʻi e pane ʻole i nā lāʻau ʻino. ʻO kahi laʻana, hoʻohana ʻia ia e kū kūʻē i kahi mea ikaika ʻO Staphylococcus(staph) maʻi maʻi maʻi i kapa ʻia MRSA.

Ua loaʻa nā hihia kūleʻa o ka hoʻohana phage therapy. ʻO kahi moʻolelo kūleʻa e pili ana i kahi kāne 68 makahiki ma San Diego, Kaleponi, i mālama ʻia no kahi ʻano kūpale kūpale i kapa ʻia Acinetobacter baumannii.

Ma hope o ʻekolu mau mahina o ka hoʻāʻo ʻana i nā antibiotic, ua hiki i kāna mau kauka ke hoʻopau i ka maʻi me nā bacteriophages.

ʻO ka lawe lawe ʻana

ʻAʻole hou ka Phage therapy, akā ʻaʻole hoʻohana maikaʻi ʻia ka hoʻohana ʻana i nā kānaka a me nā holoholona. ʻO ke ʻano o nā hoʻopaʻa naʻau o kēia manawa a me kekahi o nā hihia kūleʻa hiki ke lilo i mea maʻamau. ʻOiai ʻo phage therapy i manaʻo ʻia he palekana a ʻae ʻia no ka hoʻohana ʻana i ka ʻoihana meaʻai, hiki koke paha kēia.

ʻO ka Phage therapy ka "antibiotics" kūlohelohe a he ʻano lapaʻau maikaʻi aʻe paha. He mea maikaʻi paha ia no nā hoʻohana ʻē aʻe e like me kahi disinfectant ʻoki lāʻau a me ka haukapila. Pono e noiʻi hou aʻe ma mua o ka ʻae ʻia ʻana o ka hoʻohana no ka poʻe.