Kaohi Cholesterol: PCSK9 Inhibitors vs. Statins

Anter

• E pili ana i nā statins
• Pehea lākou e hana ai
• Nā ʻano
• E pili ana i nā mea kāohi iā PCSK9
• Ke kuhikuhi ʻia lākou
• Pehea lākou e hana ai
• Nā hopena ʻaoʻao
• Ka hoʻokō ʻana
• Kumukūʻai
• E kamaʻilio me kāu kauka
• E kamaʻilio me kāu kauka

Hoʻolauna

Ma kahi kokoke i 74 miliona mau ʻAmelika i loaʻa i ka kolesterol kiʻekiʻe, e like me ka. Eia nō naʻe, emi ma mua o ka hapalua e loaʻa ana ka lāʻau no ia. Hāʻawi kēia iā lākou i kahi makaʻu kiʻekiʻe no ka hōʻeha puʻuwai a me ka hahau. ʻOiai ʻo ka hoʻoikaika kino a me ka papaʻai olakino hiki ke kōkua pinepine i ka mālama ʻana i nā pae kolesterol, i kekahi manawa pono ka lāʻau.

ʻElua ʻano o nā lāʻau i kauoha ʻia e mālama i ke kiʻekiʻe o ke kolesterol me nā statins a me nā mea kāohi iā PCSK9. He lāʻau lapaʻau kaulana ʻo Statins i loaʻa mai nā makahiki 1980. ʻO nā mea kāohi PCSK9, ma ka ʻaoʻao ʻē aʻe, he ʻano hou o ka lāʻau kō kolesterol. Ua ʻae ʻia e ka Food and Drug Administration ma 2015.

Ke hoʻoholo nei ʻoe a me kāu kauka i ka lāʻau kolesterol no ʻoe, e noʻonoʻo paha ʻoe i nā mea e like me nā hopena, ke kumukūʻai, a me ka pono. E heluhelu e aʻo hou e pili ana i kēia mau lāʻau a pehea e hoʻohālikelike ai nā ʻano ʻelua.

E pili ana i nā statins

ʻO Statins kekahi ʻano maʻamau o nā lāʻau i hoʻohana ʻia e kōkua i ka hoʻohaʻahaʻa ʻana i ka kolesterol. Inā loaʻa ʻoe i ka kiʻekiʻe kolesterol a i ʻole nā ​​kamepiula o ka maʻi puʻuwai, e ʻōlelo paha kāu kauka e hoʻomaka ʻoe e lawe i kahi statin. Hoʻohana pinepine ʻia lākou ma ke ʻano he lālani mua no ka cholesterol kiʻekiʻe. ʻO kēia ka mea ʻo lākou ka lapaʻau mua a kāu kauka e ʻōlelo ai.

Pehea lākou e hana ai

Hana ʻo Statins ma ka pale ʻana i kahi mea i kapa ʻia ʻo HMG-CoA reductase. ʻO kēia kahi hui e pono ai i kou ake e hana i ka cholesterol. ʻO ka pale ʻana i kēia mea e hōʻemi ai i ka nui o nā kōkōpō e hana ai. Hana pū ʻo Statins ma ke kōkua ʻana i kou kino e hoʻopili hou i nā kolekoli i hōʻiliʻili ʻia ma nā paia o kou kīʻaha koko. E aʻo hou ai, e heluhelu e pili ana i ka hana ʻana o nā statins.

Nā ʻano

Hele mai nā Statins ma ke ʻano o nā papa a i ʻole nā ​​capsule āu e lawe ai ma ka waha. Nui a hewahewa nā ʻano statins i loaʻa i ʻAmelika Hui Pū ʻIa i kēia lā. Pākuʻi ʻia lākou:

• atorvastatin (Lipitor)
• fluvastatin (Lescol)
• lovastatin (Altoprev)
• pravastatin (Pravachol)
• rosuvastatin (Crestor)
• simvastatin (Zocor)
• pitavastatin (Livalo)

E pili ana i nā mea kāohi iā PCSK9

Hiki ke kuhikuhi ʻia ʻo Statins no nā poʻe he nui me ka kolesterol kiʻekiʻe, akā ʻo nā mea kūpale PCSK9 e kuhikuhi maʻamau no kekahi ʻano o nā kānaka. Ma muli o ka lōʻihi o ka lōʻihi o nā statins, ʻike hou mākou e pili ana i ka hopena o ia mau mea. ʻOi aku ka mea kāohi iā PCSK9 a no laila loaʻa ka ʻikepili palekana lōʻihi lōʻihi.

Eia kekahi, pipiʻi loa nā mea kāohi iā PCSK9 ke hoʻohālikelike ʻia i nā statins.

Hāʻawi ʻia nā mea hoʻopale PCSK9 e ka injection wale nō. ʻElua wale nō Inhibitors PCSK9 i loaʻa i kēia lā ma ʻAmelika Hui Pū ʻIa: Praluent (alirocumab) a me Repatha (evolocumab).

Ke kuhikuhi ʻia lākou

Paipai ka American College of Cardiology iā ʻoe a me kāu kauka e noʻonoʻo i kahi mea kāohi iā PCSK9 inā wale nō:

• manaʻo ʻia ʻoe he makaʻu nui no ka pilikia o ka maʻi puʻuwai a ʻaʻole kaohi ʻia kāu cholesterol me nā statins a i ʻole nā ​​lāʻau hoʻohaʻahaʻa kolesterol
• Loaʻa iā ʻoe kahi ʻano kūlohelohe i kapa ʻia he hypercholesterolemia ʻohana, kahi e pili ana i nā kiʻekiʻe kolesterol kiʻekiʻe

I kēlā me kēia hihia, hōʻike pinepine ʻia nā mea kāohi iā PCSK9 ma hope o ʻelua mau ʻano lāʻau i kōkua ʻole e hoʻohaʻahaʻa i kāu mau pae kolesterol. ʻO kahi laʻana, hiki i kāu kauka ke kuhikuhi mua i kahi statin.Inā ʻaʻole e hoʻohaʻahaʻa i kāu mau pae kolesterol a lawa paha, e ʻōlelo paha kāu kauka ezetimibe (Zetia) a i ʻole nā ​​lāʻau i kapa ʻia he resins acid bile. ʻO nā laʻana o kēia mau mea me cholestyramine (Locholest), colesevelam (Welchol), a i ʻole colestipol (Colestid).

Inā kiʻekiʻe loa kāu pae kolesterol ma hope o kēia ʻano lāʻau ʻelua, a laila e ʻōlelo paha kāu kauka i kahi mea kāohi iā PCSK9.

Pehea lākou e hana ai

Hiki ke hoʻohana i nā mea kāohi PCSK9 me ka hoʻohui a i ʻole statins. Hana ʻokoʻa kēia mau lāʻau. Hoʻolālā nā mea kāohi PCSK9 i kahi protein i ke akepaʻa i kapa ʻia proprotein convertase subtilisin kexin 9, a i ʻole PCSK9. Ma ka hoʻemi ʻana i ka nui o PCSK9 i kou kino, ʻae nā mea kāohi PCSK9 i kou kino e lawe aku i ka ʻoi aku ka ʻoi aku o ka maikaʻi.

Nā hopena ʻaoʻao

Hiki i nā mea kālaiʻike Statins a me PCSK9 ke hoʻonā i nā hopena ʻoluʻolu a me nā hopena koʻikoʻi, a ʻokoʻa nā hopena ma waena o nā lāʻau.

Ka hoʻokō ʻana

Ua hōʻike ʻia ʻo Statins e hoʻohaʻahaʻa i ka cholesterol i nā poʻe he nui. Ua hoʻohana ʻia ia mau mea mai ka makahiki 1980 a ua aʻo ʻia ko lākou hopena i loko o nā kaukani mau kānaka e lawe i statins e pale aku i ka hōʻeha puʻuwai a me ka hahau.

I ka hoʻohālikelike ʻana, ua ʻae ʻia nā mea kāohi PCSK9 i kēia manawa, no laila ʻaʻole maikaʻi ka ʻike palekana lōʻihi. Eia nō naʻe he maikaʻi loa nā mea kāohi iā PCSK9 no kekahi poʻe.Ua hōʻike ʻia kahi noiʻi ua hōʻemi ka alirocumab i nā pae kolamu e 61 pakeneka. Hoʻoemi ia i ka likelika o nā hanana cardiovascular e like me ka puʻuwai puʻuwai a me ka hahau. Ua loaʻa kahi noiʻi ʻē aʻe i nā hopena like me evolocumab.

Kumukūʻai

Loaʻa nā Statins i ka inoa brand-brand a me nā generic form. ʻOi aku ka uku o nā Generics ma mua o nā mana brand, no laila hiki i nā statins ke kumu kūʻai ʻole.

He mea hou nā mea kāohi iā PCSK9, no laila ʻaʻohe o lākou mana mana i kēia manawa. No kēia kumu, ʻoi aku ka pipiʻi ma mua o statins. ʻO ke kumukūʻai o nā mea kāohi iā PCSK9 hiki ma mua o $ 14,000 i kēlā me kēia makahiki. Eia hou, i uhi ʻia kēia kumukūʻai e kāu ʻinikua, pono ʻoe e hāʻule i loko o kekahi o nā ʻāpana ʻelua i ʻōlelo ʻia no ka hoʻohana ʻana i nā mea kāohi iā PCSK9. Inā ʻaʻole ʻoe e komo i loko o kekahi o kēlā mau ʻāpana, pono paha ʻoe e uku no kahi mea kāohi iā PCSK9 iā ʻoe iho.

E kamaʻilio me kāu kauka

ʻO nā statins a me nā mea kāohi PCSK9 he mau koho lāʻau nui i ka mālama ʻana i nā kiʻekiʻe kolesterol. ʻOiai ʻo nā ʻano lāʻau ʻelua e kōkua i ka hoʻohaʻahaʻa ʻana i nā pae kolesterol, aia kekahi mau ʻokoʻa nui. Hōʻike ka papa ma lalo i kēia mau ʻokoʻa i ka nānā ʻana.

E kamaʻilio me kāu kauka

Inā he kolesterol kiʻekiʻe kou a noʻonoʻo i kekahi o kēia ʻano lāʻau e kūpono paha iā ʻoe, ʻo kāu ʻanuʻu mua e kamaʻilio me kāu kauka. Hiki iā lākou ke haʻi hou aku iā ʻoe e pili ana i kēia mau lāʻau a me kāu koho lapaʻau ʻē aʻe. ʻO kekahi mau nīnau e kūkākūkā ai me kāu kauka:

• ʻO ka lāʻau ka hana aʻe e hiki mai ana iaʻu i ka mālama ʻana i kaʻu kolesterol kiʻekiʻe?
• Kūleʻa paha wau i nā pae ʻelua no ka poʻe i hiki ke kuhikuhi ʻia i nā mea kāohi iā PCSK9?
• E kamaʻilio paha wau me kahi loea lipid?
• E hoʻomaka paha wau i kahi hoʻolālā hoʻoikaika e kōkua i ka mālama ʻana i kaʻu kolesterol?
• Hiki iā ʻoe ke kuhikuhi iaʻu i kahi dietitian i hoʻopaʻa inoa ʻia e kōkua iaʻu e hoʻokele i kaʻu papaʻai?