Nā lāʻau no ka poʻe me ka Ulcerative Colitis

Anter

• Aminosalicylates (5-ASA)
• Mesalamine
• Sulfasalazine
• Olsalazine
• Balsalazide
• Corticosteroids
• Budesonide
• ʻO Prednisone a me prednisolone
• Immunomodulators
• ʻO Tocacitinib
• Methotrexate
• ʻO Azathioprine
• Merc laptopurine
• Nā hopena ʻaoʻao o ka methotrexate, azathioprine, a me ka merc laptopurine
• ʻO Biologics
• Hōʻalo iā NSAIDs
• E kamaʻilio me kāu kauka

Hoʻolauna

ʻO Ulcerative colitis kahi ʻano o ka maʻi ʻōpū (IBD) e hoʻopili nui i ke kolona (ʻōpū nui). Hoʻokumu ʻia paha ia e kahi pane kūpono ʻole mai ka pale o kou kino. ʻOiai ʻaʻohe lāʻau e ʻike ʻia no ka ulcerative colitis, hiki ke hoʻohana ʻia i kekahi ʻano o nā lāʻau e mālama i nā hōʻailona.

Hiki i nā ʻōuli o ke kolitis ulcerative ke hoʻopili pū me:

• ʻeha o ka ʻōpū, hōʻoluʻolu, a i ʻole ke kuʻi
• maʻi kō ʻole mau
• ke koko i ka pahu holo

Mau paha nā ʻōuli a i ʻole e ʻoi aku ka maikaʻi o lākou i ka wā o flare-up.

Hiki ke hoʻohana ʻia i nā lāʻau like ʻole e hōʻemi i ka mumū (ka pehu a me ka hoʻonāukiuki), hoʻemi i ka nui o nā uila i loaʻa iā ʻoe, ae ʻae i kāu kolone e hoʻōla. Hoʻohana ʻia nā papa nui ʻehā o ka lāʻau e mālama i ka poʻe me ka ulcerative colitis.

Aminosalicylates (5-ASA)

Manaʻo ʻia ʻo Aminosalicylates e hōʻemi i nā ʻōuli o ka ulcerative colitis ma o ka hōʻemi ʻana i ka mumū ma ke kolona. Hoʻohana ʻia kēia mau lāʻau i ka poʻe me ka colitis ulcerative ulcerative akahai. Hiki iā lākou ke kōkua i ka pale ʻana i ka lapalapa ʻana a i ʻole hoʻemi i ka nui o nā uila i loaʻa iā ʻoe.

Eia kekahi laʻana o kēia mau lāʻau:

Mesalamine

Lawe waha ʻia ʻo Mesalamine (e ka waha) ma ke ʻano he papa hoʻokuʻu hoʻokuʻu lohi, capsule hoʻokuʻu lōʻihi, a i ʻole capsule hoʻokuʻu hoʻokuʻu ʻia. Loaʻa pū ʻo Mesalamine ma ke ʻano he suppository rectal a i ʻole he enema rectal.

Loaʻa ʻo Mesalamine ma ke ʻano he lāʻau laulaha i kekahi ʻano. Loaʻa iā ia he mau mana inoa inoa, e like me Delzicol, Apriso, Pentasa, Rowasa, sfRowasa, Canasa, Asacol HD, a me Lialda.

Hiki i nā hopena ʻē aʻe maʻamau o mesalamine ke hoʻopili:

• pāhoehoe
• ʻeha poʻo
• nausea
• ʻeha o ka ʻōpū, cramp, a me ka hōʻoluʻolu ʻole
• mahuahua acidity opu a reflux paha
• ka luaʻi
• hoʻolewa
• hūwī

Hiki i nā hopena ākea akā koʻikoʻi o ka mesalamine ke hoʻopili pū i:

• ʻeha ka umauma
• pokole o ka hanu
• pā kōlewa puʻuwai

Nā laʻana o nā lāʻau i hiki i ka mesalamine ke launa pū me:

• thioguanine
• Warfarin
• lāʻau koʻokoʻo varicella zoster

Sulfasalazine

Lawe ʻia ʻo Sulfasalazine e ka waha ma ke ʻano he papa hoʻokuʻu koke a hoʻopaneʻe hoʻi. Loaʻa ʻo Sulfasalazine ma ke ʻano he lāʻau laulaha a me ke ʻano inoa inoa inoa Azulfidine.

ʻO nā hopena ʻē aʻe o ka sulfasalazine e hiki ke hoʻopili i:

• nalo ʻai ʻole
• ʻeha poʻo
• nausea
• ka luaʻi
• hoʻohuhū ʻōpū
• ua hoʻemi i nā pae semen i nā kāne

ʻO nā hopena ʻē aʻe akā koʻikoʻi ʻole o ka sulfasalazine:

• nā maʻi o ke koko e like me ka anemia
• hopena maʻi ʻino e like me Stevens-Johnson syndrome
• hoka ʻole o ke ake
• nā pilikia ʻōpū

Hiki paha i ka Sulfasalazine ke launa pū me nā lāʻau ʻē aʻe, e like me:

• digoxin
• waikawa folic

Olsalazine

Hele mai ʻo Olsalazine ma ke ʻano he capsule āu e lawe ai ma ka waha. Loaʻa iā ia e like me ka inoa ʻo ka inoa ʻo Dipentum. ʻAʻole loaʻa ia ma ke ʻano he lāʻau laulaha.

Hiki i nā hopena ʻaoʻao maʻamau o olsalazine ke hoʻopili pū.

• diarrhea a i ʻole nā ​​noho lewalewa
• ʻeha ma kou ʻōpū
• ʻākeʻakeʻa a ʻili ranei

Hiki i nā hopena ʻino o olsalazine ke hoʻopili pū.

• nā maʻi o ke koko e like me ka anemia
• hoka ʻole o ke ake
• nā pilikia puʻuwai e like me ka loli o ka puʻuwai a me ka mumū o kou puʻuwai

Nā laʻana o nā lāʻau i hiki i ka olsalazine ke launa pū me:

• heparin
• nā heparins kaumaha molakea haʻahaʻa e like me enoxaparin a i ʻole dalteparin
• merc laptopurine
• thioguanine
• lāʻau koʻokoʻo varicella zoster

Balsalazide

Lawe ʻia ʻo Balsalazide e ka waha ma ke ʻano he capsule a i ʻole papa. Loaʻa ka capsule ma ke ʻano he lāʻau laulaha a ma ke ʻano he inoa inoa Colazal. Loaʻa ka papapaʻa ma ke ʻano he lāʻau inoa inoa Giazo.

ʻO nā hopena ʻē aʻe i ʻike pinepine ʻia o ka balsalazide hiki ke hoʻopili ʻia:

• ʻeha poʻo
• abdominal eha
• pāhoehoe
• nausea
• ka luaʻi
• maʻi hanu
• ʻeha pū

Hiki i nā hopena ʻino koʻikoʻi o balsalazide ke hoʻopili pū i:

• nā maʻi o ke koko e like me ka anemia
• hoka ʻole o ke ake

Nā laʻana o nā lāʻau i hiki i ka balsalazide ke launa pū me:

• thioguanine
• Warfarin
• lāʻau koʻokoʻo varicella zoster

Corticosteroids

Hoʻemi ka Corticosteroids i ka pane o ka ʻōnaehana pale āpau o kou kino e hoʻemi i ka mumū i kou kino. Hoʻohana ʻia kēia ʻano lāʻau i mea e mālama ai i ka poʻe me ka colitis ulcerative ulcerative ʻeleu a koʻikoʻi. ʻO Corticosteroids pū kekahi:

Budesonide

ʻElua mau ʻano budesonide i ʻae ʻia no ka ulcerative colitis e hoʻonui ʻia nā papa hoʻokuʻu a me nā hua o ka rectal. Loaʻa nā mea ʻelua e like me ka inoa inoa inoa ʻo Uceris. ʻAʻole loaʻa lākou ma ke ʻano he lāʻau laulaha.

Hiki i nā hopena ʻaoʻao maʻamau o budesonide ke hoʻopili:

• ʻeha poʻo
• nausea
• ua hoʻemi i nā pae o ka hormone cortisol
• ʻeha ma kou ʻōpū luna
• luhi
• ʻōhūhū
• huehue
• maʻi maʻi urinary tract
• ʻeha pū
• kōpaʻa

Hiki i nā hopena ʻino nui o budesonide ke hoʻopili pū:

• nā pilikia ʻike e like me glaucoma, cataract, a me nā makapō
• kahe koko kiʻekiʻe

Hiki iā Budesonide ke launa pū me nā lāʻau ʻē aʻe e like me:

• nā mea hoʻopale protease e like me ritonavir, indinavir, a me saquinavir, i hoʻohana ʻia e mālama i nā maʻi HIV
• nā lāʻau antifungal e like me itraconazole a me ketoconazole
• erythromycin
• nā pale pale waha i piha i ka ethinyl estradiol

ʻO Prednisone a me prednisolone

Loaʻa ʻo Prednisone i ka papa, papa hoʻokuʻu hoʻokuʻu lohi, a me nā ʻano hopena wai. Lawe ʻoe i kekahi o kēia mau mea ma ka waha. Loaʻa ʻo Prednisone ma ke ʻano he lāʻau laulaha a me nā inoa inoa inoa Deltasone, Prednisone Intensol, a me Rayos.

ʻO nā ʻano o prednisolone i ʻae ʻia no ka ulcerative colitis:

• papa
• nā papa hoʻoheheʻe
• wai hoʻonā
• syrup

Hiki iā ʻoe ke lawe i kekahi o kēia ʻano i ka waha. Loaʻa ʻo Prednisolone ma ke ʻano he lāʻau laulaha a ma ke ʻano he inoa inoa inoa ʻo Millipred.

ʻO nā hopena ʻē aʻe i ʻike pinepine ʻia o ka prednisone a me prednisolone hiki ke hoʻopili ʻia:

• hoʻonui i nā kō kō kō
• hoʻomaha ʻole a hopohopo paha
• hoʻonui i ke kahe o ke koko
• ka pehu ma muli o ka paʻa ʻana o ka wai i kou mau wāwae a i ʻole nā ​​kuʻekuʻe wāwae
• hoʻonui i ka makemake
• loaʻa kaupaona

Hiki i nā hopena ʻino nui o ka prednisone a me prednisolone ke hoʻopili pū me:

• osteoporosis a hoʻonui i ka makaʻu o ka haki iwi
• nā pilikia puʻuwai e like me ka puʻuwai puʻuwai, ʻeha o ka umauma, a me nā loli o ka puʻuwai
• ka hopu ʻana

Nā laʻana o nā lāʻau i hiki i ka prednisone a me prednisolone ke launa pū me:

• nā lāʻau antiseizure e like me phenobarbital a me phenytoin
• lahilahi koko e like me warfarin
• rifampin
• ketoconazole
• aspirin

Immunomodulators

ʻO nā Immunomodulator nā lāʻau e hōʻemi i ka pane o ke kino i kāna ʻōnaehana pale ponoʻī. Hoʻemi ʻia ka hopena ma ke kino o ke kanaka. Hiki i nā Immunomodulator ke hōʻemi i ka helu o nā ulcerative colitis flare-up i loaʻa iā ʻoe a kōkua iā ʻoe e noho lōʻihi ʻole i nā ʻōuli.

Hoʻohana maʻamau nā Immunomodulator i ka poʻe nona nā ʻōuli i kāohi ʻole ʻia me nā aminosalicylates a me nā corticosteroids. Eia nō naʻe, lilo paha kēia mau lāʻau i mau mahina e hoʻomaka ai ka hana.

Aia nā Immunomodulator i:

ʻO Tocacitinib

A hiki i kēia manawa, ʻaʻole ʻae ʻia nā immunomodulator e ka U.S. Food and Drug Administration (FDA) e mālama i ka poʻe me ka ulcerative colitis. Eia nō naʻe, kēia papa lāʻau lāʻau ua i kekahi manawa hoʻohana ʻia ka lepili e mālama i nā poʻe me ka ulcerative colitis.

ʻO kekahi o ia ʻano inoa lepili i lilo i mea o ka wā i hala i ka makahiki 2018 i ka wā a ka FDA i ʻae ai i ka hoʻohana ʻana i kahi immunomodulator no nā poʻe me ka ulcerative colitis. Kapa ʻia kēia immunomodulator ʻo tofacitinib (Xeljanz). Ua ʻae ʻia ʻo FDA i kēia manawa no ka poʻe me ka rheumatoid arthritis akā ua hoʻohana ʻia ka inoa-ʻole no ka poʻe me ka ulcerative colitis. ʻO Xeljanz ka lāʻau mua o kāna ʻano i hāʻawi waha ʻia - ma kahi o ka hoʻopili ʻana - no ka mālama wā lōʻihi o ka poʻe me ka colitis ulcerative.

E aʻo hou aʻe e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau.

Methotrexate

Loaʻa ka Methotrexate ma ke ʻano he papa āu e lawe ai ma ka waha. Hāʻawi ʻia ia e ka infravenous (IV) infusion a me nā subcutaneite a me nā intramuscular injection. Loaʻa ka pāka ma ke ʻano he lāʻau laulaha a me ka inoa ʻo Trexall ka inoa inoa inoa. Loaʻa ka hopena IV a me ka hoʻopili intramuscular ma ke ʻano he lāʻau laula. Loaʻa ka injection subcutaneile ma ke ʻano he inoa inoa inoa inoa Otrexup a me Rasuvo.

ʻO Azathioprine

No ka hoʻomaʻamaʻa ulcerative colitis, hele mai ka azathioprine ma kahi papaha āu e lawe ai ma ka waha. Loaʻa iā ia ma ke ʻano he lāʻau laulaha a me nā inoa inoa inoa inoa Azasan a me Imuran.

Merc laptopurine

Loaʻa ʻo Merc laptopurine ma ke ʻano he papaha a i ʻole kahi hoʻomaha wai, lawe ʻelua ʻia e ka waha. Loaʻa wale ka papa ma ke ʻano he lāʻau laula, a loaʻa wale ke kau ʻia ma ke ʻano he lāʻau lapaʻau inoa Purixan.

Nā hopena ʻaoʻao o ka methotrexate, azathioprine, a me ka merc laptopurine

Hiki i nā hopena ʻaoʻao maʻamau o kēia mau immunomodulator ke hoʻopili:

• ʻeha poʻo
• nausea
• ka luaʻi
• pāhoehoe
• ʻeha nā waha
• luhi
• pae pae haʻahaʻa o ke koko

Nā laʻana o nā lāʻau i hiki i nā immunomodulator ke launa pū me:

• allopurinol
• aminosalicylates e like me sulfasalazine, mesalamine, a me olsalazine
• Angiotensin-hoʻololi i ka enzyme (ACE) nā mea kāohi e like me lisinopril a me enalapril
• Warfarin
• ribavirin
• nā lāʻau anti-inflammatory nonsteroidal (NSAIDs) e like me naproxen a me ibuprofen
• phenylbutazone
• phenytoin
• sulfonamides
• probenecid
• retinoids
• theophylline

ʻO Biologics

Hoʻolālā ʻia nā biologics i nā lāʻau i hoʻomohala ʻia i loko o kahi lab mai kahi meaola ola. Pale kēia mau lāʻau i kekahi mau protein i kou kino mai ka hoʻoulu ʻana i ka momona. Hoʻohana ʻia nā lāʻau biologic no ka poʻe me ke kolitis ulcerative ulcerative koʻikoʻi. Hoʻohana pū ʻia lākou no ka poʻe nona nā ʻōuli i kāohi ʻole ʻia me nā mālama e like me aminosalicylates, nā immunomodulator, a i ʻole nā ​​corticosteroids.

Aia he ʻelima mau lāʻau biologic i hoʻohana ʻia no ka mālama ulcerative colitis ʻōuli. Loaʻa wale kēia i nā lāʻau inoa inoa inoa, e like me:

• adalimumab (Humira), hāʻawi ʻia e subcutaneed injection
• golimumab (Simponi), hāʻawi ʻia e ka injection subcutaneous
• infliximab (Remicade), hāʻawi ʻia e IV infusion
• infliximab-dyyb (Inflectra), hāʻawi ʻia e IV infusion
• vedolizumab (Entyvio), hāʻawi ʻia e IV infusion

Pono ʻoe e lawe i ka adalimumab, golimumab, infliximab, a i ʻole infliximab-dyyb a hiki i ʻewalu mau pule ma mua o kou ʻike ʻana i kahi hoʻomaikaʻi. Hoʻomaka maʻamau ʻo Vedolizumab e hana i loko o ʻeono pule.

ʻO nā hopena ʻē aʻe maʻamau o nā lāʻau biologic hiki ke hoʻopili:

• ʻeha poʻo
• fiva
• haʻalulu
• hives a wīwī paha
• hoʻonui i nā maʻi

Hiki i nā lāʻau biologic ke hui pū me nā meaola biologic ʻē aʻe. ʻO nā laʻana o kēia mau mea:

• natalizumab
• adalimumab
• golimumab
• infliximab
• anakinra
• abatacept
• tocilizumab
• Warfarin
• cyclosporine
• theophylline
• nā lāʻau āpau e like me ka lāʻau koʻokoʻo varicella zoster

Hōʻalo iā NSAIDs

ʻO nā NSAID, e like me ka ibuprofen a me naproxen, hoʻoliʻiliʻi maʻamau i ka momona i ke kino. Inā loaʻa ʻoe i ka colitis ulcerative, akā, e hōʻeha paha kēia mau lāʻau i kāu hōʻailona. E noʻonoʻo pono e kamaʻilio me kāu kauka ma mua o ka lawe ʻana iā NSAID.

E kamaʻilio me kāu kauka

Hiki i nā lāʻau he nui ke kōkua i ka hōʻemi ʻana i kāu mau maʻi kolitis ulcerative. Inā loaʻa iā ʻoe kahi ulcerative colitis, e nānā i kēia ʻatikala me kāu kauka a kamaʻilio e pili ana i nā lāʻau i kūpono iā ʻoe. E ʻōlelo ana kāu kauka i nā lāʻau e pili ana i nā kumu e like me kou olakino holoʻokoʻa a me ke koʻikoʻi o kou ʻano.

Pono paha ʻoe e hoʻāʻo i kekahi mau lāʻau i mua o kou ʻike ʻana i kahi hoʻolālā lapaʻau e kūpono ana iā ʻoe. Inā hōʻemi ʻole ka lawe ʻana i hoʻokahi lāʻau i kāu mau hōʻailona, ​​hiki i kāu kauka ke hoʻohui i kahi lāʻau ʻelua e hana ai i ka mea mua keu. Lōʻihi paha ka manawa, akā e hana pū kāu kauka me ʻoe e ʻike i nā lāʻau kūpono e kōkua ai e hōʻoluʻolu i kāu mau maʻi kolitis ulcerative.