Mea Kākau: Randy Alexander
Lā O Ka Hana: 1 Apelila 2021
HōʻAno Hou I Ka Lā: 26 Ianuali 2025
Anonim
All About Empliciti (Elotuzumab)
Wikiō: All About Empliciti (Elotuzumab)

Anter

He aha ka Empliciti?

ʻO Empliciti kahi lāʻau lapaʻau inoa inoa inoa inoa inoa. Hoʻohana ʻia ia e mālama i kekahi ʻano maʻi ʻaʻai koko i kapa ʻia he myeloma he nui i nā mākua.

Kau ʻia ʻo Empliciti no ka poʻe i komo i hoʻokahi o kēia ʻano maʻamau.

  • Nā mākua i loaʻa i hoʻokahi a ʻekolu mau hana i ka wā i hala no ko lākou myeloma maha. No kēia poʻe, hoʻohana ʻia ʻo Empliciti i hui pū ʻia me ka lenalidomide (Revlimid) a me dexamethasone.
  • Nā mākua i loaʻa ma kahi o ʻelua mau hanana myeloma i hala e like me lenalidomide (Revlimid) a me kahi mea hoʻohiwahiwa proteasome, e like me bortezomib (Velcade) a i ʻole carfilzomib (Kyprolis). No kēia poʻe, hoʻohana ʻia ʻo Empliciti me ka pomalidomide (Pomalyst) a me dexamethasone.

No Empliciti kahi papa o nā lāʻau i kapa ʻia he monoclonal antibodies. Hana ʻia kēia mau lāʻau i loko o kahi lab mai nā pūnaewele ʻōnaehana pale. Hana ʻo Empliciti i ka hoʻoulu ʻana i kāu ʻōnaehana pale a hoʻoikaika i kou mau hunaola. Kōkua pū ka lāʻau i kou ʻōnaehana paleʻea kahi i loaʻa ai nā keena myeloma he nui i loko o kou kino i hiki ke hoʻopau ʻia kēia mau hunaola.


Loaʻa ʻo Empliciti i nā ikaika ʻelua: 300 mg a me 400 mg. Hele mai ia e like me ka pauka i hana ʻia i loko o kahi hopena wai a hāʻawi ʻia iā ʻoe e ka infravenous (IV) infusion (kahi injection i loko o kou aa i loko o kekahi manawa. Hāʻawi ʻia nā infusions ma kahi keʻena olakino a hala ma kahi o hoʻokahi hola a ʻoi paha.

Ka hoʻokō ʻana

Ua hōʻike ʻia nā noiʻi haukapila he mana ʻo Empliciti i ka hoʻōki ʻana i ka holomua (worsening) o nā myeloma he nui. Ua wehewehe ʻia ma lalo nā hopena o kekahi o kēia mau noiʻi.

Empliciti me lenalidomide (Revlimid) a me dexamethasone

I nā hoʻokolohua hoʻokolohua, hāʻawi ʻia ka poʻe me myeloma he nui iā Empliciti me lenalidomide a me dexamethasone, a i ʻole lenalidomide a me dexamethasone wale nō.

Ua hōʻike ʻia nā noiʻi ua loaʻa i ka poʻe e lawe nei i ka hui ʻo Empliciti kahi haʻahaʻa haʻahaʻa no ko lākou maʻi e holo i mua. Ma kahi o ʻelua mau makahiki, ʻo ka poʻe e lawe nei iā Empliciti me lenalidomide a me dexamethasone, he 30% ka nui o ka makaʻu ma mua o ka poʻe e lawe nei i kēlā mau lāʻau me ka ʻole o Empliciti.


I loko o kahi noi ʻē aʻe i hala nā makahiki ʻelima, ʻo ka poʻe e lawe nei i ka hui ʻo Empliciti he 27% ka nui o ka hopena o ko lākou maʻi ma mua o ka poʻe e lawe ana iā lenalidomide a me dexamethasone wale nō.

ʻO Empliciti me pomalidomide (Pomalyst) a me dexamethasone

I nā hoʻokolohua hoʻokolohua, hāʻawi ʻia ka poʻe me myeloma he nui iā Empliciti me pomalidomide a me dexamethasone, a i ʻole pomalidomide a me dexamethasone wale nō.

Loaʻa i ka poʻe e lawe nei i ka hui Empliciti ka 46% haʻahaʻa o ka hopena o ko lākou maʻi maʻi ma hope o ʻeiwa mau mahina o ka hoʻomaʻamaʻa ʻana, hoʻohālikelike ʻia me ka poʻe e lawe ana i ka pomalidomide a me dexamethasone wale nō.

Generic o Empliciti

Loaʻa ʻo Empliciti ma ke ʻano he lāʻau lapaʻau inoa. ʻAʻole i loaʻa i kēia manawa i ka palapala generic.

Aia i loko o Empliciti ka lāʻau elotuzumab e hana nei.

Nā hopena ʻē aʻe o Empliciti

Hiki i ka Empliciti ke kumu i nā hopena ʻoluʻolu a koʻikoʻi paha. Aia i ka papa inoa aʻe kekahi o nā hopena ʻaoʻao nui i hiki ke hana ʻia i ka lawe ʻana iā Empliciti. ʻAʻole pili kēia papa inoa i nā hopena ʻē aʻe āpau.


Hiki ke loli i kāu hopena ʻaoʻao ma muli o ka lawe ʻana iā Empliciti a me dexamethasone me kekahi lenalidomide (Revlimid) a i ʻole pomalidomide (Pomalyst).

No ka ʻike hou aku e pili ana i ka hopena pili o Empliciti, e kamaʻilio me kāu kauka a kauka paha. Hiki iā lākou ke hāʻawi iā ʻoe i nā ʻōlelo aʻoaʻo e pili ana i ka hana me nā hopena ʻē aʻe e hoʻonāukiuki paha.

Nā hopena ʻaoʻao hou aʻe

ʻO nā hopena ʻē aʻe maʻamau o Empliciti ke lawe ʻia me ka lenalidomide a me dexamethasone hiki ke hoʻopili ʻia:

  • luhi (nele o ka ikaika)
  • pāhoehoe
  • fiva
  • kōpaʻa
  • ʻūhā
  • nā maʻi, e like me nā maʻi sinus a i ʻole ka niumonia
  • hoʻemi i ka makemake a me ka pohō kaumaha
  • maʻi nerve peripheral (ʻinoʻino i kekahi o kou aʻa)
  • ʻeha ma kou mau lima a me kou mau wāwae
  • ʻeha poʻo
  • ka luaʻi
  • cataracts (cloudiness i ka maka aniani o kou maka)
  • ʻeha ma kou waha a me kou puʻu
  • nā loli i kekahi mau pae ma kāu hoʻāʻo ʻana i ke koko

ʻO nā hopena ʻē aʻe i ʻike pinepine ʻia o Empliciti ke lawe ʻia me pomalidomide a me dexamethasone hiki ke hoʻopili ʻia:

  • kōpaʻa
  • hoʻonui i ke kō kō kō
  • nā maʻi, e like me ka pulumonia a me nā maʻi sinus
  • pāhoehoe
  • ʻeha iwi
  • pilikia hanu
  • ʻūpē mākala
  • pehu i kou mau lima a mau wāwae paha
  • nā loli i kekahi mau pae ma kāu hoʻāʻo ʻana i ke koko

E hala paha ka hapa nui o kēia mau hopena i loko o kekahi mau lā a i ʻole ʻelua mau pule. Inā ʻoi aku ke koʻikoʻi a i ʻole hele aku, e kamaʻilio me kāu kauka a kauka paha.

Nā hopena hopena koʻikoʻi

Hiki i nā hopena ʻino ke kū me Empliciti. Kāhea koke i kāu kauka inā loaʻa nā hopena koʻikoʻi. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Hiki i nā hopena ʻē aʻe a me kā lākou mau hōʻailona ke hoʻohui i kēia:

  • ʻO nā ʻano ʻē aʻe o ka maʻi ʻaʻai, e like me ka maʻi ʻaʻai ʻili. Hiki i nā ʻōuli ke hoʻohui pū:
    • nāwaliwali
    • luhi nei
    • hoʻololi i ka helehelena o kou ʻili a me nā mole
    • pehu lymph node
  • Nā pilikia ate. Hiki i nā ʻōuli ke hoʻohui pū:
    • luhi nei
    • nāwaliwali
    • melemele o nā keʻokeʻo o kou mau maka a i ʻole kou ʻili
    • hoʻēmi ʻai
    • pehu i loko o kou ʻōpū
    • huikau

ʻO nā hopena ʻē aʻe koʻikoʻi, e kūkākūkā ʻia ma nā kikoʻī ma lalo, hiki ke hoʻopili i kēia mau mea:

  • infusion react (hiki ke kumu ʻia e ka loaʻa ʻana o kahi infravenous drug infusion)
  • hopena hopena maʻi ʻino
  • nā maʻi maʻi

Nā kikoʻī hopena ʻaoʻao

Mahalo paha ʻoe i ka hopena o kekahi mau hopena ʻē aʻe me kēia lāʻau. Eia kekahi mau kikoʻī ma kekahi o nā hopena i hiki i kēia lāʻau ke kumu.

Ka hopena hoʻowali

E like me ka nui o nā lāʻau, hiki i kekahi poʻe ke loaʻa i kahi hopena maʻi ma hope o ka lawe ʻana iā Empliciti. Hiki i nā ʻōuli o ke ʻano ʻāpiki mālie ke hoʻopili pū i:

  • ʻāwīwī o ka ʻili
  • ʻumeʻume
  • flushing (hoʻomehana a ʻulaʻula i kou ʻili)

Kākaʻikahi ka hopena maʻi ʻino ʻoi aku ka paʻakikī akā hiki. Hiki i nā ʻōuli o ke kūpilikiʻi ʻāpiki loa ke hoʻopili pū me

  • ʻōhū ma lalo o kou ʻili, maʻamau i kou lihilihi, lehelehe, lima, a mau wāwae paha
  • pehu o kou alelo, waha, a ʻāʻī paha
  • pilikia hanu

Kāhea koke i kāu kauka inā loaʻa iā ʻoe kahi maʻi maʻi ʻeha iā Empliciti. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Nā hopena infusion

Loaʻa paha iā ʻoe kahi hopena infusion ma hope o ka loaʻa ʻana o Empliciti. ʻO kēia nā hopena i hiki ke hiki i 24 mau hola ma hope o kou loaʻa ʻana i kahi lāʻau i loko o ka infravenous (IV) infusion.

I nā hoʻokolohua hoʻokolohua, 10% o ka poʻe e lawe nei iā Empliciti me lenalidomide a me dexamethasone i loaʻa kahi hopena infusion. ʻO ka hapa nui o kēia mau poʻe i loaʻa kahi hopena infusion i ka wā o ko lākou Empliciti infusion mua. Eia naʻe, ʻo 1% wale nō o ka poʻe e lawe ana i kēia hui ʻana i hōʻoki ʻia e hōʻoki i ka mālama ʻana ma muli o nā hopena infusion koʻikoʻi.

Eia kekahi i nā hoʻokolohua hoʻokolohua, 3.3% o ka poʻe e lawe nei iā Empliciti me pomalidomide a me dexamethasone i loaʻa nā hopena infusion. ʻO ka hōʻailona wale nō o kā lākou hopena infusion ka ʻeha o ka umauma.

Hiki i nā ʻōuli o ke kuhi infusion ke komo pū:

  • fiva
  • haʻalulu
  • hoʻonui a hoʻemi ʻia ke kahe o ke koko
  • lohi ka helu o ka naʻau
  • pilikia hanu
  • ʻūpā
  • ʻāwīwī o ka ʻili
  • ʻeha ka umauma

Ma mua o kāu infusion IV o Empliciti, e hāʻawi aku kāu kauka a kahu hānai paha iā ʻoe i kekahi mau lāʻau e kōkua ai i ka pale ʻana i kahi hopena infusion mai ka hanana ʻana.

Inā loaʻa iā ʻoe nā ʻōuli o ke kuhi infusion ke loaʻa nei iā ʻoe ʻo Empliciti, a i ʻole 24 mau hola ma hope o kāu hoʻopili ʻana, e haʻi koke aku i kāu kauka. I nā hihia koʻikoʻi, hiki i kāu kauka ke koi iā ʻoe e hōʻoki i ka lāʻau ʻo Empliciti.

I kekahi manawa, hiki ke hoʻomaka hou ʻia ʻo Empliciti lapaʻau ma hope o ka hopena infusion. Akā i kekahi mau hihia, ʻo ke koho ʻana i kahi lāʻau ʻokoʻa he koho maikaʻi loa paha nāu.

Nā maʻi ʻino

Loaʻa paha iā ʻoe ka nui o nā maʻi ʻoiai ʻoe e lawe nei iā Empliciti. Hoʻopili kēia i nā maʻi bacteria, viral, a me fungal. I kekahi manawa, hiki i kēia mau maʻi ke koʻikoʻi inā ʻaʻole mālama ʻia lākou. I kekahi mau hihia, hiki iā lākou ke alakaʻi i ka maʻi nui a i ka make paha.

I nā hoʻokolohua hoʻokolohua, ua loaʻa ka maʻi ma 81% o ka poʻe e lawe nei iā Empliciti me lenalidomide a me dexamethasone. No nā poʻe e lawe nei iā lenalidomide a me dexamethasone wale nō, 74% i loaʻa nā maʻi maʻi.

Eia kekahi i nā hoʻokolohua hoʻokolohua, ua loaʻa ka maʻi i 65% o ka poʻe e lawe nei iā Empliciti me pomalidomide a me dexamethasone. Ua loaʻa nā maʻi i ka pākēneka like o ka poʻe e lawe nei i ka pomalidomide a me ka dexamethasone wale nō.

Hiki ke loli nā ʻōuli o ka maʻi ma muli o ke ʻano o ka maʻi. ʻO nā laʻana o nā hōʻailona hiki ke loaʻa:

  • fiva
  • pilikia hanu
  • nā ʻōuli e like me ka flu, e like me ke ʻeha o ke kino a me ke aniani
  • ʻūhā
  • ʻāwīwī o ka ʻili
  • wela wela ke ʻino ʻoe

Inā loaʻa iā ʻoe kekahi ʻōuli o kahi maʻi, e kamaʻilio koke me kāu kauka. Paipai paha lākou iā ʻoe e hōʻoki i ka lawe ʻana iā Empliciti a hiki i ka hala ʻana o kāu maʻi. Paipai pū lākou inā pono e mālama i kāu maʻi.

Maʻi maʻi peripheral

Hiki paha iā ʻoe ke hōʻeha i ke aʻalolo inā lawe ʻoe iā Empliciti. Hiki ke kapa ʻia ka hōʻino ʻia o ke aʻa me ka maʻi nerve āpau. Hiki i kēia ʻano ke hoʻonā i ka nāwaliwali a me ka ʻeha e hana mau ʻia ma kou mau lima a me kou mau wāwae. ʻAʻole hele pinepine ka maʻi nerve peripheral, akā hiki ke mālama ʻia me kekahi mau lāʻau.

I nā hoʻokolohua hoʻokolohua, ua loaʻa ka maʻi nerve ākea ma 27% o ka poʻe e lawe nei iā Empliciti me lenalidomide a me dexamethasone. Ua hana kēia ʻano ma 21% o ka poʻe e lawe nei iā lenalidomide a me dexamethasone wale nō.

E kamaʻilio me kāu kauka inā loaʻa iā ʻoe nā ʻōuli o ka maʻi nerve peripheral. Hiki iā lākou ke ʻōlelo i ka lāʻau lapaʻau inā pono ʻoe.

Ka luhi

Loaʻa paha ʻoe i ka luhi (nele i ka ikaika) ʻoiai ʻoe e hoʻohana ana iā Empliciti. He hopena maʻamau kēia i ʻike ʻia i ka wā o ka noiʻi ʻana i ka poʻe e lawe nei iā Empliciti me lenalidomide a me dexamethasone.

I nā noiʻi, ua luhi ka luhi ma 62% o ka poʻe e lawe nei iā Empliciti me lenalidomide a me dexamethasone. ʻO ka poʻe e lawe nei iā lenalidomide a me dexamethasone wale nō, 52% i ka luhi.

E kamaʻilio me kāu kauka inā ʻike ʻoe i ka luhi i kou mālama ʻana iā Empliciti. Hiki iā lākou ke ʻōlelo i ka lāʻau lapaʻau inā pono ʻoe i kekahi a hōʻike i nā ala e hōʻemi ai i kāu mau ʻōuli.

Pohā

Loaʻa paha ka palaho iā ʻoe e lawe nei iā Empliciti. I nā hoʻokolohua hoʻokolohua, ua loaʻa ka maʻi maʻi i 47% o ka poʻe e lawe nei iā Empliciti me lenalidomide a me dexamethasone. No nā poʻe e lawe nei iā lenalidomide a me dexamethasone wale nō, 36% i loaʻa i ka maʻi pākī.

ʻO ka maʻi pākī kekahi hopena i ʻike ʻia i ka poʻe e lawe nei iā Empliciti me pomalidomide a me dexamethasone. I nā hoʻokolohua hoʻokolohua, ua loaʻa ka maʻi maʻi i 18% o ka poʻe e lawe nei i kēia hui o nā lāʻau. ʻO ka poʻe e lawe wale nei i ka pomalidomide a me dexamethasone, he 9% i loaʻa i ka maʻi pākī.

E kamaʻilio me kāu kauka inā loaʻa ʻoe i ka maʻi pākē i kou mālama ʻana iā Empliciti. Hiki iā lākou ke ʻōlelo i ka lāʻau lapaʻau inā pono ʻoe i kekahi a hōʻike i nā ala e hōʻemi ai i kāu mau ʻōuli.

Nā loli i nā waiwai lab a i ʻole nā ​​hoʻāʻo

Hiki paha iā ʻoe ke hoʻololi i kekahi mau pae hoʻokolohua koko ke lawe nei ʻoe iā Empliciti. Aia nā laʻana me nā loli i:

  • helu ka ʻaʻa koko
  • nā hoʻāʻo o ke ake a me nā hakuʻala
  • pae o ka glucose, ka puna, ka potasiuma, a me ka sodium

E nānā paha kāu kauka i nā hoʻokolohua koko ma mua o ka manawa maʻamau ke lawe nei ʻoe iā Empliciti. Hōʻike kēia i kāu kauka inā he mau loli i kāu pae hōʻike koko. Inā kū kēlā mau loli, hiki i kāu kauka ke nānā i kāu mau hōʻoia koko i nā manawa pinepine a i ʻole e ʻōlelo iā ʻoe e kāpae i ka lāʻau Empliciti.

Kumukānāwai Empliciti

E like me nā lāʻau āpau, hiki ke hoʻololi ke kumukūʻai o Empliciti. Hāʻawi ʻia kēia lāʻau lapaʻau e ka infravenous (IV) infusion ma nā keʻena mālama ola.

ʻO ke kumukūʻai maoli āu e uku ai e pili ana i kāu hoʻolālā ʻinikua, kou wahi, a me nā wahi lapaʻau e loaʻa ai iā ʻoe kāu mau lapaʻau.

Kōkua kālā a me nā ʻinikua

Inā makemake ʻoe i kākoʻo kālā e uku no Empliciti, a i ʻole inā pono ʻoe e kōkua i ka hoʻomaopopo ʻana i kāu ʻinikua uhi, loaʻa ke kōkua.

Hāʻawi ʻo Bristol-Myers Squibb, ka mea hana o Empliciti i kahi papahana i kapa ʻia ʻo BMS Access Support. No ka ʻike hou aku a e ʻike inā ua kūpono ʻoe no ke kākoʻo, kāhea iā 800-861-0048 a i ʻole kipa i ka pūnaewele pūnaewele.

Nā mea hana Empliciti

ʻO ka lāʻau Empliciti i kuhikuhi ʻia e kāu kauka e hilinaʻi ʻia i nā kumu ʻelua. Pākuʻi ʻia kēia mau mea:

  • ʻo nā lāʻau āu e lawe nei me Empliciti
  • kaumaha o kou kino

E hoʻoponopono paha kāu mahele lāʻau i ka manawa e hiki ai i ka nui e kūpono iā ʻoe. E kauoha kauka loa i kāu kauka liʻiliʻi e hāʻawi i ka hopena i makemake ʻia.

Hōʻike ka ʻikepili aʻe i nā lāʻau i hoʻohana pinepine ʻia a koi ʻia paha. Eia nō naʻe, e mālama pono i nā lāʻau a ke kauka i kuhikuhi ai nāu. E hoʻoholo kāu kauka i ke ana ʻoi loa e kūpono i kāu mau pono.

Nā ʻano lāʻau a me nā ikaika

Hele mai ʻo Empliciti me he pauma i kāwili ʻia me ka wai sterile a hana ʻia i hopena. Hāʻawi ʻia ia ma ke ʻano he infra (IV) infusion (kahi inikomo i kou aa koko ma kahi o kahi manawa). Hana ʻia ka hopena a hāʻawi ʻia ka infusion IV iā ʻoe ma kahi keʻena olakino.

Loaʻa ʻo Empliciti i nā ikaika ʻelua: 300 mg a me 400 mg.

Nā hana no ka myeloma maha

ʻO ke ana o Empliciti e loaʻa iā ʻoe ka mea i kau i kou kino kaupaona a me nā lāʻau āu e lawe nei me Empliciti.

Inā ʻoe e lawe iā Empliciti me lenalidomide (Revlimid) a me dexamethasone:

  • ʻo ka mahele maʻamau he 10 mg o Empliciti no kēlā me kēia kilokilo (ma kahi o 2.2 paona) o kou kaupaona
  • e loaʻa ʻoe i nā koina o Empliciti i kēlā me kēia pule no nā pule he ʻewalu i hala, i manaʻo ʻia he ʻelua pōʻaiapuni, o ka lapaʻau
  • ma hope o kāu mau pōʻai mua mua ʻelua, hāʻawi ʻia ʻo Empliciti hoʻokahi manawa i kēlā me kēia pule ʻelua

Inā lawe ʻoe iā Empliciti me pomalidomide (Pomalyst) a me dexamethasone:

  • ʻo ka mahele maʻamau he 10 mg o Empliciti no kēlā me kēia kilokilo (ma kahi o 2.2 paona) o kou kaupaona
  • e loaʻa ʻoe i nā koina o Empliciti i kēlā me kēia pule no nā pule he ʻewalu i hala, i manaʻo ʻia he ʻelua pōʻaiapuni, o ka lapaʻau
  • ma hope o kāu mau pōʻaiapuni mua ʻelua o ka hoʻomaʻamaʻa, hoʻonui ʻia nā mea hana i 20 mg o Empliciti no kēlā me kēia kilokilo o kou kaumaha o ke kino, hāʻawi ʻia hoʻokahi manawa i kēlā me kēia ʻehā pule.

Ma ke ʻano he laʻana o ka helu ʻana o ka mahele lāʻau, loaʻa i kahi mākua ke kaupaona he 70 kilokilo (ma kahi o 154 paona) e loaʻa he 700 mg mahele lāʻau o Empliciti. Hoʻomaulia ʻia kēia e like me 70 kilokilo i hoʻonui ʻia e 10 mg o ka lāʻau, i like 700 mg o Empliciti.

Me kēlā me kēia koho koho, e hoʻomau mau ʻoe i ka lawe ʻana iā Empliciti a hiki i ka nui ʻana o ka myeloma ou a i ʻole loaʻa iā ʻoe nā hopena ʻaoʻao pōpilikia mai Empliciti.

He aha inā e haʻo wau i kahi lāʻau?

Inā ʻoe e nalo i kahi manawa no kāu infus Empliciti, e hoʻolālā i kahi manawa hou i ka wā hiki. E kamaʻilio me kāu kauka e pili ana i ke ala ʻoi loa e hoʻonohonoho ai i kāu mau kaha i ka wā e hiki mai ana i hiki ai iā ʻoe ke hana iā ia i kāu infusions.

E mālama pono i kāu lāʻau dexamethasone e like me ke kuhikuhi a kāu kauka. Inā ʻoe e ʻike i kahi mahele lāʻau dexamethasone, e haʻi i kāu kauka ua poina ʻoe iā ʻoe e lawe. ʻO ka hoʻopoina ʻana i kahi lāʻau o kēia lāʻau hiki ke hana iā ʻoe i ka hopena iā Empliciti. Hiki i kēia i kekahi manawa ke koʻikoʻi loa.

Pono wau e hoʻohana i kēia lāʻau lōʻihi?

I kekahi manawa hiki i ka hoʻohana ʻana i nā lāʻau ke mālama i kāu myeloma maha (ʻaʻole e ʻino) no ka manawa lōʻihi. Inā ʻoe e lawe nei iā Empliciti a ʻaʻole i hele a maikaʻi ʻole kāu myeloma maha, e ʻōlelo paha kāu kauka e noho ʻoe ma ka lapaʻau ʻo Empliciti i kahi wā lōʻihi.

I nā hoʻokolohua hoʻokolohua, ma luna o ka hapalua o ka poʻe e lawe nei iā Empliciti ʻaʻole i hōʻino ʻia kā lākou myeloma maha ma mua o 10 mau mahina. ʻO ka lōʻihi o ka manawa āu e lawe ai iā Empliciti e pili ana i ka hopena o kou kino i ka lāʻau.

Nā koho ʻē aʻe iā Empliciti

Loaʻa nā lāʻau ʻē aʻe a i ʻole nā ​​hoʻoponopono i hiki ke mālama i ka myeloma he nui. Kūpono paha kekahi iā ʻoe ma mua o nā poʻe ʻē aʻe. Inā makemake ʻoe e ʻike i kahi ʻē aʻe i Empliciti, e kamaʻilio me kāu kauka. Hiki iā lākou ke haʻi iā ʻoe e pili ana i nā lāʻau ʻē aʻe a i ʻole nā ​​mālama e hana maikaʻi iā ʻoe.

ʻO nā laʻana o nā lāʻau ʻē aʻe i hoʻohana ʻia e mālama i nā myeloma he nui:

  • bortezomib (Velcade)
  • carfilzomib (Kyprolis)
  • ixazomib (Ninlaro)
  • daratumumab (Darzalex)
  • thalidomide (Thalomid)
  • lenalidomide (Revlimid)
  • pomalidomide (Pomalyst)
  • kekahi mau steroid, e like me prednisone a i ʻole dexamethasone

ʻO nā hoʻoponopono ʻē aʻe i hiki ke hoʻohana ʻia e mālama i nā myeloma he nui:

  • radiation (hoʻohana i nā kaola o ka ikehu e pepehi i nā maʻi ʻaʻai)
  • transplant cell paʻa

Empliciti (elotuzumab) vs. Darzalex (daratumumab)

E noʻonoʻo paha ʻoe pehea e hoʻohālikelike ai ʻo Empliciti i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai i ke ʻano like a like ʻole o Empliciti lāua ʻo Darzalex.

Hoʻohana

Ua ʻae ʻia ʻo Empliciti lāua ʻo Darzalex e ka Food and Drug Administration (FDA) e mālama i nā myeloma he nui i nā mākua:

  • ua hoʻāʻo mua ma kahi o ʻelua mau hana i hala e pili ana iā lenalidomide (Revlimid) a me kahi mea hoʻohiwahiwa proteasome, e like me bortezomib (Velcade) a i ʻole carfilzomib (Kyprolis). No kēia poʻe, hoʻohana ʻia ʻo Empliciti a i ʻole Darzalex me pomalidomide (Pomalyst) a me dexamethasone.

Kau ʻia ʻo Empliciti no nā mākua:

  • i loaʻa i hoʻokahi i ʻekolu mau lapaʻau i ka wā i hala no kā lākou myeloma maha. No kēia poʻe, hoʻohana ʻia ʻo Empliciti i hui pū ʻia me ka lenalidomide (Revlimid) a me dexamethasone.

Ua ʻae ʻia ʻo Darzalex e mālama i ka myeloma he nui i nā mākua i lawe i hoʻokahi a ʻoi paha mau lāʻau i ka wā i hala. Paipai ʻia no ka hoʻohana ʻana iā ia iho a me ka hui pū ʻana me nā lāʻau ʻē aʻe, e pili ana i ka mōʻaukala lapaʻau o kēlā me kēia kanaka.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Empliciti me he lepo lā. Hana ʻia i loko o kahi hopena a hāʻawi ʻia iā ʻoe ma ke ʻano he infravenous (IV) infusion (kahi injection i kou aa i loko o kekahi manawa). Loaʻa ʻo Empliciti i nā ikaika ʻelua: 300 mg a me 400 mg.

Kūlike kāu mau hana Empliciti ma muli o ke kaupaona o kou kino a me nā lāʻau ʻē aʻe āu e lawe nei me Empliciti. No ka ʻike hou aku e pili ana i nā lāʻau ʻana, e ʻike i ka ʻāpana "Empliciti dosage" ma luna.

Hāʻawi pinepine ʻia ʻo Empliciti i kēlā me kēia pule no nā pōʻaiapuni mua ʻelua (ka huina o ʻewalu pule) o ka mālama ʻana. Ma hope o kēia, e kiʻi ʻoe iā Empliciti i kēlā me kēia ʻelua a ʻehā mau pule, e pili ana i nā lāʻau āu e hoʻohana nei me Empliciti. No ka ʻike hou aku, e ʻoluʻolu e ʻike i ka ʻāpana "Empliciti dosage" ma luna.

Hele mai ʻo Darzalex ma ke ʻano he hopena wai. Hāʻawi ʻia kekahi ma ke ʻano he infra intravenous (IV). Loaʻa ʻo Darzalex i nā ikaika ʻelua: 100 mg / 5 mL a me 400 mg / 20 mL.

Pili nō hoʻi kāu mea Darzalex i kāu kaupaona. Eia nō naʻe, ʻokoʻa ka papa kuhikuhi o nā ana ma muli o nā lāʻau hea ʻoe e lawe nei me Darzalex.

Hāʻawi pinepine ʻia ʻo Darzalex i kēlā me kēia pule no ʻeono a ʻeiwa pule. Ma hope o kēia, loaʻa iā Darzalex hoʻokahi manawa i kēlā me kēia ʻelua a ʻehā mau pule, e like me ka lōʻihi o kāu hoʻohana ʻana iā ia.

Nā hopena a me nā pilikia

Loaʻa i loko o Empliciti lāua ʻo Darzalex nā lāʻau i kuhi ʻia i nā myeloma he nui. No laila, hiki i nā lāʻau ʻelua ke hana i nā hopena ʻaoʻao like loa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Hiki ke hoʻololi i kāu mau hopena ʻaoʻao e pili ana i nā lāʻau āu e lawe nei me Empliciti a i ʻole Darzalex. Hiki i kāu kauka ke wehewehe i nā hopena ʻaoʻao maʻamau āu e ʻike ai ma muli o nā lāʻau āu e lawe nei.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana me Empliciti, me Darzalex, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Empliciti:
    • cataracts (cloudiness i ka maka aniani o kou maka)
    • ʻeha ma kou waha a me kou puʻu
    • ʻeha iwi
  • Hiki ke hana me Darzalex:
    • nāwaliwali
    • nausea
    • ʻeha kua
    • ʻūpā
    • hiamoe (pilikia hiamoe)
    • hoʻonui i ke kahe o ke koko
    • ʻeha pū
  • Hiki ke hana me nā Empliciti a me Darzalex:
    • luhi (nele o ka ikaika)
    • pāhoehoe
    • kōpaʻa
    • hoʻēmi ʻai
    • fiva
    • ʻūhā
    • ka luaʻi
    • pilikia hanu
    • ʻūpē mākala
    • pehu i kou mau lima a mau wāwae paha
    • hoʻonui i ke kō kō kō
    • ʻeha poʻo

Nā hopena hopena koʻikoʻi

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana me Empliciti, me Darzalex, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Empliciti:
    • nā pilikia ate
    • ke hoʻomohala nei i nā ʻano ʻē aʻe o ka maʻi ʻaʻai, e like me ka maʻi ʻaʻai ʻili
  • Hiki ke hana me Darzalex:
    • neutropenia (pae keʻokeʻo koko keʻokeʻo haʻahaʻa)
    • thrombositopenia (pae platelet haʻahaʻa)
  • Hiki ke hana me nā Empliciti a me Darzalex:
    • nā hopena infusion
    • maʻi nerve peripheral (ʻinoʻino i kekahi o kou aʻa)
    • nā maʻi, e like me ka niumonia

Ka hoʻokō ʻana

Ua ʻae ʻia ʻo Empliciti lāua ʻo Darzalex e mālama i nā myeloma he nui i nā mākua.

ʻAʻole i hoʻohālikelike pololei ʻia kēia mau lāʻau i nā noiʻi maʻi. Akā ua loaʻa nā noiʻi ʻokoʻa ʻelua i ka Empliciti a me Darzalex i mea maikaʻi no ka mālama ʻana i nā myeloma he nui.

Nā kumukūʻai

ʻO Empliciti lāua ʻo Darzalex nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe ʻano generic o nā lāʻau āpau i kēia manawa. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Hāʻawi ʻia ʻo Empliciti lāua ʻo Darzalex i infusions intravenous (IV) ma kahi keʻena olakino. ʻO ka nui maoli āu e uku ai no kēlā me kēia lāʻau e hilinaʻi ia i kāu ʻinikua, kou wahi, a me ka haukapila a i ʻole ka haukapila kahi e loaʻa ai iā ʻoe kāu mau lapaʻau.

Empliciti vs. Ninlaro

E noʻonoʻo paha ʻoe pehea e hoʻohālikelike ai ʻo Empliciti i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai i ke ʻano like a like ʻole o Empliciti lāua ʻo Ninlaro.

Hoʻohana

Ua ʻae ʻia ʻo Empliciti lāua ʻo Ninlaro e ka Food and Drug Administration (FDA) e mālama i nā myeloma he nui.

Kau ʻia ʻo Empliciti no ka poʻe i komo i hoʻokahi o kēia ʻano maʻamau.

  • Nā mākua i loaʻa i hoʻokahi a ʻekolu mau hana i ka wā i hala no ko lākou myeloma maha. No kēia poʻe, hoʻohana ʻia ʻo Empliciti i hui pū ʻia me ka lenalidomide (Revlimid) a me dexamethasone.
  • Nā mākua i loaʻa ma kahi o ʻelua mau hanana myeloma i hala e like me lenalidomide (Revlimid) a me kahi mea hoʻohiwahiwa proteasome, e like me bortezomib (Velcade) a i ʻole carfilzomib (Kyprolis). No kēia poʻe, hoʻohana ʻia ʻo Empliciti me ka pomalidomide (Pomalyst) a me dexamethasone.

Ua ʻae ʻia ʻo Ninlaro e mālama i ka myeloma he nui i nā mākua i hoʻāʻo ma ka liʻiliʻi i hoʻokahi ʻano lāʻau ʻē aʻe i ka wā i hala. Ua ʻae ʻia ʻo Ninlaro no ka hoʻohana pū ʻia me lenalidomide (Revlimid) a me dexamethasone.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Empliciti me he lepo lā. Hana ʻia i loko o kahi hopena a hāʻawi ʻia iā ʻoe ma ke ʻano he infravenous (IV) infusion (kahi injection i kou aa i loko o kekahi manawa). Loaʻa ʻo Empliciti i nā ikaika ʻelua: 300 mg a me 400 mg.

Kūlike kāu mau hana Empliciti ma muli o ke kaupaona o kou kino a me nā lāʻau ʻē aʻe āu e lawe nei me Empliciti. No ka ʻike hou aku e pili ana i nā lāʻau ʻana, e ʻike i ka ʻāpana "Empliciti dosage" ma luna.

Hāʻawi pinepine ʻia ʻo Empliciti i kēlā me kēia pule no nā pōʻaiapuni ʻelua mua (ka huina o ʻewalu pule) o ka mālama ʻana. Ma hope o kēia, e kiʻi ʻoe iā Empliciti i kēlā me kēia ʻelua a ʻehā mau pule, e pili ana i nā lāʻau āu e hoʻohana nei me Empliciti. No ka ʻike hou aku, e ʻoluʻolu e ʻike i ka ʻāpana "Empliciti dosage" ma luna.

Hele mai ʻo Ninlaro ma ke ʻano he capsule i lawe ʻia e ka waha hoʻokahi i kēlā me kēia pule. Loaʻa ʻo Ninlaro i ʻekolu ikaika:

  • 2.3 mg
  • 3 mg
  • 4 mg

Nā hopena a me nā pilikia

Loaʻa i loko o Empliciti lāua ʻo Ninlaro nā lāʻau i kōkua i ka hoʻopau ʻana i nā hunaola myeloma he nui. No laila, hiki i nā lāʻau ʻelua ke hana i nā hopena ʻaoʻao like loa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

ʻĀpono wale ʻia ʻo Ninlaro no ka hoʻohana me lenalidomide (Revlimid) a me dexamethasone. Ma kēia ʻāpana, ke hoʻohālikelike nei mākou i nā hopena o ka hoʻowalewale ʻana Ninlaro i nā hopena ʻē aʻe o Empliciti i hui pū ʻia me ka lenalidomide (Revlimid) a me dexamethasone.

Hiki ke hoʻololi i kāu mau hopena ʻaoʻao e pili ana i nā lāʻau āu e lawe nei me Empliciti a i ʻole Ninlaro. Hiki i kāu kauka ke wehewehe i nā hopena ʻaoʻao maʻamau āu e ʻike ai ma muli o nā lāʻau āu e lawe nei.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Empliciti, me Ninlaro, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me ka hui ʻana ʻo Empliciti:
    • luhi (nele o ka ikaika)
    • fiva
    • ʻūhā
    • hoʻēmi ʻai
    • ʻeha poʻo
    • cataracts (cloudiness i ka maka aniani o kou maka)
    • ʻeha ma kou waha
  • Hiki ke hana me Ninlaro i hui pū ʻia me:
    • nausea
    • ka paʻa o ka wai, kahi e kumu ai ka pehu
    • ʻeha kua
  • Hiki ke hana me nā hui lapaʻau ʻo Empliciti a me Ninlaro.
    • pāhoehoe
    • kōpaʻa
    • ka luaʻi

Nā hopena hopena koʻikoʻi

Loaʻa i kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana me Empliciti, me Ninlaro, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me ka hui ʻana ʻo Empliciti:
    • nā hopena infusion
    • nā maʻi kūpilikiʻi
    • ke hoʻomohala nei i nā ʻano ʻano ʻē aʻe o ka maʻi ʻaʻai
  • Hiki ke hana me Ninlaro i hui pū ʻia me:
    • thrombositopenia (pae platelet haʻahaʻa)
    • ʻāwīwī o ka ʻili
  • Hiki ke hana me nā hui lapaʻau ʻo Empliciti a me Ninlaro.
    • maʻi nerve peripheral (ʻinoʻino i kekahi o kou aʻa)
    • nā pilikia ate

Ka hoʻokō ʻana

Ua ʻae ʻia ʻo Empliciti lāua ʻo Ninlaro e mālama i nā myeloma he nui i nā mākua.

ʻAʻole i hoʻohālikelike pololei ʻia kēia mau lāʻau i nā noiʻi maʻi. Akā ua loaʻa nā noiʻi ʻokoʻa ʻelua i ka Empliciti a me Ninlaro i mea maikaʻi no ka mālama ʻana i nā myeloma he nui.

Nā kumukūʻai

ʻO Empliciti lāua ʻo Ninlaro nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe ʻano generic o nā lāʻau āpau i kēia manawa. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Hāʻawi ʻia ʻo Empliciti ma ke ʻano he infravenous (IV) infusion ma kahi keʻena olakino. Hāʻawi ʻia nā capsule ʻo Ninlaro e nā hale kūʻai lāʻau lapaʻau kūikawā. ʻO ka nui maoli āu e uku ai no nā lāʻau ʻelua e pili ana i kāu ʻinikua, kou wahi, a inā e loaʻa iā ʻoe kāu mau hōʻailona ma kahi haukapila a haukapila paha.

Empliciti no myeloma maha

Ua ʻae ka Food and Drug Administration (FDA) i nā lāʻau i kuhikuhi ʻia e like me Empliciti e mālama i nā myeloma he nui. ʻO kēia ʻano he ʻano maʻi ʻaʻai e hoʻopili i kāu mau hunaola plasma. ʻO kēia mau pūnaewele kahi ʻano o ke keʻokeʻo koko keʻokeʻo e kōkua i kou kino e pale aku i nā mikamina a me nā maʻi.

Me nā myeloma he nui, hana i kou kino i nā hunaola plasma ʻokoʻa. ʻO nā hunaola plasma ʻino, i kapa ʻia he mau myeloma, e hoʻopuehu i kāu mau hunaola ola olakino. ʻO kēia ka loaʻa iā ʻoe o nā keena plasma olakino liʻiliʻi i hiki ke kaua aku i nā groc. Hana pū kekahi ʻo Myeloma i kahi protein i kapa ʻia ʻo M protein. Hiki i kēia protein ke kūkulu i loko o kou kino a hōʻino i kekahi o kāu mau lālā.

Kau ʻia ʻo Empliciti no ka poʻe i komo i hoʻokahi o kēia ʻano maʻamau.

  • Nā mākua i loaʻa i hoʻokahi a ʻekolu mau hana i ka wā i hala no ko lākou myeloma maha. No kēia poʻe, hoʻohana ʻia ʻo Empliciti i hui pū ʻia me ka lenalidomide (Revlimid) a me dexamethasone.
  • Nā mākua i loaʻa ma kahi o ʻelua mau hanana myeloma i hala e like me lenalidomide (Revlimid) a me kahi mea hoʻohiwahiwa proteasome, e like me bortezomib (Velcade) a i ʻole carfilzomib (Kyprolis). No kēia poʻe, hoʻohana ʻia ʻo Empliciti me ka pomalidomide (Pomalyst) a me dexamethasone.

Ka hopena e mālama i nā myeloma he nui

Ua hōʻike ʻia nā noiʻi haukapila he mana ʻo Empliciti i ka hoʻōki ʻana i ka holomua (worsening) o nā myeloma he nui. Ua wehewehe ʻia ma lalo nā hopena o kekahi o kēia mau noiʻi.

Empliciti me lenalidomide (Revlimid) a me dexamethasone

I nā hoʻokolohua hoʻokolohua, hāʻawi ʻia ka poʻe me myeloma he nui iā Empliciti me lenalidomide a me dexamethasone, a i ʻole lenalidomide a me dexamethasone wale nō.

Ua hōʻike ʻia nā noiʻi ua loaʻa i ka poʻe e lawe nei i ka hui ʻo Empliciti kahi haʻahaʻa haʻahaʻa no ko lākou maʻi e holo i mua. Ma kahi o ʻelua mau makahiki, ʻo ka poʻe e lawe nei iā Empliciti me lenalidomide a me dexamethasone, he 30% ka nui o ka makaʻu ma mua o ka poʻe e lawe nei i kēlā mau lāʻau me ka ʻole o Empliciti.

I loko o kahi noi ʻē aʻe i hala nā makahiki ʻelima, ʻo ka poʻe e lawe nei i ka hui ʻo Empliciti he 27% ka nui o ka hopena o ko lākou maʻi ma mua o ka poʻe e lawe ana iā lenalidomide a me dexamethasone wale nō.

ʻO Empliciti me pomalidomide (Pomalyst) a me dexamethasone

I nā hoʻokolohua hoʻokolohua, hāʻawi ʻia ka poʻe me myeloma he nui iā Empliciti me pomalidomide a me dexamethasone, a i ʻole pomalidomide a me dexamethasone wale nō.

Loaʻa i ka poʻe e lawe nei i ka hui Empliciti ka 46% haʻahaʻa o ka hopena o ko lākou maʻi maʻi ma hope o ʻeiwa mau mahina o ka hoʻomaʻamaʻa ʻana, hoʻohālikelike ʻia me ka poʻe e lawe ana i ka pomalidomide a me dexamethasone wale nō.

Hoʻohana ʻo Empliciti me nā lāʻau ʻē aʻe

Hāʻawi ʻia ʻo Empliciti me nā lāʻau ʻē aʻe ke hoʻohana ʻia e mālama i nā myeloma he nui.

Hoʻohana ʻia nā lāʻau myeloma lehulehu me Empliciti

Hoʻohana mau ʻia ʻo Empliciti me kahi steroid i kapa ʻia ʻo dexamethasone. Hoʻohana mau ʻia ia me ka hui pū me kekahi lenalidomide (Revlimid) a i ʻole pomalidomide (Pomalyst). ʻO ka hoʻohana ʻana i kēia mau lāʻau me Empliciti kōkua i ka lāʻau e ʻoi aku ka maikaʻi i ka mālama ʻana i nā myeloma he nui.

ʻO nā lāʻau lapaʻau pre-infusion i hoʻohana ʻia me Empliciti

Ma mua o kou loaʻa ʻana i kāu infravenous (IV) infusion o Empliciti, e lawe ʻoe i kekahi lāʻau i kapa ʻia he lāʻau lapaʻau mua. Hoʻohana ʻia kēia mau lāʻau e kōkua i ka pale ʻana i nā hopena ʻaoʻao (me nā hopena infusion) i hoʻokumu ʻia e ka lāʻau Empliciti.

E loaʻa iā ʻoe nā lāʻau lapaʻau ma mua o ka hoʻouluulu ʻana ma kahi o 45 a 90 paha mau minuke ma mua o kāu lapaʻau ʻana o Empliciti:

  • Dexamethasone. E loaʻa iā ʻoe i 8 mg dexamethasone e ka IV injection.
  • Diphenhydramine (Benadryl). Lawe ʻoe i 25 mg a 50 mg o diphenhydramine ma mua o kāu Empliciti infusion. Hāʻawi ʻia ka Diphenhydramine e ka inikua hoʻokomo (IV) a i ʻole he papa i lawe ʻia e ka waha.
  • Acetaminophen (Tylenol). Lawe pū ʻoe i ka 650 mg a i ka 1000 mg o ka acetaminophen e ka waha.

Pehea e hana ai ʻo Empliciti

ʻO ka myeloma maha he ʻano maʻi ʻaʻai e pili ana i kekahi o nā hunaola keokeo i kapa ʻia he mau hunaola plasma. Kōkua kēia mau hunaola i kou kino e hakakā aku i nā g germ a me nā maʻi. ʻO nā hunaola Plasma i hoʻopili ʻia e myeloma he nui i lilo i maʻi ʻaʻai a ua kapa ʻia he mau myeloma.

Hana ʻo Empliciti i kekahi ʻano ʻokoʻa o ke keʻena koko keʻokeʻo i kapa ʻia he cell killer maoli (NK). Hana nā hunaola NK i kou kino e pepehi i nā hunaola kūpono ʻole, e like me nā hunaola maʻi ʻaʻai a i ʻole nā ​​ʻola i hoʻopili ʻia me nā g germ.

Hana ʻo Empliciti ma ka hoʻoulu ʻana (hoʻohuli) i kāu mau pūnaewele NK. Kōkua kēia i kāu mau hunaola NK e ʻike i nā hunaola plasma maʻamau i hoʻopili ʻia e ka myeloma he nui. Hoʻopau nā hunaola NK i kēlā mau ʻea ʻokoʻa. Hana pū ʻo Empliciti i ka loaʻa ʻana o nā pūnaewele myeloma no kāu mau hunaola NK.

Kapa ʻia ʻo Empliciti he lāʻau hoʻomalu immunotherapy. Hana pū kēia mau lāʻau me kou ʻōnaehana pale e kōkua i kou kino e hakakā i kekahi mau ʻano.

Pehea ka lōʻihi o ka hana?

Hoʻomaka ka hana a Empliciti i kou kino ma hope o ka loaʻa ʻana o kāu infusion mua. Eia nō naʻe, ʻaʻole paha ʻoe e ʻike ke hoʻomaka ʻo Empliciti e hana. Hiki i kāu kauka ke nānā inā ke hana nei ia i ka hana ʻana i kekahi mau hoʻokolohua. Inā he mau nīnau kāu e pili ana i ka maikaʻi o ka hana a Empliciti iā ʻoe, e kamaʻilio me kāu kauka.

ʻO Empliciti a me ka waiʻona

ʻAʻohe mea i ʻike ʻia ma waena o Empliciti a me ka waiʻona. Eia nō naʻe, hiki i ka Empliciti ke kumu i nā pilikia o ke ake. Hiki i ka inu ʻana i ka waiʻona ke hoʻopōʻino i kāu hana ate.

E kamaʻilio me kāu kauka ma mua o ka inu ʻana i ka waiʻona ʻoiai ʻoe e lawe nei iā Empliciti. Hiki iā lākou ke aʻo iā ʻoe inā palekana iā ʻoe ke inu i ka waiʻona ke hoʻohana nei ʻoe i kēia lāʻau.

Nā pilina Empliciti

ʻAʻole hana maʻamau ʻo Empliciti me nā lāʻau ʻē aʻe. Eia nō naʻe, ʻike ʻia nā lāʻau i hoʻohana ʻia me Empliciti e launa pū me nā lāʻau ʻē aʻe.

Hiki i nā launa like ʻole ke kumu i nā hopena like ʻole. ʻO kahi laʻana, hiki i kekahi mau pilina ke hoʻopilikia me ka maikaʻi o ka hana ʻana o ka lāʻau. Hiki i nā pilina ʻē aʻe ke hoʻonui i nā hopena a i ʻole e hoʻonui i ke koʻikoʻi.

Hiki paha i ka lāʻau lapaʻau Empliciti ke hoʻololi i nā hopena o kekahi mau hoʻokolohua lab.

Nā hoʻokolohua Empliciti a me nā hale hana

Hiki i ka Empliciti ke hoʻopili i nā hopena o kekahi mau hoʻāʻo e hoʻohana ʻia e nānā no ka protein M i kou kino. Hana ʻia ka protein M e nā pūnaewele myeloma he nui. ʻO ke kiʻekiʻe kiʻekiʻe o ka protein M ʻo ia hoʻi ʻoi aku ka holomua o kou maʻi ʻaʻai.

E kauoha kāu kauka i nā hoʻokolohua e nānā ai no ka protein M i kou kino i ka wā o Empliciti lapaʻau. Hōʻike kēia i kāu kauka e ʻike i ka maikaʻi o ka pane ʻana o kou kino i ka lāʻau.

Eia nō naʻe, hiki i ka Empliciti ke hoʻololi i nā hopena o kāu hōʻike protein M protein. Hiki i kēia ke lilo i mea paʻakikī i kāu kauka e ʻike inā ke hoʻomaikaʻi nei kāu myeloma maha a ʻaʻole paha. Hana paha ʻo Empliciti iā ia e like me ka nui o nā protein M ma mua o kāu. E hana a puni kēia, hiki i kāu kauka ke kauoha i nā hoʻokolohua lab e pili ʻole iā Empliciti e nānā i kāu mālama ʻana.

Nā launa lāʻau ʻē aʻe

Lawe mau ʻia ʻo Empliciti me dexamethasone a i ʻole pomalidomide (Pomalyst) a i ʻole lenalidomide (Revlimid). ʻOiai ʻaʻohe ʻike ʻia o ka launa lāʻau me Empliciti, aia kahi pilina i ʻike ʻia no nā lāʻau i hoʻohana ʻia.

E kūkā kamaʻilio me kāu kauka a kauka paha i nā launa kūpono no ka hui pū ʻana o nā lāʻau āu e lawe nei.

Pehea e hāʻawi ʻia ai ʻo Empliciti

Pono ʻoe e lawe iā Empliciti e like me kāu kauka a i ʻole nā ​​ʻōkuhi mālama ola. Hāʻawi ʻia ʻo Empliciti e ka infravenous (IV) infusion, ma o ka aa ma kou lima. Hāʻawi lohi ʻia nā lāʻau i hāʻawi ʻia e IV infusion i kahi manawa o ka manawa. Hoʻokahi paha hola a ʻoi paha e loaʻa ai kāu kau palena piha o Empliciti.

Hāʻawi wale ʻia ʻo Empliciti ma ke keʻena kauka a i ʻole kahi keʻena olakino. ʻOiai ke kiʻi nei ʻoe i kāu infusion, e kiaʻi ʻia ʻoe no ka hopena maʻi ʻaʻai a i ʻole ke ʻano infusion.

I ka manawa hea e lawe ai

Hāʻawi ʻia ʻo Empliciti ma kahi pōʻaiapuni lā 28 lā. ʻO ka manawa hea ʻoe e lawe ai i ka lāʻau e pili ana i nā lāʻau ʻē aʻe āu e lawe nei me Empliciti. ʻO ka papa kuhikuhi maʻamau no ka wā e lawe ai ʻoe iā Empliciti penei:

  • Inā ʻoe e lawe ana iā Empliciti me lenalidomide (Revlimid) a me dexamethasone, e loaʻa iā ʻoe ʻo Empliciti i hoʻokahi manawa i kēlā me kēia pule no nā pōʻai mua ʻelua (ka huina o ʻewalu pule) o ka mālama. Ma hope o kēlā, loaʻa iā ʻoe ʻo Empliciti i kēlā me kēia pule.
  • Inā ʻoe e lawe ana iā Empliciti me pomalidomide (Pomalyst) a me dexamethasone, e loaʻa pū iā ʻoe ʻo Empliciti i hoʻokahi manawa i kēlā me kēia pule no nā pōʻai mua ʻelua (ka huina o ʻewalu pule) o ka mālama. Ma hope o kēlā, loaʻa iā ʻoe ʻo Empliciti i hoʻokahi manawa i kēlā me kēia pōʻaiapuni, kahi hoʻokahi mahele ma kēlā me kēia ʻehā pule.

E nānā kāu kauka i kāu lāʻau lapaʻau a hoʻoholo i ka nui o nā pōʻaiapuni o Empliciti āu e pono ai.

ʻO Empliciti a me ka hāpai keiki

ʻAʻole i loaʻa kahi noiʻi o Empliciti i nā wahine hāpai. ʻAʻole nō i hana ʻia nā ʻike holoholona i ka hāpai keiki no kēia lāʻau.

Eia nō naʻe, ʻo lenalidomide (Revlimid) a me pomalidomide (Pomalyst), i hoʻohana ʻia me kēlā me kēia me Empliciti, hiki ke hōʻeha nui i kahi ʻōpū ulu. ʻAʻole pono e hoʻohana i kēia mau lāʻau i ka wā hāpai. ʻO ka hoʻohana ʻana i kēia mau lāʻau i ka wā hāpai hiki ke hōʻeha i nā hānau hānau nui a i ʻole hānau hānau ʻole.

No ka mea ua ʻae wale ʻia ʻo Empliciti e hoʻohana ʻia me lenalidomide (Revlimid) a i ʻole pomalidomide (Pomalyst), pono hoʻi e hōʻalo ʻia ʻo Empliciti i ka wā hāpai. Pono nā poʻe e lawe ana iā Empliciti i ka kaohi hānau inā pono. E ʻike i ka ʻāpana aʻe, "Empliciti a me ka kaohi hānau," no ka nui o nā kikoʻī.

Inā he mau nīnau kāu e pili ana i ka hoʻohana ʻana iā Empliciti i ka wā hāpai, e kamaʻilio me kāu kauka.

ʻO Empliciti a me ka kaohi hānau

ʻAʻole ʻike ʻia inā palekana ʻo Empliciti i ka wā hāpai.

Eia nō naʻe, ʻo lenalidomide (Revlimid) a me pomalidomide (Pomalyst), i hoʻohana ʻia me kēlā me kēia me Empliciti, hiki ke hōʻeha nui i kahi ʻōpū ulu. ʻAʻole pono e hoʻohana i kēia mau lāʻau i ka wā hāpai. No ka mea ua ʻae wale ʻia ʻo Empliciti e hoʻohana ʻia me kekahi lenalidomide a i ʻole pomalidomide, pono e hōʻalo ʻia ʻo Empliciti i ka wā hāpai.

Ma muli o kēia, ua hoʻomohala ʻia kahi papahana kūikawā e kōkua ai i ka pale ʻana i ka hāpai ʻana i ka poʻe e hoʻohana ana i kēia mau lāʻau. Kapa ʻia kēia papahana ʻo ka papahana ʻIlikia ʻInikino a me ka Mitigation Strategy (REMS).

Pono nā wahine ʻelua a me nā kāne e hoʻohana ana iā Empliciti e ʻae a hāhai i nā ʻōkuhi no ka Revlimid REMS a i ʻole ʻo Pomalyst REMS. E hāhai ʻoe i ka papahana REMS no nā lāʻau āu e lawe nei me Empliciti. Loaʻa i kēlā me kēia papahana kekahi mau koi e pono e ukali ʻia i mea e hoʻomau ai i ka lawe ʻana i ka lenalidomide a i ʻole ka pomalidomide.

Ma waho aʻe o ke koi ʻana i ka poʻe e lawe nei iā Empliciti e hoʻohana i ka kaohi hānau, koi ʻia ka papahana RemS iā ʻoe:

  • loaʻa nā hoʻokolohua pinepine no ka hāpai keiki, inā he wahine ʻoe e hoʻohana ana i ka lāʻau
  • ʻae ʻaʻole e hāʻawi i kekahi koko a i ʻole sperm ʻoiai ʻoe e hoʻohana nei i ka lāʻau

Kaohi hānau no nā wahine

Inā he wahine ʻoe i hiki ke hāpai, pono ʻoe i ʻelua mau hoʻokolohua hāpai maikaʻi ʻole ma mua o kou hoʻomaka ʻana i ka hoʻohana ʻana i ka lenalidomide a i ʻole ka pomalidomide.

ʻOiai ʻoe e lawe nei i kekahi o kēia mau lāʻau, pono ʻoe e hoʻohana i ʻelua ʻano o ka kaohi hānau a i ʻole hōʻole i ka moekolohe i ka wā o ka lapaʻau. Pono ʻoe e hoʻomau i ka hoʻohana ʻana i ka kaohi hānau a i ʻole ka hōʻole ʻana i ka moekolohe no ʻehā mau pule ma hope o kou kū ʻana i ka lāʻau.

Ka hānau hānau no nā kāne

Inā he kāne ʻoe e lawe ana iā Empliciti me kekahi lenalidomide a i ʻole pomalidomide, a ke hana moekolohe nei ʻoe me nā wahine i hiki ke hāpai, pono ʻoe e hoʻohana i ka kaohi hānau (e like me ka condom) i ka wā o ka mālama ʻana. He mea nui kēia e hana ai inā hoʻohana kāu hoa i ka kaohi hānau. Pono ʻoe e hoʻomau i ka hoʻohana ʻana i ka kaohi hānau no ʻehā mau pule ma hope o kou hōʻoki ʻana i ka lāʻau.

Empliciti a me ka waiū hānai

ʻAʻole hōʻike ʻia kahi noiʻi inā hele ʻo Empliciti i ka waiū umauma kanaka a i ʻole ke kumu o nā hopena i kahi keiki hānai.

ʻAʻole nō i ʻike ʻia inā hiki i ka lenalidomide (Revlimid) a me ka pomalidomide (Pomalyst) ke hana i kekahi hopena i nā keiki. Eia nō naʻe, no ka hopena o ka hopena o ka hopena i nā keiki, pono e hōʻalo i ka hānai ʻana i ka wā e lawe ana iā Empliciti.

ʻO nā nīnau maʻamau e pili ana iā Empliciti

Eia nā pane i kekahi o nā nīnau e nīnau pinepine ʻia e pili ana iā Empliciti.

ʻO chemotherapy ʻo Empliciti?

ʻAʻole, ʻaʻole manaʻo ʻia ʻo Empliciti i ka chemotherapy (hoʻohana ʻia nā lāʻau kuʻuna e mālama i ka maʻi ʻaʻai). Hana ʻo Chemotherapy e ka luku ʻana i nā hunaola i kou kino e hoʻonui koke ana (e hoʻonui ana i nā hunaola). ʻOiai make kēia i nā hunaola maʻi ʻaʻai, hiki iā ia ke pepehi pū i nā hunaola olakino ʻē aʻe.

ʻAʻole like me ka chemotherapy maʻamau, ʻo Empliciti kahi therapy i hoʻomākaukau ʻia. Hana kēia ʻano lāʻau ma luna o nā hunaola kikoʻī (i kapa ʻia he mau pūnana pepehi kūlohelohe), e māka ai i nā hunaola maʻi ʻaʻai. Ma muli o ka māka ʻana o Empliciti i kahi hui kūikawā o nā hunaola, ʻaʻole ia e hoʻopili i kāu mau hunaola olakino e like me ka nui. ʻO kēia ke kumu e hōʻemi i nā hopena ʻē aʻe ma mua o ka chemotherapy maʻamau.

He aha ka mea e hana ai ma kaʻu mau hōʻailona Empliciti?

Hāʻawi ʻia ʻo Empliciti ma ke ʻano he infravenous (IV) (kahi hoʻokomo i loko o kou aa i loko o kahi manawa o ka manawa). Hoʻokomo ʻia ka IV i kou lima.

E loaʻa maʻamau iā ʻoe kekahi mahele o ka Empliciti i kēlā me kēia pule no nā ʻelua mua o ka mālama ʻana. (ʻO kēlā me kēia pōʻaiapuni he 28 mau lā.) A laila, e loaʻa ʻoe i kahi infusion hoʻokahi i kēlā me kēia pule ʻelua a i hoʻokahi manawa i kēlā me kēia ʻehā pule. Aia kēia ʻāpana o kāu papa hana dosing i nā lāʻau āu e lawe nei me Empliciti.

ʻO ka lōʻihi o ka manawa o kēlā me kēia infusion e pili ana i kou kaumaha o ke kino a ehia mau kaha o Empliciti i loaʻa iā ʻoe.

Ma hope o kāu mahele lāʻau ʻelua o Empliciti, ʻaʻole pono e hoʻolōʻihi i kāu infusion ma mua o hoʻokahi hola. He mea kōkua paha ke lawe mai i kekahi mea e hana ai i kāu infusions e wikiwiki ai ka hala ʻana o ka manawa. ʻO kahi laʻana, lawe mai paha ʻoe i kahi puke a i ʻole makasina e heluhelu a mele paha e hoʻolohe ai.

Ma mua o ka loaʻa ʻana o kāu infus Empliciti, e kiʻi ʻoe i kekahi lāʻau ʻē aʻe e kōkua i ka pale ʻana i kekahi mau hopena ʻaoʻao, me kahi hopena infusion. Kapa ʻia kēia mau lāʻau i nā lāʻau lapaʻau mua.

ʻO nā lāʻau lapaʻau pre-infusion e hāʻawi ʻia iā ʻoe ma mua o kāu infus Empliciti:

  • diphenhydramine (Benadryl)
  • dexamethasone
  • acetaminophen (Tylenol)

Pehea wau e ʻike ai inā e hana ana ʻo Empliciti iaʻu?

Hana ʻo Empliciti i ke kōkua ʻana i kāu ʻōnaehana pale pale e kaua aku i nā pūnaewele myeloma he nui. Hiki i kāu kauka ke nānā i ka maikaʻi o ka pane ʻana o kāu ʻōnaehana pale i ka lāʻau lapaʻau ma ke kauoha ʻana i kahi hoʻokolohua e nānā ai no nā protein M.

Hana ʻia nā protein M e nā pūnaewele myeloma he nui. Hiki i kēia mau protein ke kūkulu i loko o kou kino a hōʻino i kekahi o kāu mau lālā. ʻIke ʻia kahi pae kiʻekiʻe o ka protein M i ka poʻe me ka nui o myeloma holomua.

Hiki i kāu kauka ke nānā i kāu mau pae protein M e ʻike i ke ʻano o kāu pane ʻana i ka lāʻau. Hiki ke hoʻāʻo ʻia nā pae m protein ma ke kaha ʻana i kahi laʻana koko a mimi paha.

E nānā paha kāu kauka i kāu pane i ka lāʻau lapaʻau ma ke kauoha ʻana i nā scan iwi. E hōʻike kēia mau scans inā loaʻa iā ʻoe kahi mau hoʻololi iwi i hoʻokumu ʻia e myeloma maha.

Hiki i ka hoʻohana ʻana iā Empliciti ke kumu e loaʻa ai iaʻu kekahi ʻano maʻi ʻaʻai?

Hiki paha. ʻO ka hoʻohana ʻana iā Empliciti e mālama i nā myeloma he nui hiki ke hoʻonui i kou makaʻu i ka loaʻa ʻana i kekahi ʻano maʻi ʻaʻai.

I nā hoʻokolohua hoʻokolohua, 9% o ka poʻe e lawe nei iā Empliciti me lenalidomide (Revlimid) a me dexamethasone i ulu i kahi ʻano maʻi ʻē aʻe. No nā poʻe e lawe wale ana iā lenalidomide a me dexamethasone, he 6% ka hopena like. ʻO nā ʻano o ka maʻi ʻaʻai i hoʻomohala ʻia ka maʻi ʻaʻai ʻili a me nā tumors paʻa, e like me ka umauma a i ʻole prostate cancer.

Eia kekahi i nā hoʻokolohua hoʻokolohua, 1.8% o ka poʻe e lawe nei iā Empliciti me pomalidomide (Pomalyst) a me dexamethasone i kūkulu i kahi ʻano maʻi ʻē aʻe. No nā poʻe e lawe wale nei i ka pomalidomide a me dexamethasone, ʻaʻohe mea i hoʻomohala i kekahi ʻano maʻi ʻē aʻe.

I ka wā o ka mālama ʻana me Empliciti, hiki i kāu kauka ke kauoha i nā hoʻokolohua koko hou a i ʻole scans e nānā iā ʻoe no nā maʻi maʻi hou e ulu ana.

Nā hana palekana Empliciti

Ma mua o ka lawe ʻana iā Empliciti, e kamaʻilio me kāu kauka e pili ana i kāu mōʻaukala olakino. ʻAʻole kūpono paha ʻo Empliciti iā ʻoe inā loaʻa iā ʻoe kekahi ʻano olakino. Pākuʻi ʻia kēia mau mea:

  • Hapai keiki. ʻAʻole ʻike ʻia inā he mea hōʻino ʻo Empliciti i kahi fetus e ulu nei. Eia nō naʻe, hoʻohana ʻia ʻo Empliciti me lenalidomide (Revlimid) a i ʻole pomalidomide (Pomalyst). ʻO kēia mau lāʻau ʻelua i ʻike ʻia ke kumu o ka hānau ʻana. Ma muli o kēia, pono i ka poʻe e lawe ana i kekahi lenalidomide a i ʻole pomalidomide e hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana ke hoʻohana nei lākou i kēia mau lāʻau. No ka ʻike hou aku, e ʻoluʻolu e ʻike i ka ʻāpana "Empliciti a me ka hāpai keiki" ma luna.
  • Hānai umauma. ʻAʻole ʻike ʻia inā hele ʻo Empliciti i ka umauma kanaka. Eia nō naʻe, ma muli o ka hopena o nā hopena ʻino i nā keiki, pono e hōʻalo i ka hānai ʻana iā ʻoe me ka lawe ʻana iā Empliciti. No ka ʻike hou aku, e ʻoluʻolu e ʻike i ka ʻāpana "Empliciti a me ka waiū hānai" ma luna.
  • Nā maʻi i kēia manawa. ʻAʻole pono ʻoe e hoʻomaka i ka lawe ʻana iā Empliciti inā loaʻa ʻoe i kahi maʻi maʻi. Hoʻopili kēia i ke anuanu maʻamau, influenza, a i ʻole nā ​​maʻi bacterial a me nā maʻi viral. E ʻōlelo paha kāu kauka e hoʻomaka ʻoe iā Empliciti ma hope o kou mālama ʻia ʻana no nā maʻi āpau. ʻO kēia no ka mea e hoʻonāwaliwali paha ʻo Empliciti i kāu ʻōnaehana pale, a ʻoi aku ka paʻakikī o ke kaua ʻana i ka maʻi.

Kaha: No ka ʻike hou aku e pili ana i nā hopena maikaʻi ʻole o Empliciti, e ʻike i ka ʻāpana "Nā hopena ʻe Empliciti" ma luna.

ʻO ka ʻike ʻoihana no Empliciti

Hāʻawi ʻia ka ʻike aʻe no nā kauka lapaʻau a me nā ʻoihana ola.

Nā Hōʻike

Hōʻike ʻia ʻo Empliciti e mālama i ka myeloma he nui i ka poʻe i komo i hoʻokahi o kēia mau ʻano lapaʻau ʻelua.

  • Nā mākua i loaʻa mua i hoʻokahi a i ʻekolu mau hōʻailona. I kēia mau poʻe, hoʻohana ʻia ʻo Empliciti me lenalidomide (Revlimid) a me dexamethasone.
  • ʻO nā mākua i loaʻa i ʻelua mau lāʻau lapaʻau i hoʻopili ʻia me ka lenalidomide (Revlimid) a me nā mea āpau proteasome. I kēia mau poʻe, hoʻohana ʻia ʻo Empliciti me pomalidomide (Pomalyst) a me dexamethasone.

ʻAʻole hōʻike ʻia ʻo Empliciti no ka poʻe ʻōpio ma mua o 18 mau makahiki.

Mekanism o ka hana

ʻO Empliciti kahi iGG1 monoclonal antibody i pale i ka pale. Hana ʻo Empliciti i ke kuhi ʻana i ka Member Lymphocytic Activation Molecule ʻohana lālā 7 (SLAMF7).

Hōʻike ʻia ʻo SLAMF7 ʻaʻole ma nā huna kanaka kūlohelohe (NK) a me nā hunaola plasma i loko o ke koko, akā, ma nā hunaʻi myeloma he nui. Hana ʻo Empliciti ma o ka kōkua ʻana i ka luku ʻia o nā hunaola myeloma ma o ka cytotoxicity cellular-dependant cellular (ADCC). Hana kēia hana ma muli o ka pilina ma waena o nā pūnaewele NK a me nā hunaola myeloma. Hōʻike kekahi mau noiʻi e hiki i ka Empliciti ke kōkua i ka hoʻoulu ʻana i nā hunaola NK, kahi e ʻimi a luku ai i nā hunaola myeloma.

Pharmacokinetics a me ka metabolism

Hoʻonui ka hoʻomaʻemaʻe Empliciti i ka hoʻonui ʻana o ke kaumaha o ke kino. Ua hōʻike ʻo Empliciti i nā pharmacokinetics nonlinear, kahi o ka hoʻonui ʻia ʻana o ka lāʻau i hōʻike nui ʻia i ka lāʻau ma mua o ka wānana.

Nā Kūʻai Kūʻai

ʻAʻohe o contplications kikoʻī ʻo Empliciti. Eia nō naʻe, pono e hōʻalo ʻia i nā wahine hāpai ke lawe ʻia e like me ka mea i hōʻike ʻia, e pili pū ana me ka hoʻohana ʻana o pomalidomide a i ʻole lenalidomide.

Waihona

Loaʻa ʻo Empliciti ma ke ʻano he 300 mg a i ʻole 400 mg lyophilized pauka i loko o ka ipu hoʻohana hoʻokahi. Pono e hoʻoponopono hou i ka pauka a hoʻokahe ʻia ma mua o ka hiki ke lawelawe ʻia.

Pono e mālama ʻia ʻo Empliciti pauma i loko o ka pahu hau (ma kahi mahana o 36 ° F a 46 ° F / 2 ° C a 8 ° C) a pale ʻia mai ka mālamalama. Mai hoʻopili a hoʻoluliluli paha i nā hue.

Ke hoʻoponopono hou ʻia ka pauka, pono e hoʻokomo ʻia ka hopena ma loko o 24 mau hola. Ma hope o ka hoʻohuihui ʻana, inā ʻaʻole hoʻohana koke ʻia ka infusion, pono ia e hoʻomaʻamaʻa ʻia i ka pale i ka mālamalama. Pono e mālama ʻia ka hopena Empliciti no ka lōʻihi o 8 mau hola (o ka huina o 24 mau hola) ma ke ana wela o ka lumi a me nā kukui o ka lumi.

Hoʻolaha: Ua hana ʻo Nūhou Lapaʻau i kēia mau lā e hōʻoia i ka pololei, ka laulā, a me ka lā hou o nā ʻike āpau. Eia nō naʻe, ʻaʻole pono e hoʻohana i kēia ʻatikala i pani no ka ʻike a me ka mākaukau o kahi loea mālama ola laikini. E nīnau mau ʻoe i kāu kauka a i ʻole ʻoihana olakino ʻē aʻe ma mua o ka lawe ʻana i nā lāʻau. Hiki ke loli i ka ʻike o ka lāʻau i loko a ʻaʻole i manaʻo ʻia e uhi i nā hoʻohana a pau, nā kuhikuhi, ka mālama ʻana, nā ʻōlelo aʻoaʻo, nā launa lāʻau, nā hopena maʻi ʻaʻai, a me nā hopena maikaʻi ʻole. ʻO ka loaʻa ʻole o nā ʻōlelo aʻoaʻo a i ʻole nā ​​ʻike ʻē aʻe no kahi lāʻau i hāʻawi ʻia ʻaʻole ia e hōʻike i ka palekana o ka lāʻau a lāʻau paha i kūpono no nā mea maʻi āpau a i ʻole nā ​​hoʻohana kikoʻī āpau.

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