Ponesimod

Anter

• Hoʻohana ʻia ʻo Ponesimod i mea e pale aku ai i nā ʻāpana o nā hōʻailona a hoʻolohi i ka hōʻino ʻana o ke kīnā ʻole i nā mākua i loaʻa hou i nā ʻano sclerosis (MS; kahi maʻi kahi e holo pono ʻole ai nā ʻalalā a ʻike paha ka poʻe i ka nāwaliwali, numbness, nalo ʻana o ka hoʻohui ʻana o nā mākala, a nā pilikia me ka hihi, kamaʻilio, a me ka mālama ʻana i ka maʻi ʻaʻa), me: Ponesimod i loko o ka papa o nā lāʻau i kapa ʻia ʻo sphingosine l-phosphate receptor modulators. Hana ia ma ka hoʻemi ʻana i ka hana o nā hunaola ʻino e hiki ai ke hōʻino i nā nerve.
• Ma mua o ka lawe ʻana i ka ponesimod,
• Hoʻokumu paha ʻo Ponesimod i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.
• Pākuʻi ʻia paha nā ʻōuli o ka overdose:

Hoʻohana ʻia ʻo Ponesimod i mea e pale aku ai i nā ʻāpana o nā hōʻailona a hoʻolohi i ka hōʻino ʻana o ke kīnā ʻole i nā mākua i loaʻa hou i nā ʻano sclerosis (MS; kahi maʻi kahi e holo pono ʻole ai nā ʻalalā a ʻike paha ka poʻe i ka nāwaliwali, numbness, nalo ʻana o ka hoʻohui ʻana o nā mākala, a nā pilikia me ka hihi, kamaʻilio, a me ka mālama ʻana i ka maʻi ʻaʻa), me: Ponesimod i loko o ka papa o nā lāʻau i kapa ʻia ʻo sphingosine l-phosphate receptor modulators. Hana ia ma ka hoʻemi ʻana i ka hana o nā hunaola ʻino e hiki ai ke hōʻino i nā nerve.

• maʻi hoʻokaʻawale clinically (CIS; ʻāpana hōʻailona nerve mua e kū ma ka liʻiliʻi ma 24 mau hola),
• relapsing-remit maʻi (papa o ka maʻi kahi e ʻō ai nā ʻōuli mai kēlā manawa kēia manawa),
• ʻeleu holomua holomua maʻi (ma hope pae o ka maʻi me ka hoʻomau worsening o nā ʻōuli.)

Hele mai ʻo Ponesimod ma ke ʻano he papa e lawe ma ka waha. Lawe ʻia ia i hoʻokahi manawa i ka lā me ka ʻai ʻole. Lawe i ka ponesimod ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka ponesimod e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi haʻahaʻa o ponesimod a hoʻonui iki i kāu lāʻau no nā lā 15 mua.

Hiki paha iā Ponesimod ke hoʻolohi i ka puʻuwai o ka puʻuwai, keu hoʻi i nā hola 4 mua ma hope o kou lawe ʻana i kāu kau ma mua. E lawe ʻoe i kāu kau mua o ka ponesimod i ke keʻena o kāu kauka a i ʻole kahi wahi olakino ʻē aʻe. E loaʻa iā ʻoe kahi electrocardiogram (ECG; hōʻike e hoʻopaʻa i ka hana uila o ka puʻuwai) ma mua o kou lawe ʻana i kāu lāʻau mua a me 4 mau hola ma hope o kou lawe ʻana i ka lāʻau. Pono ʻoe e noho ma ke keʻena lapaʻau no 4 mau hola ma hope o kou lawe ʻana i ka lāʻau i hiki ke nānā ʻia. Pono ʻoe e noho ma ke keʻena lapaʻau no ka lōʻihi ma mua o 4 mau hola a i ʻole ka pō inā loaʻa iā ʻoe kekahi mau ʻano a i ʻole lawe i kekahi mau lāʻau e hoʻonui i ka makaʻu e lohi ai kou puʻuwai a i ʻole inā lohi paha kou puʻuwai ma mua o ka mea i manaʻo ʻia a hoʻomau i ka lohi ma hope o ka 4 mua. mau hola. Pono paha ʻoe e noho ma kahi keʻena olakino ma kahi o 4 mau hola ma hope o kou lawe ʻana i kāu hopena ʻelua inā lohi nui kou puʻuwai ke lawe ʻoe i kāu kau mua. E haʻi i kāu kauka inā ʻike ʻoe i ka lōlō, ka luhi, ka ʻeha o ka umauma, a i ʻole ke kuʻi puʻuwai a i ʻole wā maʻamau i kēlā me kēia manawa i kāu wā e lapaʻau ai.

Hiki paha i ka Ponesimod ke kōkua i ke kaohi ʻana i nā sclerosis he nui akā ʻaʻole ia e hoʻōla iā ia. Mai hōʻoki i ka lawe ʻana i ka ponesimod me ke kamaʻilio ʻole ʻana me kāu kauka.

E hāʻawi aku kāu kauka a mea kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me ponesimod a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka ponesimod,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka ponesimod, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa ponesimod. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: alemtuzumab (Campath, Lemtrada); amiodarone (Nexterone, Pacerone); beta-blockers e like me atenolol (Tenormin, ma Tenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, ma Dutoprol, ma Lopressor HCT), nadolol (Corgard, ma Corzide), nebivolol (Bystolic, ma Byvalson ), propranolol (Inderal LA, Innopran XL), sotalol (Betapace, Sorine, Sotylize) a me timolol; carbamazepine (Carbatrol, Equetro, Tegretol, a me nā mea ʻē aʻe); digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, nā mea ʻē aʻe); modafinil (Provigil); phenytoin (Dilantin); procainamide; quinidine (i Nuedexta); rifampin (Rifadin, Rimactane, ma Rifamate, nā mea ʻē aʻe); a me ka verapamil (Calan, Verelan, ma Tarka). E haʻi pū aku i kāu kauka inā lawe ʻoe i kekahi o nā lāʻau aʻe, a i ʻole inā ua lawe ʻoe iā lākou i ka wā ma mua: ʻo corticosteroids e like me dexamethasone, methylprednisolone (Medrol), a me prednisone (Rayos); nā lāʻau no ka maʻi ʻaʻai; a me nā lāʻau e hoʻonāwaliwali ai ʻole kaohi ʻana i ka ʻōnaehana pale e like me glatiramer acetate (Copaxone, Glatopa) a me interferon beta (Betaseron, Extavia, Plegridy). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me ponesimod, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole kekahi o kēia mau ʻano i loko o nā mahina ʻeono i hala iho nei: ka puʻuwai puʻuwai, angina (ʻeha o ka umauma), hahau a i ʻole hahau iki ʻana, a i ʻole nā ​​puʻuwai puʻuwai. E haʻi pū aku i kāu kauka inā loaʻa kahi puʻuwai puʻuwai kūpono ʻole a i ʻole kekahi ʻano poloka puʻuwai, ke ʻole ʻoe he pacemaker. E haʻi paha kāu kauka iā ʻoe mai lawe i ka ponesimod.
• e haʻi i kāu kauka inā he kuni kou a i ʻole he maʻi ʻaʻai a inā he maʻi paha kāu e hele mai ana a i ʻole hele aku paha. Eia kekahi, e haʻi aku i kāu kauka inā ua loaʻa paha iā ʻoe ka maʻi puʻuwai, ka hahau ʻana, ka maʻi liʻiliʻi, ka maʻi kō, ka maʻi hiamoe (ke ʻano hoʻomaha iki ʻoe i ka hanu ʻana i nā manawa he nui i ka pō) a i ʻole nā ​​pilikia hanu ʻē aʻe, ke koko kiʻekiʻe, uveitis (pehu o ka maka) a i ʻole nā ​​pilikia o ka maka, ka maʻi ʻaʻai ʻili, a i ʻole ka maʻi puʻuwai a i ʻole ate. E haʻi pū aku i kāu kauka inā lōʻihi kou QT syndrome (ke ʻano e hoʻonui ai i ka makaʻu o ke kūkulu ʻana i kahi puʻuwai puʻuwai ʻole, a he mea paha ia e maʻule ai a make koke paha), ka puʻuwai puʻuwai ʻole, a inā ua loaʻa iā ʻoe kahi lāʻau lapaʻau.
• e haʻi i kāu kauka inā hāpai ʻoe a hoʻolālā paha e hāpai, a i ʻole e hānai umauma ʻana.Pono ʻoe e hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā lapaʻau a ma ka liʻiliʻi he 1 pule ma hope o kāu hopena hope loa. Inā hāpai ʻoe i ka lawe ʻana i ka ponesimod a i ʻole ma waena o 1 pule ma hope o kāu hopena hope loa, e kāhea i kāu kauka. Pōʻino paha ʻo Ponesimod i ka fetus.
• ʻaʻohe o nā lāʻau āpau no 1 mahina ma mua o kou hoʻomaka ʻana i kāu lāʻau me ponesimod, i kou wā e hoʻomaʻamaʻa ai, a no 1 a 2 mau pule ma hope o kāu hopena hope loa me ke kamaʻilio ʻole ʻana me kāu kauka. E kamaʻilio me kāu kauka e pili ana i nā lāʻau āpau āu e pono ai e loaʻa ma mua o ka hoʻomaka ʻana i kāu lāʻau me ponesimod.
• e haʻi i kāu kauka inā ʻaʻole i loaʻa i ka pox moa a ʻaʻole i loaʻa iā ʻoe ka lāʻau lapaʻau ʻo ka moa. Kauoha paha kāu kauka i kahi hoʻokolohua koko e ʻike inā ua ʻike ʻia ʻoe i ka moa moa. Pono ʻoe e loaʻa i ka lāʻau laʻau moa a laila kali i 4 mau pule ma mua o ka hoʻomaka ʻana i kāu lāʻau me ponesimod.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā haʻalele ʻoe iā 1 a 3 mau lā o ka ponesimod i ka wā titration (14-lā hoʻomaka pack), e lawe i ka papa i hala i kou wā e hoʻomanaʻo ai a hoʻomau i kāu mālama ʻana ma ka lawe ʻana i hoʻokahi papa i kēlā lā i kēia lā i ka pack starter e like me ka hoʻolālā. Inā haʻalele ʻoe i ka lawe ʻana i 4 a ʻoi mau lā i ka lālani o ponesimod i ka wā titration (14-lā hoʻomaka pack), kāhea i kāu kauka no ka mea pono ʻoe e hoʻomaka hou i ka mālama ʻana me kahi pack hoʻomaka mua he 14 mau lā. Inā loaʻa iā ʻoe kekahi ʻano naʻau, pono paha ʻoe e kiaʻi ʻia e kāu kauka no 4 mau hola ke lawe ʻoe i kāu kaukana aʻe.

Inā haʻalele ʻoe iā 1 a 3 mau lā o ka ponesimod ma hope o ka wā titration (mālama mahele lāʻau) e lawe i ka papa i hala i kou wā e hoʻomanaʻo ai a hoʻomau i kāu lāʻau. Inā haʻalele ʻoe i ka lawe ʻana i 4 a ʻoi mau lā i ka lālani o ponesimod ma hope o ka wā titration (mālama mahele lāʻau), kāhea i kāu kauka no ka mea pono ʻoe e hoʻomaka hou i ka mālama ʻana me kahi pack hoʻomaka mua he 14 mau lā. Inā loaʻa iā ʻoe kekahi mau ʻano puʻuwai, pono paha ʻoe e kiaʻi ʻia e kāu kauka no 4 mau hola ke lawe ʻoe i kāu hopena aʻe.

Hoʻokumu paha ʻo Ponesimod i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻūpā
• ʻūhā
• ʻeha ma nā lima a me nā wāwae

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• ʻūlū puʻuwai
• ʻeha ka ʻāʻī, ka pōkole o ka hanu, ʻeha ke kino, ke kuni, ka wela me ka urination, ke anuanu, ka ʻū, a me nā hōʻailona ʻē aʻe o ka maʻi i ka wā o ka mālama ʻana a i 1 a 2 mau pule ma hope o kāu lapaʻau
• nāwaliwali ma kekahi ʻaoʻao o ke kino a i ʻole nā ​​clumsiness o nā lima a mau wāwae paha e ʻino i ka holo ʻana o ka manawa. nā hoʻololi i kou noʻonoʻo, hoʻomanaʻo, a kaulike paha; huikau a ʻano pilikino paha; aiʻole ka nalowale o ka ikaika
• blurriness, aka, a i ʻole kahi makapō i waenakonu o kāu ʻike; ʻike i ka mālamalama; kala ʻokoʻa i kāu hihiʻo a i ʻole nā ​​pilikia ʻike
• nausea, luaʻi, nalo o ka makemake ʻole, ʻeha o ka ʻōpū, melemele o ka ʻili a me nā maka, a i ʻole ka mimi ʻeleʻele
• pōkole hou o ka hanu

Hiki i ka Ponesimod ke hoʻonui i ka makaʻu o ka ulu ʻana i ka maʻi ʻaʻai ʻili. E haʻi i kāu kauka inā he loli kāu i kahi mole e kū nei; kahi ʻeleʻele hou i ka ʻili; nā ʻeha e hoʻōla ʻole ai; nā ulu ma kou ʻili e like me ka puʻupuʻu e hinuhinu paha, keʻokeʻo momi, ʻulaʻula, a ʻulaʻula, a i ʻole nā ​​hoʻololi ʻē aʻe i kou ʻili. Pono kāu kauka e nānā i kou ʻili no nā loli i ka wā o ka mālama ʻana me ponesimod. Ka palena o ka manawa āu e lilo ai i ka lā a me ke kukui ultraviolet (UV). E komo i nā lole pale a hoʻohana i ka sunscreen me kahi kumu pale lā kiʻekiʻe. E kamaʻilio me kāu kauka e pili ana i ka makaʻu i ka lawe ʻana i kēia lāʻau.

Hoʻokumu paha ʻo Ponesimod i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua. Inā hele mai kāu lāʻau lapaʻau me kahi ʻeke desiccant (ʻāpana liʻiliʻi i loaʻa kahi mea e omo ai i ka wai e hoʻomau i ka maloʻo o ka lāʻau), e waiho i ka pūʻolo i loko o ka hue akā e akahele ʻoe i ka moni ʻole iā ia.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Pākuʻi ʻia paha nā ʻōuli o ka overdose:

• lohi a kuʻi ʻole paha ka puʻuwai puʻuwai

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha aku kāu kauka i kekahi mau hoʻokolohua lab a me nā hoʻāʻo ʻana o ka maka, a e nānā i kou kahe koko ma mua a i kou wā o ka mālama ʻana e maopopo he palekana ia nou e hoʻomaka i ka lawe ʻana a i ʻole hoʻomau i ka lawe ʻana i ka ponesimod.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Ponvory^®