Mea Kākau: Gregory Harris
Lā O Ka Hana: 9 Apelila 2021
HōʻAno Hou I Ka Lā: 22 Nowemapa 2024
Anonim
All about Abecma (Idecabtagene Vicleucel)
Wikiō: All about Abecma (Idecabtagene Vicleucel)

Anter

Hiki i ke kuikahi Idecabtagene vicleucel ke kumu i kahi hopena koʻikoʻi a weliweli paha i kapa ʻia ʻo cytokine hoʻokuʻu syndrome (CRS). E nānā pono kahi kauka a kahu hānai paha iā ʻoe i kāu infusion a no 4 mau pule ma hope. E haʻi i kāu kauka inā loaʻa ʻoe i kahi maʻi hōʻeha a i ʻole inā manaʻo a manaʻo paha ʻoe he ʻano maʻi paha kāu i kēia manawa. Hāʻawi ʻia ʻoe i nā lāʻau i 30 a 60 mau minuke ma mua o kou hoʻokomo ʻana e kōkua i ka pale ʻana i nā hopena i ka idecabtagene vicleucel. Inā ʻoe e ʻike i kekahi o nā ʻōuli ma hope a ma hope o kou hoʻokomo ʻana, e haʻi koke aku i kāu kauka: ke kuni, ka haʻalulu, ka puʻuwai puʻuwai wikiwiki a i ʻole kūpono ʻole, ʻehaʻeha, haʻalulu, maʻi pākī, māluhiluhi, nāwaliwali, paʻakikī hanu, ka liʻiliʻi o ka hanu, kahe, huikau, nausea, ka luaʻi, lū, a i ʻūlū ʻia paha.

Hiki i ka idecabtagene vicleucel injection ke kumu i ka hopena a i ʻole hoʻoweliweli ola i nā hopena o ke kikowaena. Hiki ke hana i kēia mau hopena ma hope o ka mālama ʻana me idecabtagene vicleucel. E haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha i nā kuʻi ʻana, ka hahau, a me ka nalo ʻana o ka hoʻomanaʻo. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e haʻi koke aku i kāu kauka: ʻeha ke poʻo, ʻūpē, paʻakikī e hiamoe a hiamoe paha, hoʻomaha ʻole, huikau, hopohopo, haʻalulu ʻole o kahi ʻāpana o ke kino, nalowale o ka ʻike, hoʻonāukiuki, hopu ʻana, nalo ʻana o ke kaulike, a i ʻole ka paʻakikī e ʻōlelo.


Hiki i ka idecabtagene vicleucel injection ke kumu o ka hōʻemi nui ʻana i ka helu o kekahi ʻano o nā hunaola koko i loko o kou koko. Hiki i kēia ke kumu i kekahi mau hōʻailona a hoʻonui paha i ka makaʻu e hoʻomohala ʻoe i kahi maʻi nui a i ʻole ke kahe ʻana o ke kahe. Inā ʻoe e ʻike i kekahi o nā ʻōuli ma hope o kāu lapaʻau ʻana, e haʻi koke aku i kāu kauka: ke kuni, ka luhi, a me ka ʻeha a me ke kahe ʻana.

Loaʻa ʻo Idecabtagene vicleucel ma o kahi papahana hoʻokaʻawale palena kūikawā. Ua hoʻonohonoho ʻia kahi papahana Abecma REMS (ʻIlikai Loiloi a me ka Strategic Mitigation) ma muli o nā makaʻu o CRS, ke kikowaena ʻōnaehana, a me nā pilikia o ke koko. Hiki iā ʻoe ke loaʻa nā lāʻau mai ke kauka a me nā lawelawe mālama ola e komo i ka papahana. E nīnau i kāu kauka inā he nīnau kāu e pili ana i kēia polokalamu.

E hāʻawi aku kāu kauka a mea kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Ke alakaʻi alakaʻi) ke hoʻomaka ʻoe i ka lāʻau me idecabtagene vicleucel a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.


Hoʻohana ʻia ʻo Idecabtagene vicleucel injection e mālama i kekahi ʻano o ka myeloma maha (kahi ʻano maʻi ʻaʻai o ka iwi iwi) i nā mākua i hoʻi a maʻi ʻole paha ka maʻi ʻaʻai i ʻehā mau lapaʻau ʻē aʻe. ʻO Idecabtagene vicleucel injection ka i loko o ka papa o nā lāʻau i kapa ʻia autologous cellular immunotherapy, kahi ʻano o ka lāʻau i hoʻomākaukau ʻia me ka hoʻohana ʻana i nā hunaola mai ke koko ponoʻī o ka mea maʻi. Hana ia e ke kumu o ke kino o ke kino (kahi hui o nā hunaola, nāʻaʻaʻa, a me nā mea i pale i ke kino mai ka hoʻouka ʻia ʻana e nā koʻohune, nā mea ʻino, nā hunaola maʻi ʻaʻai, a me nā mea like ʻē aʻe e hōʻeha i nā maʻi) e hakakā me nā hunaola maʻi ʻaʻai.

ʻO Idecabtagene vicleucel injection e hele mai ma ke ʻano he wehe (wai) e ʻimi ʻino ʻia (i loko o kahi aa) e ke kauka a kahu wahine paha i ke keʻena o ke kauka a infusion kikowaena paha. Hāʻawi pinepine ʻia ia ma luna o kahi wā holoʻokoʻa o 30 mau minuke ma ke ʻano he mahele manawa hoʻokahi. Ma mua o ka loaʻa ʻana o kāu idecabtagene vicleucel mahele lāʻau, na kāu kauka a kahu wahine paha e lawelawe i nā lāʻau chemotherapy ʻē aʻe e hoʻomākaukau ai i kou kino no ka idecabtagene vicleucel.


Ma mua o ka hāʻawi ʻia ʻana o ka lāʻau o idecabtagene vicleucel injection, e lawe ʻia kahi laʻana o kou mau keʻokeʻo keʻokeʻo ma kahi kikowaena ohi cell e hoʻohana ana i kahi hana i kapa ʻia ʻo leukapheresis (kahi hana e lawe i nā hunaola keokeo mai ke kino) Ma muli o ka hana ʻia ʻana o kēia lāʻau i kou mau huna ponoʻī, pono e hāʻawi ʻia iā ʻoe wale nō. He mea nui ia ma ka manawa kūpono a mai haʻalele i kāu koho ʻana i ka ʻohiʻohi a hoʻonohonoho ʻia a i ʻole e loaʻa i kāu mahele lāʻau. Pono ʻoe e hoʻolālā e noho ma waena o 2 mau hola o kahi i loaʻa ai iā ʻoe kāu idecabtagene vicleucel lapaʻau no 4 mau pule ma hope o kāu kau lāʻau. E nānā kāu mea olakino e ʻike inā e hana ana kāu lāʻau a nānā iā ʻoe no nā hopena ʻē aʻe. E kamaʻilio me kāu kauka e pili ana pehea e hoʻomākaukau ai no ka leukapheresis a me ka mea e kali ai i ka wā a ma hope o ke kaʻina hana.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka loaʻa ʻana o ka idecabtagene vicleucel injection,

  • e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka idecabtagene vicleucel, nā lāʻau ʻē aʻe, dimethyl suloxide (DMSO), a i ʻole kekahi o nā mea hana i ka idecabtagene vicleucel injection. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻōlelo pono i kekahi o kēia mau mea: nā steroid e like me dexamethasone, methylprednisolone (Medrol), prednisolone, a me prednisone (Rayos). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi i kāu kauka inā ua loaʻa iā ʻoe nā hopena mai nā hoʻomaʻamaʻa chemotherapy ma mua e like me nā pilikia hanu a i ʻole ke kuʻi puʻuwai ʻole. Eia kekahi, e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa i ka maʻi ākea, nā konā, ka puʻuwai, a i ʻole nā ​​maʻi ate.
  • e haʻi i kāu kauka inā hāpai ʻoe, hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Pono ʻoe e hana i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i idecabtagene vicleucel. Inā hāpai ʻoe i ka loaʻa ʻana iā idecabtagene vicleucel, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Idecabtagene vicleucel i ka fetus.
  • pono ʻoe e ʻike ʻo ka hoʻopili ʻana i ka vicleucel idecabtagene e hiamoe ai ʻoe a hoʻolilo i ka huikau, nāwaliwali, ʻū, nā hopu ʻana, a me nā pilikia hoʻohui. Mai hoʻokele i kahi kaʻa a hana i nā mīkini ma kahi o 8 mau pule ma hope o kāu idecabtagene vicleucel.
  • mai hāʻawi manawaleʻa i ke koko, nā lālā, nā aʻa, a i ʻole nā ​​hunaola no ke kanu ʻana ma hope o kou loaʻa ʻana i kāu idecabtagene vicleucel injection.
  • nānā me kāu kauka e ʻike inā pono ʻoe e loaʻa i nā lāʻau āpau. Mai loaʻa i nā lāʻau āpau me ke kamaʻilio ʻole ʻana me kāu kauka no 6 mau pule ma mua o ka hoʻomaka ʻana o ka chemotherapy, i ka wā o kāu idecabtagene vicleucel lapaʻau, a hiki i ka haʻi ʻana o ke kauka iā ʻoe ua ola kāu pale.

Inā haʻalele ʻoe i ka manawa e hōʻiliʻili ai i kāu mau hunaola, pono ʻoe e kāhea koke i kāu kauka a me ke kikowaena hōʻiliʻili. Inā ʻike ʻoe i kahi manawa e loaʻa ai kāu lāʻau idecabtagene vicleucel, pono ʻoe e kelepona koke i kāu kauka.

Hiki i nā vecucucel Idecabtagene ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • kōpaʻa
  • Kaumaha emi
  • nalo ʻai ʻole
  • ʻeha ka waha
  • waha maloo
  • maka maloʻo

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • hoʻemi i ke alapine urination a i ʻole ka nui
  • ka pehu o nā maka, ka maka, ka lehelehe, ka elelo, ka ʻāʻī, ka lima, ka lima, ka wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
  • paʻakikī i ka ale ʻana
  • hūwī
  • hives
  • ʻūlili

Hiki i ka Idecabtagene vicleucel ke hoʻonui i kou makaʻu i ka hoʻomohala ʻana i kekahi mau maʻi ʻaʻai. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka loaʻa ʻana o kēia lāʻau.

Hoʻokumu paha ʻo Idecabtagene vicleucel i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i nā manawa a pau me kāu kauka, ke kikowaena ohi cell, a me ka hale hana. Hiki paha i kāu kauka ke kauoha i kekahi mau hoʻokolohua lab ma mua, i ka wā, a ma hope o kāu mālama ʻana e nānā i ka pane o kou kino i ka idecabtagene vicleucel injection.

Ma mua o ka hoʻāʻo ʻana i kahi keʻena hoʻokolohua, e haʻi i kāu kauka a me nā limahana o ke keʻena hoʻokolohua ke loaʻa nei iā ʻoe ka idecabtagene vicleucel. Hiki i kēia lāʻau ke hoʻololi i nā hopena o kekahi mau hoʻokolohua hoʻokolohua.

E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka idecabtagene vicleucel injection.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • Abecma®
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