ʻO Tezacaftor lāua ʻo Ivacaftor

Anter

• Ma mua o ka lawe ʻana i ka tezacaftor a me ivacaftor,
• Hiki i ka Tezacaftor a me ka ivacaftor ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e hoʻōki i ka lawe ʻana i ka tezacaftor a me ivacaftor a kāhea koke aku i kāu kauka:

Hoʻohana ʻia ka hui ʻana o ka tezacaftor a me ivacaftor me ka ivacaftor e mālama ai i kekahi ʻano o ka cystic fibrosis (kahi maʻi i loko e hoʻopilikia ai i ka hanu ʻana, digestion, a me ka reproduction) i nā mākua a me nā keiki he 6 mau makahiki a ʻoi paha. E hoʻohana wale ʻia ʻo Tezacaftor a me ivacaftor i nā kānaka wale nō me kahi ʻano make-up. Kauoha paha kāu kauka i kahi hoʻokolohua koko e kōkua ai e hoʻoholo inā kūpono kēia lāʻau iā ʻoe. Aia ʻo Tezacaftor i kahi papa o nā lāʻau i kapa ʻia he cystic fibrosis transmembrane conductance regulator (CFTR) hoʻoponopono. Aia ʻo Ivacaftor i kahi papa o nā lāʻau i kapa ʻia he cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Hana ʻia kēia mau lāʻau ʻelua ma o ka hoʻomaikaʻi ʻana i ka hana o kahi protein i ke kino e hōʻemi ai i ke kūkulu ʻia ʻana o nā mucus mānoanoa i nā akemāmā a hoʻomaikaʻi i nā hōʻailona cystic fibrosis ʻē aʻe.

ʻO ka hui pū ʻana o tezacaftor a me ivacaftor a me ivacaftor e hele mai ma ke ʻano he papa e lawe ʻia e ka waha. Hele mai kēia lāʻau i loko o kahi pūʻolo me 4 mau pule o ka lāʻau. He mau papa like ʻole kēlā me kēia lā o kēlā me kēia lā: ʻo ka papa hoʻokahi ka hui pū ʻana o ka tezacaftor a me ka ivacaftor a ʻo ka papa ʻē aʻe he ivacaftor. E lawe i ka tezacaftor a me ivacaftor (1 pā melemele) i kēlā me kēia kakahiaka me kahi meaʻai momona a me ivacaftor (1 papa polū) i kēlā me kēia ahiahi me kahi meaʻai momona, 12 mau hola ke kaʻawale. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i kēia mau lāʻau e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.

Lawe i ka hui pū ʻana o ka tezacaftor a me ivacaftor a me ivacaftor me nā mea momona e like me nā hua manu, ka bata, nā nati, ka wai pīnī, ka waiū waiū, a me nā huahana waiū waiū holoʻokoʻa (e like me ka waiū piha, ka tī, a me ka yogurt). E kamaʻilio me kāu kauka e pili ana i nā meaʻai momona ʻē aʻe e ʻai ai me kēia mau lāʻau.

ʻO ka hui pū ʻana o ka tezacaftor a me ka ivacaftor me nā hana ivacaftor e kaohi ai i ka cystic fibrosis, akā ʻaʻole lākou e hoʻōla. E hoʻomau i ka lawe ʻana i kēia mau lāʻau inā ʻoluʻolu ʻoe. Mai hōʻoki i ka lawe ʻana i kēia mau lāʻau me ke kamaʻilio ʻole ʻana me kāu kauka.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka tezacaftor a me ivacaftor,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka tezacaftor, ivacaftor, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka tezacaftor a me ivacaftor a me nā papa ivacaftor. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, lawe ʻoe a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: kekahi antibiotic e like me clarithromycin (Biaxin, i PrevPac), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), a me telithromycin (Ketek); kekahi mau antifungals e like me fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), a me voriconazole (Vfend); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); everolimus (Afinitor, Zortress); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Carbatrol, Epitol, Tegretol, a me nā mea ʻē aʻe), phenobarbital, a me phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifampin (Rifadin, ma Rifamate, ma Rifater, Rimactane); sirolimus (Rapamune); aiʻole tacrolimus (Astagraf, Prograf). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Pili pū paha nā lāʻau ʻē aʻe he nui me ka tezacaftor a me ivacaftor, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka wort a St. John ʻoiai ke lawe nei i ka hui o tezacaftor a me ivacaftor me ka ivacaftor.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha iā ʻoe ka maʻi puʻuwai a i ʻole ate.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka hui o tezacaftor a me ivacaftor me ka ivacaftor, e kāhea i kāu kauka.
• pono ʻoe e ʻike i kēia mau lāʻau ʻana e hiamoe ai ʻoe. Mai hoʻokele i kahi kaʻa a hana i nā mīkini a ʻike ʻoe i ka hopena o kēia mau lāʻau iā ʻoe.

Mai ʻai i ka huaʻikuʻi a i ʻole nā ​​ʻalani ʻo Seville a inu paha i ka wai huaʻikuʻi ke lawe nei i kēia mau lāʻau.

Inā hoʻomanaʻo ʻoe i ka mahele lāʻau i hala ʻole o kēlā me kēia papa i loko o 6 mau hola o ka manawa āu i hoʻonohonoho ʻia ai e lawe, lawe koke i ka lāʻau i hala me kahi meaʻai momona. Eia nō naʻe, inā ua hala ma mua o 6 mau hola mai ka manawa i hoʻonohonoho ʻia e lawe i kēlā me kēia papa, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i ka Tezacaftor a me ka ivacaftor ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻeha poʻo
• paheʻe ihu
• ʻūpā

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e hoʻōki i ka lawe ʻana i ka tezacaftor a me ivacaftor a kāhea koke aku i kāu kauka:

• melemele o ka ʻili a me nā maka
• nalo ʻai ʻole
• nausea
• ka luaʻi
• noho humuhumu
• ʻeha ka ʻōpū
• mimi ʻeleʻele

Hiki i ka Tezacaftor a me ka ivacaftor ke kumu o ka cataract (ke ao ʻana o nā aniani o ka maka e hoʻopilikia i ka ʻike maka) i nā keiki a me nā ʻōpio. ʻO nā keiki a me nā ʻōpio e lawe ana i ka tezacaftor a me ivacaftor e ʻike i ke kauka maka ma mua a i ka wā o kā lākou mālama ʻia. E kamaʻilio me kāu kauka o kāu keiki e pili ana i nā makaʻu o ka hāʻawi ʻana i ka tezacaftor a me ivacaftor i kāu keiki.

Hiki i ka Tezacaftor a me ka ivacaftor ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kahi hoʻokolohua maka (no nā keiki a me nā ʻōpio) a me kekahi mau hoʻokolohua hoʻokolohua ma mua a i kāu wā e mālama ai e nānā i ka pane o kou kino i ka tezacaftor a me ivacaftor.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Symdeko^®