Mea Kākau: Gregory Harris
Lā O Ka Hana: 14 Apelila 2021
HōʻAno Hou I Ka Lā: 21 Nowemapa 2024
Anonim
Bioequivalence of HTX-019 (aprepitant IV) and fosaprepitant - Video Abstract ID 155875
Wikiō: Bioequivalence of HTX-019 (aprepitant IV) and fosaprepitant - Video Abstract ID 155875

Anter

Hoʻohana ʻia ka puʻupuʻu Aprepitant a me ka hoʻopili ʻana fosaprepitant me nā lāʻau ʻē aʻe e pale aku i ka nausea a me ka luaʻi ʻana i nā mākua e hiki ke hana ʻia ma loko o 24 mau hola a i ʻole he mau lā ma hope o ka loaʻa ʻana o kekahi lāʻau chemotherapy chemotherapy.Hiki ke hoʻohana ʻia ka injection Fosaprepitant i nā keiki 6 mau makahiki a ʻoi paha. ʻO nā aprepitant a me nā fosaprepitant injection he ʻaʻole hoʻohana ʻia e mālama i ka nausea a me ka luaʻi i loaʻa iā ʻoe. Aprepitant a me fosaprepitant injection i loko o ka papa o nā lāʻau i kapa ʻia antiemetics. Hana lākou ma ka pale ʻana i ka hana o neurokinin, kahi mea kūlohelohe i ka lolo e hana ai i ka nausea a me ka luaʻi.

ʻO ke kīpē Aprepitant e hele mai ma ke ʻano he emulsion (wai) a ʻo ka injection fosaprepitant e hele mai me he pauma e hoʻopili ʻia me ka wai a hāʻawi ʻia intravenously (i kahi aa) e ke kauka a kahu wahine paha i kahi wahi lapaʻau. Hāʻawi pinepine ʻia ʻo ka aprepitant injection a i ʻole ka fosaprepitant injection ma ke ʻano he hoʻokahi manawa ma ka lā 1 o kahi pōʻaiapaau chemotherapy, e hoʻopau ana ma kahi o 30 mau minuke ma mua o ka hoʻomaka ʻana o ka chemotherapy. No nā keiki a me nā ʻōpio e loaʻa ana i ka injection aprepitant a me nā mākua e loaʻa ana i ka fosaprepitant me kekahi mau chemotherapy, hiki ke hāʻawi ʻia i ka aprepitant waha i nā lā 2 a me 3 o ka pōʻaiapuni lāʻau chemotherapy.


Hiki paha iā ʻoe ke ʻike i kahi hopena i ka manawa a ma hope paha o kou loaʻa ʻana i kahi lāʻau o ka inikopa aprepitant a i ʻole ka fosaprepitant injection. E haʻi koke i kāu kauka inā ʻike ʻoe i kekahi o kēia mau ʻōuli i ka manawa a ma hope paha o ka loaʻa ʻana o ka lāʻau: pehu i kou mau maka, ʻehu, hives, ʻili, ʻulaʻula, pīpī, paʻakikī i ka hanu ʻana a me ka ale ʻana paha, ka paupauā a maʻule paha, a i ʻole ka wikiwiki a palupalu paha o ka puʻuwai. E hōʻoki paha kāu kauka i ka infusion, a mālama paha i ka hopena me nā lāʻau ʻē aʻe.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka hoʻohana ʻana i ka pahu kui aprepitant a i ʻole fosaprepitant,

  • e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka fosaprepitant, aprepitant, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka inikopa aprepitant a i ʻole ka fosaprepitant injection. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka inā lawe ʻoe i ka pimozide (Orap). E haʻi paha kāu kauka iā ʻoe mai hoʻohana i ka inikopa aprepitant a i ʻole fosaprepitant inā lawe ʻoe i kēia lāʻau.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E hōʻoia e haʻi i kekahi o kēia mau mea: anticoagulants ('nā mea hōʻemi koko') e like me warfarin (Coumadin, Jantoven); kekahi mau antifungals e like me itraconazole (Onmel, Sporanox) a me ketoconazole; nā benzodiazepines e like me alprazolam (Xanax), midazolam, a me triazolam (Halcion); kekahi mau lāʻau chemotherapy chemotherapy e like me ifosfamide (Ifex), vinblastine (Velban), a me vincristine (Marqibo); carbamazepine (Tegretol, Teril, a me nā mea ʻē aʻe); clarithromycin (Biaxin, i Prevpac); diltiazem (Cardizem, Cartia, Diltzac, nā mea ʻē aʻe); kekahi o nā mea kūpale protease HIV e like me nelfinavir (Viracept) a me ritonavir (Norvir, ma Kaletra, Technivie, Viekira Pak); nefazodone; nā steroid e like me dexamethasone a me methylprednisolone (Depo-medrol, Medrol, Solu-medrol); phenytoin (Dilantin, Phenytek); a me rifampin (Rifadin, Rimactane, ma Rifamate, Rifater). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Hiki paha i nā lāʻau lapaʻau ʻē aʻe ke launa pū me ka aprepitant a me ka fosaprepitant, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
  • e haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi ate.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā ʻoe e hoʻohana ana i nā mea pale hormonal (nā lāʻau kaohi hānau, nā pā, nā apo, nā implant, a i ʻole nā ​​injection) i ka wā o ka mālama ʻana me ka aprepitant a i ʻole ka fosaprepitant pono ʻoe e hoʻohana i kahi hana nonhormonal hou o ka kaohi hānau (spermicide, condom) e hōʻalo i ka hāpai ʻana i ka wā o ka mālama ʻana me ka aprepitant a i ʻole. fosaprepitant a no 1 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu. Inā hāpai ʻoe i ka hoʻohana ʻana i ka hoʻopiʻi aprepitant a i ʻole fosaprepitant, e kāhea i kāu kauka.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


ʻO ke kīpē Aprepitant a me ka hoʻopili ʻana o fosaprepitant i kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • nāwaliwali a nāwaliwali paha
  • pāhoehoe
  • ʻeha, ʻulaʻula, ʻili, paʻakikī, a huʻi paha ma ka pūnaewele injection
  • nāwaliwali, numbness, tingling, a i ʻole ʻeha ma nā lima a me nā wāwae
  • ʻeha poʻo
  • puʻuwai puʻuwai

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

  • ʻili a ʻōʻili paha o ka ʻili
  • urination pinepine a ʻeha paha, pono koke ka mimiki koke

Hiki i ka Aprepitant a me ka fosaprepitant ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka hoʻohana ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).


Mālama i nā manawa āpau me kāu kauka.

Mai ʻae i kekahi e hoʻohana i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • ʻO Cinvanti®
  • Emend®
Nānā Hou - 06/15/2019

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