Nusinersen Pākuʻi

Anter

• Ma mua o ka lawe ʻana i ka nusinersen injection,
• Hoʻokumu paha ka injection Nusinersen i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

Hoʻohana ʻia ka injection Nusinersen no ka mālama ʻana i ka atrophy muscular spinal (kahi ʻano hoʻoilina e hoʻemi ana i ka ikaika a me ka neʻe ʻana o nā mākala) i nā pēpē, nā keiki, a me nā mākua. ʻO Nusinersen injection kahi i loko o ka papa o nā lāʻau i kapa ʻia he antisense oligonucleotide inhibitors. Hana ia ma ka hoʻonui ʻana i ka nui o kahi protein i pono no nā mākala a me nā aʻalolo e hana maʻamau.

Hele mai ka injection Nusinersen ma ke ʻano he hopena (wai) e hoʻokomo i ka intrathecally (i kahi i piha i ka wai o ka canal spinal). Hāʻawi ʻia ʻo Nusinersen injection e ke kauka i kahi keʻena olakino a i ʻole kahi keʻena lapaʻau. Hāʻawi pinepine ʻia ia ma ke ʻano he 4 nā lālani mua (hoʻokahi manawa i kēlā me kēia 2 mau pule no nā mahele he 3 a ma hope he 30 mau lā ma hope o ke kolu o ka mahele lāʻau) a laila hāʻawi ʻia hoʻokahi manawa i kēlā me kēia 4 mahina ma hope.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka nusinersen injection,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka nusinersen, i nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka nusinersen injection. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā loaʻa ʻoe a i ʻole loaʻa i ka maʻi maʻi kidney.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka loaʻa ʻana o ka inikua nusinersen, kāhea i kāu kauka.
• inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha ke loaʻa nei ʻoe i ka nusinersen injection.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā haʻalele ʻoe i kahi manawa e loaʻa ai ka inikū nusinersen, kāhea koke aku i kāu kauka e hoʻoponopono hou i kāu wā i hoʻopaʻa ai. E haʻi paha kāu kauka iā ʻoe e hoʻomaka hou i kāu papa hana mua e loaʻa ai ka inikiona nusinersen, me ka liʻiliʻi he 14 mau lā ma waena o nā ʻaoʻao mua he 4 a me 4 mau mahina ma waena o nā mahele hope.

Hoʻokumu paha ka injection Nusinersen i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• kōpaʻa
• ʻenekini
• Kaumaha emi
• ʻeha poʻo
• ka luaʻi
• ʻeha kua
• hāʻule ʻana
• ihu ihu a ihu paha, ʻūlū, ʻāʻī ʻeha
• ʻeha pepeiao, kuni, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi pepeiao
• fiva

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

• kahe koko ʻole ʻana a palapū paha
• hoʻemi i ka urination; mimi, ʻākala, a i ʻole mimi kala ʻeleʻele; pehu i nā lima, ka maka, ka wāwae a me ka ʻōpū
• pinepine, wikiwiki, paʻakikī, a i ʻole ka mimi ʻeha
• ʻū, ka pōkole o ka hanu, ke kuni, ke anu

Hiki i ka inikina Nusinersen ke hoʻolohi i ka ulu ʻana o kahi pēpē. E nānā pono ke kauka o kāu keiki i kona ulu pono ʻana. E kamaʻilio me kāu kauka inā loaʻa kāu hopohopo e pili ana i ka ulu ʻana o kāu keiki ʻoiai ke loaʻa nei kēia lāʻau iā ia.

Hoʻokumu paha ka injection Nusinersen i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha aku kāu kauka i kekahi mau labs ma mua o ka hoʻomaka ʻana i ka lāʻau, ma mua o ka loaʻa ʻana o kēlā me kēia lāʻau, a e like me ka mea e pono ai i ka wā o ka mālama ʻana e nānā i ka pane o kou kino i ka nusinersen injection.

E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka nusinersen injection.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Spinraza^®