Macitentan

Anter

• Ma mua o ka lawe ʻana i macitentan,
• Hoʻokumu paha ʻo Macitentan i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e hōʻoki i ka lawe ʻana i ka macitentan a kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.
• Pākuʻi ʻia paha nā ʻōuli o ka overdose:

No nā maʻi wahine:

Mai lawe i ka macitentan inā hāpai ʻoe a hoʻolālā paha e hāpai. Aia kahi makaʻu nui i ka macitentan e hōʻeha i ka fetus.

Ma muli o ka makaʻu o ka ʻeha fetal, ua hoʻonohonoho ʻia kahi papahana i kapa ʻia ʻo OPSUMIT Risk Evaluation and Mitigation Strategy (OPSUMIT REMS) e hōʻoia i ka lawe ʻole ʻana o ka wahine hāpai i macitentan, a ʻaʻole hāpai ka wahine i ka wā e lawe ana i ka macitentan. ʻO nā wahine āpau, me nā wahine ʻaʻole hiki ke hāpai, hiki ke loaʻa iā lākou ka macitentan inā lākou i hoʻopaʻa inoa ʻia me OPSUMIT REMS, he palapala mai ke kauka i hoʻopaʻa inoa ʻia me OPSUMIT REMS, a hoʻopiha i ke kauka i kahi hale kūʻai lāʻau i hoʻopaʻa inoa ʻia me OPSUMIT. ʻO REMS.

E hoʻopaʻa inoa kāu kauka iā ʻoe ma OPSUMIT REMS. E haʻi aku kāu kauka iā ʻoe e pili ana i nā makaʻi o macitentan, ʻoi aku hoʻi i nā pilikia o nā hānau hānau koʻikoʻi inā lawe ʻia i ka wā hāpai. Pono ʻoe e kau inoa i kahi pepa ʻae ʻae e hōʻike ana ua ʻike ʻoe i kēia ʻike i mea e kau inoa ai kāu kauka.

E hoʻoholo pū kāu kauka inā hiki iā ʻoe ke hāpai. Inā ua hōʻea ʻoe i ka wā ʻōpio (ke ulu a kino ke kino o ke keiki a hiki ke loaʻa kahi keiki), he pūpū, a ʻaʻole i hele i loko o ka menopause ('hoʻololi i ke ola' hopena o kēlā me kēia manawa menstrual) manaʻo ʻia ʻoe he wahine ʻo wai ka mea hiki ke hāpai, a pono ʻoe e hāhai i kekahi mau rula hou i loaʻa ai ka macitentan.

No nā wahine i hiki ke hāpai:

Pono ʻoe e hoʻohana i ka kaohi hānau pono i loko o kāu mālama ʻana me macitentan, a no 1 mau mahina ma hope o kāu hopena hope loa. E haʻi aku kāu kauka iā ʻoe i ke ʻano o ka kaohi hānau e ʻae ʻia, a e hāʻawi i kāu ʻike i kākau ʻia e pili ana i ka kaohi hānau. I ka hapanui o nā hihia e koi ʻia ʻoe e hoʻohana i ʻelua mau ʻano o ka kaohi hānau i mea e pale ai i ka hāpai ʻana ʻoiai e lawe ana i ka macitentan.

Pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o ka hoʻomaka ʻana o ka mālama ʻana, i kēlā me kēia mahina i ka wā o ka mālama ʻana, a me 1 mau mahina ma hope o kāu hopena hope loa i hiki ai ke loaʻa ka macitentan. Kauoha kāu kauka i nā hoʻokolohua hāpai ou. ʻAʻole e hāʻawi ka lāʻau kūʻai i ka macitentan iā ʻoe a hiki i ka wā i hōʻoia ai lākou ua lawe ʻoe i kāu mau hōʻike hāpai keiki koi.

ʻAʻole pono ʻoe i ka moekolohe ʻole ʻia ke lawe nei i ka macitentan.

Kāhea koke i kāu kauka inā loaʻa iā ʻoe ka moekolohe ʻole ʻia, manaʻo ʻole ua maikaʻi ʻole kāu kaohi hānau ʻana, ua hala kou wā, a manaʻo paha ʻoe ua hāpai no kekahi kumu. E kūkākūkā ʻo ia i kāu koho lapaʻau me ʻoe. Mai kali a hiki i kāu koho hou ʻana e kūkākūkā i kēia me kāu kauka.

E haʻi i kāu kauka inā ʻaʻole ʻoe e maopopo i nā mea āpau āu i haʻi ʻia ai e pili ana i ka kaohi hānau, a i ʻole inā ʻaʻole ʻoe e manaʻo hiki iā ʻoe ke hoʻohana i nā ʻano ʻoluʻolu o ka kaohi hānau i nā manawa āpau i kāu mālama ʻana.

Inā he makua a kahu paha ʻoe no ka wahine ʻaʻole i oʻo i ka wā ʻōpio, e nānā pinepine i kāu keiki e ʻike inā ke ulu nei ʻo ia i nā ʻōuli o ka ʻōpio (ʻōpuʻu umauma, lauoho pubic) a hōʻike i kāna kauka e pili ana i nā loli.

No nā mea maʻi āpau:

ʻAʻole loaʻa ʻo Macitentan ma nā hale kūʻai lāʻau kūʻai. E leka uila ʻia kāu lāʻau mai iā ʻoe mai kahi hale kūʻai lāʻau lapaʻau kūikawā i hoʻopaʻa inoa ʻia me OPSUMIT REMS. Inā he wahine ʻoe ʻaʻole i oʻo i ka wā ʻōpio a i ʻole wahine wahine hiki ke hāpai keiki e loaʻa wale iā ʻoe kahi lako o 30 lā i kēlā me kēia manawa. E nīnau i kāu kauka inā he nīnau kāu e pili ana pehea e loaʻa ai kāu lāʻau.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka pepa ʻikepili a ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me macitentan a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Hoʻohana ʻia ʻo Macitentan e hoʻokele i nā ʻōuli o ka pulmonary arterial hypertension (PAH; ke koko kiʻekiʻe i loko o nā kīʻaha e lawe i ke koko i nā akemāmā). Aia ʻo Macitentan i kahi papa o nā lāʻau i kapa ʻia he endagonhel receptor antagonists. Hana ia ma ka hoʻōki ʻana i ka hana o endothelin, kahi mea kūlohelohe e hoʻoliʻiliʻi ai nā kīʻaha koko a pale i ke kahe o ke koko maʻamau i ka poʻe i loaʻa iā PAH.

Hele mai ʻo Macitentan ma ke ʻano he papa e lawe ma ka waha. Lawe pinepine ʻia me ka ʻai ʻole a ʻai ʻole hoʻokahi manawa i ka lā. Lawe i ka macitentan ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka macitentan e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i macitentan,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka macitentan, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o ka papa macitentan. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, a me nā mea hoʻopihaʻaiʻai āu e lawe nei a hoʻolālā paha e lawe. E ʻōlelo pono i kekahi o kēia mau mea: carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), clarithromycin (Biaxin, i Prevpac); efavirenz (Sustiva); kekahi o nā mea kūpale protease HIV e like me nelfinavir (Viracept), indinavir (Crixivan), a me ritonavir (Norvir, ma Kaletra); itraconazole (Onmel, Sporanox); ketoconazole; nefazodone; nevirapine Viramune); phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); a me rifampin (Rifadin, Rifamate, Rifater, Rimactane). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me ka macitentan, no laila e ʻike pono e haʻi aku i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe ka anemia (ke ʻano i lawe ʻole nā ​​hunaola ʻulaʻula i lawa ka oxygen i nā ʻokena) a i ʻole nā ​​maʻi ate.
• mai hānai waiu i ka wā e lawe ana i kēia lāʻau.
• pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i ka macitentan.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Macitentan i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ihu ihu
• eha ka 'ā'ī
• ʻūhā
• flu e like me nā hōʻailona
• ʻeha poʻo
• urination, pinepine, a i ʻole urination ʻeha
• hūwī

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e hōʻoki i ka lawe ʻana i ka macitentan a kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• ʻili ʻili
• mimi ʻeleʻele
• melemele o kou ʻili a mau maka paha
• ʻeha ma ka ʻaoʻao ʻākau o luna o kou ʻōpū
• nausea i hōʻike ʻole ʻia a i ʻole ka luaʻi
• nalo ʻai ʻole
• luhi loa
• fiva
• pehu o ka maka, puʻu, alelo, lehelehe, a me nā maka
• pilikia i ka ale ʻana a me ka hanu ʻana
• hulahula
• pōkole o ka hanu, keu hoʻi i ka wā e moe ana i lalo
• ke kuʻi nei i ka poni, ka huʻi a me ke koko
• hoʻonui māhuahua ke kaumaha
• pehu o nā kuʻekuʻe wāwae a i ʻole nā ​​wāwae

Hoʻokumu paha ʻo Macitentan i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Pākuʻi ʻia paha nā ʻōuli o ka overdose:

• ʻeha poʻo
• nausea
• ka luaʻi

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i nā hoʻokolohua e ʻike ai i ka maikaʻi o ka hana o kou ake, a e nānā no ka anemia ma mua o ka hoʻomaka ʻana o ka lāʻau ʻana a mai kēlā me kēia manawa i kāu mālama ʻana me ka macitentan.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Opsumit^®