Ibrutinib

Anter

• Hoʻohana ʻia ʻo Ibrutinib:
• Ma mua o ka lawe ʻana i ibrutinib,
• Hiki iā Ibrutinib ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Ibrutinib:

• e mālama i ka poʻe me ka limle cell lymphoma (MCL; kahi maʻi ʻaʻai e ulu wikiwiki ana e hoʻomaka i nā hunaola o ka ʻōnaehana pale) i mālama ʻia me hoʻokahi lāʻau chemotherapy ʻē aʻe.
• e mālama i ka poʻe me ka leukemia lymphocytic mau (CLL; kahi ʻano o ka maʻi ʻaʻai e hoʻomaka i nā kahe koko keʻokeʻo) a me ka lymphocytic lymphoma liʻiliʻi (SLL; kahi ʻano maʻi ʻaʻai e hoʻomaka ka hapanui ma nā lymph node),
• e mālama i ka poʻe me ka macroglobulinemia (Waldenstrom's macroglobulinemia) (WM; kahi maʻi maʻi lohi e hoʻomaka ana i loko o kekahi mau kikoʻī koko keʻokeʻo i loko o kou iwi iwi),
• e mālama i ka poʻe me ka lymphoma palena liʻiliʻi (MZL; kahi maʻi kanesa ulu lohi e hoʻomaka i kahi ʻano o nā hunaola keokeo e hakakā maʻamau i ka maʻi) i mālama ʻia me kekahi ʻano chemotherapy chemotherapy,
• a me ka mālama ʻana i ka poʻe me ka maʻi mau a me nā maʻi hoʻokipa (cGVHD; kahi pilikia o ka hematopoietic stem-cell transplant [HSCT; kahi hana e hoʻololi ai i ka iwi iwi me nā iwi iwi maikaʻi] i hoʻomaka paha i kahi manawa ma hope o ke kanu ʻana a mau no ka manawa lōʻihi. ) ma hope o ka mālama kūleʻa ʻole ʻia me 1 a ʻoi aku paha nā lāʻau.

Aia ʻo Ibrutinib i kahi papa o nā lāʻau i kapa ʻia nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o ka protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hōʻoki ʻana i nā hunaola maʻi ʻaʻai.

Hele mai ʻo Ibrutinib ma ke ʻano he capsule a me kahi papa e lawe ma ka waha. Lawe ʻia ia i hoʻokahi manawa i kēlā me kēia lā. Lawe iā ibrutinib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono iā ibrutinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i ka capsule piha me kahi kīʻaha wai; mai wehe, haki, a nau ʻole iā lākou. E ale i ka papa piha me kahi kīʻaha wai; mai ʻoki, ʻokiʻoki a nau hoʻi iā lākou.

Inā ʻoe e loaʻa ana i ka inikua obinutuzumab (Gazyva) a i ʻole ka inikua rituximab (Rituxan), e haʻi paha kāu kauka iā ʻoe e lawe i kāu lāʻau o imbrutinib ma mua o ka loaʻa ʻana o kāu kuni.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau, a hoʻopau a hoʻopau paha i kāu treament. Aia kēia i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a me nā hopena ʻē aʻe āu e ʻike ai. E kamaʻilio me kāu kauka e pili ana i kou ʻano i kāu mālama ʻana. E hoʻomau i ka lawe i ibrutinib ʻoiai ʻoe e manaʻo maikaʻi. Mai hōʻoki i ka lawe ʻana i ka ibrutinib me ke kamaʻilio ʻole ʻana me kāu kauka.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ibrutinib,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka ibrutinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā capsule ibrutinib a i ʻole nā ​​papa E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E hōʻoia e haʻi i kekahi o kēia mau mea: anticoagulants ('nā mea hōʻemi koko') e like me warfarin (Coumadin, Jantoven); nā antifungals e like me fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), a me voriconazole (Vfend); nā lāʻau antiplatelet e like me clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta), a me ticlopidine; aprepitant (Emend); carbamazepine (Carbatrol, Epitol, Tegretol, Teril); clarithromycin (Biaxin, Prevpac), digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, nā mea ʻē aʻe); erythromycin (EES, Erythrocin, a me nā mea ʻē aʻe), kekahi mau lāʻau e mālama ai i ka maʻi pale maʻi kanaka (HIV) a i ʻole loaʻa i ka maʻi maʻi (AIDS) e like me efavirenz (Sustiva, i Atripla), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, i Kaletra), a me saquinavir (Invirase); methotrexate (Otrexup, Rasuvo, Trexall, Xatmep); nefazodone; phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rifamate, Rimactane, nā mea ʻē aʻe); verapamil (Calan, Covera, i Tarka, nā mea ʻē aʻe); a me telithromycin (ʻaʻole loaʻa hou ma ka US; Ketek). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo keu ʻo St. John's Wort.
• e haʻi i kāu kauka inā loaʻa ʻoe i kahi maʻi a i ʻole ʻokiʻoki hou ʻia. E haʻi pū aku i kāu kauka inā puhipaka ʻoe a inā i loaʻa a loaʻa paha iā ʻoe ka maʻi diabetes, kahi puʻuwai kūpono ʻole, hypertension (ke koko kiʻekiʻe), kiʻekiʻe o ke kōkō, nā pilikia kahe ʻana o ke kahe, a i ʻole ka puʻuwai, nā puʻupaʻa, a me nā maʻi ate.
• e haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, e hānai umauma ana, a inā ʻoe e hoʻolālā i ka hānau keiki ʻana. ʻAʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i ka ibrutinib. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau lapaʻau a pono e hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i ka wā o kāu mālama ʻana me ibrutinib a no 1 mahina ma hope o kou hoʻōki ʻana i ka lawe ʻana i ka lāʻau. Inā he kāne ʻoe, pono ʻoe a me kāu hoa wahine e hoʻohana i ka kaohi hānau i ka wā o kāu mālama ʻana me ibrutinib a hoʻomau no 1 mahina ma hope o kāu hopena hope loa. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana iā ibrutinib, e kāhea koke i kāu kauka. Hiki iā Ibrutinib ke hōʻeha i ka fetal.
• inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha ʻoe e lawe nei iā ibrutinib. E haʻi paha kāu kauka iā ʻoe e haʻalele i ka lawe ʻana iā ibrutinib 3 a 7 mau lā ma mua o ke kaha ʻana a i ʻole ke kaʻina hana.

Mai ʻai i ka huaʻikuʻi a i nā ʻalani ʻo Seville (hoʻohana ʻia i kekahi manawa i nā marmalades), a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

E hōʻoia e inu nui i ka wai a i ʻole nā ​​wai ʻē aʻe i kēlā me kēia lā ʻoiai ʻoe e lawe nei i ka ibrutinib.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai i kēlā lā. Eia nō naʻe, inā ʻaʻole ʻoe e hoʻomanaʻo a hiki i ka lā aʻe, kāpae i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki iā Ibrutinib ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• pāhoehoe
• nausea
• kōpaʻa
• ka luaʻi
• ʻeha ka ʻōpū
• puʻuwai puʻuwai a i ʻole indigestion
• hoʻēmi ʻai
• ka luhi nui a i ʻole ka nāwaliwali
• ʻeha, iwi, a ʻeha pū
• ʻūpē mākala
• ka pehu o nā lima, ka wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
• hūwī
• ʻūlili
• ʻeha ma ka waha a me ka puʻu
• hopohopo
• paʻakikī e hiamoe a hiamoe paha
• ihu, ihu a ihu i hoʻopiha ʻia
• ʻike hihi
• mau maka maloʻo a wai paha
• maka ʻākala

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• pehu o ka maka, puʻu, alelo, lehelehe, a me nā maka
• pilikia i ka ale ʻana a me ka hanu ʻana
• hives
• ʻāpā ʻaʻano ʻole a hoʻokahe koko paha
• mimi, ʻulaʻula, a i ʻole mimi eleele ʻeleʻele
• koko a ʻeleʻele paha, noho aliʻi
• kahe ʻana ka ihu
• luaʻi koko; a i ʻole ka luaʻi ʻana i ke koko a i ʻole nā ​​mea ʻeleʻele e like me ke kahua kope
• ka hopu ʻana
• wikiwiki a i ʻole kuʻi puʻuwai puʻuwai
• pokole o ka hanu
• hōʻoluʻolu umauma
• ʻino, puʻupuʻu a me nāwaliwali paha
• loli ka hihiʻo
• ʻeha poʻo (lōʻihi loa kēlā)
• ke kuni, ke anu, ka ʻū, ka ʻula, ka ʻili mehana, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• huikau
• nā hoʻololi i kāu haʻiʻōlelo
• hoʻemi urination
• ʻeha, pinepine, a i ʻole urination urinary

Hiki paha iā Ibrutinib ke hoʻonui i kou makaʻu i ka hoʻomohala ʻana i kekahi ʻano maʻi ʻaʻai me ka maʻi ʻaʻai o ka ʻili a i ʻole nā ​​mea ʻē aʻe. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i ibrutinib.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a mamao aku mai ka mālamalama, ka wela a me ka makū ʻole ma ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua lab a nānā i kou kaomi koko e nānā i ka pane o kou kino iā ibrutinib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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