Bedaquiline

Anter

• Ma mua o ka lawe ʻana i bedaquiline,
• Hoʻokumu paha ʻo Bedaquiline i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

E hoʻohana wale ʻia ʻo Bedaquiline e mālama ai i ka poʻe i loaʻa i ka tuberculosis kūpikipiki (MDR-TB) mālama i ke ʻano) ke hiki ʻole ke hoʻohana ʻia i nā ʻano lāʻau ʻē aʻe. I kahi noiʻi hoʻokolohua, ua nui nā make i waena o ka poʻe i lawe i ka bedaquiline ma mua o ka poʻe i lawe ʻole i ka lāʻau. Eia nō naʻe, he maʻi hoʻoweliweli ke ola ʻo MDR-TB, no laila hiki iā ʻoe a me kāu kauka ke hoʻoholo e mālama ʻia ʻoe me ka bedaquiline inā ʻaʻole hiki ke hoʻohana ʻia i kekahi mau lāʻau ʻē aʻe.

Hoʻokumu paha ʻo Bedaquiline i nā loli koʻikoʻi a hoʻoweliweli paha i kou puʻuwai puʻuwai. Pono ʻoe e loaʻa i kahi electrocardiogram (ECG; kahi hoʻāʻo e ana i ka hana uila o ka puʻuwai) ma mua o kāu lapaʻau a me nā manawa he nui i kou wā e mālama ai e ʻike pehea ka hopena o kēia lāʻau i ka puʻuwai o kou puʻuwai. E haʻi i kāu kauka inā ʻo ʻoe a ʻo kekahi paha o kou ʻohana ua hoʻolōʻihi i ka QT Syndrome (kahi pilikia puʻuwai laha ʻole e hiki ai ke hōʻeha i ka puʻuwai ʻole, maʻule paha, a make koke paha) a inā loaʻa iā ʻoe a i ʻole loaʻa paha iā ʻoe kahi puʻuwai lohi a i ʻole maʻamau, kahi pākeke thyroid paʻa ʻole, nā pae haʻahaʻa o ka kalipuna, magnesium, a i ʻole potassium i loko o kou koko, maikaʻi ʻole o ka puʻuwai, a i ʻole ka hōʻeha puʻuwai hou. E haʻi i kāu kauka a me kāu kauka lāʻau inā ʻoe e lawe i kekahi o nā lāʻau aʻe: azithromycin (Zithromax), ciprofloxacin (Cipro), clarithromycin (Biaxin), clofazimine (Lamprene), erythromycin (EES, E-Mycin, Erythrocin), gemifloxacin (Factive) , levofloxacin (Levaquin), moxifloxacin (Avelox), a me telithromycin (Ketek). Inā hoʻomohala ʻoe i kahi puʻuwai wikiwiki a i ʻole kaulike a inā e maule ʻoe, e kelepona koke i kāu kauka.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Ke alakaʻi lāʻau) ke hoʻomaka ʻoe i ka lāʻau me ka bedaquiline a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

E kamaʻilio me kāu kauka e pili ana i nā makaʻu o ka lawe ʻana i ka bedaquiline.

Hoʻohana ʻia ʻo Bedaquiline a me ʻekolu mau lāʻau ʻē aʻe e mālama ai i ka tuberculosis lāʻau kūpona (MDR-TB; kahi maʻi nui e pili ana i nā akemāmā a me nā ʻāpana ʻē aʻe o ke kino a ʻaʻole hiki ke mālama ʻia me nā lāʻau ʻē aʻe e maʻa mau ʻia e mālama i ka ke kūlana) i nā mākua a me nā keiki he 5 mau makahiki a ʻoi paha e kaupaona ana ma kahi o 33 lbs (15 kg) i hoʻopili i nā akemāmā. ʻAʻole pono e hoʻohana ʻia ʻo Bedaquiline e mālama ai i ka TB e hoʻopili nui i nā ʻāpana ʻē aʻe o ke kino. Aia ʻo Bedaquiline i ka papa o nā lāʻau i kapa ʻia anti-mycobacterial. Hana ia ma ka luku ʻana i nā koʻohune i kumu i ka MDR-TB.

Hele mai ʻo Bedaquiline ma ke ʻano he papa e lawe ma ka waha me ka wai. Lawe pinepine ʻia me ka meaʻai i hoʻokahi manawa i ka lā no 2 mau pule a laila ʻekolu manawa i ka pule no 22 mau pule. Ke lawe nei ʻoe i ka bedaquiline ʻekolu manawa i ka pule, e ʻae ma ka liʻiliʻi he 48 mau hola ma waena o nā kau. E lawe i ka bedaquiline i ka manawa like o ka lā a ma nā lā like o ka pule i kēlā me kēia pule. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka bedaquiline e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Inā ʻaʻole hiki iā ʻoe a kāu keiki paha ke ale i ka papakaukau he 20 mg, haki paha ʻoe iā lākou i ka hapalua ma ka māka māka.

Inā ʻaʻole hiki iā ʻoe a me kāu keiki ke ale i nā papa 20 mg āpau a i ʻole hapalua, hiki ke hoʻoheheʻe ʻia nā papa i 1 teaspoon (5 ml) o ka wai i loko o ke kīʻaha inu (ʻaʻole i ʻoi aku ma mua o 5 mau papa) Hiki iā ʻoe ke inu koke i kēia hui a i ʻole e maʻalahi ai ia, e hoʻohui ma ka liʻiliʻi he 1 teaspoon (5 ml) o ka wai hou, ka waiū huahana, wai ʻāpala, wai ʻalani, wai wai cranberry, a i ʻole mea inu carbonated, a i ʻole ʻē aʻe, hiki i kahi meaʻai palupalu hoʻohui ʻia A laila, ale koke i ka hui holoʻokoʻa. Ma hope o ka lawe ʻana i ka lāʻau, holoi i ke kīʻaha me kahi liʻiliʻi o ka wai hou a i ʻole nā ​​meaʻai palupalu a lawe koke ia e ʻike pono i ka loaʻa ʻana o ka mahele lāʻau āpau. Inā makemake ʻoe ma mua o ʻelima mau 20 mg-papa o bedaquiline, e hana hou i nā ʻanuʻu ma luna a hiki i kou hiki ʻana i kāu lāʻau i kauoha ʻia.

ʻOkoʻa, i mea e maʻalahi ai ke ale, hiki iā ʻoe ke ʻūlū i nā papa 20 mg a hoʻohui i kahi meaʻai palupalu e like me ka yogurt, applesauce, banana banana, a i ʻole ka oatmeal a ale koke i ka hui holoʻokoʻa. Ma hope o ka lawe ʻana i ka lāʻau, e hoʻohui i kahi meaʻai liʻuliʻu hou a lawe koke ia e ʻike pono i ka loaʻa ʻana o ka lāʻau.

Inā loaʻa iā ʻoe kahi paipu nasogastric (NG), e wehewehe kāu kauka a kauka paha pehea e hoʻomākaukau ai i ka bedaquiline e hāʻawi ai ma o kahi Tube NG.

E hoʻomau i ka lawe i ka bedaquiline a hiki i kou hoʻopau ʻana i ke kuhikuhi a mai haʻalele i nā lāʻau, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi. Inā kū ʻoe i ka lawe ʻana i ka bedaquiline koke a lele i nā lāʻau, ʻaʻole hiki ke mālama pono ʻia i kāu maʻi a hiki i ke kūpikipiki ke kūʻē i nā antibiotic. E paʻakikī kēia i kāu maʻi e mālama i ka wā e hiki mai ana. I mea e maʻalahi ai iā ʻoe e lawe i kāu lāʻau āpau e like me ke kuhikuhi, hiki iā ʻoe ke komo i kahi papahana hoʻomaʻamaʻa nānā pono ʻia. I kēia papahana, hāʻawi kahi limahana olakino iā ʻoe i kēlā me kēia lāʻau o ka lāʻau lapaʻau a e nānā ʻo ia iā ʻoe e ale i ka lāʻau.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i bedaquiline,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka bedaquiline, i nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka papa bedaquiline. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, a me nā mea hoʻopihaʻaiʻai āu e lawe nei a hoʻolālā paha e lawe. E ʻōlelo pono i nā lāʻau i helu ʻia i ka ʻARlelo Aʻo IMPORTANT a me kekahi o kēia mau mea: carbamazepine (Equetro, Tegretol, Teril, a me nā mea ʻē aʻe); kekahi mau lāʻau no ka maʻi maʻi HIV (HIV) e like me efavirenz (Sustiva, i Atripla), indinavir (Crixivan), lopinavir (ma Kaletra), nelfinavir (Viracept), ritonavir (Norvir, ma Kaletra, ma Viekira Pak); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); nefazodone; phenobarbital; phenytoin (Dilantin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ma Rifamate, ma Rifater); a me rifapentine (Priftin). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū me ka bedaquiline, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa iā ʻoe ka maʻi HIV, a i ʻole ate a i ʻole nā ​​maʻi puʻupaʻa.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka wā e lawe ana i ka bedaquiline, e kāhea i kāu kauka. Inā hānai ʻoe i ka waiū, e haʻi i kāu kauka inā he maka melemele a ʻili paha kāu pēpē a i ʻole hoʻololi i ke kala o kā lākou mimi a i ʻole ka noho.
• e hōʻalo i ka inu ʻana i nā mea inu ʻona ʻoiai ʻoe e lawe nei i ka bedaquiline. Hoʻonui ka inu ʻana i ka waiʻona i ka makaʻala e ʻike ʻoe i nā hopena koʻikoʻi mai ka bedaquiline.

E kamaʻilio me kāu kauka e pili ana i ka ʻai ʻana i ka huaʻulu a me ka inu ʻana i ka wai momona a ke lawe nei ʻoe i kēia lāʻau.

Inā ʻoe e nalo i kahi mahele lāʻau i loko o nā pule 2 mua o kāu mālama ʻana, e lele i ka lāʻau i hala ʻole a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Inā ʻoe e nalo i kahi mahele lāʻau mai ka hebedoma 3 i loko o nā pule i koe o kāu mālama ʻana, e lawe i ka lāʻau i hala me ka meaʻai ke hoʻomanaʻo ʻoe iā ia a hoʻomau i kāu manawa 3 i hoʻokahi pule pule. E ʻike pono aia ma ka liʻiliʻi he 24 mau hola ma waena o ka lawe ʻana i ka mahele hala a me ka hopena o ka lā aʻe. Mai lawe i kahi lāʻau pālua e pani no kahi mea i nalo ʻia a i ʻole lawe i nā mea i ʻoi aku ma mua o kāu kaukana hebedoma i kahi manawa 7-lā.

Hoʻokumu paha ʻo Bedaquiline i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻeha pū
• ʻeha poʻo
• hūwī

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• luhi nui loa
• nalo ʻai ʻole
• nausea
• melemele o ka ʻili a me nā maka
• mimi kala ʻeleʻele
• nā ʻōniʻoniʻo o ke ʻōpū māmā
• ʻeha ma ka ʻaoʻao ʻākau i luna o ka ʻōpū
• fiva
• kahe ana ke koko
• ʻeha ka umauma

Hoʻokumu paha ʻo Bedaquiline i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a mamao aku mai ka mālamalama, ka wela a me ka momona o ka wela (ʻaʻole i loko o ka lua. E mālama i ka pack desiccant (maloʻo maloʻo) i loko o ka hue o ka lāʻau e hoʻomau i nā papa maloʻo.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino i ka bedaquiline.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Sirturo^®