Regorafenib

Anter

• Ma mua o ka lawe ʻana i regorafenib,
• Hoʻokumu paha ʻo Regorafenib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.
• Pākuʻi ʻia paha nā ʻōuli o ka overdose:

Hoʻokumu paha ʻo Regorafenib i ka hōʻino o ke ake, he ʻeha a weliweli paha ke ola. E haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi ate. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: melemele o ka ʻili a me nā maka, nausea, luaʻi, mimi ʻeleʻele, ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū, luhi nui, kahe nui ʻana o ke kahe a ʻeha hoʻi, ka nele o ka ikaika. , nalo o ka makemake ʻole, nā ʻōuli e like me ka flu, a i ʻole ka hoʻololi ʻana i nā ʻano hiamoe.

E mālama i nā wā a pau me ka keʻena hoʻokolohua. E kauoha aku kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kou wā o ka mālama ʻana e hōʻoia he palekana ia no ʻoe e lawe i ka regorafenib a e nānā i ka pane o kou kino i ka lāʻau.

Hoʻohana ʻia ʻo Regorafenib e mālama i ke kolone a me ka maʻi ʻaʻai ʻopa (kanesa e hoʻomaka i ka ʻōpū nui a i ʻole ke kiko) i pālahalaha ʻia i nā ʻāpana ʻē aʻe o ke kino i ka poʻe i mālama ʻole ʻia me nā lāʻau ʻē aʻe. Hoʻohana ʻia ia e mālama i nā ʻōpū stromal gastrointestinal (GIST; kahi ʻano tumo e ulu ana i loko o ka ʻōpū, ʻōpū [ʻōpū], a i ʻole esophagus [paipu e hoʻopili ana i ka puʻu me ka ʻōpū]) i ka poʻe i mālama maikaʻi ʻole ʻia me kekahi mau nā lāʻau. Hoʻohana pū ʻia ʻo Regorafenib e mālama i ka carcinoma hepatocellular (HCC; kahi ʻano maʻi ʻaʻai ate) i ka poʻe i mālama mua ʻia me sorafenib (Nexafar). Aia ʻo Regorafenib i kahi papa o nā lāʻau i kapa ʻia nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kahi protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hoʻolohi a hoʻopau paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Regorafenib ma ke ʻano he papa e lawe ma ka waha. Lawe ʻia ia me kahi papaʻaina momona momona (loaʻa ma lalo o 600 mau calorie a ʻoi aku ma mua o 30% o nā calorie mai ka momona) hoʻokahi manawa i ka lā no 3 mau pule a laila haʻalele wau no 1 pule Kapa ʻia kēia wā lapaʻau he pōʻaiapuni, a hiki ke hana hou ʻia ke kekona no ka mea ke koi aku kāu kauka. Lawe i ka regorafenib i ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pololei i ka regorafenib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau o regorafenib a i ʻole e haʻi iā ʻoe e haʻalele i ka lawe ʻana i ka regorafenib no kekahi manawa i ka wā o kāu mālama ʻana. E pili kēia i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a me nā hopena ʻē aʻe āu e ʻike ai. E hoʻomau i ka lawe regorafenib ʻoiai inā maikaʻi ʻoe. Mai hōʻoki i ka lawe regorafenib me ke kamaʻilio ʻole ʻana me kāu kauka.

ʻAʻole loaʻa ʻo Regorafenib ma nā hale kūʻai lāʻau kūʻai. E hoʻouna leka ʻia kāu lāʻau iā ʻoe a i kāu kauka paha mai kahi kauka lāʻau lapaʻau kūikawā. E nīnau i kāu kauka inā he nīnau kāu e pili ana pehea e loaʻa ai kāu lāʻau.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i regorafenib,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i regorafenib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa regorafenib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā huaora, a me nā mea hoʻopihaʻai pono ʻole e lawe ai. E hōʻoia e haʻi i kekahi o kēia mau mea: anticoagulants ('' nā mea hōʻemi koko '') e like me warfarin (Coumadin, Jantoven); kekahi mau lāʻau lapaʻau antifungal e like me itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), a me voriconazole (Vfend); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital, a me phenytoin (Dilantin, Phenytek); atorvastatin (Lipitor, ma Caduet); clarithromycin (Biaxin, i Prevpac); fluvastatin (Lescol); irinotecan (Camptosar); methotrexate (Otrexup, Rasuvo, Trexall); rifampin (Rifadin, Rifamate, ma Rifater); aiʻole telithromycin (Ketek). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St. ʻAʻole pono ʻoe e lawe iā St. John's wort ʻoiai e lawe ana i ka regorafenib.
• e haʻi i kāu kauka inā he ʻeha kou i hōʻola ʻole a i ʻole loaʻa paha iā ʻoe nā pilikia kahe o ke kahe, ke koko kiʻekiʻe, ka ʻeha o ka umauma, a me ka puʻuwai, ka puʻuwai a me ka maʻi ate. E haʻi pū i kāu kauka inā ʻokiʻoki ʻoe.
• e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. Inā he wahine ʻoe, ʻaʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i ka regorafenib a no 2 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā wahine e hoʻohana i ka kaohi hānau i ka wā o kāu mālama ʻana a hoʻomau i ka hoʻohana ʻana i ka kaohi hānau no 2 mau mahina ma hope o kāu hopena hope loa. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana i ka regorafenib, e kāhea i kāu kauka. Hoʻopilikia paha ʻo Regorafenib i ka fetus.
• e haʻi i kāu kauka inā ʻoe e hānai umauma ana. ʻAʻole pono ʻoe e hānai i ka wā o kāu mālama ʻana me regorafenib a no 2 mau pule ma hope o kāu hopena hope loa.
• inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe ana ʻoe i ka regorafenib. E haʻi paha kāu kauka iā ʻoe e haʻalele i ka lawe ʻana i ka regorafenib ma kahi o 2 mau pule ma mua o kou ʻoki ʻana. E haʻi aku kāu kauka iā ʻoe inā palekana ʻoe e hoʻomaka hou i ka lawe ʻana i ka regorafenib ma hope o kāu ʻoki ʻana.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā ʻoe e nalo i kahi mahele o regorafenib, e lawe i ka lāʻau i hala i kou hoʻomanaʻo ʻana ia lā. Mai lawe i ʻelua mau lāʻau i ka lā like e pani no kahi mea i hala.

Hoʻokumu paha ʻo Regorafenib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• luhi
• nāwaliwali
• nalo ʻai ʻole
• pāhoehoe
• ka pehu, ka ʻeha, a me ka ʻulaʻula o ka uhi o kou waha a me kou puʻu
• Kaumaha emi
• keu a i ʻole ka hoʻololi ʻana i ke kani o kou leo

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• ʻeha ka umauma
• pokole o ka hanu
• hemo ʻole a he ukiuki paha
• ʻāʻī a ʻeha paha i ka wā e urination
• ʻūpī a palupalu paha
• fiva, uha, ʻāʻī ʻeha, haʻalulu, a me nā ʻōuli ʻē aʻe o ka maʻi
• pehu o ka ʻōpū
• wela wela
• haʻalulu
• ʻōpū nui loa
• ʻeha poʻo poʻo
• ka hopu ʻana
• huikau
• nā hoʻololi i ka hihiʻo
• waha maloʻo, hoʻohaʻahaʻa nāʻiʻo, a i ʻole hoʻemi ʻia ka urination
• ʻulaʻula, ʻeha, ʻūlū, kahe ʻana ke kahe, a i ʻole ka pehu ʻana ma nā poho o kou mau lima a i ʻole nā ​​kapuaʻi o kou mau wāwae
• hūwī
• luaʻi i ke koko a i ʻole ka luaʻi o nā mea e like me ke kahua kope
• mimi ʻākala a ʻeleʻele paha
• noho ʻulaʻula a ʻeleʻele (tarry)
• ke kuʻi nei i ke koko a i ʻole ke koko
• normalewa kaumaha menstrual kahe ana (kau)
• hoʻokahe keu
• ihu ihu pinepine

Hoʻokumu paha ʻo Regorafenib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. Mai hoʻokomo i nā papa i loko o nā ipu ʻē aʻe, e like me nā pahu pila o kēlā me kēia pule, a mai hemo i ka desiccant (mea hoʻomaloʻo) mai ka ipu. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua. E hoʻolei i nā papa i hoʻohana ʻole ʻia 7 mau pule ma hope o ka wehe mua ʻia ʻana o ka ʻōmole.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Pākuʻi ʻia paha nā ʻōuli o ka overdose:

• loli ka ʻili a i ʻole nā ​​ʻili ʻē aʻe
• hoʻololi a leo paha ka leo
• pāhoehoe
• pehu i loko o ka ihu a waha paha
• waha maloo
• hoʻēmi ʻai
• luhi

Mālama i nā manawa āpau me kāu kauka. E nānā kāu kauka i kou kaʻe koko ma mua o kou hoʻomaka ʻana i ka regorafenib a maʻa mau i kāu wā e lapaʻau ai.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Stivarga^®