Ipilimumab Injection

Anter

• Ma mua o ka loaʻa ʻana o ka ipilimumab injection,
• Hoʻokumu paha ʻo Ipilimumab i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o nā ʻōuli, e kāhea koke i kāu kauka a i ʻole e loaʻa i kahi lāʻau lapaʻau olakino.

Hoʻohana ʻia ka pahu kui Ipilimumab:

• e mālama i ka melanoma (kahi ʻano maʻi ʻaʻai o ka ʻili) i nā mākua a me nā keiki he 12 mau makahiki a ʻoi paha i hiki ʻole ke mālama ʻia me ke ʻoki a i ʻole ua pāhola aʻe i nā ʻāpana ʻē aʻe o ke kino.
• e kōkua i ka pale ʻana i ka melanoma mai ka hoʻi ʻana ma hope o ke kaha ʻana e kāpae iā ia a me nā lymph node i hoʻopili ʻia.
• i ka hui pū ʻana me nivolumab (Opdivo) e mālama i ka carcinoma ʻōiwi holomua (RCC; kahi ʻano maʻi ʻaʻai e hoʻomaka i nā hunaola o nā puʻupaʻa).
• i ka hui pū ʻana me nivolumab e mālama i kekahi ʻano o ka maʻi ʻaʻai kala (colorer i hoʻomaka i ka ʻōpū nui) i nā mākua a me nā keiki he 12 mau makahiki a ʻoi paha i pālahalaha ʻia i nā ʻāpana ʻē aʻe o ke kino a ua ʻoi aku ka maikaʻi ma hope o ka lapaʻau ʻana me nā lāʻau chemotherapy ʻē aʻe.
• i ka hui pū ʻana me nivolumab e mālama i ka carcinoma hepatocellular (HCC; kahi ʻano maʻi ʻaʻai ate) i ka poʻe i mālama mua ʻia me sorafenib (Nexafar).
• i ka hui pū ʻana me nivolumab i kekahi ʻano maʻi ʻaʻai o ka maʻi (non-small cell lung cancer; NSCLC) i nā mākua i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino.
• i ka hui pū ʻana me nivolumab a me ka platinum chemotherapy e mālama i kekahi ʻano o ka NSCLC i nā mākua i hoʻi a i pāhola paha i nā ʻāpana ʻē aʻe o ke kino.
• i ka hui pū me nivolumab e mālama i nā mesothelioma pleural malignant (kahi ʻano o ke kanesa e pili ana i ka pale o ka māmā a me ka lua o ka pahu) i nā mākua ʻaʻole hiki ke hemo e ke ʻoki.

Aia ka ipilimumab injection i loko o ka papa o nā lāʻau i kapa ʻia he monoclonal antibodies. Hana ia ma ke kōkua ʻana i ke kino e hoʻolohi a kū i ka ulu ʻana o nā hunaola maʻi ʻaʻai.

ʻO ke kūpili Ipilimumab e hele mai ma ke ʻano he wai (wai) e ʻākoʻi ʻia me ke komo (i loko o ke aa) e ke kauka a kahu hānai paha i kahi haukapila a i ʻole kahi wahi olakino. Ke hāʻawi ʻia ka ipilimumab e mālama i ka melanoma, hāʻawi pinepine ʻia ma luna o 90 mau minuke hoʻokahi i kēlā me kēia 3 mau pule no ka mea ke koi aku kāu kauka e loaʻa iā ʻoe ka lāʻau. Ke hāʻawi ʻia ka ipilimumab me ka nivolumab e mālama ai i ka maʻi kanesa o ke kōkō, ka maʻi ʻohe hepatocellular, a i ʻole ka maʻi ʻaʻai kala, hāʻawi pinepine ʻia ia ma 30 mau minuke i hoʻokahi manawa i kēlā me kēia 3 mau pule a hiki i nā kaukū 4. Ke hāʻawi ʻia ka ipilimumab me ka nivolumab a i ʻole me ka nivolumab a me ka chemotherapy platinum e mālama ai iā NSCLC, hāʻawi pinepine ʻia ia ma 30 mau minuke i hoʻokahi manawa i kēlā me kēia 6 pule no ka lōʻihi a ke kauka e koi ai iā ʻoe e mālama. Ke hāʻawi ʻia ka ipilimumab me ka nivolumab e mālama i ka mesothelioma pleural malignant, hāʻawi pinepine ʻia ma 30 mau minuke i hoʻokahi manawa i kēlā me kēia 6 pule no ka lōʻihi o ke koi ʻana o kāu kauka e loaʻa iā ʻoe ka lāʻau.

Hoʻokumu paha ka pahu kui Ipilimumab i nā hopena koʻikoʻi a hoʻoweliweli paha i ke ola. E nānā pono kahi kauka a kahu hānai paha iā ʻoe ke loaʻa nei ʻoe i ka infusion a ma hope koke iho o ka infusion e hōʻoia ʻaʻole ʻoe i kahi hopena koʻikoʻi i ka lāʻau. E haʻi koke aku i kāu kauka a kahu hānai paha inā ʻike ʻoe i kekahi o nā ʻōuli e hiki ke hana ʻia i ka wā o ka infusion: haʻalulu a haʻalulu, ʻili, ʻehu, pīpī, paʻakikī i ka hanu ʻana, pākī, pehu, a me ka maʻule.

E hoʻolohi paha kāu kauka i kāu infusion, hoʻolohi, a i ʻole hoʻopau i kāu mālama ʻana me ka ipilimumab injection, a i ʻole mālama iā ʻoe me nā lāʻau hou aʻe e like me kāu pane i ka lāʻau a me nā hopena ʻē aʻe āu e ʻike ai. E kamaʻilio me kāu kauka e pili ana i kou ʻano i kāu mālama ʻana.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Ke alakaʻi lāʻau) ke hoʻomaka ʻoe i ka lāʻau me ipilimumab a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka loaʻa ʻana o ka ipilimumab injection,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka ipilimumab injection, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka ipilimumab injection. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻai, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā loaʻa iā ʻoe kahi transplant organ, maʻi maʻi ate, a i ʻole ua hōʻino ʻia kou akepa e ka lāʻau a i ʻole kahi maʻi. Eia kekahi, e haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe kahi maʻi autoimmune (ke ʻano e hoʻouka ai ka ʻōnaehana pale i kahi ʻaoʻao olakino o ke kino) e like me ka maʻi o Crohn (ke ʻano e hoʻouka ai ka ʻōnaehana pale i ka uhi o ka ʻaoʻao digestive e hōʻeha ai i ka ʻeha. , diarrhea, weight loss, and fever), ulcerative colitis (kahi ʻano e hoʻoheheʻe ai a me nā ʻeha ma ka ʻaoʻao o ke kolona [ʻōpū nui] a me ke kīhā), lupus kaʻili, nā hono, ke koko, a me nā puʻupaʻa), a i ʻole sarcoidosis (ke ʻano e ulu ai nā ʻōpuʻu o nā hunaola ʻē aʻe i nā ʻāpana like ʻole o ke kino e like me nā akemāmā, ʻili, a me nā maka).
• e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. Pono ʻoe e lawe i kahi hōʻike hāpai ma mua o kou loaʻa ʻana i ka ipilimumab. Pono ʻoe e hoʻohana i ka kaohi hānau kūpono e pale i ka hāpai ʻana i ka wā o kāu mālama ʻana me ka ipilimumab injection a no 3 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu. Inā hāpai ʻoe i ka loaʻa ʻana o ka ipilimumab injection, e kelepona koke i kāu kauka. Hiki i ka ipilimumab injection ke hōʻino i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū a i ʻole hoʻolālā e hānai. ʻAʻole pono ʻoe e hānai i ka wā e loaʻa ana ka ipilimumab injection a no 3 mau mahina ma hope o kāu hopena hope loa.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Hoʻokumu paha ʻo Ipilimumab i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• paʻakikī e hiamoe a hiamoe paha
• ʻeha pū

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o nā ʻōuli, e kāhea koke i kāu kauka a i ʻole e loaʻa i kahi lāʻau lapaʻau olakino.

• hoʻemi i ka urination, ke koko i ka mimi, ka pehu ʻana o nā wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo, a me ka nalo ʻole o ka makemake
• diarrhea, kōkō a ʻeleʻele paha, hoʻolōʻihi, noho humuhumu, ʻeha o ka ʻōpū a palupalu paha, a me ke kuni
• uha, ʻeha o ka umauma, a me ka liʻiliʻi o ka hanu
• ka luhi, ka huikau, nā pilikia hoʻomanaʻo, nā haʻalulu, ka hopu ʻana, a me ka ʻāʻī ʻoʻoleʻa
• luhi, hoʻonui i ka makemake, hoʻonui i ka make wai, hoʻonui i ka urination, a me ka pohō kaumaha
• ka wikiwiki o ka puʻuwai, ka haʻalulu ʻole o kahi ʻāpana o ke kino, hoʻonui i ka makemake, a i ʻole ka hou ʻana
• luhi a palaualelo paha, hoʻonui i ka ʻike i ke anuanu, ka paʻa paʻa, ka ʻeha a me ka nāwaliwali o ka momona, ʻoi aku ke kaumaha, ʻoi aku ka nui o ke kaumaha ma mua o ka manawa maʻamau a maʻamau ʻole paha, ka lauoho lahilahi, ʻeha poʻo, ʻūpī, huhū, hoʻopoina, hoʻoliʻiliʻi hoʻokele wahine, a kaumaha
• melemele o ka ʻili a me nā maka, ʻeleʻele (tī-ʻeleʻele) mimi, ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū, nausea, luaʻi, a maʻalahi a palu a kahe paha.
• nāwaliwali kūikawā o nā wāwae, nā lima, a i ʻole ke alo; a i ʻole ka helu a i ʻole ka ʻūlū ʻana i nā lima a me nā wāwae paha
• hū me ka ʻole o ka ʻili, ʻōwili a ʻili paha i ka ʻili, a ʻeha hoʻi ka waha
• ʻike maka ʻole, ʻike ʻālua, ʻeha ka maka a ʻulaʻula paha, a i ʻole nā ​​pilikia ʻike ʻē aʻe

Hiki i ka ipilimumab injection ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia ʻē aʻe ke loaʻa iā ʻoe kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka ipilimumab injection.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua ma mua a i kou wā o ka mālama ʻana e ʻike inā palekana iā ʻoe e loaʻa i ka ipilimumab injection a e nānā i ka pane o kou kino i ka ipilimumab injection.

No kekahi mau kūlana, e kauoha kāu kauka i kahi hoʻokolohua hoʻokolohua ma mua o kou hoʻomaka ʻana i kāu lāʻau e ʻike inā hiki ke mālama ʻia i kou maʻi ʻaʻai me ipilimumab.

E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka ipilimumab injection.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Yervoy^®