Sunitinib

Anter

• Ma mua o ka lawe ʻana i sunitinib,
• Hoʻokumu ʻo Sunitinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i nā ʻARlelo AOAO IMPORTANT a i ʻole SPECIAL PRECAUTIONS ʻāpana, e kelepona koke i kāu kauka.

Hiki i ka Sunitinib ke kumu i ka hōʻeha koʻikoʻi a i ʻole ke ola i ke ake. E haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi ate a i ʻole nā ​​pilikia me kou ake. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: ʻili, maka melemele a me ka ʻili, mimi ʻeleʻele, a i ʻole ʻeha a ʻoluʻolu ʻole paha ma ka ʻaoʻao o ka ʻōpū ma luna pono. Pono paha i kāu kauka e hōʻemi i kāu lāʻau o sunitinib a i ʻole kūmau manawa a kūloko paha i kāu lāʻau.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha aku kāu kauka i kekahi mau hoʻokolohua koko ma mua a i kou wā o ka mālama ʻana e hōʻoia he palekana ia no ʻoe e lawe i ka sunitinib a e nānā i ka pane o kou kino i ka lāʻau.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me sunitinib a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana i sunitinib.

Hoʻohana ʻia ʻo Sunitinib e mālama i nā ʻōpū stromal gastrointestinal (GIST; kahi ʻano tumo e ulu ana i loko o ka ʻōpū, ʻōpū (bowel), a i ʻole esophagus (Tube e hoʻopili ana i ka ʻāʻī me ka ʻōpū) i ka poʻe me nā tumors i mālama ʻole ʻia me imatinib ( Gleevec) a i ʻole ka poʻe hiki ʻole ke lawe imatinib. Hoʻohana pū ʻia ʻo Sunitinib e mālama i ka carcinoma cell renal holomua (RCC, kahi ʻano maʻi ʻaʻai e hoʻomaka i nā hunaola o nā puʻupaʻa). Hoʻohana pū ʻia ʻo Sunitinib e pale i ka hoʻi ʻana o ka RCC i ka poʻe nāna loaʻa ʻo RCC ʻaʻole pālahalaha a lawe ʻia kahi puʻupaʻa. Hoʻohana ʻia ʻo Sunitinib e mālama i nā tumora neuroendocrine pancreatic (pNET, kahi ʻano tumo e hoʻomaka i loko o kekahi mau huna o ka pancreas) i ka poʻe me nā puʻupuʻu i ʻino a ʻaʻole hiki ke mālama ʻia. ʻoki kino. Aia ʻo Sunitinib i loko o ka papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ʻia ia ma ke kāpae ʻana i ka hana o ka protein kūlohelohe e hōʻailona ana i nā hunaola maʻi ʻea e hoʻonui. Kōkua kēia i ka hōʻoki a hoʻolohi paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai a kōkua paha e hoʻēmi i nā ʻōpuʻu.

Hele mai ʻo Sunitinib ma ke ʻano he capsule e lawe ma ka waha me ka ʻole o ka meaʻai. No ka mālama ʻana i nā ʻōpū stromal gastrointestinal (GIST), a i ʻole no ka mālama ʻana i ka maʻi puʻupaʻa puʻupaʻa (RCC), lawe pinepine ʻia ka sunitinib i hoʻokahi manawa i ka lā no 4 mau pule (28 mau lā) a ma hope o ka hoʻomaha he 2 mau pule ma mua o ka hoʻomaka ʻana o ka pōʻaiapuni dosing aʻe a hana hou ʻia i kēlā me kēia 6 pule no ka lōʻihi o ke kauka. No ka pale ʻana i ka RCC, lawe pinepine ʻia ka sunitinib i hoʻokahi manawa i kēlā me kēia lā no 4 mau pule (28 mau lā) a ukali ʻia e kahi hoʻomaha he 2 mau pule ma mua o ka hoʻomaka ʻana o ka pōʻai hana hou aʻe a hana hou i kēlā me kēia 6 pule no 9 mau pōʻaiapuni. No ka mālama ʻana i nā tumora neuroendocrine pancreatic (pNET), lawe pinepine ʻia ka sunitinib i hoʻokahi manawa i kēlā me kēia lā. Lawe iā sunitinib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe iā sunitinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā capsule holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou. Mai wehe i nā capsule.

Pono ʻoe e lawe i hoʻokahi a ʻoi paha mau capsule i ka manawa kaukaʻi ʻia i kāu mahele lāʻau o sunitinib.

E hoʻonui a hoʻoliʻiliʻi paha kāu kauka i kāu mahele lāʻau o sunitinib i kāu mālama ʻana. Aia kēia i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a me nā hopena ʻē aʻe āu e ʻike ai. E kamaʻilio me kāu kauka e pili ana i kou ʻano i kāu mālama ʻana. E hoʻomau i ka lawe sunitinib ʻoiai inā maikaʻi ʻoe. Mai hoʻōki i ka lawe ʻana i sunitinib me ke kamaʻilio ʻole ʻana me kāu kauka.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i sunitinib,

• e haʻi aku i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka sunitinib, nā mea hoʻohui o nā capsule sunitinib, a i ʻole nā ​​lāʻau ʻē aʻe. E noi i kāu kauka lāʻau a nānā paha i ka palapala ʻike hoʻomanawanui o ka mea hana (Medication Guide) no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, a me nā mea hoʻopihaʻaiʻai āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: kekahi antibiotic e like me clarithromycin (Biaxin, ma Prevpac), rifampin (Rifadin, Rimactane, ma Rifamate, ma Rifater), rifabutin (Mycobutin), rifapentine (Priftin), a me telithromycin (Ketek); kekahi mau antifungals e like me itraconazole (Onmel, Sporanox), ketoconazole, a me voriconazole (Vfend); dexamethasone; nā lāʻau no ka maʻi kō; kekahi mau lāʻau no ka maʻi pale maʻi (HIV) a i ʻole loaʻa i ka maʻi maʻi maʻi maʻi (AIDS) me atazanavir (Reyataz, ma Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ma Kaletra), a me saquinavir (Invirase); nefazodone; kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, a me phenytoin (Dilantin, Phenytek). E haʻi pū i kāu kauka inā lawe a lawe paha ʻoe i alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), a i ʻole zoledronic acid injection (Reclast, Zometa), pili pū kekahi mau lāʻau ʻē aʻe sunitinib, no laila e pono e haʻi aku i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka a me kāu kauka lāʻau he aha nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St. Mai lawe iā St. John's wort ʻoiai e lawe ana i sunitinib.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa i kahi kahe koko; he hāpule koko i loko o ka hanu; kahi hoʻolōʻihi lōʻihi QT (kahi puʻuwai puʻuwai kūpono ʻole e hiki ai i ka nāwaliwali, nalowale o ka ʻike, hopu ʻana, a make koke paha); kahi puʻuwai lohi, wikiwiki, a i ʻole kaulike ʻole; he puʻuwai puʻuwai; puʻuwai puʻuwai; ke koko kiʻekiʻe; ka hopu ʻana; haʻahaʻa kō kō a i ʻole diabetes; nā pae haʻahaʻa o ka potassium a me ka magnesium i kou koko; nā pilikia me kou waha, nā niho a i ʻole nā ​​gum; a i ʻole ka hakuʻala, thyroid, a i ʻole maʻi maʻi puʻuwai.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i kahi keiki i kahi keiki. ʻAʻole ʻoe a ʻo kāu hoa paha e hāpai i ka wā e lawe ana ʻoe i sunitinib. Inā he wahine ʻoe, pono ʻoe e hoʻokolohua hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau, a pono ʻoe e hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu mālama sunitinib a no 4 mau pule ma hope o kāu hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā e hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i ka wā o kāu mālama ʻana me sunitinib a no 7 mau pule ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Hiki i ka Sunitinib ke hoʻemi i ka momona i nā kāne a me nā wahine. Eia nō naʻe, ʻaʻole pono ʻoe e kuhi ʻaʻole hiki iā ʻoe a i ʻole kāu pakanā ke hāpai. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana i sunitinib, e kāhea i kāu kauka. Hiki iā Sunitinib ke hōʻeha i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻAʻole pono ʻoe e hānai i ka wā o kāu mālama ʻana me sunitinib a no 4 mau pule ma hope o kāu hopena hope loa.
• inā ke hana ʻoki nei ʻoe e haʻi i ke kauka a i ʻole kauka niho paha e lawe nei ʻoe i sunitinib. E haʻi paha kāu kauka iā ʻoe e haʻalele i ka lawe ʻana i sunitinib ma ka liʻiliʻi he 3 mau pule ma mua o kāu kaʻina i hoʻonohonoho ʻia no ka mea hiki ke hoʻopili i ka hōʻeha ʻana i ka ʻeha. E haʻi aku kāu kauka iā ʻoe i ka manawa e hoʻomaka ai e lawe hou i sunitinib ma hope o kāu ʻoki ʻana.
• pono ʻoe e ʻike i ka sunitinib e hoʻolilo i kou ʻili e huli melemele a e hoʻomālamalama kou lauoho a lilo ke kala. Hoʻokumu ʻia paha kēia e ke kala melemele o ka lāʻau lapaʻau a ʻaʻole ʻino a ʻeha hoʻi.
• pono ʻoe e ʻike ʻo ka sunitinib ke kumu o ke koko kiʻekiʻe. Pono e nānā pinepine ʻia kou kaomi koko ke lawe ʻoe i sunitinib.
• pono ʻoe e ʻike i ka sunitinib ke kumu osteonecrosis o ka iwi ā (ONJ, kahi kūlana koʻikoʻi o ka iwi ā), keu hoʻi inā he ʻoki niho ʻoe a i ʻole ke mālama ʻana ʻoiai ʻoe e lawe nei i ka lāʻau. Pono kahi kauka niho e nānā i kou mau niho a hana i nā hana e pono ai, e like me ka hoʻomaʻemaʻe ʻana a i ʻole ka hoʻoponopono ʻana i nā niho ʻino ʻole, ma mua o kou hoʻomaka ʻana e lawe sunitinib. E nānā pono e palaki i kou mau niho a hoʻomaʻemaʻe i kou waha pono ke lawe ʻoe i sunitinib. E haʻi i kāu kauka a kauka niho paha inā he waha kou, he niho, a ʻeha kaʻi; ʻeha ka waha a pehu paha; numbness a i ʻole ke ʻano kaumaha i ka iwi ā; a i ʻole nā ​​niho hāmau. E kamaʻilio me kāu kauka ma mua o ka loaʻa ʻana o nā lāʻau lapaʻau iā ʻoe e lawe nei i kēia lāʻau.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

Inā ʻoe e nalo i kahi mahele o sunitinib ma lalo o 12 mau hola, e lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai a laila lawe i ka lāʻau aʻe i ka manawa i hoʻopaʻa ʻia. Eia nō naʻe, inā ʻoe e nalo i kahi mahele ma mua o 12 mau hola, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu ʻo Sunitinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• nāwaliwali
• nausea
• ka luaʻi
• pāhoehoe
• kōpaʻa
• puʻuwai puʻuwai
• ʻenekini
• hemorrhoids
• ʻeha, huhū, a i ʻole ʻā wela o nā lehelehe, elelo, waha a ʻāʻī paha
• waha maloo
• hoʻololi i ke ʻano o ka ʻono o nā mea
• nalo ʻai ʻole
• loli ke kaupaona
• poho lauoho
• lahilahi, manamana mānoanoa a hulu lauoho paha
• ʻōlelo lohi
• ʻili mae a maloʻo paha
• luliluli ʻana
• kaumaha, kūlike ʻole, a i hala paha i ka wā menstrual
• kaumaha
• paʻakikī e hiamoe a hiamoe paha
• ka maloʻo, ka mānoanoa, ka haki ʻana a i ʻole ka ʻā ʻana o ka ʻili ma nā poho o nā lima a me nā kapuwaʻi o nā wāwae
• ʻeha, ʻami, hoʻi, a ʻeha hoʻi o ka lālā
• ihu ihu pinepine
• e kahe ana ke kahe o kou gums
• ʻoluʻolu maʻamau i nā mahana anuanu

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i nā ʻARlelo AOAO IMPORTANT a i ʻole SPECIAL PRECAUTIONS ʻāpana, e kelepona koke i kāu kauka.

• ʻāpā ʻaʻano ʻole a hoʻokahe koko paha
• nā noho koko a ʻeleʻele a tarry
• koko i ka mimi
• ka luaʻi ʻulaʻula ʻulaʻula a ʻano like paha me nā kahua kope
• kahe ana ke koko
• ʻeha o ka ʻōpū, pehu, a palupalu paha
• ʻeha poʻo
• fiva
• pehu, palupalu, mehana, a ʻulaʻula o ka wāwae
• pehu o nā wāwae a i ʻole nā ​​kuʻekuʻe wāwae
• wikiwiki, kūlike ʻole, a kuʻi paha i ka puʻuwai puʻuwai
• paupauaho a maʻule paha
• hoʻemi i ka makaʻala a i ʻole ka noʻonoʻo nui
• huikau
• kaumaha
• hopohopo
• ka hopu ʻana
• loli ka hihiʻo
• ʻeha ka umauma a i ʻole kaomi
• luhi loa
• pokole o ka hanu
• ʻeha me ka hanu hohonu
• loaʻa kaumaha kaumaha ʻole
• hoʻemi urination
• mimi ʻōpua
• pehu o nā maka, maka, lehelehe, alelo, a puʻu paha
• hūwī
• hives
• ʻili a ʻili paha i ka ʻili a i ʻole ma loko o ka waha
• pilikia i ka ale ʻana a me ka hanu ʻana
• hulahula

Hoʻokumu ʻo Sunitinib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua e like me electrocardiograms (EKG, hōʻike e hoʻopaʻa i ka hana uila o ka puʻuwai), echocardiograms (hoʻāʻo e hoʻohana ana i nā nalu kani e ana i ka hiki i kou puʻuwai ke pauma i ke koko), a me nā hoʻokolohua mimi ma mua a i kou wā e mālama ai me sunitinib e mālama pono palekana iā ʻoe e lawe i ka sunitinib, a e nānā i ka pane o kou kino i ka lāʻau.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Sutent^®