Natalizumab Injection

Anter

• Hoʻohana ʻia ʻo Natalizumab i mea e pale aku ai i nā ʻāpana o nā hōʻailona a hoʻolohi i ka hōʻino ʻana o ke kīnā ʻole i nā mākua i loaʻa hou i nā ʻano sclerosis maha (MS; kahi maʻi kahi e holo pono ʻole ai nā ʻalalā a ʻike paha ka poʻe i ka nāwaliwali, numbness, nalo ʻana o ka hoʻopili ʻana o nā mākala, a nā pilikia me ka hihiʻo, haʻi ʻōlelo, a me ka mālama ʻana i ka maʻi ʻaʻa), me:
• Ma mua o ka loaʻa ʻana o ka injection natalizumab,
• Hoʻokumu paha ʻo Natalizumab i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o nā ʻōuli aʻe a i ʻole i ʻōlelo ʻia i ka ʻĀKAUAHI A ME NĀ WAIWAI MAHU, e kelepona koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino pilikia

ʻO ka loaʻa ʻana o ka inikua natalizumab e hoʻonui paha i ka makaʻu e hoʻomohala ʻoe i ka leukoencephalopathy multifocal holomua (PML; kahi maʻi laha ʻole o ka lolo i hiki ʻole ke mālama ʻia, pale ʻia, a hoʻōla ʻia a ʻo ka mea maʻamau ka make a i ʻole ke kīnā koʻikoʻi). ʻO ka manawa kūpono e hoʻomohala ʻoe i ka PML i kou wā e lapaʻau ai me ka natalizumab ʻoi aku ka kiʻekiʻe inā he hoʻokahi a ʻoi paha kāu o nā kumuhana ʻino aʻe.

• Ua loaʻa iā ʻoe nā kaona he nui o natalizumab, keu hoʻi inā ua loaʻa iā ʻoe ka lāʻau no ka ʻoi aku o 2 mau makahiki.
• Ua mālama ʻia ʻoe me nā lāʻau e hoʻonāwaliwali i ka ʻōnaehana pale pale, e like me azathioprine (Azasan, Imuran), cyclophosphamide, methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), mitoxantrone, a me mycophenolate mofetil (CellCept).
• Hōʻike kahi hōʻike koko ua ʻike ʻia ʻoe i ka maʻi maʻi ʻo John Cunningham (JCV; kahi maʻi i ʻike ʻia i nā poʻe he nui i ka wā kamaliʻi e kumu pinepine ʻole ai nā hōʻailona akā hiki ke kumu iā PML i ka poʻe me nā ʻōnaehana pale nawaliwali).

E kauoha paha kāu kauka i kahi hoʻokolohua koko ma mua a i ʻole i kāu mālama ʻana me ka inikua natalizumab e ʻike inā ua ʻike ʻia ʻoe i ka JCV. Inā hōʻike ka hōʻike ua hōʻike ʻia ʻoe i ka JCV, hoʻoholo paha ʻoe a me kāu kauka ʻaʻole pono e loaʻa iā ʻoe ka injection natalizumab, keu hoʻi inā he ʻelua a ʻelua paha nā kumu pilikia ʻē aʻe i helu ʻia ma luna. Inā hōʻike ʻole ka hōʻike ua hōʻike ʻia ʻoe i ka JCV, hiki i kāu kauka ke hana hou i ka hoʻokolohua mai kēlā me kēia manawa i ka wā o kāu mālama ʻana me ka injection natalizumab. ʻAʻole pono ʻoe e hoʻāʻo inā loaʻa iā ʻoe kahi pānaʻi plasma (lapaʻau kahi e lawe ʻia ai ka ʻāpana o ke koko mai ke kino a hoʻololi ʻia me nā wai ʻē aʻe) i nā pule he 2 i hala aku nei no ka mea ʻaʻole pololei nā hopena hōʻike.

Aia kekahi mau kumu ʻē aʻe e hoʻonui paha i ka makaʻu e hoʻomohala ʻoe iā PML. E haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa iā PML, kahi transplant organ, a i ʻole kahi ʻano e pili ana i kāu ʻōnaehana pale pale e like me ka maʻi pale maʻi (HIV), loaʻa ka maʻi maʻi (AIDS), leukemia (maʻi ʻaʻai e kumu ai i nā huna koko he nui. e hana a hoʻokuʻu ʻia i loko o ke kahe o ke koko), a i ʻole lymphoma (maʻi ʻaʻai e hoʻomohala i nā hunaola o ka ʻōnaehana pale. E haʻi pū aku i kāu kauka inā ʻoe e lawe a i ʻole inā ua lawe ʻoe i nā lāʻau ʻē aʻe e hoʻopili i ka ʻōnaehana pale e like me adalimumab (Humira); cyclosporine (Gengraf, Neoral, Sandimmune); etanercept (Enbrel); glatiramer (Copaxone, Glatopa); infliximab (Remicade); interferon beta (Avonex, Betaseron, Rebif); nā lāʻau no ka maʻi ʻaʻai; merc laptopurine (Purinethol, Purixan); nā steroid ʻo waha e like me dexamethasone, methylprednisolone (Depo-medrol, Medrol, Solu-medrol), prednisolone (Prelone), a me prednisone (Rayos); sirolimus (Rapamune); a me tacrolimus (Astagraf, Envarsus XR, Prograf). E haʻi paha kāu kauka iā ʻoe ʻaʻole pono e loaʻa iā ʻoe kahi natalizumab injection.

Ua hoʻonohonoho ʻia kahi papahana i kapa ʻia ʻo ka polokalamu TOUCH e kōkua i ka mālama ʻana i nā pilikia o ka mālama natalizumab. Hiki iā ʻoe ke loaʻa ka inikua natalizumab inā ʻoe i hoʻopaʻa inoa ʻia me ka papahana TOUCH, inā kuhikuhi ʻia ʻo natalizumab e kahi kauka i hoʻopaʻa inoa ʻia me ka papahana, a inā loaʻa iā ʻoe ka lāʻau i kahi kikowaena infusion i hoʻopaʻa inoa ʻia me ka papahana. E hāʻawi aku kāu kauka iā ʻoe i ka ʻike hou aʻe e pili ana i ka papahana, e kau inoa iā ʻoe i kahi palapala inoa inoa, a e pane i kāu mau nīnau āu e pili ana i ka papahana a me kāu mālama ʻana me ka injection natalizumab.

Ma ke ʻāpana o ka papahana TOUCH, e hāʻawi aku kāu kauka a kahu wahine paha iā ʻoe i kahi kope o ka Medication Guide ma mua o kou hoʻomaka ʻana i ka lāʻau me ka inikua natalizumab a ma mua o ka loaʻa ʻana o kēlā me kēia infusion. E heluhelu pono i kēia ʻike i kēlā me kēia manawa ke loaʻa iā ʻoe a nīnau i kāu kauka a kahu maʻi paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Ma ke ʻano he ʻāpana o ka papahana TOUCH, pono ʻoe i kāu kauka e ʻike iā ʻoe i kēlā me kēia 3 mau mahina i ka hoʻomaka o kāu lapaʻau a ma ka liʻiliʻi ma kēlā me kēia 6 mau mahina e hoʻoholo inā ʻoe e hoʻomau i ka hoʻohana ʻana i ka natalizumab. Pono ʻoe e pane i kekahi mau nīnau ma mua o ka loaʻa ʻana o kēlā me kēia infusion e ʻike pono no ka pono ʻo natalizumab iā ʻoe.

Kāhea koke i kāu kauka inā hoʻomohala ʻoe i nā pilikia olakino hou a maikaʻi ʻole paha i kou wā e lapaʻau ai, a no 6 mau mahina ma hope o kāu hopena hope loa. E kāhea pono i kāu kauka inā ʻike ʻoe i kekahi o nā ʻōuli penei: nāwaliwali ma kekahi ʻaoʻao o ke kino e ʻino ana i ka hala ʻana o ka manawa. clumsiness o nā lima a mau wāwae paha; nā hoʻololi i kou noʻonoʻo, hoʻomanaʻo, hele wāwae, kaulike, ʻōlelo, ʻike maka, a i ʻole ikaika i hala i mau lā; ʻeha poʻo poʻo; ka hopu ʻana; huikau; a i ʻole hoʻololi i ke ʻano.

Inā kū kou lapaʻau ʻana me ka injection natalizumab no ka mea he PML kāu, hiki paha iā ʻoe ke hoʻomohala i kahi ʻano ʻē aʻe i kapa ʻia ʻo immune reconstitution inflammatory syndrome (IRIS; ka pehu ʻana a me ka hoʻomāhuahua ʻana o nā ʻōuli e hiki ke hana i ka hoʻomaka ʻana o ka ʻōnaehana pale e hana hou ma hope o ka hoʻomaka ʻana o kekahi mau lāʻau e hoʻopili iā ia. a i ʻole kū paha), ʻoiaʻiʻo inā loaʻa iā ʻoe kahi lapaʻau e wehe koke i ka natalizumab mai kou koko. E nānā pono kāu kauka iā ʻoe no nā hōʻailona o IRIS a e mālama i kēia mau hōʻailona inā kū lākou.

E haʻi i nā kauka āpau e mālama iā ʻoe ke loaʻa nei ʻoe i ka lāʻau natalizumab.

E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka loaʻa ʻana o ka inikua natalizumab.

Hoʻohana ʻia ʻo Natalizumab i mea e pale aku ai i nā ʻāpana o nā hōʻailona a hoʻolohi i ka hōʻino ʻana o ke kīnā ʻole i nā mākua i loaʻa hou i nā ʻano sclerosis maha (MS; kahi maʻi kahi e holo pono ʻole ai nā ʻalalā a ʻike paha ka poʻe i ka nāwaliwali, numbness, nalo ʻana o ka hoʻopili ʻana o nā mākala, a nā pilikia me ka hihiʻo, haʻi ʻōlelo, a me ka mālama ʻana i ka maʻi ʻaʻa), me:

• maʻi hoʻokaʻawale clinically (CIS; ʻāpana hōʻailona nerve mua e kū ma ka liʻiliʻi ma 24 mau hola),
• relapsing-remit maʻi (papa o ka maʻi kahi e ʻō ai nā ʻōuli mai kēlā manawa kēia manawa),
• ʻeleu holomua holomua maʻi (ma hope pae o ka maʻi me ka hoʻomau worsening o nā ʻōuli.)

Hoʻohana ʻia ʻo Natalizumab e mālama a pale i nā ʻāpana o nā ʻōuli i nā mākua i loaʻa i ka maʻi o Crohn (kahi ʻano e hoʻouka ai ke kino i ka uhi o ka digestive tract, e hōʻeha ana i ka ʻeha, ka maʻi pākī, ka pohō kaumaha, a me ke kuni) i kōkua ʻole ʻia e nā poʻe ʻē aʻe. nā lāʻau a i ʻole hiki ke lawe i nā lāʻau ʻē aʻe. Aia ʻo Natalizumab i kahi papa o nā lāʻau i kapa ʻia he monoclonal antibodies. Hana ia ma ke kāpae ʻana i kekahi mau pūnaewele o ka ʻōnaehana pale maʻi mai ka hiki ʻana i ka lolo a me ka iwi kuamoo a i ʻole ka digestive tract a hana i ka ʻino.

Hele mai ʻo Natalizumab ma ke ʻano he hopena paʻa (wai) e hoʻoheheʻe ʻia a injected me ka lohi i kahi aa e ke kauka a kahu hānai paha. Hāʻawi pinepine ʻia hoʻokahi manawa i kēlā me kēia 4 pule ma kahi kikowaena infusion i hoʻopaʻa inoa ʻia. Ma kahi o 1 mau hola e loaʻa ai iā ʻoe kahi kaona o natalizumab.

Hiki iā Natalizumab ke hana i nā hopena maʻi kūpilikiʻi e hiki ke hana ʻia ma loko o 2 mau hola ma hope o ka hoʻomaka ʻana o kahi infusion akā hiki paha i kēlā me kēia manawa i kāu wā e lapaʻau ai. Pono ʻoe e noho ma ke kikowaena infusion no 1 mau hola ma hope o ka pau ʻana o kāu infusion. E nānā kahi kauka a kahu hānai paha iā ʻoe i kēia manawa e ʻike inā loaʻa ka hopena koʻikoʻi i ka lāʻau. E haʻi i kāu kauka a kahu hānai paha inā ʻike ʻoe i nā ʻōuli maʻamau e like me ka hives, ka pehu, ka ʻū, ka paʻakikī ʻana i ka ale ʻana a me ka hanu ʻana, ka fiva, ka liholiho, ka ʻeha, ka ʻeha o ka umauma, ka pīpī ʻana, ka nausea, a me ke aniani, ʻoiai inā kū lākou i loko o 2 mau hola ma hope o ka hoʻomaka. o kāu hoʻopili.

Inā ʻoe e loaʻa ana i ka injection natalizumab e mālama ai i ka maʻi o Crohn, pono e hoʻomaikaʻi i kāu mau hōʻailona ma nā mahina mua o kāu mālama ʻana. E haʻi i kāu kauka inā ʻaʻole i hoʻomaikaʻi kāu mau hōʻailona ma hope o 12 mau pule o ka mālama ʻana. Hiki paha i kāu kauka ke hoʻōla iā ʻoe me ka injection natalizumab.

Hiki paha iā Natalizumab ke kōkua i ke kaohi ʻana i kāu mau ʻōuli akā ʻaʻole e hoʻōla i kou ʻano. Mālama i nā wā koho āpau e loaʻa ai ka injection natalizumab ʻoiai inā ʻoluʻolu ʻoe.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka loaʻa ʻana o ka injection natalizumab,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka natalizumab, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka inikua natalizumab. E noi i kāu kauka a kauka paha no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻowaiwai a me nā huahana lāʻau āu e lawe nei. E ʻōlelo pono i nā lāʻau i helu ʻia i ka ʻARlelo Aʻo IMPORTANT. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā ua loaʻa mua iā ʻoe kahi natalizumab injection a inā ua loaʻa a i ʻole loaʻa iā ʻoe kekahi o nā ʻano i helu ʻia i ka ʻARlelo Aʻo IMPORTANT. Ma mua o ka loaʻa ʻana o kēlā me kēia infusion o natalizumab, e haʻi aku i kāu kauka inā he kuni kou a i ʻole kekahi ʻano maʻi, me nā maʻi hoʻi e mau ana no ka manawa lōʻihi e like me nā shingles (kahi ʻāwīwī e kū mai i kēlā me kēia manawa i ka poʻe i loaʻa i ka paukū i ka wā i hala).
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka loaʻa ʻana o ka inikua natalizumab, kāhea i kāu kauka.
• ʻaʻohe o nā lāʻau āpau ke kamaʻilio ʻole ʻia me kāu kauka.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā haʻalele ʻoe i kahi manawa e loaʻa ai kahi infusion natalizumab, kāhea koke i kāu kauka.

Hoʻokumu paha ʻo Natalizumab i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻeha poʻo
• luhi loa
• hiamoe
• ʻeha puʻupuʻu a huʻi paha
• ʻeha ma nā lima a me nā wāwae
• ʻeha kua
• ka pehu ʻana o nā lima, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a i nā wāwae lalo
• ʻūpē mākala
• ʻeha ka ʻōpū
• pāhoehoe
• puʻuwai puʻuwai
• kōpaʻa
• ʻenekini
• loaʻa kaupaona a pohō paha
• kaumaha
• puhū pō
• ʻeha, kūlike ʻole, a i ʻole haule menstruation (wā)
• pehu, ʻulaʻula, puhi ʻana, a i ʻole ʻili kaʻi o ka ʻōpū
• hoʻokuʻu hoʻokuʻu keʻokeʻo
• pilikia e kaohi ana i ka urination
• ʻeha ka niho
• ʻeha nā waha
• hūwī
• ʻili maloʻo
• ʻūlili

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o nā ʻōuli aʻe a i ʻole i ʻōlelo ʻia i ka ʻĀKAUAHI A ME NĀ WAIWAI MAHU, e kelepona koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino pilikia

• ʻeha ka ʻāʻī, ka fiva, ka ʻū, ka haʻalulu, ka maʻi flu e like me nā ʻōuli, ka ʻōpū o ka ʻōpū, ka maʻi diarrhea, ka urination pinepine a ʻeha paha, pono e mimiki koke, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi.
• melemele o ka ʻili a i ʻole nā ​​maka, kahoihoi, ka luaʻi, ka luhi nui loa, nalo o ka makemake, ka mimi ʻeleʻele, ʻeha o ka ʻōpū o luna pono.
• loli ka ʻike, ʻulaʻula ka maka, a ʻeha paha
• kahe koko ʻole ʻana a palapū paha
• nā kiko liʻiliʻi, poepoe, ʻulaʻula a poni paha i ka ʻili
• kahe nui ke haehae

Hoʻokumu paha ʻo Natalizumab injection i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino i ka inikua natalizumab.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Tysabri^®