Hōʻike isoenzymes CPK

Hoʻomaopopo ka Creatine phosphokinase (CPK) isoenzymes i nā ʻano ʻokoʻa o CPK i ke koko. ʻO CPK kahi enzyme i loaʻa ma ka puʻuwai, ka lolo, a me nā mākala iwi.

Pono kahi laʻana koko. Lawe ʻia paha kēia mai kahi aa. Kapa ʻia ka hoʻāʻo he venipuncture.

Inā ʻoe ma ka haukapila, hiki ke hana hou ʻia kēia hōʻike ma kahi o 2 a 3 mau lā. ʻO kahi piʻi nui a hina paha i loko o ka CPK a i ʻole CPK isoenzymes hiki ke kōkua i kāu kahu mālama ola e hōʻoia i kekahi mau ʻano.

ʻAʻole pono kahi hoʻomākaukau kūikawā i ka hapanui o nā hihia.

E haʻi i kāu mea hoʻolako e pili ana i nā lāʻau āpau āu e lawe nei. Hiki i kekahi mau lāʻau ke hoʻopilikia i nā hopena hōʻike. ʻO nā lāʻau i hiki ke hoʻonui i nā ana CPK i kēia mau mea:

• ʻAlekohola
• ʻO Amphotericin B
• Kekahi anesthetics
• ʻO Cocaine
• Nā lāʻau lapaʻau Fibrate
• Statins
• ʻO Steroids, e like me dexamethasone

ʻAʻole pili kēia papa inoa.

Hiki paha iā ʻoe ke ʻeha iki i ka wā e hoʻokomo ʻia ai ke kui kele e huki i ke koko. ʻO ka manaʻo o kekahi poʻe he prick a wīwī wale paha ka manaʻo. Ma hope, aia paha kekahi ʻōkā.

Hana ʻia kēia hōʻike inā hōʻike kahi hōʻike CPK e hoʻokiʻekiʻe ʻia kāu pae CPK āpau. Hiki i ka hoʻāʻo CPK isoenzyme ke kōkua i ka loaʻa o ke kumu kikoʻī o ka iʻa i hōʻino ʻia.

Hana ʻia ka CPK i ʻekolu mau mea ʻokoʻa iki:

• Loaʻa ka hapanui o ka CPK-1 (i kapa ʻia ʻo CPK-BB) i ka lolo a me nā akemāmā
• Loaʻa ka hapanui o ka CPK-2 (i kapa ʻia ʻo CPK-MB) i ka puʻuwai
• Loaʻa ka hapanui o ka CPK-3 (i kapa ʻia ʻo CPK-MM) i nāʻiʻo iwi

Nā pae CPK-1 kiʻekiʻe aʻe ma mua o ka maʻamau:

Ma muli o ka loaʻa pinepine o ka CPK-1 i ka lolo a me ka māmā, hiki i ka hōʻeha i kekahi o kēia mau wahi ke hoʻonui i nā kiʻekiʻe CPK-1. Hoʻonui ʻia nā pae CPK-1 ma muli o:

• Maʻi ʻaʻai lolo
• ʻEha lolo (ma muli o kekahi ʻano ʻeha e like me, hahau ʻana, a i ʻole ke kahe ʻana o ka lolo i ka lolo)
• Hoʻoikaika electroconvulsive
• Infarction pulmonary
• Ka hopu ʻana

Nā pae CPK-2 kiʻekiʻe aʻe ma mua o ka maʻamau:

Piʻi nā pae CPK-2 i 3 a 6 mau hola ma hope o ka puʻuwai puʻuwai. Inā ʻaʻohe mea e hōʻino hou i ka puʻuwai puʻuwai, piʻi ka pae ma 12 a 24 mau hola a hoʻi i ka maʻamau 12 a 48 mau hola ma hope o ka make ʻana o nā mea.

Hoʻonui ʻia paha nā pae CPK-2 ma muli o:

• Nā hōʻeha uila
• Ka defibrillation puʻuwai (kahi weliweli o ka puʻuwai e nā limahana lapaʻau)
• Ka hōʻeha puʻuwai (no ka laʻana, mai kahi ulia kaʻa)
• ʻO ka hoʻohaunaele o ka puʻuwai puʻuwai ma muli o ka maʻi (myocarditis)
• ʻOki puʻuwai puʻuwai

ʻO nā kiʻekiʻe ʻoi aku ma mua o ka maʻamau CPK-3 ka hōʻailona pinepine o ka hōʻeha ʻana i nā mākala a i ʻole ke koʻikoʻi koʻikoʻi. Pili paha lākou iā:

• E hōʻeha i nā ʻeha
• Poino Muscle ma muli o nā lāʻau a i ʻole ke neʻe no ka manawa lōʻihi (rhabdomyolysis)
• Hoʻoiho muscular
• Myositis (ʻōiwi mākala iwi)
• Ke loaʻa nei i nā injection intramuscular he nui
• ʻO nā hoʻāʻo ʻana o nā aʻalolo a me nā mākala hou
• Ka hopu ʻana i kēia manawa
• ʻOki kino hou
• Hoʻoikaika ikaika

Nā kumu i hiki ke hoʻopili i nā hopena hōʻike e pili ana i ka catheterization o ka naʻau, nā inikōkiō intramuscular, ke kahakaha ʻana o kēia manawa, a me ka hoʻoikaika ikaika a hoʻolōʻihi ʻia a i ʻole immobilization.

ʻO ka hoʻāʻo ʻana ʻo Isoenzyme no nā kūlana kikoʻī ma kahi o 90% pololei.

Creatine phosphokinase - isoenzymes; Creatine kinase - isoenzymes; CK - isoenzymes; Puʻuwai puʻuwai - CPK; Pākuʻi - CPK

• Hōʻaʻo koko

ʻO Anderson JL. St segment hoʻokiwikā myocardial infarction a me nā pilikia o ka myocardial infarction. I: Goldman L, Schafer AI, eds. ʻO ka lāʻau lapaʻau Goldman-Cecil. 25th hua. Piladelapia, PA: Elsevier Saunders; 2016: chap 73.

Marshall WJ, Lā A, Lapsley M. Nā protein a me nā enzyme o ka Plasma. I: Marshall WJ, Lā A, Lapsley M, eds. ʻO Kelemānia Clinical. 8th ed. Piladelapia, PA: Elsevier; 2017: chap 16.

Nagaraju K, Gladue HS, Lundberg IE. Nā maʻi hōʻeha o nā mākala a me nā myopathies ʻē aʻe. I: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, nā hua. ʻO Kelley lāua ʻo Firestein's Bookbook of Rheumatology. 10 o ka lā. Piladelapia, PA: Elsevier Saunders; 2017: chap 85.

Selcen D. Nā maʻi maʻi. I: Goldman L, Schafer AI, eds. ʻO ka lāʻau lapaʻau Goldman-Cecil. 25th hua. Piladelapia, PA: Elsevier Saunders; 2016: chap 421.