Ka nele o Factor VII

ʻO ka mea nui VII (ʻehiku) hemahema kahi maʻi i hoʻokumu ʻia e ka nele o kahi protein i kapa ʻia he factor VII i loko o ke koko. Alakaʻi ia i nā pilikia me ke kō ʻana o ke koko (coagulation).

Ke kahe nei ʻoe i ke kahe, hana ʻia kahi hopena o nā hopena i loko o ke kino e kōkua ai i ke kōkō ʻana o ke koko. Kapa ʻia kēia hana ke cascade coagulation. Pili ia i nā proteins kūikawā i kapa ʻia ʻo ka coagulation, a i ʻole nā ​​mea hoʻopili. Loaʻa paha iā ʻoe kahi manawa kiʻekiʻe o ke kahe ʻana o ke kahe inā e nalowale ana hoʻokahi a ʻoi paha o kēia mau kumu a hana ʻole paha e like me ka mea e pono ai.

ʻO ka ʻoihana VII kahi ʻano coagulation. Holo ka hemahema Factor VII i nā ʻohana (hoʻoilina) a kākaʻikahi loa ia. Pono i nā mākua ʻelua ke ʻae e hoʻoili i ka maʻi i kā lākou keiki. ʻO kahi moʻolelo ʻohana o kahi maʻi kahe e hiki ke lilo i mea pilikia.

Ma muli o kekahi ʻano a i ʻole ka hoʻohana ʻana o kekahi mau lāʻau i ka hemahema o nā mea VII. Kāhea ʻia kēia mea ʻo ka loaʻa ʻole o ka helu VII. Hiki ke kumu ʻia e:

• Low wikamina K (hānau ʻia kekahi mau pēpē me ka lawa ʻole ka wikamina K)
• Maʻi maʻi ʻeha nui
• Hoʻohana i nā lāʻau e pale ai i ka hoʻopili ʻana (anticoagulants e like me warfarin)

Pākuʻi ʻia paha nā ʻōuli i kekahi o kēia mau mea:

• Kahe ʻana o ke kahe mai nā membrane mucus
• Kahe ʻana i loko o nā hono
• Kahe i nā mākala
• Māmā maʻalahi
• Kahe nui ka haehae
• Nā Nosebleeds e kū mālie ʻole
• Kahe ʻana ke kaula uila ma hope o ka hānau ʻana

ʻO nā hoʻāʻo e hana ʻia ana paha:

• Wā thromboplastin manawa (PTT)
• ʻO ka hana Plasma factor VII
• Ka manawa Prothrombin (PT)
• Hoʻohui aʻoaʻo, kahi hōʻike PTT kūikawā e hōʻoia i ka hemahema o ka mea VII

Hiki ke kāohi ʻia ke kahe ʻana e ka loaʻa ʻana o ka infravenous (IV) infusions o ka plasma maʻamau, nā concentrates o ka mea VII, a i hana ʻia paha (recombinant) mea VII.

Pono ʻoe i ka mālama pinepine ʻana i nā hanana kahe o ke kahe no ka mea ʻaʻole paʻa ka mea VII i loko o ke kino. Hiki ke hoʻohana ʻia kekahi ʻano o nā mea VII i kapa ʻia ʻo NovoSeven.

Inā loaʻa iā ʻoe ka hemahema o ka mea VII ma muli o ka nele o ka wikamina K, hiki iā ʻoe ke lawe i kēia huaora e ka waha, ma o nā hoʻopili ʻana ma lalo o ka ʻili, a ma o kahi aa (intravenously).

Inā loaʻa kēia maʻi kolohe iā ʻoe, e pono e:

• E haʻi aku i kāu poʻe mālama ola ma mua o kāu loaʻa ʻana i kekahi ʻano o ke kaʻina hana, e like me ka hana ʻoki ʻana a me nā hana niho.
• E haʻi i nā ʻohana o kou ʻohana no ka mea he maʻi like paha kā lākou akā ʻaʻole ʻike ia manawa.

Hiki i kēia mau kumuwaiwai ke hāʻawi i ka ʻike hou aku e pili ana i ka hemahema o Factor VII:

• National Hemophilia Foundation: Nā Mea Kūpono ʻē aʻe - www.hemophilia.org/Bleeding-Disorder/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies
• National Organization for Rare Disorder - rarediseases.org/rare-diseases/factor-vii-deficiency
• NLM Genetics Home Reference - ghr.nlm.nih.gov/condition/factor-vii-deficiency

Hiki iā ʻoe ke manaʻo i kahi hopena maikaʻi me ka lapaʻau kūpono.

ʻO ka hoʻoilina hoʻoilina hoʻoilina VII kahi ola holoʻokoʻa.

ʻO ka nānā no ke kumu o ka loaʻa ʻana o ka hemahema VII ma muli o ke kumu. Inā kumu ʻia e ka maʻi akepau, pili ka hopena i ka maikaʻi e mālama ʻia ai kou maʻi ate. ʻO ka lawe ʻana i nā mea kōkua Kaminamina K e mālama pono ai i ka wikamina K.

Komo pū nā pilikia:

• Kahe nui ʻana o ke kahe (hemorrhage)
• ʻO ka hahau a i ʻole nā ​​pilikia ʻōnaehana hopohopo mai ke kahe koko waena
• Nā pilikia hui pū i nā hihia koʻikoʻi ke kū pinepine ke kahe

E kiʻi koke i ka mālama ulia pōpilikia inā loaʻa ʻoe i ke kahe koko koʻikoʻi ʻole.

ʻAʻohe pale e ʻike ʻia no ka hemahema o nā mea hoʻoilina. Ke loaʻa ʻole ka huaʻai K i ke kumu, hoʻohana i ka wikamina K hiki ke kōkua.

Ka hemahema Proconvertin; Deficiant factor deficiant; Ka hemahema prothrombin hoʻololi i ka hōʻemi; Maʻi ʻo Alexander

• Hoʻomaʻamaʻa koko
• Huʻi koko

ʻO Gailani D, Wheeler AP, Neff AT. Nā hemahema coagulation ololi. I: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Nā Kumumanaʻo a me ka Hoʻomeheu. ʻEpekema 7 Piladelapia, PA: Elsevier; 2018: chap 137.

Halelu JE. Hemostasis a me ka coagulation koko. Ma Hall JE, ed. ʻO Guyton a me Hall Textbook of Medical Physiology. 13th ed. Piladelapia, PA: Elsevier; 2016: chap 37.

ʻO Ragni MV. Nā maʻi hemorrhagic: deficiencies factor coagulation. I: Goldman L, Schafer AI, eds. ʻO ka lāʻau lapaʻau Goldman-Cecil. 25th hua. Piladelapia, PA: Elsevier Saunders; 2016: chap 174.