Hōʻike TP53 Genetic

Anter

• He aha ka hoʻokolohua moʻokalaleo TP53?
• No ke aha ia e hoʻohana ai?
• No ke aha wau e pono ai i kahi hōʻike hoʻāno TP53?
• He aha ka hana i ka wā o ka hoʻāʻo genetika TP53?
• Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?
• Aia kekahi mau pilikia i ka hoʻāʻo?
• He aha ke ʻano o nā hopena?
• Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i kahi hōʻike TP53?
• Nā kūmole

He aha ka hoʻokolohua moʻokalaleo TP53?

Nānā kahi hōʻike hoʻāʻo TP53 i kahi loli, i ʻike ʻia ma ke ʻano he mutation, i kahi moʻokūʻauhau i kapa ʻia ʻo TP53 (tumor protein 53). ʻO nā Genes nā ʻāpana maʻamau o ka hoʻoilina i hoʻoili ʻia mai kou makuahine a me kou makuakāne.

ʻO TP53 kahi ʻāpana e kōkua i ka hōʻoki ʻana i ka ulu ʻana o nā tumors. ʻIke ʻia ia me kahi mea hōʻoki ʻoki. Hana ka ʻenemi suppressor tumor e like me ka paleki ma ke kaʻa. Kau ia i nā "palaka" ma nā hunaola, no laila ʻaʻole lākou e māhele wikiwiki. Inā loaʻa iā ʻoe kahi hoʻololi TP53, ʻaʻole hiki i ka ʻāpana ke kāohi i ka ulu ʻana o kāu mau hunaola. Hiki i ke ulu ʻana o ke koleke ke alakaʻi ʻole ʻia i ka maʻi ʻaʻai.

Hiki ke hoʻoili ʻia kahi hoʻololi TP53 mai kou mau mākua, a i ʻole loaʻa ma hope i ke ola mai ke kaiapuni a i ʻole i kahi kuhihewa i hiki i kou kino i ka wā o ka mahele o ka cell.

• ʻO kahi mutation TP53 hoʻoilina i ʻike ʻia ʻo Li-Fraumeni Syndrome.
• ʻO Li-Fraumeni Syndrome kahi ʻano laha ʻole e hiki ke hoʻonui i kou makaʻi i kekahi ʻano maʻi maʻi ʻaʻai.
• ʻO kēia mau maʻi ʻaʻai pū me ka maʻi ʻaʻai umauma, maʻi ʻaʻai iwi, leukemia, a me nā maʻi ʻaʻa palupalu, i kapa ʻia hoʻi ʻo sarcomas.

Loaʻa ʻia (ʻike ʻia ʻo somatic) ʻo TP53 mutations ka mea maʻamau. Ua loaʻa kēia mau hoʻololi ma kahi o ka hapalua o nā hihia āpau o ka maʻi ʻaʻai, a ma nā ʻano like ʻole o ka maʻi ʻaʻai.

Nā inoa ʻē aʻe: TP53 mutation analysis, TP53 full gene analysis, TP53 somatic mutation

No ke aha ia e hoʻohana ai?

Hoʻohana ʻia ka hoʻokolohua e nānā no kahi hoʻololi TP53. ʻAʻole ia he hōʻike maʻamau.Hāʻawi pinepine ʻia i ka poʻe e pili ana i ka mōʻaukala ʻohana, nā ʻōuli, a i ʻole ka ʻike mua o ka maʻi ʻaʻai.

No ke aha wau e pono ai i kahi hōʻike hoʻāno TP53?

Pono ʻoe i kahi hoʻokolohua TP53 inā:

• Ua hōʻoia ʻia ʻoe me ka iwi a i ʻole ka maʻi ʻaʻai palupalu ma mua o ka makahiki 45
• Ua ʻike ʻia ʻoe me ka maʻi ʻaʻai umauma pre-menopausal, kahi tumo lolo, leukemia, a i ʻole ka maʻi ʻaʻai māmā ma mua o ka makahiki 46.
• Ua loaʻa iā ʻoe i hoʻokahi a ʻoi aku nā tumors ma mua o ka makahiki 46
• Ua ʻike ʻia hoʻokahi a ʻoi paha o nā lālā o kou ʻohana me ka maʻi Li-Fraumeni a / a i loaʻa i ka maʻi ʻaʻai ma mua o ka makahiki 45.

ʻO kēia nā hōʻailona loaʻa paha iā ʻoe kahi hoʻololi hoʻoilina o ka ʻohana TP53.

Inā ua hōʻoia ʻia ʻoe me ka maʻi ʻaʻai a ʻaʻohe ou moʻolelo ʻohana o ka maʻi, hiki i kāu mea mālama ola ke kauoha i kēia hoʻokolohua e ʻike inā he TP53 mutation ka mea e hoʻomaka ai kou maʻi ʻaʻai. ʻO ka ʻike inā loaʻa iā ʻoe kahi hoʻololi hiki ke kōkua i kāu mea hoʻolako e hoʻolālā i ka lāʻau lapaʻau a wānana i ka hopena o kāu maʻi.

He aha ka hana i ka wā o ka hoʻāʻo genetika TP53?

Hana pinepine ʻia kahi hōʻike TP53 ma ke koko a i ʻole ka iwi iwi.

Inā ʻoe e hōʻoia i ke koko, e lawe kahi loea mālama ola i kahi laʻana koko mai kahi aa i loko o kou lima, e hoʻohana ana i kahi nila liʻiliʻi. Ma hope o ka hoʻokomo ʻia ʻana o ka nila, e hōʻiliʻili ʻia kahi koko liʻiliʻi i loko o kahi pahu hoʻāʻo a ipu paha. Hiki paha iā ʻoe ke ʻoni iki i ka wā e hele ai a kuʻi paha ka nila. Lōʻihi kēia ma mua o ʻelima mau minuke.

Inā ʻoe e hoʻāʻo nei i kahi iwi o ka iwi, hiki i kāu kaʻina hana ke hoʻopili i nā kaʻina hana penei:

• E moe ʻoe i kou ʻaoʻao a i ʻole kou ʻōpū, e hilinaʻi ana i ka iwi hea e hoʻohana ai no ka hoʻāʻo ʻana. Lawe ʻia ka hapa nui o nā hoʻā o ka iwi iwi mai ka iwi iwi.
• E uhi ʻia kou kino i ka lole, i hōʻike wale ʻia nā wahi a puni ka pūnaewele hoʻāʻo.
• E hoʻomaʻemaʻe ka pūnaewele me kahi antiseptic.
• E loaʻa ʻoe i ka ʻoki o kahi hopena numbing. ʻEwehi paha ia.
• Ke pulu ka ʻāpana, e lawe ka mea mālama ola i kahi laʻana. Pono ʻoe e moe mālie i ka wā o nā hoʻokolohua.
• E hoʻohana ka mea mālama ola i kahi pono hana e wili i loko o ka iwi e lawe i kahi laʻana o ka iwi pūpū iwi. ʻIke paha ʻoe i kekahi kaomi ma ka pūnaewele ʻoiai e lawe ʻia nei kahi laʻana.
• Ma hope o ka hoʻāʻo, e uhi ka mea mālama ola i ka pūnaewele me kahi bandage.
• E hoʻolālā e hoʻokele iā ʻoe i kahi home, no ka mea hiki ke hāʻawi ʻia iā ʻoe kahi mea hōʻoluʻolu ma mua o nā hoʻokolohua, e hiamoe ai paha ʻoe.

Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?

ʻAʻole pono ʻoe i kahi hoʻomākaukau kūikawā no ka hoʻāʻo ʻana o ke koko a iwi paha.

Aia kekahi mau pilikia i ka hoʻāʻo?

ʻAʻohe liʻiliʻi loa i ka hōʻoia ʻana o ke koko. Loaʻa paha iā ʻoe ka ʻeha a ʻeha paha ma kahi o ka nila i hoʻokomo ʻia ai, akā ʻo ka hapa nui o nā ʻōuli e hele wikiwiki aku.

Ma hope o ka hoʻāʻo ʻana o ka iwi iwi, ʻāʻī paha ʻoe a ʻeha paha ma ka pūnaewele injection. Hele maʻamau kēia i kekahi mau lā. Koi aku kāu kauka olakino iā ʻoe a kauoha paha i kahi mea kōkua ʻeha e kōkua.

He aha ke ʻano o nā hopena?

Inā ua hōʻoia ʻia ʻoe me ka maʻi Li-Fraumeni, ʻo ia ʻaʻole ʻO ka manaʻo he maʻi maʻi kou, akā ʻoi aku kou kiʻekiʻe ma mua o ka hapa nui o ka poʻe. Akā inā loaʻa iā ʻoe ka hoʻololi, hiki iā ʻoe ke hana i nā hana e hōʻemi ai i kou makaʻu, e like me:

• ʻO ka loiloi pinepine ʻana i ka maʻi ʻaʻai. ʻOi aku ka mālama ʻia o ka maʻi ʻaʻai ke loaʻa i nā wā mua.
• Ke hoʻololi nei i ka nohona, e like me ka loaʻa ʻana o ka hoʻoikaika kino hou ʻana a me ka ʻai ʻana i kahi papaʻai olakino
• ʻO Chemoprevention, ka lawe ʻana i kekahi mau lāʻau, nā wikamina, a i ʻole nā ​​mea ʻē aʻe e hōʻemi i ka makaʻu a hoʻolohi paha i ka ulu ʻana o ka maʻi ʻaʻai.
• Ke kāpae ʻana i nā aʻa "at-risk"

E loli kēia mau ʻanuʻu e pili ana i kāu mōʻaukala olakino a me ka ʻaoʻao o kou ʻohana.

Inā loaʻa ʻoe i ka maʻi ʻaʻai a hōʻike kāu mau hopena i kahi mutation TP53 i loaʻa (loaʻa kahi mutation, akā ʻaʻohe ou moʻolelo ʻohana o ka maʻi ʻaʻai a i ʻole Li-Fraumeni syndrome), hiki i kāu mea hāʻawi ke hoʻohana i ka ʻike e kōkua i ka wānana ʻana pehea e ulu ai kāu maʻi a alakaʻi i kāu lapaau.

E aʻo hou aʻe e pili ana i nā hoʻokolohua hoʻokolohua, nā pae kuhikuhi, a me ka hoʻomaopopo ʻana i nā hopena.

Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i kahi hōʻike TP53?

Inā ua kuhi ʻia ʻoe a manaʻo paha he maʻi Li-Fraumeni kāu, kōkua paha ia e kamaʻilio me ke kākāʻōlelo. He loea aʻoaʻo aʻo loea kūikawā i ka genetics a me ka hoʻāʻo genetic. Inā ʻaʻole ʻoe i hoʻokolohua ʻia, hiki i ke kākāʻōlelo ke kōkua iā ʻoe e hoʻomaopopo i nā pilikia a me nā pono o ka hoʻāʻo ʻana. Inā ua hoʻāʻo ʻia ʻoe, hiki i ke kākāʻōlelo ke kōkua iā ʻoe e hoʻomaopopo i nā hopena a kuhikuhi iā ʻoe e kākoʻo i nā lawelawe a me nā kumuwaiwai ʻē aʻe.

Nā kūmole

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ʻAʻole pono e hoʻohana i ka ʻike ma kēia pūnaewele i pani no ka mālama olakino ʻoihana a ʻōlelo aʻoaʻo paha. Kāhea aku i ka mea mālama ola inā he nīnau kāu e pili ana i kou olakino.