ʻO Hereditary Cancer Pancreatic? E aʻo i nā kumu a me nā kumu pilikia

Anter

• He aha ke kumu o ka maʻi ʻaʻai pancreatic, a ʻo wai ka makaʻu?
• Pehea ka maʻamau o ka maʻi ʻaʻai pancreatic?
• Nā ʻōuli e nānā pono ai
• I ka manawa e ʻike ai i kāu kauka
• He aha ka mea e manaʻo ai mai ka hōʻailona
• He aha ka hana aʻe?

Hōʻike Overview

Hoʻomaka ka maʻi kanesa Pancreatic ke hoʻomohala nā hunaola i ka pancreas i kā lākou DNA.

ʻAʻole e make kēia mau hunaola ʻino, e like me ka make ʻana o nā hunaola maʻamau, akā hoʻomau mau i ka hana hou. ʻO ia ke kūkulu ʻana i kēia mau hunaola maʻi ʻea nāna e hana kahi tumo.

Hoʻomaka pinepine kēia ʻano maʻi ʻaʻai i loko o nā hunaola e kū laina ana i nā aʻa o ka pancreas. Hiki iā ia ke hoʻomaka i nā neuroendocrine cells a i ʻole nā ​​ʻola e hana ana i ka hormone.

Holo ka maʻi ʻaʻai Pancreatic i kekahi mau ʻohana. Ua hoʻoili ʻia kahi pākēneka liʻiliʻi o nā hoʻololi kūpuna i komo i ka maʻi ʻaʻai pancreatic. Loaʻa ka hapa nui.

Aia kekahi mau kumu ʻē aʻe i hiki ke hoʻonui i kou makaʻu i ka hoʻomohala ʻana i ka maʻi ʻaʻai pancreatic. Hiki ke hoʻololi i kekahi o kēia, akā ʻaʻole hiki i kekahi. E hoʻomau i ka heluhelu ʻana e aʻo hou aʻe.

He aha ke kumu o ka maʻi ʻaʻai pancreatic, a ʻo wai ka makaʻu?

ʻAʻole hiki ke ʻike ʻia ke kumu pololei o ka maʻi ʻaʻai pancreatic. Pili kekahi mau hoʻololi kūʻē, nā mea hoʻoilina a loaʻa hoʻi, i ka maʻi ʻaʻai pancreatic. Aia kekahi mau mea pilikia no ka maʻi ʻaʻai pancreatic, ʻoiai ka loaʻa ʻole ʻana o kekahi o ia mau mea e loaʻa ʻoe i ka maʻi ʻaʻai pancreatic. E kamaʻilio me kāu kauka e pili ana i kāu pae pilikia.

ʻO nā hoʻoilina hoʻoilina hoʻoilina i hoʻoili ʻia me kēia maʻi ʻo:

• ataxia telangiectasia, i hoʻokumu ʻia e nā hoʻololi hoʻololi i ka ʻohana ATM
• ʻohana (a hoʻoilina paha) pancreatitis, ma muli o ka hoʻololi ʻana i ka gen PRSS1
• polyposis adenomatous ʻohana, i hoʻokumu ʻia e kahi ʻāpana APC hemahema
• ʻohana mole melanoma maʻi ʻehā, ma muli o nā hoʻololi i ka p16 / CDKN2A
• hoʻoilina hoʻoilina a me ka maʻi ʻaʻai ovarian cancer, i hoʻokumu ʻia e BRCA1 a me BRCA2 hoʻololi mutation
• Li-Fraumeni maʻi, ka hopena o kahi kīnā ma ka ʻaoʻao p53
• Maʻi ʻo Lynch (hereditary nonpolyposis colorectal cancer), maʻa mau ʻia e nā genes MLH1 a MSH2 hemahema paha.
• mau neoplasia endocrine, ʻano 1, i hoʻokumu ʻia e ka hewa MEN1 hewa
• neurofibromatosis, ʻano 1, ma muli o nā hoʻololi i ka gen NF1
• ʻO Peutz-Jeghers Syndrome, i kumu ʻia e nā kīnā ma ka gen STK11
• ʻO Von Hippel-Lindau maʻi, ka hopena o nā hoʻololi i ka gen VHL

"Ka maʻi ʻaʻai pancreatic" ʻo ia hoʻi ke holo nei i loko o kahi ʻohana kikoʻī kahi:

• Ma ka liʻiliʻi he ʻelua mau mākelē degere mua (makua, hoahānau, a keiki) i loaʻa i ka maʻi ʻaʻai pancreatic.
• ʻEkolu a ʻoi paha mau ʻohana me ka maʻi ʻaʻai pancreatic ma ka ʻaoʻao like o ka ʻohana.
• Aia kekahi maʻi maʻi maʻi ʻohana i ʻike ʻia a me hoʻokahi lālā o ka ʻohana me ka maʻi ʻaʻai pancreatic.

ʻO nā kūlana ʻē aʻe i hiki ke hoʻonui i ka makaʻu o ka maʻi ʻaʻai pancreatic:

• pancreatitis mau
• cirrhosis o ke ake
• ʻO ka maʻi Helicobacter pylori (H. pylori)
• ʻano 2 diabetes

ʻO nā kumu ʻē aʻe e pili pū me:

• Makahiki. Ma mua o 80 pākēneka o nā kanesa pancreatic e hoʻomohala i ka poʻe ma waena o nā makahiki o 60 a me 80.
• Hoohanau. Loaʻa i kahi kāne kahi kiʻekiʻe kiʻekiʻe ma mua o nā wahine.
• Heihei. ʻOi aku ka nui o ka makaʻu o ʻAmelika-ʻAmelika ma mua o nā Caucasians.

Hiki i nā mea ola ke hoʻonui i ka makaʻu o ka maʻi ʻaʻai pancreatic. O kahi laʻana:

• Puhipaka ua pāpālua ka paka i kou makaʻu i ka ulu ʻana i ka maʻi ʻaʻai pancreatic. ʻO nā cigar, nā paipu, a me nā huahana paka ʻole ʻole e hoʻāla aʻe i kou makaʻu.
• Momona hāpai i ka makaʻu o ka maʻi ʻaʻai pancreatic ma kahi o 20 pakeneka.
• Hōʻike kaumaha i nā kemika hoʻohana ʻia i ka hana hao a me nā ʻoihana hoʻomaʻemaʻe maloʻo hiki ke hāpai i kāu makaʻikaʻi.

Pehea ka maʻamau o ka maʻi ʻaʻai pancreatic?

He ʻano maʻi maʻi ʻaʻai liʻiliʻi loa ia. Ma kahi o 1.6 pākēneka o ka poʻe e hoʻomohala i ka maʻi ʻaʻai pancreatic i ko lākou ola.

Nā ʻōuli e nānā pono ai

ʻO ka hapa nui o ka manawa, ʻaʻole maopopo nā ʻōuli i ka maʻi ʻaʻai pancreatic mua.

Ke holo mua nei ka maʻi ʻaʻai, hiki i nā hōʻailona a me nā ʻōuli ke hoʻopili pū.

• ʻeha ma kou ʻōpū o luna, e hoʻomālamalama ana paha i kou kua
• nalo ʻai ʻole
• Kaumaha emi
• luhi
• melemele o ka ʻili a me nā maka (jaundice)
• ka hoʻomaka ʻana o ka maʻi kō
• kaumaha

I ka manawa e ʻike ai i kāu kauka

ʻAʻohe hōʻike loiloi maʻamau no ka poʻe ma ka awelika o ka maʻi ʻaʻai pancreatic.

E noʻonoʻo ʻia ʻoe i ka hoʻonui ʻia o ka makaʻu inā he moʻolelo ʻohana kāu no ka maʻi ʻaʻai pancreatic a i ʻole he pancreatitis mau. Inā ʻo ia ka hihia, hiki i kāu kauka ke kauoha i nā hoʻokolohua koko e kānana no nā hoʻololi ʻana o nā gen e pili ana i ka maʻi ʻaʻai pancreatic.

Hiki i kēia mau hoʻāʻo ke haʻi iā ʻoe inā loaʻa iā ʻoe nā hoʻololi, akā ʻaʻole inā loaʻa ʻoe i ka maʻi ʻaʻai pancreatic. Eia kekahi, ʻo ka loaʻa ʻana o nā hoʻololi ʻana o ka ʻāpana ʻaʻole ia he kumu e loaʻa ai ʻoe i ka maʻi ʻaʻai pancreatic.

Inā ʻoe ma ka awelika a kiʻekiʻe paha o ka makaʻu, nā ʻōuli e like me ka ʻeha o ka ʻōpū a me ka pohō kaumaha ʻaʻole ia he kumu no ka maʻi ʻaʻai pancreatic. Hiki i kēia mau mea ke hōʻailona o nā ʻano ʻano like ʻole, akā he mea nui e ʻike i kāu kauka no ke kuhi. Inā loaʻa iā ʻoe nā hōʻailona o ka jaundice, e ʻike koke i kāu kauka.

He aha ka mea e manaʻo ai mai ka hōʻailona

E makemake kāu kauka e lawe i kahi mōʻaukala olakino maikaʻi.

Ma hope o kahi hoʻokolohua kino, hiki i nā hoʻokolohua diagnostics ke:

• Nā hoʻāʻo kiʻi. Hiki ke hoʻohana ʻia ka ultrasound, CT scans, MRI, a me PET scans e hana i nā kiʻi kikoʻī e ʻimi ai i nā mea kūpono ʻole o kāu pancreas a me nā mea ʻā o loko.
• Endoscopic ultrasound. I kēia kaʻina hana, ua hāʻawi ʻia i kahi ʻōiwi lahilahi a maʻalahi (endoscope) i kāu esophagus a i loko o kou ʻōpū e ʻike i kāu pancreas.
• ʻO Biopsy. E hoʻokomo ke kauka i kahi kui kele ma o kou ʻōpū a i loko o ka pancreas e kiʻi i kahi laʻana o ka mea hoʻohuoi. E nānā kahi pathologist i ka specimen ma lalo o kahi microscope e hoʻoholo inā maʻi maʻi nā hunaola.

Hiki i kāu kauka ke hōʻoia i kou koko no nā hōʻailona tumo i pili me ka maʻi ʻaʻai pancreatic. Akā ʻaʻole kēia hōʻike he mea pono diagnostic pono; hoʻohana mau ʻia ia e loiloi i ke ʻano o ka maikaʻi o ka mālama ʻana.

He aha ka hana aʻe?

Ma hope o ka hōʻoia ʻana, pono e hoʻonohonoho ʻia ka maʻi ʻaʻai e like me ka nui o kona hoʻolaha ʻana. Hoʻokumu ʻia ka maʻi ʻaʻai Pancreatic mai 0 a 4, me 4 ʻo ia ka holomua loa. Kōkua kēia i ka hoʻoholo ʻana i kāu mau koho lapaʻau, i komo pū me ke kahakaha ʻana, ka radiation radiation, a me ka chemotherapy.

No nā kumu lapaʻau, hiki ke hoʻonohonoho ʻia i ka maʻi ʻaʻai pancreatic e like me:

• Resectable. ʻIke ʻia hiki ke wehe ʻia i ka tumo i loko o kāna holoʻokoʻa.
• Kuhi ʻia ka palena palena palena. Ua hiki aku ka maʻi ʻaʻai i nā moku koko kokoke, akā hiki nō paha i ka mea hōʻoki ke wehe loa iā ia.
• Unresectable. ʻAʻole hiki ke hemo loa i ke kahakaha.

E noʻonoʻo kāu kauka i kēia, me kāu ʻike olakino piha, e kōkua i ka hoʻoholo ʻana i nā lāʻau maikaʻi loa nāu.