Nicotinamide Riboside: nā pono, nā hopena ʻaoʻao a me nā hana

Anter

• He aha ʻo Nicotinamide Riboside?
• Nā Pōmaikaʻi kūpono
• Hoʻololi maʻalahi i NAD +
• Hoʻoulu i nā Enzymes e hoʻoulu i ke ola olakino
• Hiki ke kōkua i ka pale ʻana i nā keena lolo
• Hiki i ka maʻi maʻi puʻuwai haʻahaʻa
• Nā Pōmaikaʻi kūpono ʻē aʻe
• Nā Pilikia Hiki a me nā ʻaoʻao ʻaoʻao
• Nā hana a me nā ʻōlelo aʻoaʻo
• Ka Laina Lalo

I kēlā me kēia makahiki, hoʻolilo nā ʻAmelika i nā piliona kālā ma nā huahana anti-kūnewa.

ʻOiai ka hapanui o nā huahana anti-kūnewa e hoʻāʻo e hoʻohuli i nā hōʻailona o ka ʻelemakule ma kou ʻili, ʻo ka nicotinamide riboside - i kapa ʻia hoʻi ʻo niagen - makemake e hoʻohuli i nā hōʻailona o ka ʻelemakule mai loko o kou kino.

Ma loko o kou kino, hoʻololi ʻia ʻo ribotide nikotinamide i NAD +, kahi mole kōkua i loaʻa i loko o kēlā me kēia o kou keena a kākoʻo i nā ʻano he nui o ka ʻelemakule olakino.

Hōʻike kēia ʻatikala i nā mea āpau e pono ai ʻoe e ʻike e pili ana i ka ribotide nikotinamide, me nā pono, nā hopena ʻaoʻao a me nā ana.

He aha ʻo Nicotinamide Riboside?

ʻO Nicotinamide riboside, a niagen paha, kahi ʻano ʻokoʻa o ka wikamina B3, i kapa ʻia hoʻi ʻo niacin.

E like me nā ʻano huaola B3, ua hoʻohuli ʻia ka ribotide nikotinamide e kou kino i nicotinamide adenine dinucleotide (NAD +), kahi coenzyme a i ʻole ka mole kōkua.

Hana ʻo NAD + i wahie no nā kiʻinaolaolaola kī nui, e like me (,):

• Hoʻohuli i ka meaʻai i ka ikehu
• Ke hoʻoponopono nei i ka DNA i hōʻino ʻia
• ʻO nā ʻōnaehana pale pale pale paʻa
• Ke hoʻonohonoho nei i ka uaki o loko o kou kino a i ʻole ka ritima circadian

Eia nō naʻe, hāʻule maoli ka nui o NAD + i kou kino me ka makahiki ().

Ua pili nā pae haʻahaʻa ʻo NAD + i nā hopohopo olakino e like me ka ʻelemakule a me nā maʻi mau, e like me ka maʻi kō, ka maʻi puʻuwai, ka maʻi ʻo Alzheimer a me ka nalo ʻana o ka ʻike ().

ʻO ka mea hoihoi, ua ʻike ka noiʻi holoholona i ka hāpai ʻana i nā pae NAD + i hiki ke kōkua i ka hoʻohuli i nā hōʻailona o ka ʻelemakule a hoʻohaʻahaʻa i ka nui o nā maʻi maʻi (,,).

Ua lilo wikiwiki nā Nicotinamide riboside - e like me ka niagen - no ka mea he mea maikaʻi loa ia i ka hāpai ʻana i nā pae NAD + ().

Loaʻa pū ʻo Nicotinamide riboside i nā huina helu i ka waiū o nā bipi, ka hū a me ka pia ().

ʻO Nicotinamide riboside, a niagen paha, kahi ʻano ʻokoʻa o ka wikamina B3. Hoʻonui ʻia ia ma ke ʻano he anti-ʻelemakule kumukanawai no ka mea hoʻonui ia i nā pae o kou kino o NAD +, ka mea e hana ma ke ʻano he wahie no nā hana biolo kī nui.

Nā Pōmaikaʻi kūpono

Ma muli o ka hapanui o ka noiʻi ʻana ma ka ribotide nikotinamide a me ka NAD + mai ka noiʻi holoholona ʻana, ʻaʻole hiki ke hoʻoholo ʻia i ka hopena maopopo e pili ana i ka hopena no nā kānaka.

ʻLelo ʻia, eia kekahi mau pono ke olakino maikaʻi o ka ribotide nikotinamide.

Hoʻololi maʻalahi i NAD +

ʻO NAD + kahi coenzyme, a i ʻole ka mole kōkua, i komo i loko o nā hopena biology.

ʻOiai he mea nui ia no ke olakino maikaʻi, hōʻike ka noiʻi e hoʻomau ka hāʻule o nā pae NAD + me ka makahiki. Pili nā pae haʻahaʻa NAD + i ka ʻelemakule ʻelemakule a me nā ʻano maʻi ʻino (,).

ʻO kahi ala e hāpai ai i nā pae NAD + e hoʻopau i ka NAD + precursors - nā hale kūkulu o NAD + - e like me ka ribotide nikotinamide.

Hōʻike nā haʻawina holoholona e hāpai ana ʻo nicotinamide riboside i ke kiʻekiʻe o ke koko NAD + a i ka 2.7 mau manawa. ʻO ka mea hou aku, hoʻohana maʻalahi ʻia ia e kou kino ma mua o nā mea mua o NAD + ().

Hoʻoulu i nā Enzymes e hoʻoulu i ke ola olakino

Kōkua ka Nicotinamide riboside i ka hoʻonui ʻana i nā pae NAD + i kou kino.

I ka pane, hoʻāʻo ʻo NAD + i kekahi mau enzyme i hāpai i ka ʻelemakule olakino.

Hoʻokahi hui he sirtuins, i ʻike ʻia e hoʻomaikaʻi ai i ke ola a me ke olakino holoʻokoʻa i nā holoholona. Hōʻike nā noiʻi e hiki i nā sirtuins ke hoʻoponopono i ka DNA i hōʻino ʻia, hoʻonui i ke kūpaʻa o ke koʻikoʻi, hōʻemi i ka mumū a hāʻawi i nā keu pono ʻē aʻe e hāpai i ka ʻelemakule olakino

ʻO nā Sirtuins ke kuleana no ka pōmaikaʻi ke hoʻonui nei i ke ola o ka kaohi calorie ().

ʻO kekahi hui ʻo Poly (ADP-Ribose) polymerases (PARPs), kahi e hoʻoponopono ai i ka DNA i hōʻino ʻia. Loulou nā haʻawina i ka hana PARP ʻoi aku i ka hōʻemi ʻana i ka DNA a me ka lōʻihi o ke ola (,).

Hiki ke kōkua i ka pale ʻana i nā keena lolo

He kuleana nui ʻo NAD + i ke kōkua maikaʻi ʻana i nā pūnaewele lolo.

Ma loko o nā pūnaewele lolo, kōkua ka NAD + i ka hana ʻana o PGC-1-alpha, kahi protein i ʻike ʻia e kōkua i ka pale ʻana i nā hunaola mai ke koʻikoʻi oxidative a me ka hana mitochondrial hōʻino ().

Manaʻo nā kānaka noiʻi pili ke kaumaha oxidative a me ka hana mitochondrial maikaʻi ʻole i pili i nā maʻi lolo e pili ana i ka makahiki e like me ka maʻi Alzheimer a me Parkinson (,,).

I nāʻiole me ka maʻi o Alzheimer, hoʻokiʻekiʻe ka nicotinamide riboside i ka lolo NAD + pae a me ka hana PGC-1-alpha a hiki i 70% a me 50%. Ma ka hopena o ke aʻo ʻana, hana ʻoi aku ka maikaʻi o nāʻiole i nā hana hoʻomanaʻo hoʻomanaʻo ().

I kahi hoʻokolohua paipu hoʻowalewale, hāpai ʻo nikotinamide riboside i nā pae NAD + a hoʻomaikaʻi maikaʻi i ka hana mitochondrial i nā hunaola i lawe ʻia mai kahi maʻi maʻi Parkinson ().

Eia nō naʻe, ʻaʻole maopopo leʻa ke kōkua o ka hāpai ʻana i nā pae NAD + i nā poʻe me nā maʻi lolo e pili ana i ka makahiki. Pono hou nā aʻo kanaka e pono ai.

Hiki i ka maʻi maʻi puʻuwai haʻahaʻa

ʻO ka ʻelemakule kahi pilikia nui no ka maʻi puʻuwai, ʻo ia ke kumu nui o ka make o ka honua ().

Hiki iā ia ke hana i nā kīʻaha koko e like me kou aorta e lilo i mānoanoa, ʻoʻoleʻa a me ka liʻiliʻi o ka maʻalahi.

Hiki i nā loli ke hāpai i nā kiʻekiʻe o ke koko a hoʻoikaika i kou puʻuwai e hana ʻoi aku ka paʻakikī.

I nā holoholona, ​​ʻo ka hāpai ʻana iā NAD + i kōkua i ka hoʻohuli i nā hoʻololi pili i ka makahiki i nā aʻa ().

I nā kānaka, hāpai ka nicotinamide riboside i nā pae NAD +, kōkua i ka hoʻēmi ʻana i ka ʻoʻoleʻa ma ke aorta a hoʻohaʻahaʻa i ke kahe o ke koko systolic i nā mākua i ka makaʻu i ke kiʻekiʻe o ke koko (22).

ʻLelo ʻia, pono hou ʻia ka noiʻi kanaka.

Nā Pōmaikaʻi kūpono ʻē aʻe

Hoʻohui ʻia, hāʻawi ʻo nicotinamide riboside i kekahi mau pono ʻē aʻe:

• Hiki ke kōkua i ka pohō kaumaha: Ua kōkua ʻo Nicotinamide riboside i ka wikiwiki o ka metabolism o nāʻiole. Eia nō naʻe, maopopo ʻole inā hopena like ka hopena i loko o ke kanaka a pehea ka ikaika o kēia hopena ().
• Hiki ke hoʻoweliweli i ka maʻi ʻaʻai. Kōkua nā pae kiʻekiʻe NAD + i ka pale ʻana i ka hōʻino ʻana o DNA a me ke koʻikoʻi oxidative, e pili ana i ka ulu ʻana o ka maʻi ʻaʻai (,).
• Hiki ke kōkua i ka mālama ʻana i ka jet lag: Kōkua ʻo NAD + i ka hoʻoponopono ʻana i ka uaki o loko o kou kino, no laila ke kōkua ʻana i ka niagen e kōkua i ka mālama ʻana i ka jet lag a i ʻole nā ​​maʻi leʻa circadian ʻē aʻe e ka hoʻonohonoho hou ʻana i ka uaki o kou kino ().
• Paipai i ke ola ʻana i nā mākala olakino: ʻO ka hāpai ʻana i nā pae NAD + i kōkua i ka hoʻomaikaʻi ʻana i ka hana o ka mākala, ka ikaika a me ka hoʻomanawanui i nā ʻiole ʻelemakule (,).

Hoʻonui ka Nicotinamide riboside i nā pae o NAD +, pili i nā pono olakino hiki ke loaʻa e pili ana i ka ʻelemakule, olakino lolo, pilikia maʻi puʻuwai a me nā mea hou aʻe.

Nā Pilikia Hiki a me nā ʻaoʻao ʻaoʻao

Maluhia paha ʻo Nicotinamide riboside me ka liʻiliʻi - inā loaʻa - nā hopena ʻaoʻao.

I nā noiʻi kanaka, ʻo ka lawe ʻana i ka 1000-2,000 mg i kēlā me kēia lā ʻaʻole i loaʻa nā hopena ʻino (,).

Eia nō naʻe, pōkole ka hapanui o nā noiʻi kanaka a he kakaikahi wale nā ​​mea komo. No kahi manaʻo pololei o kona palekana, pono i nā aʻo kanaka ikaika hou aku.

Ua hōʻike kekahi poʻe i nā hopena ʻoluʻolu a me ke kaulike, e like me ka nausea, luhi, headache, diarrhea, discomfort o ka ʻōpū a me ka huhū ().

I nā holoholona, ​​lawe 300 mg no kg o ke kaumaha o ke kino (136 mg i ka paona) i kēlā me kēia lā no 90 mau lā i loaʻa ʻole nā ​​hopena ʻino ().

ʻO ka mea hou aku, ʻaʻole like me nā huaʻai B3 (niacin), pono ʻole nā ​​ribotide nikotinamide e hoʻoulu i ka helehelena ().

Kūpono ʻo Nicotinamide riboside me kahi palekana. Eia nō naʻe, ʻike ʻole ʻia kona hopena lōkahi i nā kānaka.

Nā hana a me nā ʻōlelo aʻoaʻo

Loaʻa ʻo Nicotinamide riboside i ka papa a i ʻole ke ʻano capsule a kapa ʻia he niagen.

Loaʻa ia ma nā hale kūʻai meaʻai olakino koho ʻia, ma Amazon a i ʻole ma o nā mea kūʻai aku pūnaewele.

Aia nā mea hoʻopili Niagen ma loko o ka riboside nikotinamide wale nō, akā hoʻohui ʻia kekahi mau mea hana me nā mea like e like me Pterostilbene, kahi polyphenol - kahi antioxidant e like me chemically like me resveratrol ().

Paipai ka hapa nui o nā niagen supplement brand e lawe i ka 250-300 mg i kēlā me kēia lā, ka like o 1-2 capsule i kēlā me kēia lā ke kaukaʻi ʻia.

Paipai ka hapa nui o nā mea hana niagen e lawe i ka 250-300 mg o ka nikotinamide riboside i kēlā me kēia lā.

Ka Laina Lalo

ʻO Nicotinamide riboside kahi ʻano koho o ka huaʻai B3 me nā hopena ʻē aʻe. Kūʻai ʻia aku ia ma ke ʻano he huahana anti-kūnewa.

Hoʻohuli kou kino iā ia i NAD +, kahi e hoʻoulu ai i kāu mau hunaola āpau. ʻOiai hāʻule kūlohelohe nā pae NAD + me ka makahiki, e hoʻonui ana i nā pae NAD + i mau hōʻailona o ka ʻelemakule.

Eia nō naʻe, ʻo ka hapanui o ka noiʻi ʻana ma ka ribotide nikotinamide a me NAD + i loko o nā holoholona. Pono nā aʻo kanaka kiʻekiʻe kiʻekiʻe e pono ai ma mua o ka paipai ʻana iā ia ma ke ʻano he lapaʻau.