Nā hana hou a me nā lāʻau no Ulcerative Colitis

Anter

• Nā hoʻoponopono o kēia manawa
• ʻO Aminosalicylates
• Corticosteroids
• Immunomodulators
• Nā poloka TNF
• ʻOki kino
• Nā lāʻau hou
• ʻO Tofacitinib (Xeljanz)
• ʻO Biosimilars
• Nā hana i lalo o ka hoʻokolokolo ʻana
• Ke kuʻi fecal
• ʻO ka hoʻōla pūnana paʻa
• Nā hoʻāʻo hoʻokolohua
• Lawe aku

Hōʻike Overview

Ke loaʻa ʻoe i ka colitis ulcerative (UC), ʻo ka pahuhopu o ka mālama ʻana e hōʻoki i kāu ʻōnaehana pale maʻi mai ka hoʻouka ʻana i ka uhi o kou ʻōpū. E hoʻohaʻahaʻa kēia i ka mumū e hiki ai i kāu mau hōʻailona, ​​a waiho iā ʻoe i ke kala. Hiki i kāu kauka ke koho mai nā ʻano lāʻau like ʻole e kōkua iā ʻoe e hoʻokō i kēia mau pahuhopu.

I nā makahiki i hala iho nei, ua hoʻonui ʻia ka nui o nā lāʻau i hoʻohana ʻia e mālama iā UC. Ke aʻo nei nā kānaka noiʻi i nā lāʻau lapaʻau hou aʻe a hoʻomaikaʻi paha i nā hoʻokolohua hoʻokolohua.

Nā hoʻoponopono o kēia manawa

Loaʻa kekahi mau ʻano lāʻau like ʻole e mālama iā UC. E kōkua kāu kauka iā ʻoe e koho i kekahi o kēia mau therapies e pili ana i:

• ke koʻikoʻi o kāu maʻi (ʻoluʻolu, akahai, a koʻikoʻi paha)
• ʻo nā lāʻau hea i lawe mua ʻia
• pehea kāu pane i kēlā mau lāʻau
• kou olakino holoʻokoʻa

ʻO Aminosalicylates

Loaʻa kēia hui o nā lāʻau i ka mea hoʻohui 5-aminosalicylic acid (5-ASA). Pākuʻi ʻia lākou:

• sulfasalazine (Azulfidine)
• mesalamine (Canasa)
• olsalazine (Dipentum)
• balsalazide (Colazal, Giazo)

Ke lawe ʻoe i kēia mau lāʻau i ka waha a i ʻole ma ke ʻano he enema, kōkua lākou i ka lawe ʻana i ka mumū i loko o kou ʻōpū. Hana maikaʻi ʻo Aminosalicylates no ka UC akahai i ka waena, a hiki ke kōkua i ka pale ʻana i nā lapalapa ahi.

Corticosteroids

ʻO Corticosteroids (lāʻau lāʻau steroid) kaomi i ka ʻōnaehana pale e lawe i lalo i ka mumū. ʻO nā laʻana me:

• prednisone
• prednisolone
• methylprednisolone
• budesonide

Kauoha paha kāu kauka i kekahi o kēia mau lāʻau i ka wā pōkole e hoʻomaha i kahi lapalapa hōʻailona. ʻAʻole ia he manaʻo maikaʻi e noho ma ka wā lōʻihi ʻo steroid, no ka mea hiki iā lākou ke hoʻopilikia i nā pilikia e like me ke kō kiʻekiʻe o ke kō, ka loaʻa ʻana o ke kaumaha, nā maʻi, a me ka nalo ʻana o ka iwi.

Immunomodulators

Hoʻopau kēia mau lāʻau i kou ʻōnaehana pale e pale iā ia mai ka hoʻoulu ʻana i ka momona. E hoʻomaka paha ʻoe i ka lawe ʻana i kekahi o kēia mau lāʻau inā ʻaʻole i kōkua nā aminosalicylates i kāu mau hōʻailona. ʻO nā laʻana o nā immunomodulator:

• azathioprine (Azasan)
• 6-merc laptopurine (6MP) (Purinethol)
• cyclosporine (Sandimmune, Neoral, a me nā mea ʻē aʻe)

Nā poloka TNF

ʻO nā mea pale TNF kahi ʻano o ka lāʻau biologic. Hana ʻia nā meaolaolaola mai nā protein i hana ʻia i genetically a i ʻole nā ​​mea kūlohelohe. Hana lākou i nā ʻāpana kikoʻī o kāu ʻōnaehana pale maʻi e hoʻokau i ka mumū.

Pākuʻi nā lāʻau anti-TNF i kahi protein immune system i kapa ʻia ʻo tumrosis factor (TNF) e hoʻonāukiuki i ka mumū. Hiki iā lākou ke kōkua i ka poʻe me ka UC kaulike a koʻikoʻi paha nona nā ʻōuli i hoʻomaikaʻi ʻole ʻia ma nā lāʻau ʻē aʻe.

Pākuʻi ʻia ʻo TNF i:

• adalimumab (Humira)
• golimumab (Simponi)
• infliximab (Remicade)
• vedolizumab (Entyvio)

ʻOki kino

Inā ʻaʻole i kāohi ka lāʻau āu i hoʻāʻo ai i kāu mau ʻōuli a i ʻole oki ka hana ʻana, pono paha ʻoe i ke ʻoki. ʻO ke kaʻina hana i kapa ʻia ʻo proctocolectomy e kāpae i ke kolona holoʻokoʻa a me ka pololei e pale ai i ka hoʻā hou.

Ma hope o ke kahakaha ʻana, ʻaʻole āu kolone e mālama i nā ʻōpala. E hana kāu mea lōkō i kahi ʻeke ma waho o kou kino i kapa ʻia he ileostomy, a i ʻole i loko o kou kino mai kahi ʻāpana o kou ʻōpū liʻiliʻi (ileum).

He ʻanuʻu nui ke ʻoki kino, akā e hoʻomaha ia i nā ʻōuli o UC.

Nā lāʻau hou

I nā makahiki i hala iho nei, ua kupu mai kekahi mau ʻano lapaʻau hou o ka UC.

ʻO Tofacitinib (Xeljanz)

ʻO Xeljanz kahi papa o nā lāʻau i ʻike ʻia ʻo nā mea kāohi ʻo Janus kinase (JAK). Paʻa kēia mau lāʻau i ka enzyme JAK, ka mea e hoʻoulu ai i nā hunaola o ka ʻōnaehana pale e hoʻohua i ka momona.

Ua ʻae ʻia ʻo Xeljanz mai ka makahiki 2012 e mālama i ka rheumatoid arthritis (RA), a mai ka 2017 e mālama i ka psoriatic arthritis (PsA). I ka makahiki 2018, ua ʻae pū ka FDA e mālama i nā poʻe me ka UC kaulike a koʻikoʻi ʻole i pane ʻole i nā poloka TNF.

ʻO kēia lāʻau lapaʻau ka lāʻau lapaʻau mua lōʻihi no ka UC kaulike a koʻikoʻi. Pono nā lāʻau ʻē aʻe i kahi infusion a i ʻole injection. ʻO nā hopena ʻē aʻe mai Xeljanz me nā kolesterol kiʻekiʻe, ʻeha poʻo, diarrhea, colds, rashes, a me nā shingles.

ʻO Biosimilars

ʻO Biosimilars kahi papa hou o nā lāʻau i hoʻolālā ʻia e mimic i nā hopena o nā biologics. E like me nā biologics, hoʻopili kēia mau lāʻau i nā protein immune system e kōkua i ka puhū.

Hana like nā Biosimilars ma ke ʻano like me nā biologics, akā ʻoi aku ka liʻiliʻi o kā lākou kumukūʻai. Pākuʻi ʻia nā leka ʻehā i ka hopena o ka inoa e kōkua i ka hoʻokaʻawale ʻana i ka lāʻau biosimilar mai ka biologic kumu.

Ua ʻae ʻo FDA i kekahi mau biosimilars no UC i nā makahiki i hala iho nei, e like me:

• infliximab-abda (Renflexis)
• infliximab-dyyb (Inflectra)
• infliximab-qbtx (Ixifi)
• adalimumab-adbm (Cyltezo)
• adalimumab-atto (Amjevita)

Nā hana i lalo o ka hoʻokolokolo ʻana

Ke ʻimi mau nei nā mea noiʻi i nā ala maikaʻi e kāohi ai iā UC. Eia kekahi mau lapaʻau hou e hoʻokolokolo ʻia ana.

Ke kuʻi fecal

ʻO kahi transplant fecal, a i ʻole transcooles transcision, kahi hana hoʻokolohua e hoʻonoho i nā koʻohune olakino mai kahi pahu o ka mea hāʻawi i loko o ke kolona o kekahi me UC.ʻAno maikaʻi ʻole paha ka manaʻo, akā kōkua ka bacteria maikaʻi i ka hoʻōla ʻana i ka pōʻino mai UC a hoʻihoʻi i ke kaulike olakino o nā g germ i loko o ka ʻōpū.

ʻO ka hoʻōla pūnana paʻa

ʻO nā pūnaʻi koʻokoʻo nā hunaola ʻōpio e ulu a pau i nā hunaola a me nā ʻano i loko o kā mākou kino. He hiki nō iā lākou ke hoʻōla i nā ʻano ʻino āpau inā mākou e hoʻohana a hoʻohana pololei. I UC, hoʻololi paha nā hunaola i ka ʻōnaehana pale i kahi ala e kōkua ai i ka lawe ʻana i lalo i ka mumū a hoʻōla i ka pohō.

Nā hoʻāʻo hoʻokolohua

Loaʻa ka laulā o nā koho lapaʻau no nā kauka no UC ma mua. ʻOiai me nā lāʻau he nui, pilikia kekahi poʻe i ka ʻimi ʻana i hoʻokahi e pono ai no lākou.

Ke aʻo mau nei nā mea noiʻi i nā ala lapaʻau hou i nā hoʻokolohua hoʻokolohua. ʻO ka hui ʻana i hoʻokahi o kēia mau noiʻi hiki ke hāʻawi iā ʻoe i ke komo i ka lāʻau i mua o ka loaʻa ʻana i ka lehulehu. E noi i ke kauka nāna e mālama i kāu UC inā he hoʻokolohua hoʻokolohua i kou wahi i kūpono no ʻoe.

Lawe aku

ʻOi aku ka maikaʻi o ke kuanaʻike no ka poʻe me UC i kēia lā, mahalo i nā lāʻau hou i hiki ke hoʻomaha i ka ʻōpū o ka ʻōpū. Inā ua hoʻāʻo ʻoe i kahi lāʻau ʻaʻole kōkua ia iā ʻoe, e ʻike i nā koho ʻē aʻe e hoʻomaikaʻi ai i kāu mau ʻōuli. E kūpaʻa, a hana pū me kāu kauka e ʻike i kahi hoʻomaʻamaʻa e hana pono iā ʻoe.