Mea Kākau: Roger Morrison
Lā O Ka Hana: 28 Kepakemapa 2021
HōʻAno Hou I Ka Lā: 13 Nowemapa 2024
Anonim
Methotrexate - Pharmacology (DMARDs, mechanism of action, side effects)
Wikiō: Methotrexate - Pharmacology (DMARDs, mechanism of action, side effects)

Anter

ʻO ka Methotrexate papa kahi lāʻau i hōʻike ʻia no ka mālama ʻana i ka rheumatoid arthritis a me ka psoriasis koʻikoʻi ʻaʻole e pane i nā ʻano lāʻau ʻē aʻe. Hoʻohui ʻia, loaʻa pū ka methotrexate ma ke ʻano he injectable, hoʻohana ʻia i ka chemotherapy no ka mālama ʻana i ka maʻi ʻaʻai.

Loaʻa kēia lāʻau i ke ʻano o ka pill a i ʻole ka injection a hiki ke loaʻa i nā hale kūʻai lāʻau ma lalo o nā inoa o Tecnomet, Enbrel a me Endofolin, no ka laʻana.

No ke aha ia

Hōʻike ʻia ka Methotrexate i loko o nā papa no ka mālama ʻana i ka rheumatoid arthritis, ʻoiai he hopena ia i ka ʻōnaehana pale, hoʻemi i ka mumū, ʻike ʻia kāna hana mai ka pule 3 o ka lapaʻau.I ka mālama ʻana i ka psoriasis, hoʻemi ka methotrexate i ka hoʻolaha a me ka mumuna o nā huna o ka ʻili a ʻike ʻia nā hopena i 1 a 4 mau pule ma hope o ka hoʻomaka ʻana o ka lapaʻau.


Hōʻike ʻia ka methotrexate injectable e mālama i ka psoriasis koʻikoʻi a me nā ʻano like ʻole o ka maʻi ʻaʻai.

  • Nā neoplasms trophoblastic gestational;
  • Leukemias lymphocytic huikau;
  • Maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi;
  • Maʻi ʻaʻai poʻo a me ka ʻāʻī;
  • Maʻi ʻaʻai umauma;
  • Osteosarcoma;
  • Iapaau ana a me prophylaxis o lymphoma a meningeal leukemia;
  • Palliative therapy no nā tumors paʻa paʻa ʻole i hiki ʻole ke hoʻohana ʻia;
  • Nā lymphomas Non-Hodgkin a me Burkitt's lymphoma.

Pehea e ho ohana

1. Rheumatoid arthritis

Hiki i ka mahele oral paipai ke 7.5 mg, hoʻokahi manawa i ka pule a i ʻole 2.5 mg, i kēlā me kēia 12 hola, no ʻekolu mau kaha, lawelawe ʻia ma ke ʻano he pōʻai, hoʻokahi manawa i ka pule.

Pono e hoʻoponopono mālie i nā lāʻau no kēlā me kēia regimen e hoʻokō i kahi pane kūpono, akā ʻaʻole pono e ʻoi aku i ka nui o nā mahele o 20 mg i kēlā me kēia pule.

2. ʻO Psoriasis

ʻO ka mahele lāʻau i ʻōlelo ʻia 10 - 25 mg i kēlā me kēia pule, a hiki i ka loaʻa ʻana o kahi pane kūpono a i ʻole, 2.5 mg, i kēlā me kēia 12 hola, no ʻekolu pahu.


Hiki ke hoʻololi mālie i nā lāʻau i kēlā me kēia regimen e hoʻokō i kahi pane olakino maikaʻi loa, e hōʻalo ana i ka ʻoi loa o 30 mg i kēlā me kēia pule.

No nā hihia o ka psoriasis koʻikoʻi, kahi e hoʻohana ʻia ai ka methotrexate i hoʻokomo ʻia, pono e lawelawe ʻia kahi mahele lāʻau he 10 a 25 mg i kēlā me kēia pule a hiki i ka loaʻa ʻana o kahi pane kūpono. E aʻo e ʻike i nā ʻōuli o psoriasis a me ka mālama pono āu e mālama pono ai.

3. Ka maʻi ʻaʻai

ʻO ka laulā lāʻau lapaʻau o ka methotrexate no nā hōʻailona oncological ākea ākea, kaukaʻi ʻia i ke ʻano o ka maʻi ʻaʻai, ke kaumaha o ke kino a me nā kūlana o ka mea maʻi.

Nā hopena ʻē aʻe

ʻO nā hopena ʻē aʻe i hiki ke hana ʻia i ka wā o ka mālama ʻana me nā papa methotrexate ka maʻi ʻeha nui, ka ʻāʻī o ka ʻāʻī, ka luaʻi, ke kuni, ka ʻulaʻula o ka ʻili, ka hoʻonui ʻia o ka uric acid a me ka hoʻēmi ʻana i ka helu o ka sperm, ke ʻano o nā puʻupuʻu waha, ka palahu o ka alelo a gums, diarrhea, hoʻemi ʻia ke keʻena koko keʻokeʻo a me ka helu platelet, ʻole kōkō a me ka pharyngitis.


ʻO wai ka mea pono ʻole e hoʻohana

Hoʻohālikelike ʻia ka papa Methotrexate no nā mea maʻi me ka maʻi āpau i ka methotrexate a i ʻole nā ​​ʻāpana o ka hoʻokumu ʻana, nā wahine hāpai, nā wahine lactating, nā kānaka me nā ʻōnaehana pale pale, nā ake nui a me nā maʻi kīnā ʻole a me nā loli i nā hunaola e like me ka hoʻemi ʻia o nā hunaola keokeo i nā hunaola keokeo nā huna koko a me nā platelet.

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