Hōʻoiaʻiʻo ʻo HER2 (Ka maʻi ʻaʻai umauma)

Anter

• He aha ka hoʻāʻo ʻana o ka maʻi ʻaʻai HER2?
• No ke aha ia e hoʻohana ai?
• No ke aha e pono ai iaʻu ka hōʻoia ʻana i ka maʻi ʻaʻai umauma HER2?
• He aha ka hana i ka wā o ka hōʻike HER2 umauma maʻi ʻaʻai.
• Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?
• Aia kekahi mau pilikia i ka hoʻāʻo?
• He aha ke ʻano o nā hopena?
• Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i ka hoʻāʻo ʻana o ka maʻi ʻaʻai umauma HER2?
• Nā kūmole

He aha ka hoʻāʻo ʻana o ka maʻi ʻaʻai HER2?

Kū ʻo HER2 i ka mea ulu kanaka epidermal factor receptor 2. ʻO ia kahi ʻāpana e hana i kahi protein i loaʻa ma luna o nā umauma umauma. Hoʻopili ʻia i ka ulu ulu maʻamau.

ʻO Genes nā ʻāpana maʻamau o ka hoʻoilina, hoʻoiho ʻia mai kou makuahine a me kou makuakāne. I kekahi mau maʻi maʻi maʻi, ʻoi loa hoʻi i ka maʻi ʻaʻai o ka umauma, hoʻololi ka ʻohana HER2 (hoʻololi) a hana i nā kope keu o ka ʻāpana. Ke kū kēia, hana ka ʻāpana HER2 i ka protein HER2 nui loa, e hoʻokaʻawale i nā pūnaewele a ulu wikiwiki.

ʻO nā kanesa me nā pae kiʻekiʻe o ka protein HER2 i ʻike ʻia ma ke ʻano he HER2-maikaʻi. ʻIke ʻia nā hōʻino me nā pae haʻahaʻa o ka protein ʻo HER2-maikaʻi ʻole. Ma kahi o 20 pākēneka o nā maʻi ʻaʻai umauma HER2-maikaʻi.

Nānā ʻo HER2 i kahi laʻana o kaʻiʻo tumora. ʻO nā ala maʻamau e hoʻāʻo i nā kiko o ka tumo:

• Ke ana nei ʻo Immunohistochemistry (IHC) i ka protein HER2 ma luna o nā hunaola
• Ke nānā nei ʻo Fluorescence in situ hybridization (FISH) no nā kope keu o ka ʻāpana HER2

Hiki i nā ʻano hoʻokolohua ʻelua ke haʻi inā loaʻa iā ʻoe i ka maʻi ʻaʻai HER2-maikaʻi. ʻO nā kuʻina e kuhikuhi pono i ka HER2-maikaʻi umauma maʻi ʻaʻaiole hiki ke maikaʻi loa.

Nā inoa ʻē aʻe: receptor 2 ulu epidermal ulu kanaka, ERBB2 hoʻonui, HER2 overexpression, HER2 / neu nā hoʻāʻo.

No ke aha ia e hoʻohana ai?

Hoʻohana nui ʻia ka hoʻāʻo HER2 e ʻike inā he HER2-maikaʻi ka maʻi ʻaʻai. Hoʻohana ʻia ia i kekahi manawa e ʻike inā e pane ana ka maʻi ʻaʻai i ka lāʻau lapaʻau a inā ua hoʻi ka maʻi ʻaʻai ma hope o ka lapaʻau.

No ke aha e pono ai iaʻu ka hōʻoia ʻana i ka maʻi ʻaʻai umauma HER2?

Inā ua hōʻoia ʻia ʻoe me ka maʻi ʻaʻai o ka umauma, pono paha ʻoe i kēia hōʻike e ʻike inā he HER2-maikaʻi a he HER2-maikaʻi ʻole kāu maʻi maʻi. Inā ʻoe e mālama ʻia nei no ka maʻi maʻi umauma HER2-maikaʻi, pono paha ʻoe i kēia hōʻoia iā:

• E ʻike inā ke hana nei kāu lāʻau. ʻO nā pae maʻamau o HER2 ke ʻano paha ʻoe e pane nei i ka lāʻau. ʻO nā kiʻekiʻe kiʻekiʻe paha ka manaʻo ʻaʻole holo ka lāʻau.
• E ʻike inā ua hoʻi mai ka maʻi ʻaʻai ma hope o ka lapaʻau ʻana.

He aha ka hana i ka wā o ka hōʻike HER2 umauma maʻi ʻaʻai.

ʻO ka hapa nui o ka hoʻāʻo ʻana ʻo HER2 e pili ana i ka lawe ʻana i kahi laʻana o nā kiko tumora i kahi hana i kapa ʻia he biopsy. ʻEkolu ʻano nui o ke kaʻina hana biopsy:

• ʻO ka biopsy e makemake ai ka nila. e hoʻohana ana i kahi nila keleawe lahilahi loa e wehe i kahi laʻana o nā hunaola umauma a i ʻole ka wai
• ʻO ka biopsy o ka nila nui, e hoʻohana ana i kahi nila nui e wehe i kahi laʻana
• ʻO kahi biopsy ʻoki lāʻau, ka mea e hoʻoneʻe i kahi laʻana i ke kaʻina hana o nā keiki ʻōpio

ʻO ka moʻo o ka nila maikaʻi a me nā biopsies o ka nila nui hoʻohui pū i kēia mau ʻanuʻu:

• E moe ʻoe ma kou ʻaoʻao a noho paha i ka papa hōʻike.
• E hoʻomaʻemaʻe kahi mea mālama ola i ka pūnaewele biopsy a hoʻopili iā ia me kahi anesthetic no laila ʻaʻole ʻoe e ʻike i kahi ʻeha i ka wā o ke kaʻina hana.
• Ke pulu ka ʻāpana, e hoʻokomo ka mea hāʻawi i kahi nila kuʻina maikaʻi a i ʻole ka nila biopsy kumu i loko o ka pūnaewele biopsy a hemo i kahi laʻana o ka aʻa a me ka wai.
• ʻIke paha ʻoe i kahi kaomi iki ke huki ʻia ka hāpana.
• E kau ʻia ka pihi ma ka pūnaewele biopsy a hiki i ke kū ʻana o ke kahe.
• E hoʻopili kāu mea hāʻawi i kahi bandage sterile ma ka pūnaewele biopsy.

I loko o kahi biopsy ʻoki lāʻau, e hana kahi mea ʻokiʻoki i kahi ʻoki liʻiliʻi i kou ʻili e hoʻoneʻe i nā mea āpau a ʻāpana paha o kahi puʻupuʻu umauma. Hana ʻia kahi biopsy ʻoki lāʻau i kekahi manawa inā ʻaʻole hiki ke kiʻi ʻia ka puʻupuʻu me kahi biopsy nila. Hoʻokomo pinepine nā biopsies ʻoki i nā kaʻina hana penei.

• E moe ʻoe ma ka papaʻaina. Hoʻokomo ʻia kahi IV (laina intravenous) i loko o kou lima a lima paha.
• Hāʻawi ʻia ʻoe i ka lāʻau, kapa ʻia he lāʻau hoʻonanea, e kōkua ai iā ʻoe e hoʻomaha.
• Hāʻawi ʻia ʻoe i ka anesthesia kūloko a i ʻole ia no laila ʻaʻole ʻoe e ʻeha i ka wā o ke kaʻina hana.
  • No ka anesthesia kūloko, e hoʻopili kahi mea mālama ola i ka pūnaewele biopsy me ka lāʻau e hoʻopau i ka wahi.
  • No ka anesthesia laulā, kahi mea loea i kapa ʻia he anesthesiologist e hāʻawi iā ʻoe i ka lāʻau no laila e makaʻu ʻole ʻoe i ka wā o ke kaʻina hana.
• I ka manawa e nū ai ka wahi biopsy a i ʻole ʻoe e ʻike ʻole, e ʻokiʻoki ke kaukipoki i ka umauma a hemo i kahi ʻāpana a i ʻole nā ​​puʻupuʻu āpau. Hiki ke hoʻoneʻe ʻia kekahi kiko a puni ka puʻupuʻu.
• E ʻoki ʻia ka ʻoki o kou ʻili me nā humuhumu a i ʻole nā ​​ʻāpana hoʻopili.

ʻO ke ʻano o ka biopsy āu e hilinaʻi ai i nā kumu like ʻole, e like me ka nui a me kahi o ka tumo. Hiki ke ana ʻia ʻo HER2 i kahi hoʻokolohua koko, akā ʻaʻole i hōʻoia ʻia ka hoʻomaʻamaʻa koko no HER2 i mea pono no ka hapanui o nā mea maʻi. No laila ʻaʻole ia e paipai pinepine ʻia.

Ma hope o ka lawe ʻia ʻana o kāu hāpana kiko, e hoʻāʻo ʻia ia ma kekahi o nā ʻano ʻelua:

• E ana ʻia nā pae protein HER2.
• E nānā ʻia ka laʻana no nā kope keu o ka ʻāpana HER2.

Pono wau e hana i kekahi mea e hoʻomākaukau ai no ka hoʻāʻo?

ʻAʻole ʻoe e pono i kahi hoʻomākaukau kūikawā inā loaʻa iā ʻoe kahi anesthesia kūloko (numbing o ka pūnaewele biopsy). Inā loaʻa iā ʻoe ka anesthesia laulaha, pono paha ʻoe e hoʻokē ʻai (ʻaʻole ʻai a inu) no kekahi mau hola ma mua o ke kaha ʻana. E hāʻawi aku kāu mea lapaʻau iā ʻoe i nā ʻōkuhi kikoʻī hou aʻe. Eia kekahi, inā e kiʻi ana ʻoe i kahi lāʻau hoʻohiamoe a anesthesia paha, e mālama pono i kekahi e hoʻokele iā ʻoe i kou home. E huhū paha ʻoe a huikau paha ma hope o kou ala ʻana mai ke kaʻina hana.

Aia kekahi mau pilikia i ka hoʻāʻo?

Loaʻa paha iā ʻoe kahi palapū a kōkō liʻiliʻi paha ma ka pūnaewele biopsy. I kekahi manawa loaʻa ka maʻi i ka pūnaewele. Inā kū kēlā, e mālama ʻia ʻoe me nā antibiotic. Hiki i kahi biopsy ʻoki ke hana i kekahi ʻeha hou a me ka hōʻoluʻolu ʻole. Koi paha kāu kauka olakino i kauka a kauoha paha i ka lāʻau e kōkua iā ʻoe e hōʻoluʻolu.

ʻAʻohe liʻiliʻi loa i ka hōʻoia ʻana o ke koko. Loaʻa paha iā ʻoe ka ʻeha a ʻeha paha ma kahi o ka nila i hoʻokomo ʻia ai, akā ʻo ka hapa nui o nā ʻōuli e hele wikiwiki aku.

He aha ke ʻano o nā hopena?

Inā kiʻekiʻe ke kiʻekiʻe o ka protein HER2 ma mua o nā kope maʻamau a i ʻole keu o ka HER2 gen, loaʻa paha iā ʻoe he maʻi ʻaʻai HER2-maikaʻi. Inā hōʻike kāu hopena i nā helu maʻamau o ka HER2 protein a i ʻole nā ​​helu gen HER2 maʻamau, loaʻa paha iā ʻoe ka maʻi ʻaʻai HER2-maikaʻi ʻole.

Inā ʻaʻole maikaʻi a maikaʻi ʻole paha kāu mau hopena, e hoʻāʻo hou ʻia ʻoe, e hoʻohana ana paha i kahi laʻana tumo ʻokoʻa a i ʻole ka hoʻohana ʻana i kahi ʻano hoʻokolohua ʻokoʻa. ʻO ka hapanui pinepine, IHC (hoʻāʻo no ka protein HER2) i hana mua ʻia, a ukali ʻia e FISH (e hoʻāʻo nei no nā kope keu o ka ʻāpana). ʻOi aku ka pipiʻi o ka hoʻāʻo IHC a hāʻawi i nā hopena wikiwiki ma mua o ka FISH. Akā manaʻo ka hapanui o nā loea i ka umauma ʻoi aku ka pololei o ka hoʻāʻo lawaiʻa FISH.

ʻO nā mālama ʻana no ka HER2-maikaʻi i ka maʻi ʻaʻai umauma hiki ke hoʻoliʻiliʻi nui i nā maʻi maʻi ʻaʻai, me nā hopena liʻiliʻi. ʻAʻole maikaʻi kēia mau mālama ʻana i nā maʻi ʻino HER2-maikaʻi ʻole.

Inā mālama ʻia ʻoe no ka maʻi ʻaʻai HER2-maikaʻi, manaʻo paha nā hopena maʻamau ke pane nei ʻoe i ka lāʻau. Nā hualoaʻa e hōʻike ana i ke kiʻekiʻe ma mua o nā maʻamau maʻamau ke kumu o ka hana ʻole o kāu lapaʻau, a i ʻole hoʻi ua hoʻi mai ka maʻi ʻaʻai ma hope o ka lapaʻau ʻana.

E aʻo hou aʻe e pili ana i nā hoʻokolohua hoʻokolohua, nā pae kuhikuhi, a me ka hoʻomaopopo ʻana i nā hopena.

Aia kekahi mea ʻē aʻe e pono iaʻu e ʻike e pili ana i ka hoʻāʻo ʻana o ka maʻi ʻaʻai umauma HER2?

ʻOiai ʻoi aku ka nui o nā wahine i ʻike ʻia, ʻo ka maʻi ʻaʻai umauma, me HER2-maikaʻi umauma maʻi ʻaʻai, hiki ke hoʻopili i nā kāne. Inā ua hōʻoia ʻia kahi kāne me ka maʻi ʻaʻai umauma, e ʻōlelo ʻia paha ka hoʻāʻo HER2.

Hoʻohui, pono paha i nā kāne a me nā wahine i ka hoʻokolohua HER2 inā ua hōʻoia ʻia lākou me kekahi mau maʻi maʻi ʻōpū o ka ʻōpū a me ka esophagus. ʻO kēia mau maʻi ʻaʻa i nā manawa kiʻekiʻe o ka protein HER2 a hiki ke pane maikaʻi i nā mālama maʻi ʻaʻai HER2-maikaʻi.

Nā kūmole

1. ʻAhahui Kanaka ʻAmelika [Pūnaewele]. Atlanta: ʻAmelika Hui Pū ʻIa ʻAmelika Hui Pū ʻIa. c2018. Biopsy umauma [hōʻano 2017 2017 9; i helu ʻia 2018 Aug 11]; [ma kahi o 4 pale]. Loaʻa mai: https://www.cancer.org/cancer/breast-cancer/screening-tests-and-early-detection/breast-biopsy.html
2. ʻAhahui Kanaka ʻAmelika [Pūnaewele]. Atlanta: ʻAmelika Hui Pū ʻIa ʻAmelika Hui Pū ʻIa. c2018. Kūlana HER2 Ka maʻi ʻaʻai umauma [updated 2017 Sep 25; i helu ʻia 2018 Aug 11]; [ma kahi o 4 pale]. Loaʻa mai: https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancer-diagnosis/breast-cancer-her2-status.html
3. Breastcancer.org [Pūnaewele]. Ardmore (PA): Breastcancer.org; c2018. Kūlana HER2 [hōʻano hou ʻia 2018 Feb 19; i helu ʻia 2018 Aug 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.breastcancer.org/symptoms/diagnosis/her2
4. Cancer.net [Pūnaewele]. Alexandria (VA): ʻAmelika Hui Pū ʻIa o Oncology Lapaʻau; c2005–2018. Ka maʻi ʻaʻai umauma: Diagnosis; 2017 Apr [helu ʻia 2018 ʻAukake 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.cancer.net/cancer-types/breast-cancer/diagnosis
5. Cancer.net [Pūnaewele]. Alexandria (VA): ʻAmelika Hui Pū ʻIa o Oncology Lapaʻau; c2005–2018. Ka maʻi ʻaʻai umauma: Hoʻolauna; 2017 Apr [helu ʻia 2018 ʻAukake 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.cancer.net/cancer-types/breast-cancer/introduction
6. Johns Hopkins Medicine [Pūnaewele]. Ke Kulanui ʻo Johns Hopkins; Waihona Puke Ola: Ka maʻi ʻaʻai umauma: nā papa a me nā pae [i helu ʻia 2018 Aug 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.hopkinsmedisin.org/healthlibrary/conditions/adult/breast_health/breast_cancer_grades_and_stages_34,8535-1
7. Nā Hoʻokolohua Lab ma ka Pūnaewele [Pūnaewele]. Wakinekona D.C.; ʻAhahui ʻAmelika no ka Chemical Clinical; c2001–2018. HER2 [hōʻano hou ʻia 2018 Jul 27; i helu ʻia 2018 Aug 11]; [ma kahi o 2 pale]. Loaʻa mai: https://labtestsonline.org/tests/her2
8. Mayo Clinic [Pūnaewele]. Mayo Foundation no ka Hoʻomaʻamaʻa Lapaʻau a me ka noiʻi; c1998–2018. Biopsy umauma: Ma kahi o 2018 Mar 22 [i helu ʻia 2018 Aug 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.mayoclinic.org/tests-procedures/breast-biopsy/about/pac-20384812
9. Mayo Clinic [Pūnaewele]. Mayo Foundation no ka Hoʻomaʻamaʻa Lapaʻau a me ka noiʻi; c1998–2018. Anesthesia Nui: About; 2017 Dec 29 [i helu ʻia 2018 Aug 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.mayoclinic.org/tests-procedures/anesthesia/about/pac-20384568
10. Mayo Clinic [Pūnaewele]. Mayo Foundation no ka Hoʻomaʻamaʻa Lapaʻau a me ka noiʻi; c1998–2018. Ka maʻi ʻaʻai umauma HER2-maikaʻi: He aha ia ?; 2018 Mar 29 [i helu ʻia 2018 Aug 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.mayoclinic.org/breast-cancer/expert-answers/faq-20058066
11. Kalinika Mayo: Laboratories Lapaʻau ʻo Mayo [Pūnaewele]. Mayo Foundation no ka Hoʻomaʻamaʻa Lapaʻau a me ka noiʻi; c1995–2018. Hōʻike Hōʻike: HERDN: HER2, umauma, DCIS, Immunohistochemistry Quantitative, Manuahi ʻAʻohe Reflex: Clinical a Interpretive [i ʻōlelo ʻia 2018 Aug 11]; [ma kahi o 4 pale]. Loaʻa mai: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/71498
12. MD Anderson Kanaka Maʻi [Pūnaewele]. Ke Kulanui o Texas MD Anderson Cancer Center; c2018. Ka maʻi ʻaʻai umauma [cited 2018 Aug 11]; [ma kahi o 4 pale]. Loaʻa mai: https://www.mdanderson.org/cancer-types/breast-cancer.html
13. Kahi hoʻomanaʻo ʻo Sloan Kettering Cancer Center [Pūnaewele]. Nu Ioka: Hale Hoʻomanaʻo ʻo Sloan Kettering Cancer Center; c2018. He aha kāu e ʻike ai e pili ana i ka maʻi ʻaʻai Metastatic umauma; 2016 ʻOkakopa 27 [i helu ʻia 2018 Aug 11]; [ma kahi o 4 pale]. Loaʻa mai: https://www.mskcc.org/blog/what-you-should- know-about-metastatic-breast
14. Merck Manual Mea Kūʻai Manuahi [Pūnaewele]. Kenilworth (NJ): Merck & Co., Inc. c2018. Ka maʻi ʻaʻai umauma [cited 2018 Aug 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.merckmanuals.com/home/women-s-health-issues/breast-disorder/breast-cancer
15. National Breast Cancer Foundation [Pūnaewele]. Frisco (TX): National Breast Cancer Foundation Inc. c2016. Nā Hoʻokolohua Lab [cited 2018 Aug 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.nationalbreastcancer.org/breast-cancer-lab-tests
16. National Heart, Lung, and Blood Institute [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Nā ho'āʻo koko [i helu ʻia 2018 Aug 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.nhlbi.nih.gov/health-topics/blood-tests
17. Ka Papa ʻInikena Kanaka Makahiki [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Ka Papa Kuhikuhi NCI o nā ʻōlelo maʻi ʻaʻai: ʻāpana [i helu ʻia 2018 ʻAukake 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=gene
18. Ka Papa ʻInikena Kanaka Makahiki [Pūnaewele]. Bethesda (MD): Ke Keʻena ʻOihana Ola a me nā lawelawe kanaka; Ka Papa Kuhikuhi NCI o nā ʻōlelo maʻi ʻaʻai: HER2 hōʻike [i ʻōlelo ʻia 2018 Aug 11]; [ma kahi o 3 pale]. Loaʻa mai: https://www.cancer.gov/publications/dictionaries/cancer-terms/search?contains=false&q=HER2
19. Kulanui o Rochester Medical Center [Pūnaewele]. Rochester (NY): Kulanui o Rochester Medical Center; c2018. Encyclopedia Health: HER2 / neu [helu ʻia 2018 Aug 11]; [ma kahi o 2 pale].Loaʻa mai: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=her2neu

ʻAʻole pono e hoʻohana i ka ʻike ma kēia pūnaewele i pani no ka mālama olakino ʻoihana a ʻōlelo aʻoaʻo paha. Kāhea aku i ka mea mālama ola inā he nīnau kāu e pili ana i kou olakino.