Hiki iaʻu ke loaʻa i ka hua waina i ka lawe ʻana i ka Metformin?

Anter

• He aha ka metformin?
• Pehea e hana ai i nā launa lāʻau me ka huaʻulu
• He aha nā lāʻau e launa pū me ka grapefruit?
• Pehea ka grapefruit e pili ai i ka metformin?
• Nā mea ʻē aʻe e pale aku ai ma metformin
• Pehea e hiki ai i ka grapefruit ke kōkua i ka poʻe me ka maʻi kō
• Lawe aku

I Mei 2020, ua paipai ʻia i kekahi mau mea hana o metformin hoʻolōʻihi hoʻokuʻu ʻia e kāpae i kekahi o kā lākou papa mai ka mākeke U.S. ʻO kēia no ka mea he pae i ʻae ʻole ʻia o kahi carcinogen probable (ʻākena e hana ana i ka maʻi ʻaʻai) i loaʻa i kekahi mau papa metformin hoʻolōʻihi ʻia. Inā lawe ʻoe i kēia lāʻau i kēia manawa, e kāhea i kāu kauka. E ʻōlelo aʻoaʻo lākou inā ʻoe e hoʻomau i ka lawe ʻana i kāu lāʻau a i ʻole inā makemake ʻoe i kahi palapala hou.

Nui nā lāʻau lapaʻau, e like me statins a me kekahi antihistamines, i ka launa maikaʻi ʻole ʻana me ka huaora. Hoʻohana ʻia ʻo Metformin i ka mālama ʻana i ka maʻi diabetes type 2.

ʻO ka loaʻa ʻana o ka huaʻulu i ka wā e lawe ana i ka metformin e alakaʻi i nā hopena ʻino? Loaʻa ka noiʻi liʻiliʻi, akā eia ka mea e pono ai ʻoe e ʻike.

He aha ka metformin?

ʻO Metformin kahi lāʻau i kauoha ʻia e mālama i ka maʻi diabetes type 2. ʻAʻole hiki i ka poʻe me ka maʻi diabetes 2 ke hoʻohana maʻamau i ka insulin. ʻO kēia ʻaʻole hiki iā lākou ke kaohi i ka nui o ke kō i loko o kā lākou koko. Kōkua ʻo Metformin i ka poʻe me ka maʻi diabetes type 2 e kāohi i ka pae o ke kō i loko o kā lākou koko i nā ʻano like ʻole, e like me:

• ke hoʻemi nei i ka nui o ke kō i lawe ʻia i kou kino mai ka meaʻai
• ke hoʻemi nei i ka nui o ke kō i hana ʻia e kou ake
• ke hoʻonui nei i ka pane o kou kino i ka insulin e hana maʻamau

ʻAʻole hiki i ka Metformin ke hana i kahi ʻano koʻikoʻi a hoʻoweliweli hoʻi i kapa ʻia ʻo lactic acidosis. ʻO ka poʻe me ke ake, ka hakuʻala, a me nā pilikia puʻuwai pono e hōʻalo i ka lawe ʻana i ka metformin.

Pehea e hana ai i nā launa lāʻau me ka huaʻulu

Aia kekahi mau mea i ʻike ʻia e launa pū me ka huaora. ʻO kēia mau lāʻau, hiki ke alakaʻi i nā hopena maikaʻi ʻole. ʻO nā ʻano grapefruit āpau - e komo pū me ka wai hou i ʻono ʻia, ka noʻonoʻo paʻahau, a me nā hua holoʻokoʻa - hiki ke alakaʻi i ka launa lāʻau.

ʻO kekahi o nā kemika i loaʻa i ka grapefruit hiki ke hoʻopaʻa a inactivate i kahi enzyme i kou kino i loaʻa i loko o kou ʻōpū a me ke ake. Kōkua kēia enzyme e wāwahi i ka lāʻau āu e lawe ai.

ʻO ka maʻamau ke lawe ʻoe i ka lāʻau ma ka waha, ua wāwahi liʻiliʻi ʻia e nā enzymes ma mua o ka hiki ʻana i kāu kahe koko. ʻO kēia ka loaʻa ʻana iā ʻoe ka liʻiliʻi o ka lāʻau i loko o kou kahena koko ma mua o ka nui āu i hoʻohana mua ai.

Akā i ka wā e pāpā ʻia ai ka enzyme - e like me ka wā e launa pū ai me nā kemika i ka huaʻōlani - aia kahi nui nui loa o ka lāʻau i hiki i kou kahe koko. Hiki i kēia i kahi makaʻu kiʻekiʻe o ka overdose. E nānā hou i ka pilina o ka grapefruit-drug.

He aha nā lāʻau e launa pū me ka grapefruit?

Wahi a ka, hiki i nā ʻano lāʻau aʻe ke loaʻa kahi launa maikaʻi ʻole me ka huaʻulu.

• statins, e like me simvastatin (Zocor) a me atorvastatin (Lipitor)
• nā lāʻau no ke koko kiʻekiʻe, e like me nifedipine (Procardia)
• nā lāʻau immunosuppressive, e like me cyclosporine (Sandimmune)
• hoʻohana ʻia nā corticosteroids e mālama i ka maʻi o Crohn a i ʻole colitis ulcerative, e like me budesonide (Entocort EC)
• nā lāʻau e mālama ai i nā puʻuwai puʻuwai maikaʻi ʻole, e like me amiodarone (Pacerone)
• antihistamines, e like me fexofenadine (Allegra)
• kekahi mau lāʻau anti-hopohopo, e like me buspirone (BuSpar)

ʻAʻohe hopena o ka wai huaʻai i kēlā me kēia lāʻau i nā mahele i luna. ʻO ka launa pū ʻana me ka wai huaʻōlū, he kikoʻī ia no ka lāʻau, ʻaʻole kikoʻī mahele lāʻau.

Ke hoʻomaka nei i kahi lāʻau hou, he mea nui e nīnau ʻoe i kāu kauka a i ʻole ka lāʻau lapaʻau inā hiki iā ʻoe ke hoʻopau i nā huaʻalani a me nā hua ʻalani.

Pehea ka grapefruit e pili ai i ka metformin?

He mea nui ia e ʻike ʻia ʻaʻole i wāwahi ʻia ka metformin e ka enzyme like me nā lāʻau i helu ʻia ma luna. ʻAʻole lawelawe ʻia e kou kino a kipaku ʻia i kāu mimi.

Loaʻa ka palena o ka ʻike e pili ana i ka loaʻa ʻana o ka grapefruit i ka lawe ʻana i ka metformin i nā poʻe me ka maʻi diabetes type 2.

Kūkākūkā i nā hopena o ka huaʻalani me metformin i nā ʻiole nondiabetic. Ua hōʻike ʻia kekahi mau ʻiole i ka wai huaʻikuʻi a me ka metformin. Ua hōʻike ʻia kekahi i ka metformin wale nō. Ua ʻike nā kānaka noiʻi he piʻi ka nui o ka hana lactic acid i nā ʻiole i hōʻike ʻia i ka wai huaʻakai a me ka metformin.

Ua koho nā kānaka noiʻi ua hoʻonui ka wai momona i ka metformin i loko o ke ake. ʻO kēia, ma ke ʻano, ua hoʻonui i ka hana o ka waikawa lactic. Ma muli o kēia, ua ʻōlelo nā mea noiʻi e inu i ka wai huaʻalani a hiki i ka hoʻonui ʻana i ka makaʻu o ka lactic acidosis i ka poʻe e lawe ana i ka metformin.

Eia naʻe, ua ʻike ʻia kēia mau hopena i nā iole nondiabetic, ʻaʻole i nā kānaka me ka maʻi kōkō ʻelua. I kēia lā, ʻaʻole i loaʻa kahi hihia hihia i nā kānaka e hōʻike ana i ka lawe ʻana i ka metformin me ka wai huaʻōlau e alakaʻi aku ai i ka lactic acidosis.

Nā mea ʻē aʻe e pale aku ai ma metformin

Lawe i kekahi mau lāʻau i ka wā e lawe ana i ka metformin hiki ke hoʻonui i ka makaʻu o ka hoʻomohala ʻana i ka lactic acidosis. E hoʻomaopopo ʻoe i kāu kauka inā lawe ʻoe i kekahi o nā lāʻau aʻe:

• diuretics, e like me acetazolamide
• corticosteroids, e like me prednisone
• ka lāʻau hoʻokaumaha koko, e like me amlodipine (Norvasc)
• anticonvulsants, e like me topiramate (Topamax) a me zonisamide (Zonegran)
• nā pale pale waha
• nā lāʻau antipsychotic, e like me chlorpromazine

Hōʻalo i ka inu ʻana i ka nui o ka waiʻona i ka manawa ma metformin. ʻO ka inu ʻana i ka waiʻona i ka wā e lawe ana i ka metformin e hoʻonui ai i kou makaʻu i ka hoʻomohala ʻana i ke kō kō a i ʻole a me ka acidosis lactic.

Wahi a ke Kulanui o Michigan, pono ʻoe e hōʻalo i ka ʻai ʻana i nā meaʻai kiʻekiʻe-fiber ma hope o ka lawe ʻana i ka metformin. ʻO kēia no ka mea hiki i ka fiber ke hoʻopaʻa i nā lāʻau a hoʻohaʻahaʻa i ko lākou manaʻo nui. Hoʻoemi nā pae Metformin ke lawe ʻia me ka nui o nā fiber (ʻoi aku ma mua o 30 milligrams i kēlā me kēia lā).

ʻO kekahi mau kulekele papaʻai maʻamau no nā poʻe me ka maʻi diabetes penei:

• Pākuʻi ʻia i nā haʻalā i hiki mai i nā mea kanu, nā huaʻai, a me nā hua holoʻokoʻa. E nānā pono i kāu lawe ʻana i ka waiʻopa, no ka mea e hoʻopili pololei kēia i kāu kō kō.
• Hōʻalo i ka meaʻai kiʻekiʻe i nā momona a momona. Akā, hoʻopau i nā momona mai ka iʻa, nā nati, a me ka ʻaila ʻoliva. Eia nā ala 10 e hoʻohui i nā momona olakino i kāu papaʻai.
• ʻO ka ʻai ʻana he 25 a 30 mau milligrams o ka puluniu i kēlā me kēia lā e kōkua i ke kaohi ʻana i nā pae kō glucose. E ʻike i kēia papa inoa o 22 mau meaʻai kiʻekiʻe fiber e hoʻomaka ai.
• Hōʻalo i ka sodium. E hoʻāʻo e ʻai ma lalo o 2,300 milligrams i kēlā me kēia lā.

Pehea e hiki ai i ka grapefruit ke kōkua i ka poʻe me ka maʻi kō

He mea maikaʻi paha ka inu ʻana i ka wai grapefruit inā he maʻi diabetes ʻoe.

Ua hōʻike ʻia i ka hoʻomākaukau ʻana i ka wai momona i hoʻoliʻiliʻi ka hōʻemi ʻana i ka glucose a me ke kaupaona. Ua like nā hopena i ʻike ʻia me nā hopena o metformin. ʻAʻohe hopena i hoʻonui ʻia ke hoʻāʻo pū ʻia ka wai momona a me ka metformin.

ʻOiai e hoʻohiki ana, he mea nui e hoʻomaopopo i kēia mau nānā ʻana i hana ʻia i kahi mole kope o ka maʻi kō.

A kekahi o ke kuleana o ka huaʻulu i ka papaʻai a me ka launa pū ʻana o ka lāʻau i manaʻo ʻia e pili ka grapefruit me ka pohō o ke kaupaona ʻana a me ka hoʻoikaika ʻana o ka hoʻoikaika o ka insulin. ʻO ka mea hou aʻe, hōʻike pū ʻia ka loiloi i kahi hui i ka wai momona (naringin) i loaʻa e hoʻomaikaʻi i ka hyperglycemia a me ke kiʻekiʻe o ke kolesterol i kahi ʻano holoholona holoholona ʻano diabetes. E aʻo hou e pili ana i ka noho ʻana me ka maʻi kō a me ka kiʻekiʻe o ke kō.

Lawe aku

Alakai ka hua hua i nā pilina maikaʻi ʻole me kekahi mau lāʻau. Eia nō naʻe, ʻaʻohe hihia hihia kahi e ʻai ai i ka wai momona ma ka wā e lawe ana i ka metformin i hopena i nā hopena maikaʻi ʻole i nā kānaka.

Aia kekahi mau hōʻike hoʻokolohua hoʻohiki e pili ana i ka grapefruit i kāu papaʻai hiki ke kōkua i ka hoʻoliʻiliʻi kaumaha a hoʻemi i nā pae glucose i hoʻokē ʻai.

Inā lawe ʻoe i ka metformin a hopohopo e pili ana i ka launa lāʻau lāʻau a i ʻole ka launa lāʻau lāʻau, e kamaʻilio me kāu kauka.