ʻO Myeloid Leukemia

Anter

• Hōʻuluʻulu Manaʻo
• He aha ka leukemia?
• He aha ka leukemia myeloid maʻi (CML)?
• He aha ke kumu o ka leukemia myeloid maʻi (CML)?
• ʻO wai ka mea e makaʻu i ka maʻi myeloid leukemia (CML)?
• He aha nā hōʻailona o ka leukemia myeloid mau (CML)?
• Pehea e ʻike ʻia ai ka maʻi myeloid leukemia (CML)?
• He aha nā pae o ka leukemia myeloid maʻi (CML)?
• He aha nā ʻano lāʻau no ka maʻi myeloid leukemia (CML)?

Hōʻuluʻulu Manaʻo

He aha ka leukemia?

ʻO Leukemia kahi manawa no nā maʻi ʻaʻai o nā hunaola koko. Hoʻomaka ka leukemia i loko o nā aʻa koko e like me ka iwi o ka iwi. Hana kou iwi iwi i nā hunaola e lilo i mau hunaola keokeo, nā hunaola ʻulaʻula, a me nā platelet. He hana ʻokoʻa ko kēlā me kēia ʻāpana o ke kelepona.

• Kōkua ke koko keokeo i kou kino e hakakā i ka maʻi
• Hāʻawi nā hunaola ʻulaʻula i ka oxygen mai kou mau māmā i kāu mau pūnaewele a me nā meaola
• Kōkua nā platelet i nā clots e hoʻōki i ke kahe ʻana o ke kahe

Ke loaʻa ʻoe i ka leukemia, hana ka iwi o kou iwi i nā helu lehulehu o nā hunaola ʻokoʻa. Hana pinepine kēia pilikia me nā hunaola keokeo. Kūkulu kēia mau pūnaewele ʻino i loko o kou iwi iwi a me ke koko. Hoʻopili lākou i nā hunaola olakino a paʻakikī i kāu mau pūnaewele a me ke koko e hana i kā lākou hana.

He aha ka leukemia myeloid maʻi (CML)?

ʻO ka leukemia myeloid maʻi (CML) kahi ʻano leukemia mau. ʻO ka "Chronic" ʻo ia hoʻi ka hōʻoluʻolu o ka leukemia ma mua o ka lohi. I ka CML, hana ka iwi iwi i nā granulocytes ʻokoʻa (kahi ʻano o ke keʻokeʻo koko keʻokeʻo). Kāhea ʻia kēia mau keena ʻino he blasts. Ke hōʻuluʻulu nā hunaola ʻino i nā hunaola olakino, hiki iā ia ke alakaʻi i ka maʻi, anemia, a me ke kahe maʻalahi. Hiki ke hoʻolaha aku nā hunaola ʻē ma waho o ke koko i nā ʻāpana ʻē aʻe o ke kino.

Hana ʻia ʻo CML i nā mākua i ka wā ma hope o ka makahiki waena. He kākaʻikahi wale nō i nā keiki.

He aha ke kumu o ka leukemia myeloid maʻi (CML)?

ʻO ka hapanui o ka poʻe me CML i loaʻa kahi loli i kapa ʻia ʻo chromosome Philadelphia. Kāhea ʻia kēlā no ka mea ua ʻike ka poʻe noiʻi ma Piladelapia iā ia. Loaʻa i nā kānaka he mau pālua chromosome he 23 i kēlā me kēia cell. Aia i loko o kēia mau chromosome kāu DNA (nā genetic material). I ka CML, neʻe kahi ʻāpana o ka DNA mai hoʻokahi chromosome i kahi chromosome ʻē aʻe. Hoʻohui ʻia me kekahi DNA ma laila, kahi e hana nei i kahi moʻokūʻauhau hou i kapa ʻia ʻo BCR-ABL. Hoʻokumu kēia gen i kou iwi iwi e hana i kahi protein pono ʻole. ʻAe kēia protein i nā hunaola leukemia e ulu i waho o ka kaohi.

ʻAʻole i hoʻoili ʻia ka chromosome Philadelphia mai ka makua a ke keiki. Hana ʻia ia i kou wā e ola ana. ʻAʻole ʻike ʻia ke kumu.

ʻO wai ka mea e makaʻu i ka maʻi myeloid leukemia (CML)?

He paʻakikī e wānana i ka mea e loaʻa iā CML. Aia kekahi mau kumu i hiki ke hāpai i kāu makaʻi:

• Makahiki - piʻi kou makaʻu i kou ʻelemakule ʻana
• Ke kāne - He mea maʻamau ʻo CML i nā kāne
• Hōʻike i ka radiation radiation kiʻekiʻe

He aha nā hōʻailona o ka leukemia myeloid mau (CML)?

I kekahi manawa ʻaʻole kumu ʻo CML i nā ʻōuli. Inā loaʻa iā ʻoe nā hōʻailona, ​​hiki iā lākou ke hoʻopili

• Luhi nui loa
• ʻO ka hōʻemi kaumaha no ke kumu ʻole
• Hoʻoulu ka pulu o ka pō
• Fiva
• ʻO kaʻeha a i ʻole ka manaʻo o ka piha ma lalo o nā iwi ʻaoʻao ma ka ʻaoʻao hema

Pehea e ʻike ʻia ai ka maʻi myeloid leukemia (CML)?

E hoʻohana paha kāu mea mālama ola i nā pono hana he nui e ʻike pono ai i ka CML.

• He hoʻāʻo kino
• He moʻolelo olakino
• Nā ho'āʻo koko, e like me ka helu piha o ke koko (CBC) me ka ʻokoʻa a me nā hoʻāʻo kemika koko. ʻO nā hoʻokolohua kemika koko e ana i nā mea like ʻole i ke koko, e like me nā electrolytes, nā momona, nā protein, glucose (kō), a me nā enzymes. ʻO nā hoʻokolohua kemika koko kikoʻī e pili ana i kahi paneli metaboliko maʻamau (BMP), kahi paneli metabolic ākea (CMP), nā hoʻāʻo ʻana o ka hakuʻala, nā hoʻokolohua hana ate, a me kahi paneli uila
• Nā hoʻāʻo iwi iwi. Aia he ʻano nui ʻelua - ka ʻiʻini o ka iwi a me ka biopsy iwi pū. Pili nā hōʻike ʻelua i ka hemo ʻana i kahi laʻana o ka iwi iwi a me ka iwi. Hoʻouna ʻia nā laʻana i kahi lab no ka hoʻāʻo ʻana.
• ʻO nā hoʻāʻo genetic e nānā no nā loli a me nā chromosome, me nā hoʻāʻo e nānā ai no ka chromosome Philadelphia

Inā ʻike ʻia ʻoe me CML, loaʻa paha iā ʻoe nā hoʻokolohua hou aʻe e like me nā hoʻokolohua kiʻi ʻana e ʻike ai inā ua laha ka maʻi ʻaʻai.

He aha nā pae o ka leukemia myeloid maʻi (CML)?

ʻEkolu mau ʻāpana o CML. Hoʻokumu ʻia nā pae ma ka nui o ka ulu ʻana a hoʻolaha ʻana o ka CML.

• ʻO ka pae lōʻihi, kahi ma lalo o 10% o nā hunaola i loko o ke koko a me ka iwi o ka iwi nā pūhū pahū (nā leukemia cells). Hoʻomaopopo ka hapanui o ka poʻe i kēia pae, a ʻaʻohe o nā ʻōuli i ka nui. ʻO ka maʻamau maʻamau kōkua i kēia pae.
• ʻO ka papa wikiwiki, 10% a 19% o nā hunaola i ke koko a me ka iwi o ka iwi nā pūhū pupuhi. I kēia pae, loaʻa pinepine nā kānaka i nā ʻōuli a me ka mālama maʻamau ʻaʻole paha e like ka maikaʻi me ka maʻa mau.
• ʻO ka wā Blastic, kahi o 20% a ʻoi aku o nā hunaola i loko o ke koko a i ʻole ka iwi iwi he mau puʻupuʻi pupuhi. Ua pālahalaha nā hunaola i nā mea ʻē aʻe a me nā meaola. Inā he luhi ʻoe, kuni, a me kahi ʻāpala hoʻonui i ka wā blastic, ua kapa ʻia ia he pilikia puhi. ʻOi aku ka paʻakikī o kēia kaʻina e mālama.

He aha nā ʻano lāʻau no ka maʻi myeloid leukemia (CML)?

Aia kekahi mau ʻano lapaʻau like ʻole no CML:

• Hoʻolālā pahuhopu, kahi e hoʻohana ai i nā lāʻau a i ʻole nā ​​mea ʻē aʻe e hoʻouka i nā hunaola maʻi ʻaʻai me ka hōʻemi iki ʻana i nā hunaola maʻamau. No CML, nā lāʻau lapaʻau he tyrosine kinase inhibitors (TKI). Pā lākou i ka tyrosine kinase, kahi enzyme e hoʻonāukiuki i kou iwi iwi.
• ʻO Chemotherapy
• Immunotherapy
• ʻO ka chemotherapy kiʻekiʻe me ka transplant cell stem
• Hoʻokomo lymphocyte infor (DLI). He lapaʻau ʻo DLI i hiki ke hoʻohana ʻia ma hope o ka transplant cell stem. Pili ia i ka hāʻawi ʻana iā ʻoe i kahi infusion (i loko o kou kahe o ke koko) o nā lymphocytes olakino mai ka mea hāʻawi transplant trans cell. ʻO Lymphocytes kahi ʻano o ke keʻokeʻo koko keʻokeʻo. Pepehi paha kēia mau limahana limahana hāʻawi i nā hunaola maʻi ʻē i koe.
• Keʻoki e wehe i ka spleen (splenectomy)

ʻO nā hōʻailona āu e loaʻa ai e pili i ka manawa āu i loko, kou makahiki, kou olakino holoʻokoʻa, a me nā kumu ʻē aʻe. Ke hoʻemi ʻia a nalowale paha nā hōʻailona a me nā ʻōuli o CML, kapa ʻia ia kala kala. E hoʻi paha ka CML ma hope o ke kala ʻana, a pono ʻoe i kahi lapaʻau hou aʻe.

NIH: Ke Kula Kaiapuni ʻAi Mokuʻāina