He aha nā pūnaewele dendritic a no nā mea no lākou

Anter

• He aha ka waiwai no
• Nā ʻano o nā hunaola dendritic
• Pehea e hiki ai iā lākou ke kōkua i ka mālama ʻana i ka maʻi ʻaʻai

ʻO nā hunaola Dendritic, a i ʻole DC, nā aʻa i hana ʻia i loko o ka iwi o ka iwi i hiki ke loaʻa i ke koko, ka ʻili a me ka digestive a me nā ʻōpū hanu, no ka laʻana, a he ʻāpana ia o ka ʻōnaehana pale, ke kuleana no ka ʻike ʻana i ka maʻi a me ka hoʻomohala ʻana i ka pale pane.

No laila, ke hoʻoweliweli ka ʻōnaehana paleʻoniʻoni, hana nui kēia mau pūnaewele i mea e ʻike ai i ka mea maʻi infectious a hāpai i kona hoʻopau ʻana. No laila, inā ʻaʻole holo pono nā hunaola dendritic, ʻoi aku ka paʻakikī o ka ʻōnaehana pale i ka pale ʻana i ke kino, me ka manawa kūpono e hoʻomohala i kahi maʻi a i ʻole ka maʻi ʻaʻai.

He aha ka waiwai no

Na Dendritic cells ke kuleana o ka hopu ʻana i ka microorganism komo hewa a me ka hōʻike ʻana i nā antigens, i loaʻa ma luna o ka ʻili, no nā lymphocytes T, e hoʻomaka ana i ka pane pale pale kūʻē i ka agena infectious, e hakakā ana i ka maʻi.

Ma muli o ka hopu a hōʻike ʻana i nā antigens ma luna o ko lākou ʻili, nā ʻāpana o ka agena infectious, ua kapa ʻia nā hunaola dendritic i kapa ʻia nā Antigen-Presenting Cells, a i ʻole nā ​​APC.

Ma waho aʻe o ka paepae ʻana i ka pane pale pale mua e kūʻē i kekahi agena komo hewa a me ka hōʻoia ʻana i ka palekana o loko, he mea nui nā hunaola dendritic no ka hoʻomohala ʻana i ka pale pilikino adaptive, ʻo ia ka mea e hana ʻia ai nā hunaola hoʻomanaʻo, e pale ana i ka hanana hou ʻana a i ʻole ke ala haʻahaʻa. . maʻi maʻi ma ka meaola hoʻokahi.

Hoʻomaopopo pehea e holo ai ka ʻōnaehana pale.

Nā ʻano o nā hunaola dendritic

Hiki ke hoʻokaʻawale ʻia nā pūnaewele Dendritic e like me ko lākou neʻe ʻana i ke ʻano, ka hōʻike o nā māka ma ko lākou ʻilikai, kahi a me kā lākou hana. No laila, hiki ke hoʻokaʻawale nui ʻia nā hunaola dendritic i ʻelua mau ʻano:

• Nā hunaola dendritic Plasmocytoid, kahi i loaʻa nui i loko o ke koko a me nā limana limfhoid, e like me ka pelupelu, thymus, ka iwi iwi a me nā pūnana lymph, no ka laʻana. Hana kūʻē kēia mau pūnaewele i nā maʻi ʻino a, ma muli o ko lākou hiki ke hana i ka Interferon alpha a me ka beta, nā protein i kuleana no ka hoʻoponopono ʻana i ka ʻōnaehana pale, he waiwai anti-tumor kekahi i loko o kekahi mau hihia, me ka hoʻohui i ka antiviral.
• Nā pūnaewele delo mole myeloid, aia ma ka ʻili, ke koko a me ka mucosa. Kāhea ʻia nā hunaola i loko o ke koko i ka DC radiation, kahi e hoʻopuka ai i ka TNF-alpha, kahi ʻano o ka cytokine e pili ana i ka make ʻana o nā hunaola tumele a me ke kaʻina hoʻolaʻa. I ke kiko, hiki ke kapa ʻia kēia mau hunaola interstitial a i ʻole mucosal DC a, ke loaʻa i ka ʻili, ua kapa ʻia lākou he mau huna ʻo Langerhans a i ʻole nā ​​neʻe neʻe, mai ka wā o kā lākou hoʻouluulu ʻana, neʻe lākou ma o ka ʻili i nā lymph node, kahi e hōʻike ai i nā antigens i nā lymphocytes T.

Ke aʻo nui ʻia nei ke kumu o nā hunaola dendritic, akā manaʻo ʻia nō ia i kū mai i ka moʻokūʻauhau lymphoid a me myeloid. Hoʻohui ʻia, aia ʻelua mau manaʻo e hoʻāʻo e wehewehe i ke kumu o kēia mau pūnaewele.

1. Launch o Modelity plasticity, ka mea i manaʻo i nā ʻano ʻokoʻa o nā hunaola dendritic e hōʻike i nā pae like ʻole o ke ʻano ʻana o ka laina lōkahi, nā hana ʻokoʻa nā hopena o kahi a lākou e noho ai.
2. Hoʻohālikelike Lineage Kūpono, ka mea i manaʻo i nā ʻano ʻokoʻa o nā hunaola dendritic i loaʻa mai nā laina pūnaewele like ʻole, ʻo ia ke kumu o nā hana ʻokoʻa.

Manaʻo ʻia he kumu ko nā kumumanaʻo ʻelua a i loko o ka meaola e manaʻo ʻia e hoʻokō like ʻia nā manaʻo ʻelua.

Pehea e hiki ai iā lākou ke kōkua i ka mālama ʻana i ka maʻi ʻaʻai

Ma muli o kāna kuleana nui i loko o ka ʻōnaehana pale a me ka hiki ke hoʻokele i nā kaʻina hana āpau e pili ana i ka pale ʻana, ua hoʻokō ʻia nā noiʻi me ka pahuhopu o ka hōʻoia ʻana i kona hopena i ka mālama ʻana i ka maʻi ʻaʻai, ʻo ka mea nui ma ke ʻano o ka lāʻau lapaʻau.

I loko o ke keʻena hoʻokolohua, hoʻonoho ʻia nā hunaola dendritic i ka launa pū ʻana me nā hāpana cell tumole a hōʻoia ʻia ko lākou hiki ke hoʻopau i nā hunaola maʻi ʻaʻai. Inā ʻike ʻia nā hopena o nā hoʻāʻo ma nā mana hoʻokolohua a me nā holoholona i kūpono, hiki paha i nā hoʻokolohua no ka lāʻau lapaʻau maʻi ʻaʻai me nā hunaola dendritic ke loaʻa i ka heluna kanaka. ʻOiai ke hoʻohiki ʻia, pono hou nā noiʻi no ka hoʻomohala ʻana i kēia lāʻau āpau, a me ke ʻano o ka maʻi ʻaʻai e hiki ai i kēia lāʻau koʻokoʻo ke kaua.

Ma waho aʻe o ka hiki ke hoʻohana ʻia e kūʻē i ka maʻi ʻaʻai, ua aʻo ʻia ka noi ʻana o nā hunaola dendritic i ka mālama ʻana e kūʻē iā AIDS a me ka sporotrichosis ʻōnaehana, ʻo ia nā maʻi nui a alakaʻi i ka hōʻemi ʻana o ka ʻōnaehana pale. Eia kekahi mau ala e hoʻomaikaʻi ai a hoʻoikaika i kāu ʻōnaehana pale maʻi.