Antinuclear Antibody Panel (ANA Hōʻike)

Anter

• I ka manawa hea e pono ai kahi panalā antinuclear antibody?
• Pono wau e hoʻomākaukau no ka hōʻoia?
• He aha kaʻu e manaʻo ai i ka papa ANA?
• Aia kekahi mau pilikia me ka hoʻāʻo?
• Unuhi i nā hopena

He aha ka papa hana antinuclear antibody panel?

ʻO nā Antibodies nā protein i hana ʻia e kāu ʻōnaehana pale. Kōkua lākou i kou kino e ʻike a hakakā i nā maʻi. Hoʻopaʻa pinepine nā Antibodies i nā mea hoʻopilikia, e like me nā bacteria a me nā mea ʻino, ma o ka hoʻoulu ʻana i ka ʻōnaehana pale e kāpae iā lākou.

I kekahi manawa kuhi hewa nā antibodies i kāu mau pūnaewele olakino a me nā mākele. ʻIke ʻia kēia ma ke ʻano he pane autoimmune. ʻO nā Antibodies e hoʻouka i nā protein olakino i loko o ka nukleus - ke kikowaena o kāu mau pūnaewele - i kapa ʻia nā antinuclear antibodies (ANA).

Ke loaʻa i ke kino nā hōʻailona e hoʻouka iā ia iho, hiki iā ia ke hoʻāla i nā maʻi autoimmune e like me lupus, scleroderma, hoʻohui ʻia i nā maʻi āpau hoʻohui, autoimmune hepatitis, a me nā mea ʻē aʻe. Hoʻololi nā ʻōuli i ka maʻi, akā pili pū paha lākou i ka huehue, ka pehu ʻana, ka arthritis, a me ka luhi.

ʻOiai he mea maʻamau ka loaʻa ʻana o kekahi ANA, ʻo ka nui o kēia mau protein i hōʻailona no kahi maʻi autoimmune hana. Kōkua kahi papa ANA i ka pae o ANA i kou koko. Loaʻa paha iā ʻoe kahi maʻi autoimmune inā kiʻekiʻe ke kiʻekiʻe. Eia nō naʻe, hiki i nā kūlana e like me nā maʻi, ka maʻi ʻaʻai, a me nā pilikia olakino ʻē aʻe ke hopena i kahi hōʻike ANA maikaʻi.

I ka manawa hea e pono ai kahi panalā antinuclear antibody?

E kauoha paha kāu kauka i kahi panapa ANA inā he mau hōʻailona a hōʻailona paha kāu o kahi maʻi autoimmune. Hōʻike paha kahi hoʻokolohua ANA he ʻano ʻano autoimmune kāu, akā ʻaʻole hiki ke hoʻohana ʻia e kuhikuhi i kahi maʻi kikoʻī. Inā hoʻi kāu hōʻoia me kahi hopena maikaʻi, pono i kāu kauka e hana i nā hoʻokolohua kikoʻī a kikoʻī e hoʻoholo inā loaʻa kahi maʻi autoimmune i kāu mau ʻōuli.

Pono wau e hoʻomākaukau no ka hōʻoia?

ʻAʻole pono ka hoʻomākaukau no ka panela ANA.Eia nō naʻe, he mea nui e haʻi aku i kāu kauka e pili ana i nā lāʻau a i ʻole nā ​​mea hoʻopihapiha āu e lawe nei, ʻoi aku ma mua o ka-counter. ʻO kekahi mau lāʻau, e like me ke ka hopu ʻana a me nā lāʻau o ka puʻuwai, hiki ke hoʻopili i ka pololei o ka hoʻāʻo.

He aha kaʻu e manaʻo ai i ka papa ANA?

Ua like ka paneli ANA me nā hoʻokolohua koko ʻē aʻe. ʻO kahi phlebotomist (kahi loea e hana i nā hoʻokolohua koko) e nakinaki i kahi kāʻei elima a puni kou lima o luna a pehu kou veins me ke koko. He mea maʻalahi kēia iā lākou e loaʻa kahi aa.

Ma hope o ka hoʻomaʻemaʻe i ka pūnaewele me kahi antiseptic, e hoʻokomo lākou i kahi nila i loko o kahi aa. ʻIke paha ʻoe i kahi ʻeha kaulike ke hele ke nila, akā ʻaʻole ʻeha ka hoʻāʻo iho.

Hōʻiliʻili ʻia ke koko i loko o kahi paipu e pili ana i ka nila. Ke hōʻiliʻili ʻia ke koko, e wehe ka phlebotomist i ka nila mai kou aa a uhi i ka pūnaewele puncture.

No nā pēpē a mau keiki paha, hiki ke hoʻohana ʻia kahi lancet (scalpel liʻiliʻi) e hou ai ka ʻili, a e hōʻiliʻili ʻia paha ke koko i loko o kahi pahu liʻiliʻi i kapa ʻia he pipette. E hōʻiliʻili ʻia paha ia ma kahi kaha hoʻāʻo.

Hoʻouna ʻia ke koko i kahi hale hōʻike no ka nānā ʻana.

Aia kekahi mau pilikia me ka hoʻāʻo?

Heʻuʻuku ka makaʻu o ka hana ʻana i kahi panela ANA. ʻO ka poʻe me nā uaua e ʻoi aku ka paʻakikī e kiʻi i hiki ke ʻike i ka hōʻoluʻolu hou aʻe ma mua o nā poʻe ʻē aʻe i ka hoʻāʻo ʻana o ke koko. Hiki i nā pilikia ʻē aʻe ke komo pū me:

• kahe nui ke koko
• maʻi ma ka puncture kahua
• maule ana
• hematoma (ke kūkulu nei ke koko ma lalo o ka ʻili)

Unuhi i nā hopena

ʻO kahi hōʻike maikaʻi ʻole e hōʻemi ʻia kekahi mau maʻi autoimmune. Eia nō naʻe, pono paha i nā hoʻokolohua ʻē aʻe e pili ana i kāu mau ʻōuli. Hiki i kekahi poʻe me nā maʻi autoimmune ke loaʻa i kahi hopena hōʻike maikaʻi ʻole no ANA akā maikaʻi no nā mea ʻino ʻē aʻe.

ʻO kahi hōʻike ANA maikaʻi he pae kiʻekiʻe kāu o ANA i kou koko. Hōʻike pinepine ʻia kahi hōʻike ANA maikaʻi ma ke ʻano he lakio (i kapa ʻia he titer) a me kahi kumu, e like me ka laumania a me nā kiko. Loaʻa paha kekahi mau maʻi i kekahi mau hiʻohiʻona.

ʻO ke kiʻekiʻe o ka titer, ʻo ka hopena ka hopena "hopena maikaʻi", ʻo ia hoʻi he ANA koʻikoʻi kou a me kahi maʻi autoimmune.

ʻO kahi laʻana, no ka lakio o 1:40 a i ʻole 1:80, manaʻo ʻia he haʻahaʻa ka loaʻa ʻana o kahi maʻi autoimmune. ʻO ka lakio o 1: 640 a ʻoi aku paha e hōʻike ana i kahi kiʻekiʻe o ka maʻi autoimmune, akā pono e kālailai ʻia nā hopena e ke kauka a me nā hoʻokolohua hou aʻe e hana ai i kahi hopena.

Eia naʻe, ʻo ka hopena maikaʻi ʻaʻole ia he manaʻo he maʻi autoimmune kāu. Aia i ka 15 pākēneka o nā kānaka olakino piha kahi hōʻike ANA maikaʻi. Kapa ʻia kēia he hopena hōʻoia maikaʻi ʻole. Hiki i ka ANA titers ke hoʻonui pū me ka makahiki i waena o ka poʻe olakino, no laila he mea nui e kamaʻilio me kāu kauka e pili ana i kāu mau hōʻailona a me ke ʻano o kāu hopena iā ʻoe.

Inā ua kau kauka mua i ka hoʻokolohua, hiki iā lākou ke ʻōlelo i kahi mea i hāʻawi ʻia i ka rheumatologist - he loea no ka maʻi autoimmune - e nānā i nā hopena ANA pono ʻole. Hiki iā lākou ke kōkua pinepine i ka hoʻoholo inā pili kāu hopena hōʻike i kahi kūlana kikoʻī.

ʻAʻole hiki i kahi hōʻike ANA maikaʻi wale nō ke kuhi i kahi maʻi kikoʻī. Eia nō naʻe, kekahi mau ʻano pili e pili ana me kahi hōʻike ANA maikaʻi pū kekahi:

• systemic lupus erythematosus (lupus): kahi maʻi autoimmune i hiki ke hoʻopili i nā ʻāpana like ʻole o kou kino, e like me ka puʻuwai, nā puʻupaʻa, nā hono, a me ka ʻili.
• ʻo ka hepatitis autoimmune: kahi maʻi autoimmune nāna e hoʻāla i ke ake, me nā huehue, nā ʻeha pū, ka luhi, nā makemake maikaʻi ʻole, a me ka nausea
• rheumatoid arthritis: kahi maʻi autoimmune e kumu ai ka luku pū, ʻeha, pehu, a me ka ʻoʻoleʻa i nā hono a pili i nā akemāmā, puʻuwai, maka, a me nā mea ʻē aʻe
• ʻO Sjögren Syndrome: kahi maʻi autoimmune e hoʻopili i ka salivary a me nā lacrimal glands, kahi e hua ai ka lawehala a me nā waimaka.
• scleroderma: kahi maʻi autoimmune e hoʻopili nui i ka ʻili a me nā mea hoʻopili ʻē aʻe akā hiki ke hoʻopili i nā ʻōpū
• maʻi thyroid autoimmune: kahi ʻano o nā kūlana e pili ana i kāu thyroid, me hypothyroidism a me hyperthyroidism
• polymyositis a i ʻole dermatomyositis: nā kūlana autoimmune e hōʻeha ai i ka ʻeha, nāwaliwali, a me ka mumū o nā mākala, a hiki ke hoʻopili i kahi ʻāʻī.

Hiki i nā Labs ke ʻokoʻa i kā lākou mau kūlana no ka hoʻāʻo maikaʻi. E kamaʻilio me kāu kauka e pili ana i ka manaʻo o kāu pae a pehea e wehewehe ai i kāu mau hōʻailona e ke alo o ANA. Inā hoʻi maikaʻi kāu hōʻike ANA, pono i kāu kauka e holo hou i nā hoʻokolohua i mea e kōkua ai e hoʻoholo inā pili nā hopena i kahi kūlana kikoʻī.

He kōkua nui ka hōʻike ANA i ke kuhi ʻana i ka lupus. Ma mua o 95 pākēneka o ka poʻe me ka lupus e loaʻa kahi hopena hōʻike ANA maikaʻi. Eia nō naʻe, ʻaʻole kēlā me kēia mea i loaʻa kahi hopena hōʻike maikaʻi he lupus, a ʻaʻole kēlā me kēia me ka lupus e loaʻa kahi hopena hōʻike maikaʻi. No laila ʻaʻole hiki ke hoʻohana ʻia ka hōʻike ANA ma ke ʻano he kiʻina ʻike wale nō.

E kamaʻilio me kāu kauka e pili ana i nā hoʻokolohua hou aʻe i hiki ke hana e hoʻoholo inā aia kekahi kumu kumu no ka hoʻonui ANA i kou koko.