Mea Kākau: Virginia Floyd
Lā O Ka Hana: 7 Aukake 2021
HōʻAno Hou I Ka Lā: 15 Nowemapa 2024
Anonim
Quick Take: Cardiovascular Safety of Celecoxib
Wikiō: Quick Take: Cardiovascular Safety of Celecoxib

Anter

ʻO ka poʻe e lawe i nā lāʻau anti-inflammatory nonsteroidal (NSAIDs) (ʻē aʻe ma mua o ka aspirin) e like me celecoxib e ʻoi aku paha ka nui o ka hopena o ka puʻuwai puʻuwai a i ʻole ka hahau ma mua o ka poʻe ʻaʻole e lawe i kēia mau lāʻau. Hiki paha kēia mau hanana me ka ʻōlelo ʻole ʻole a make paha. Kiʻekiʻena paha kēia kiʻekiʻe no nā poʻe e lawe i nā NSAID no kekahi manawa lōʻihi. Mai lawe i kahi NSAID e like me celecoxib inā he maʻi puʻuwai kāu i neʻi nei, ke ʻole ke kuhikuhi ʻia e kāu kauka. E haʻi i kāu kauka inā loaʻa ʻoe a i ʻole kekahi i kou ʻohana i ka maʻi puʻuwai, ka puʻuwai puʻuwai, a i ʻole ka hahau ʻana, inā ʻoe e puhipaka, a inā he kolesterol kiʻekiʻe ʻoe, ke koko kiʻekiʻe, a diabetes paha. E kiʻi koke i ke kōkua olakino pilikia inā ʻike ʻoe i kekahi o nā ʻōuli penei: ka ʻeha o ka umauma, ka pōkole o ka hanu, nāwaliwali ma kahi ʻāpana a ʻaoʻao paha o ke kino, a i ʻole ʻōlelo lohi.

Inā ʻoe e hele i kahi pale bypass artery coronary (CABG; kahi ʻano o ke ʻoki puʻuwai), ʻaʻole pono ʻoe e lawe i ka celecoxib ma mua pono a ma hope pono paha o ke ʻoki.


Hiki i nā NSAID e like me celecoxib ke hana i nā maʻi ulcer, ke kahe ʻana o ke kō, a i ʻole nā ​​puka o ka ʻōpū a me ka ʻōpū. E ulu paha kēia mau pilikia i kēlā me kēia manawa i ka wā o ka mālama ʻana. ʻOi aku ka kiʻekiʻe o ka makaʻi no ka poʻe lawe i nā NSAID no ka manawa lōʻihi, ʻelemakule i ka makahiki, maikaʻi ʻole ke olakino, a inu paha i ka nui o ka waiʻona i ka wā e lawe ana i ka celecoxib. E haʻi i kāu kauka inā inu ʻoe i ka nui o ka waiʻona a i ʻole inā lawe ʻoe i kekahi o nā lāʻau aʻe: anticoagulants ('blood thinners') e like me warfarin (Coumadin, Jantoven); aspirin; nā NSAID ʻē aʻe e like me ibuprofen (Advil, Motrin) a i ʻole naproxen (Aleve, Naprosyn); nā steroid ʻo waha e like me dexamethasone, methylprednisolone (Medrol), a me prednisone (Rayos); nā mea hoʻoliʻiliʻi hou i nā serotonin reuptake (SSRI) e like me citalopram (Celexa), fluoxetine (Prozac, Sarafem, ma Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), a me sertraline (Zoloft); aiʻole nā ​​serotonin norepinephrine reuptake inhibitors (SNRI) e like me desvenlafaxine (Pristiq), duloxetine (Cymbalta), a me venlafaxine (Effexor XR). E haʻi aku i kāu kauka inā loaʻa iā ʻoe a i ʻole he mau maʻi ulcer a kōkō paha i kou ʻōpū a i ʻole nā ​​ʻōpū a i ʻole nā ​​maʻi kahe ʻē aʻe. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e hoʻōki i ka lawe ʻana i ka celecoxib a kāhea i kāu kauka: ʻeha ka ʻōpū, ʻeha ka puʻuwai, luaʻi i kahi mea koko a ʻano like paha me nā papa kope, ke koko i loko o ka pahu, a i ʻole nā ​​papa noho ʻeleʻele a lohi hoʻi.


E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E nānā pono kāu kauka i kāu mau hōʻailona a e kauoha paha i kekahi mau hoʻokolohua e nānā i ka pane o kou kino i ka celecoxib. E ʻike pono i kāu kauka pehea kou ʻano i hiki i kāu kauka ke kuhikuhi i ka nui kūpono o ka lāʻau e mālama ai i kou ʻano me ka makaʻu haʻahaʻa o nā hopena ʻino.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me celecoxib a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Hoʻohana ʻia ʻo Celecoxib e hōʻoluʻolu i ka ʻeha, palupalu, pehu a me ka ʻoʻoleʻa i hoʻokumu ʻia e ka osteoarthritis (arthritis i hoʻokumu ʻia e ka haki o nā ʻami o nā hono), rheumatoid arthritis (arthritis arthritis, i hoʻā ʻia e ka uhi o nā hono), a me ka ankylosing spondylitis (arthritis that pili nui i ka iwi kuamoʻo). Hoʻohana pū ʻia ʻo Celecoxib e mālama i nā ʻōpio ʻo rheumatoid ʻōpio (kahi ʻano o ke ahulau e pili ana i nā keiki) i nā keiki he 2 makahiki a ʻoi paha. Hoʻohana pū ʻia ʻo Celecoxib e mālama i nā wā menstrual ʻeha a e hōʻoluʻolu i nā ʻano ʻeha o ka wā pōkole e like me ka ʻeha i hoʻokumu ʻia e nā ʻeha, ke ʻoki a me nā kaʻina hana lapaʻau a niho paha, a i ʻole nā ​​kūlana olakino e kū mau ana no kahi manawa palena. Aia ʻo Celecoxib i kahi papa o nā NSAID i kapa ʻia ʻo COX-2 mea kāohi. Hana ia ma ka hoʻōki ʻana i ka hana o ke kino i kahi mea e hana i ka ʻeha a me ka mumū.


Hele mai ʻo Celecoxib ma ke ʻano he capsule e lawe ma ka waha. Lawe pinepine ʻia nā capsule Celecoxib i hoʻokahi a i ʻole ʻelua mau manawa i ka lā. Inā ʻoe e lawe ana i 200 mg o nā capsule celecoxib i ka manawa, hiki iā ʻoe ke lawe i ka lāʻau me ka ʻole o ka meaʻai.Inā ʻoe e lawe ana ma mua o 200 mg o nā capsule celecoxib i ka manawa hoʻokahi, pono ʻoe e lawe i ka lāʻau me ka meaʻai. E noi i kāu kauka a kauka paha inā ʻaʻole ʻoe maopopo inā ʻoe pono e lawe i kāu lāʻau me ka meaʻai. E kōkua iā ʻoe e hoʻomanaʻo e lawe i nā capsule celecoxib, e lawe a puni ka manawa like (s) i kēlā me kēia lā.

E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka celecoxib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Inā ʻaʻole hiki iā ʻoe ke ale i nā capsule a i ʻole inā e hāʻawi ana ʻoe i kēia lāʻau i kahi keiki, hiki iā ʻoe ke wehe i nā capsule a kāpīpī i nā mea i loko o kahi teaspoon o ke anuanu a me nā ʻume mahana wela o ka lumi. E hoʻomākaukau paha ʻoe i ka hui ma mua a mālama iā ia a 6 mau hola i loko o ka pahu hau. Ke mākaukau ʻoe e lawe i kāu lāʻau, ale i nā huikau. A laila e inu i ka wai e holoi i ka hui a ʻike pono ua ale ʻoe i nā mea āpau.

Hoʻohana pū ʻia ʻo Celecoxib i kekahi manawa me ke ʻoki a me nā ʻano lāʻau ʻē aʻe e hōʻemi i ka helu o nā polyps (ulu ulu ʻole) i ke kolona (ʻōpū nui) a me nā kīʻaha i nā mea maʻi me ka polyposis adenomatous ʻohana (kahi ʻano e hana ai nā haneli he haneli a mau tausani polyps i ke kolona a ulu ke kanesa). E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka hoʻohana ʻana i kēia lāʻau no kou maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i celecoxib,

  • e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka celecoxib, aspirin a i ʻole nā ​​NSAID ʻē aʻe e like me ibuprofen (Advil, Motrin) a me naproxen (Aleve, Naprosyn), nā lāʻau sulfa, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana ʻole i loko o nā capsule celecoxib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hana ʻole.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻai, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe E hoʻomaopopo pono i nā lāʻau i helu ʻia i ka ʻĀINA WAIWAI nui a me kekahi o kēia mau mea: nā mea hoʻopaneʻe enzyme angiotensin (ACE) e like me benazepril (Lotensin, ma Lotrel), captopril, enalapril (Epaned, Vasotec, ma Vaseretic), fosinopril, lisinopril (Qbrelis, ma Zestoretic), moexipril (Univasc), perindopril (Aceon, ma Prestalia), quinapril (Accupril, ma Quinaretic), ramipril (Altace), a me trandolapril (i Tarka); angiotensin receptor blockers like candesartan (Atacand, in Atacand HCT), eprosartan, irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardart) , ma Micardis HCT, ma Twynsta), a me valsartan (Dioavan, i Entresto, i Exforge HCT); atomoxetine (Strattera); beta blockers e like me atenolol (Tenormin, ma Tenoretic), labetalol (Trandate), metoprolol (Kapspargo Sprinkle, Lopressor, Toprol XL, ma Dutoprol), nadolol (Corgard, ma Corzide), a me propranolol (Hemangeol, Inderal, Innopran); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); diuretics ('pills wai'); fluconazole (Diflucan); lithium (Lithobid); methotrexate (Otrexup, Rasuvo, Reditrex, Trexall); a me pemtrexed (Alimta, Pemfexy). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me ka celecoxib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
  • e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa i kekahi o nā ʻano i ʻōlelo ʻia i ka ʻARlelo AOAO IMPORTANT a i ʻole hānō, keu hoʻi inā ʻoe i ukuhi pinepine a i ʻole ka ihu ihu a i ʻole nā ​​polyps nasal (ka pehu ʻana o ka uhi o ka ihu); ka pehu ʻana o nā lima, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo; puʻuwai puʻuwai; aiʻole ka ate a me nā maʻi pākī.
  • e haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai. aiʻole e hānai umauma ana. Hoʻopilikia paha ʻo Celecoxib i ka fetus a hana i nā pilikia me ka lawe ʻana inā lawe ʻia ma kahi o 20 mau pule a i ʻole ma hope o ka hāpai ʻana. Mai lawe i ka celecoxib a puni a ma hope paha o 20 mau pule o ka hāpai ʻana, ke ʻole ʻoe e haʻi ʻia e kāu kauka. Inā hāpai ʻoe i ka lawe ʻana i ka celecoxib, e kāhea i kāu kauka.
  • inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe nei ʻoe i ka celecoxib.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā ʻoe e lawe i ka celecoxib, e lawe i ka lāʻau i hala i kou hoʻomanaʻo ʻana iā ia. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i ka Celecoxib ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • ʻenekini a kolo paha
  • eha ka 'ā'ī
  • ʻōuli anu
  • kōpaʻa
  • ʻūpā
  • disgeusia

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i ʻōlelo ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka. Mai lawe hou i ka celecoxib a hiki i kou wā e ʻōlelo ai i kāu kauka.

  • loaʻa kaumaha kaumaha ʻole
  • pōkole o ka hanu a paʻakikī hoʻi i ka hanu ʻana
  • ka pehu o ka ʻōpū, ka wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
  • pāhoehoe
  • nausea
  • luhi nui loa
  • kahe koko ʻole ʻana a palapū paha
  • ʻūlili
  • nele i ka ikaika
  • nalo ʻai ʻole
  • ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū
  • melemele o ka ʻili a me nā maka
  • nā ʻōuli like flu
  • ʻōhū
  • fiva
  • hūwī
  • hives
  • pehu o ka maka, ʻāʻī, elelo, lehelehe, maka, a i ʻole nā ​​lima
  • hulahula
  • pilikia i ka ale ʻana a me ka hanu ʻana
  • ʻili mae
  • puʻuwai wikiwiki
  • ʻōpua, paʻalulu, a i ʻole mimi koko
  • ʻeha kua
  • urination paʻakikī a ʻeha paha
  • urination pinepine, keu hoʻi i ka pō

Hiki i Celecoxib ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau ke lawe nei ʻoe i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Pākuʻi ʻia paha nā ʻōuli o ka overdose:

  • nele i ka ikaika
  • hiamoe
  • nausea
  • ka luaʻi
  • ʻeha ka ʻōpū
  • luaʻi i nā mea koko a ʻano like paha me nā papa kope
  • koko a ʻeleʻele paha, noho aliʻi
  • nalowale o ka ʻike
  • hives
  • hūwī
  • ka pehu o nā maka, ka maka, ke elelo, nā lehelehe, ka ʻāʻī, nā lima, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
  • pilikia i ka hanu ʻana a i ʻole ke ale ʻana

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

Pono e nānā pinepine i kou kaomi koko i kou wā e lapaʻau ai.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • Celebrex®
  • ʻO Elyxyb®
  • ʻO Consensi® (i loaʻa ʻo Amlodipine, Celecoxib)

ʻAʻole kēia huahana māka i ka mākeke hou. Hiki ke loaʻa nā koho ʻē aʻe.

Nānā Hou - 03/15/2021

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