Mea Kākau: Virginia Floyd
Lā O Ka Hana: 12 Aukake 2021
HōʻAno Hou I Ka Lā: 14 Nowemapa 2024
Anonim
Polycythemia vera: When to move from hydroxyurea to second-line therapy
Wikiō: Polycythemia vera: When to move from hydroxyurea to second-line therapy

Anter

Hiki i ka Hydroxyurea ke hōʻemi i ka nui o nā hunaola i loko o kou iwi iwi. Hiki i kēia ke hoʻonui i ka makaʻu e hoʻomohala ʻoe i kahi maʻi nui a i ʻole ke kahe ʻana o ke kahe. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: fever, chills, luhi nui a i ʻole nāwaliwali, ʻeha o ke kino, ʻeha ka ʻāʻī, ka hā o ka hanu, ka ʻū a me ka paʻa mau ʻana, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi. kahe koko ʻole a ʻeha paha; koko a ʻeleʻele paha, noho humuhumu; a i ʻole ka luaʻi ʻana i ke koko a i ʻole nā ​​mea ʻeleʻele e like me ke kahua kope.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua ma ka manawa maʻamau e nānā i ka pane o kou kino i ka hydroxyurea a ʻike inā ua heleleʻi kou helu koko. Pono paha kāu kauka e hoʻololi i kāu lāʻau a i ʻole e haʻi iā ʻoe e haʻalele i ka lawe ʻana i ka hydroxyurea no kekahi manawa e ʻae i kou helu ʻana i ke koko e hoʻi i ka maʻamau inā ua haʻahaʻa loa ia.

Hiki i ka Hydroxyurea ke hoʻonui i ka makaʻu e hoʻomohala ʻoe i nā maʻi ʻē aʻe, e like me ka maʻi ʻaʻai ʻili. E hoʻolālā e hōʻalo i ka hōʻike kūpono ʻole a hoʻolōʻihi ʻia i ka lā a komo i nā lole pale, nā aniani aniani, a me ka sunscreen. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i ka hydroxyurea.


E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka pepa ʻikepili a ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me hydroxyurea a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) e kiʻi i ke alakaʻi Medication.

Hoʻohana hoʻokahi ʻo Hydroxyurea (Hydrea) a i ʻole me nā lāʻau ʻē aʻe a i ʻole radiation radiation e mālama i kekahi ʻano leukemia myelogenous mau (CML; kahi ʻano maʻi ʻaʻai o nā hunaola keʻokeʻo) a me kekahi ʻano o ke poʻo a me ka ʻāʻī pūhaka (me ka maʻi ʻaʻai o ka waha , pāpālina, alelo, ʻāʻī, tonsons, a me nā sinus). Hoʻohana ʻia ʻo Hydroxyurea (Droxia, Siklos) e hōʻemi i ke alapine o nā pilikia ʻeha a hōʻemi i ka pono o ke kahe ʻana o ke koko i nā mākua a me nā keiki he 2 mau makahiki a ʻoi aku me ka anemia ʻili maʻi maʻi [like e like me ka maʻi ʻaʻai] a ʻaʻole hiki ke lawe mai i ka nui o ka oxygen i nā ʻāpana āpau o ke kino). Aia ʻo Hydroxyurea i ka papa o nā lāʻau i kapa ʻia antimetabolites. Mālama ʻo Hydroxyurea i ka maʻi ʻaʻai ma o ka hoʻolohi ʻana a hoʻokū ʻana paha i ka ulu ʻana o nā hunaola maʻi ʻaʻai i loko o kou kino. Mālama ʻo Hydroxyurea i ka anemia o ka maʻi sickle e ke kōkua ʻana e pale aku i ke kūkulu ʻia ʻana o nā aʻa koko ʻulaʻula.


Hele mai ʻo Hydroxyurea ma ke ʻano he capsule a me ka papa e lawe ʻia e ka waha. Lawe ʻia ia hoʻokahi manawa i ka lā me ke kīʻaha wai. Ke hoʻohana ʻia ʻo hydroxyurea e mālama i kekahi ʻano o ka maʻi ʻaʻai, lawe ʻia ia i hoʻokahi manawa i kēlā me kēia kolu o ka lā. Lawe iā hydroxyurea ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka hydroxyurea e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Pono paha kāu kauka e hoʻolohi i kāu lāʻau a hoʻoponopono paha i kāu lāʻau o ka hydroxyurea ma muli o kāu pane i ka lāʻau a me nā hopena ʻē aʻe āu e ʻike ai. E kamaʻilio me kāu kauka e pili ana i kou ʻano i kāu mālama ʻana. Mai hōʻoki i ka lawe ʻana i ka hydroxyurea me ke kamaʻilio ʻole ʻana me kāu kauka.

E haʻi paha kāu kauka iā ʻoe e lawe i kahi lāʻau hou, ka waikawa folic (kahi wikamina), e hoʻēmi i kekahi o nā hopena ʻē aʻe o kēia lāʻau. Lawe i kēia lāʻau e like me ke kuhikuhi.


E ale i nā capsule holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.

Helu ʻia nā pākuʻi hydroxyurea 1,000-mg (Siklos) i hiki ke mahele maʻalahi ʻia i mau ʻāpana a i ʻole nā ​​ʻāpana e hāʻawi i nā mea liʻiliʻi. Mai uhaʻi i ka pāhola hydroxyurea 100-mg i mau ʻāpana liʻiliʻi. E haʻi aku kāu kauka iā ʻoe pehea e uhaʻi ai i nā papa a ehia mau papa a i ʻole nā ​​ʻāpana o kahi papaha e lawe ʻoe.

Inā hiki ʻole iā ʻoe ke ale i nā papa hydroxyurea a i ʻole nā ​​ʻāpana (s) o nā papa, hiki iā ʻoe ke hoʻopau i kāu mahele lāʻau i ka wai. E kau i kāu lāʻau i loko o kahi teaspoon a hoʻonui i kahi wai liʻiliʻi. E kali ma kahi o 1 mau minuke e ʻae i ka pā (s) e hoʻoheheʻe, a laila e ale koke i ka hui.

Pono ʻoe e komo i nā mīkina lima a i ʻole ka latex ke lawelawe ʻoe i nā capsule a i ʻole nā ​​papa i ʻole e hoʻopili ʻia kou ʻili me ka lāʻau. E holoi i kou mau lima me ke kopa a me ka wai ma mua a ma hope o kou hoʻopā ʻana i ka ʻōmole a i ʻole ka lāʻau. Inā komo ka hydroxyurea i kou mau maka, holoi koke i kou mau maka me ka wai no 15 mau minuke. Inā kahe ka pauka mai ka capsule a i ʻole ka papa, holoi koke iā ia me kahi kāwele hiki ke maʻū. A laila kau i ke kāwele i loko o kahi ipu paʻa, e like me kahi ʻeke ea, a hoʻolei aku i loko o kahi ʻōpala i hiki ʻole i nā keiki a me nā holoholona. E hoʻomaʻemaʻe i ka wahi ninini e hoʻohana ana i kahi hopena detergent a ukali ʻia e ka wai maʻemaʻe.

Hoʻohana ʻia ʻo Hydroxyurea i kekahi manawa e mālama i ka polycythemia vera (kahi maʻi maʻi koko kahi e hoʻonui ai kou kino i nā hunaola ʻulaʻula). E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka hoʻohana ʻana i kēia lāʻau no kou maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka hydroxyurea,

  • e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka hydroxyurea, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana ʻole i loko o nā capsule hydroxyurea a i ʻole nā ​​papa. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻai, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe E mālama pono i kekahi o kēia mau mea: kekahi mau lāʻau no ka HIV (virus immune kanaka) e like me didanosine (Videx) a me stavudine (Zerit) a me interferon (Actimmune, Avonex, Betaseron, Infergen, Intron A, a me nā mea ʻē aʻe). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi i kāu kauka inā loaʻa iā ʻoe ka maʻi pale maʻi (HIV), loaʻa i nā maʻi maʻi (AIDS), nā pae kiʻekiʻe o ka uric acid i loko o kou koko, a me nā ulcer wāwae; inā mālama ʻia ʻoe me a i ʻole e mālama ʻia me ka radiation radiation, chemotherapy cancer, a i ʻole hemodialysis; aiʻole inā ua loaʻa a loaʻa paha ʻoe i ka maʻi puʻupaʻa a i ʻole ate.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. ʻAʻole ʻoe e hāpai a hānai waiu paha ke lawe nei ʻoe i ka hydroxyurea. Pono ʻoe e loaʻa i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau me ka hydroxyurea. Inā he wahine ʻoe, pono ʻoe e hoʻohana i ka kaohi hānau pono i ka wā e lawe ana i ka hydroxyurea a no ka liʻiliʻi he 6 mau mahina ma hope o ka hoʻōki ʻana i kāu lāʻau. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā wahine e hoʻohana i ka kaohi hānau pono i ka wā e lawe ana i ka hydroxyurea a no 6 mau mahina (Siklos) a i ʻole 1 mau makahiki (Droxia, Hydrea) ma hope o ka hōʻoki ʻana i kāu lapaʻau. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau hiki iā ʻoe ke hoʻohana i ka wā a ma hope o kāu lāʻau a pehea ka lōʻihi e hoʻomau ai i kā lākou hoʻohana. Inā hāpai ʻoe i ka lawe ʻana i ka hydroxyurea, e kāhea koke i kāu kauka. Hiki paha i ka Hydroxyurea ke hōʻeha i ka fetus.
  • pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i ka hydroxyurea.
  • ʻaʻohe o nā lāʻau āpau ke kamaʻilio ʻole ʻia me kāu kauka.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i ka Hydroxyurea ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • nausea
  • ka luaʻi
  • pāhoehoe
  • nalo ʻai ʻole
  • loaʻa kaupaona
  • ʻeha ma ka waha a me ka puʻu
  • kōpaʻa
  • hūwī
  • ʻili mae
  • ʻūpā
  • ʻeha poʻo
  • poho lauoho
  • nā hoʻololi i kaʻili a me nā kui

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • puʻuwai wikiwiki
  • ʻeha mau e hoʻomaka i ka wahi o ka ʻōpū akā e pālahalaha paha i ka hope
  • ʻeha o ka wāwae a ulcer paha
  • ʻeha, ʻili, ʻulaʻula, pehu, a i ʻole ʻūlū ma ka ʻili
  • ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū
  • melemele o ka ʻili a me nā maka
  • numbness, puhi ʻana, a i ʻole ka ʻūlū ʻana i nā lima a me nā wāwae paha
  • fiva, uha, pōkole o ka hanu, a me nā pilikia hanu ʻē aʻe

Hiki i ka Hydroxyurea ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā keiki a me nā holoholona. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua. Pono e mālama ʻia nā pāhaʻi 1000-mg haki i loko o ka ipu a pono e hoʻohana ʻia i loko o 3 mau mahina.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

  • ʻeha ma ka waha a me ka puʻu
  • kaʻeha, kaʻulaʻula, ka pehuʻana, a me ka hōʻāʻana i nā lima a me nā wāwae
  • ʻeleʻele o ka ʻili

Ma mua o ka hoʻāʻo ʻana i kahi lumi hoʻokolohua, e haʻi i kāu kauka a me nā limahana o ke keʻena hoʻokolohua āu e lawe nei i ka hydroxyurea.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau.ʻO ka poʻe lawe ʻole i ka hydroxyurea pono e hōʻalo i ka hoʻopā ʻana i ka lāʻau a i ka hue i loaʻa ka lāʻau.

E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • ʻO Droxia®
  • ʻO Hydrea®
  • Siklos®
  • ʻO Hydroxycarbamide
Nānā Hou - 01/15/2020

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