ʻO Avapritinib

Anter

• Ma mua o ka lawe ʻana i ka avapritinib,
• Hoʻokumu ʻo Avapritinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e hōʻoki i ka lawe ʻana i ka avapritinib a kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Avapritinib e mālama i kekahi ʻano o ka ʻōpū stromal gastrointestinal (GIST; kahi ʻano tumo e ulu ana i ka paia o ka ʻōpū, ʻōpū, a i ʻole ka esophagus [paipu e hoʻopili ana i ka ʻāʻī me ka ʻōpū]) i nā mākua i loaʻa hohola i nā ʻāpana ʻē aʻe o ke kino a i ʻole hiki ʻole ke wehe ʻia e ke ʻoki. Aia ʻo Avapritinib i kahi papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o ka protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i mea e hōʻoki a hoʻolohi ai paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Avapritinib ma ke ʻano he papa e lawe ma ka waha. Lawe ʻia ia i hoʻokahi manawa i kēlā me kēia lā ma kahi ʻōpū hakahaka, ma ka liʻiliʻi he 1 hola ma mua a me 2 mau hola ma hope o ka pāʻina. E lawe i ka avapritinib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E lawe pololei i ka avapritinib. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Inā luaʻi ʻoe ma hope o ka lawe ʻana i ka avapritinib, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau avapritinib a i ʻole hoʻōki i kāu mālama ʻana e pili ana i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a inā ʻoe e ʻike i nā hopena ʻaoʻao. E pono e haʻi aku i kāu kauka i kou ʻano i kou wā e mālama ai me ka avapritinib. Mai hoʻōki i ka lawe ʻana i ka avapritinib me ke kamaʻilio ʻole ʻana me kāu kauka.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka avapritinib,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka avapritinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa avapritinib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, a me nā mea hoʻopihaʻai pono ʻole āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i ka mea aʻe: aprepitant (Emend); kekahi mau lāʻau antifungal e like me fluconazole (Diflucan), itraconazole (Onmel, Sporanox), a i ʻole ketoconazole; clarithromycin (Biaxin, i Prevpac); diltiazem (Cardizem, Tiazac, nā mea ʻē aʻe); erythromycin (E.E.S., Erythrocin, nā mea ʻē aʻe); kekahi mau lāʻau HIV e like me efavirenz (Sustiva, i Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ma Kaletra, kekahi poʻe ʻē aʻe), a i ʻole saquinavir (Invirase); modafinil (Provigil); nefazodone; oxcarbazepine (Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, i Actoplus, Duetact, Oseni); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ma Rifater); a me ka verapamil (Calan). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.Nui paha nā lāʻau ʻē aʻe e launa pū paha me ka avapritinib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi ate a me nā puʻupaʻa.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i ka hānau keiki ʻana. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o kou hoʻomaka ʻana i ka lāʻau a hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā lapaʻau a no 6 mau pule ma hope o kāu hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu hoa e hoʻohana i ka kaohi hānau ma kāu wā e mālama ai a no 6 mau pule ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana i ka avapritinib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Avapritinib i ka fetus.
• e haʻi i kāu kauka inā ʻoe e hānai umauma ana. ʻAʻole pono ʻoe e hānai i ka umauma ʻoiai ʻoe e lawe ana i ka avapritinib a no 2 mau pule ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne a me nā wahine. E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i ka avapritinib.
• pono ʻoe e ʻike ʻo ka avapritinib paha ʻoe e hoʻoluhi ai, e hiamoe ai, a e huikau ai paha. Mai hoʻokele i kahi kaʻa a hana i nā mīkini a ʻike ʻoe i ka hopena o kēia lāʻau iā ʻoe.

E kamaʻilio me kāu kauka e pili ana i ka ʻai ʻana i ka huaʻōlau a me ka inu ʻana i ka wai momona a ke lawe nei ʻoe i kēia lāʻau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā ma muli o ka mahele ma hope o 8 mau hola, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu ʻo Avapritinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻeha ka ʻōpū
• ka luaʻi
• nausea
• pāhoehoe
• puʻuwai puʻuwai
• ʻeha poʻo
• luhi
• paʻakikī e hiamoe a hiamoe paha
• poho lauoho
• loli ke oho lauoho
• Kaumaha emi
• waimaka waimaka
• loli ka ʻono

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e hōʻoki i ka lawe ʻana i ka avapritinib a kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• pehu o ka maka, maka, waha, a ʻāʻī paha
• pehu o nā lima, nā kuʻekuʻe wāwae, a me nā wāwae
• ke luaʻi nei i ke koko a i ʻole nā ​​mea e like me ke kahua kope a i ʻole ʻulaʻula a palau paha nā noho ʻeleʻele
• ʻeha poʻo, pilikia ʻike maka, hiamoe, luhi nui, a nawaliwali paha ma kekahi ʻaoʻao o kou kino
• poina, huikau, hiamoe, hoʻoluhi, paʻakikī e hiamoe, paʻakikī e ʻōlelo, hallucination, a i ʻole nā ​​loli i ke ʻano a me ke ʻano.
• hūwī
• pokole o ka hanu
• fiva a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi

Hoʻokumu paha ʻo Avapritinib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela a mamao aku mai ka nui o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kahi hoʻokolohua lab ma mua o kou hoʻomaka ʻana i kāu lāʻau e ʻike ai hiki ke mālama ʻia i kou maʻi ʻaʻai me ka avapritinib. E kauoha paha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino iā avapritinib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Ayvakit^®