Entrectinib

Anter

• Ma mua o ka entrectinib,
• Hoʻokumu paha ʻo Entrectinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Entrectinib e mālama i kekahi ʻano maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi (NSCLC) i nā mākua i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino. Hoʻohana ʻia ia e mālama i kekahi ʻano o nā tumors paʻa i ka poʻe mākua a me nā keiki he 12 mau makahiki a ʻoi paha i hiki ʻole ke mālama ʻia e ke ʻoki a i pālahalaha ʻia i nā ʻāpana ʻē aʻe o ke kino a ua ʻoi aku ka maikaʻi ma hope o ka lapaʻau ʻana me nā lāʻau chemotherapy ʻē aʻe. Aia ʻo Entrectinib i kahi papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o ka protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i mea e hōʻoki a hoʻolohi ai paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Entrectinib ma ke ʻano he capsule e lawe ma ka waha. Lawe mau ʻia me ka ʻai ʻole a ʻai ʻole hoʻokahi manawa i kēlā me kēia lā. Lawe i ka entrectinib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka entrectinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā capsule holoʻokoʻa; mai wehe, nau, a wāwahi paha iā lākou.

Inā luaʻi koke ʻoe ma hope o kou lawe ʻana i ka entrectinib, lawe i kahi lāʻau ma kahi hiki ke hiki.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka entrectinib,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka entrectinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hoʻohui i loko o ka capsule entrectinib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E hoʻomaopopo pono i ka mea aʻe: aprepitant (Emend), kekahi mau lāʻau antifungal e like me fluconazole (Diflucan), itraconazole (Omel, Sporanox), a i ʻole ketoconazole; kekahi mau lāʻau no arrhythmia e like me amiodarone (Nexterone, Pacerone), procainamide, quinidine (i Nuedexta), a me sotalol (Betapace, Sorine, Sotylize); azithromycin (Zithromax); clarithromycin (Biaxin, i Prevpac); diltiazem (Cardizem, Tiazac, nā mea ʻē aʻe); erythromycin (E.E.S., Erythrocin, nā mea ʻē aʻe); enzalutamide (Xtandi); kekahi mau lāʻau HIV e like me efavirenz (Sustiva, i Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ma Kaletra, kekahi poʻe ʻē aʻe), a i ʻole saquinavir (Invirase); lithium (Lithobid); modafinil (Provigil); nefazodone; oxcarbazepine (Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, i Actoplus, Duetact, Oseni); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ma Rifater); nā steroid ʻo waha e like me dexamethasone, methylprednisolone (Medrol), a me prednisone (Rayos); a me ka verapamil (Calan). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me entrectinib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo keu ʻo St. John's Wort.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha i kahi ʻōnaehana nūnū, kahi wā QT hoʻolōʻihi (kahi pilikia puʻuwai laha ʻole e hiki ai ke hōʻeha i ka puʻuwai ʻole, maʻule paha, a make koke paha), kahi puʻuwai lohi a i ʻole kaulike ʻole, hōʻeha puʻuwai, hōʻeha puʻuwai a maʻi puʻuwai a i ʻole ate.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i ka hānau keiki ʻana. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o kou hoʻomaka ʻana i ka mālama ʻana a hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā lapaʻau a no 5 mau pule ma hope o kāu hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā e hoʻohana i ka kaohi hānau i ka wā o kāu mālama ʻana me entrectinib a no 3 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana i ka entrectinib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Entrectinib i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana ʻoe i ka entrectinib a no 7 mau lā ma hope o ka hopena hope loa.
• pono ʻoe e ʻike i ka entrectinib i hana ai i ka loli a i ʻole ka huikau. Mai hoʻokele i kahi kaʻa a hana i nā mīkini a ʻike ʻoe i ka hopena o kēia lāʻau iā ʻoe.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

Inā ʻoe e nalo i kahi mahele ma lalo o 12 mau hola, e lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai a laila lawe i ka lāʻau aʻe i ka manawa i hoʻopaʻa ʻia. Eia nō naʻe, inā ʻoe e nalo i kahi mahele ma mua o 12 mau hola, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Entrectinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• luhi
• kōpaʻa
• pāhoehoe
• loli ka ʻono
• ʻeha poʻo
• ka hano, ka fiva, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• ʻehaʻeha a ʻeha pū paha
• ʻeha kua
• loli ke kaupaona
• hūwī
• hāʻule paʻakikī a hiamoe paha

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• ka paʻakikī me ke aʻo ʻana, ka hoʻomanaʻo ʻana, ka nānā ʻana, a me ka hoʻoponopono pilikia ʻana
• hoʻololi i ke ʻano e like me ka hopohopo, kaumaha, huikau, a i ʻole hoʻonāukiuki
• ʻeha iwi a paʻakikī paha i ka neʻe ʻana
• pilikia pilikia a i ʻole hoʻololi i ka hihiʻo
• ʻeha puʻupuʻu, ʻoʻoleʻa, ʻulaʻula, a ʻōhū paha
• ʻeha ma ka ʻaoʻao ʻākau i luna o ka ʻōpū, melemele o ka ʻili a i ʻole nā ​​maka, nalowale o ka makemake, a i ʻole ke kahe ʻana a palupalu paha
• pokole o ka hanu; paʻakikī ka hanu ke moe i lalo; aiʻole ka pehu ʻana o nā lima, nā wāwae, nā lima a i ʻole nā ​​wāwae

Hoʻokumu paha ʻo Entrectinib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kahi hoʻokolohua hoʻokolohua ma mua o kou hoʻomaka ʻana i kāu lāʻau e ʻike inā hiki ke mālama ʻia i kou maʻi ʻaʻai me entrectinib. Hiki i kāu kauka ke kauoha i kekahi mau hoʻokolohua lab a ma mua a i kāu wā e mālama ai e nānā i ka pane o kou kino i entrectinib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Rozlytrek^®