ʻO Glasdegib

Anter

• Ma mua o ka lawe ʻana i glasdegib,
• Hoʻokumu ʻo Glasdegib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:
• Pākuʻi ʻia paha nā ʻōuli o ka overdose:

ʻAʻole pono e lawe ʻia ʻo Glasdegib e nā mea maʻi e hāpai a hāpai paha. Aia kahi makaʻu nui i ka glasdegib e hana i nā kīnā hānau koʻikoʻi (nā pilikia o ke kino e kū nei i ka wā hānau) a i ʻole ka make o ka pēpē i hānau ʻole ʻia.

Inā he wahine ʻoe i hiki ke hāpai, pono ʻoe i kahi hōʻoia hāpai maikaʻi ʻole i loko o 7 mau lā ma mua o kou hoʻomaka ʻana i ka lāʻau me glasdegib. Pono ʻoe e hoʻohana i ka kaohi hānau kūpono ma kāu mālama ʻana me glasdegib a no 30 mau lā ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā koho kaohi hānau e holo pono nāu.

Inā he kāne ʻoe me ka hoa wahine hiki ke hāpai a hāpai paha, pono ʻoe e ʻike aia paha ʻo glasdegib i loko o ka semen a hōʻeha paha i ka pēpē i hānau ʻole ʻia. E hoʻohana i kahi condom i kou wā e mālama ai me glasdegib a no 30 mau lā ma hope o ka hopena hope inā ua loaʻa iā ʻoe kahi vasectomy (ʻoki e pale ai i ka sperm mai ka haʻalele ʻana i kou kino a hāpai i ka hāpai ʻana). Mai hāʻawi manawaleʻa i ka wā o kāu mālama ʻana a ma kahi o 30 mau lā ma hope o kāu hopena hope loa.

Inā loaʻa iā ʻoe ka moekolohe ʻole ʻia, e noʻonoʻo ua holo pono ʻole kāu kaohi hānau ʻana, a i ʻole manaʻo paha ʻoe e hāpai ana kāu wahine paha e kāhea koke aku i kāu kauka.

Mai hāʻawi manawaleʻa i ke koko a i ʻole nā ​​huahana koko i ka wā o kou mālama ʻana me glasdegib a no 30 mau lā ma hope o kāu kau hope loa.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka pepa ʻikepili a ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me glasdegib a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Hoʻohana ʻia ʻo Glasdegib me cytarabine ma ke ʻano he lapaʻau mua loa no ka myeloid leukemia (AML; kahi ʻano maʻi ʻaʻai e hoʻomaka i nā hunaola keokeo) i ka poʻe ma mua o 75 mau makahiki, a i ʻole nā ​​mākua i loaʻa nā ʻano olakino ʻē aʻe a ʻaʻole hiki ke mālama ʻia. me nā lāʻau chemotherapy ʻē aʻe. Aia ʻo Glasdegib i loko o ka papa o nā lāʻau i kapa ʻia he hedgehog pathway inhibitors. Hana ia ma ka pale ʻana i ka hana o kahi protein i hōʻailona i nā hunaola maʻi ʻaʻa e hoʻonui. Kōkua kēia i ka hōʻoki a hoʻolohi paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Glasdegib ma ke ʻano he papa e lawe ma ka waha. Hāʻawi ʻia ia me ka ʻole a me ka ʻole o ka ʻai i hoʻokahi manawa i ka lā no ka liʻiliʻi he 6 mau mahina, a ʻoiai paha e koi ana kāu kauka i ka lāʻau. Lawe iā glasdegib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka glasdegib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou.

Inā luaʻi ʻoe ma hope o ka lawe ʻana i ka glasdegib, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

Pono paha kāu kauka e hoʻopau i kāu lāʻau, hōʻemi i kāu lāʻau, a i ʻole hoʻokū i kāu lāʻau e like me kāu pane i ka lāʻau a me nā hopena ʻē aʻe āu e ʻike ai. E haʻi pono i kāu kauka i kou ʻano i kou wā e mālama ai me glasdegib.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i glasdegib,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka glasdegib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa glasdegib. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, a me nā mea hoʻopihaʻaiʻai āu e lawe nei a hoʻolālā paha e lawe. E hoʻomaopopo pono e ʻōlelo i kekahi o kēia mau mea: amiodarone (Nexterone, Pacerone), carbamazepine (Carbatrol, Equetro, Tegretol, a me nā mea ʻē aʻe), chlorpromazine, cilostazol, citalopram (Celexa), clarithromycin, disopyramide (Norpace), dofetilide, donepezil (Aricept) dronedarone (Multaq), efavirenz (Sustiva, i Atripla, Symfi), escitalopram (Lexapro), flecainide (Tambocor), fluconazole (Diflucan), haloperidol (Haldol), ibutilide (Corvert), indinavir (Crixivonaz, Onrac) ), ketaconazole, methadone (Dolophine, Methadose), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), ondansetron (Zofran, Zuplenz), phenobarbital, phenytoin (Dilantin, Phenytek), pimozide (Orap), pioglitazone , Duetact, Actoplus Met), procainamide, quinidine (i Nuedexta), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, ma Rifater, Rifamate), ritonavir (Norvir, ma Viekira Pak, Kaletra, Technivie), sotalol (Betapace, Sorine , Sotylize), a me thioridazine. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Hiki paha i nā lāʻau ʻē aʻe ke launa pū me glasdegib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi i kāu kauka inā ua lōʻihi a hoʻolōʻihi paha ʻoe i ka wā QT (kahi pilikia puʻuwai laha ʻole e hiki ai ke hōʻeha i ka puʻuwai ʻole, maʻule, a make koke paha), ka puʻuwai puʻuwai , a i ʻole nā ​​pae haʻahaʻa o ka magnesium a potassium paha i kou koko.
• e haʻi i kāu kauka inā ʻoe e hānai umauma ana. ʻAʻole pono ʻoe e hānai i ka umauma i kāu mālama ʻana me glasdegib a no 30 mau lā ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana i glasdegib.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā emi ma mua o 12 mau hola a hiki i kāu kau ma hope, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu ʻo Glasdegib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻūpē mākala
• ʻeha, iwi a ʻeha pū paha
• luhi loa
• nausea
• ka luaʻi
• abdominal eha
• kōpaʻa
• ʻeha a ʻeha hoʻi i kou waha a i ʻole ka ʻāʻī
• hoʻēmi ʻai
• hoʻololi i ke ʻano o ka ʻono o nā mea
• Kaumaha emi
• ʻeha poʻo
• hūwī
• pehu o nā lima a me nā wāwae
• poho lauoho
• ʻeha ʻeha

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

• ʻano palupalu, ʻālohilohi, a ʻōpule paha; wikiwiki a i ʻole kuʻi puʻuwai puʻuwai
• ʻāpā ʻaʻano ʻole a hoʻokahe koko paha
• ʻo ke kuni wale nō a me ka haʻalulu, nāwaliwali aiʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• hoʻemi urination
• ʻeha ka umauma

Hoʻokumu paha ʻo Glasdegib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Pākuʻi ʻia paha nā ʻōuli o ka overdose:

• nausea
• ka luaʻi
• luhi loa
• ʻūpā

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha aku kāu kauka i kekahi mau hoʻokolohua lab e like me electrocardiograms (EKG, hōʻike e hoʻopaʻa i ka hana uila o ka puʻuwai) a me nā hoʻokolohua koko ma mua a i ka wā o ka hoʻomaʻamaʻa e mālama pono ai palekana iā ʻoe e lawe i ka glasdegib a nānā i ka pane o kou kino i ka lāʻau. .

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Daurismo^®