Burosumab-twza ka pahu kui

Anter

• Ma mua o ka hoʻohana ʻana i ka inikū burosumab-twza,
• Burosumab-twza injection hiki ke hopena i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea i kāu kauka:

Hoʻohana ʻia ka injection Burosumab-twza e mālama i ka hypophosphatemia pili X (XLH; kahi maʻi hoʻoilina kahi e mālama ʻole ai ke kino i ka phosphore a hiki i nā iwi nāwaliwali) i nā mākua a me nā keiki 6 mau makahiki a ʻoi paha. Hoʻohana ʻia ia e mālama i ka osteomalacia i hoʻokomo ʻia e ka tumo (kahi tumo e kumu o ka nalo ʻana o ka phosphore i loko o ke kino e hiki ai i nā iwi nāwaliwali) ʻaʻole hiki ke hemo ʻia i nā mākua a me nā keiki ʻo 2 mau makahiki a ʻoi paha, ʻo Burosumab-twza injection ka i kahi papa o nā lāʻau i kapa ʻia ʻo fibroblast ulu mea 23 (FGF23) e pale ana i nā mea pale. Hana ia ma ka pale ʻana i ka hana o kekahi mea kūlohelohe i ke kino e kumu ai nā ʻōuli o XLH.

ʻO ka injection Burosumab-twza ke hele mai ma ke ʻano he hopena (wai) e injected subcutaneously (ma lalo o ka ʻili) e ke kauka a kahu hānai paha. No ka mālama ʻana i ka hypophosphatemia pili X, e hoʻouka pinepine ʻia ia i hoʻokahi manawa i kēlā me kēia 2 pule no nā keiki 6 mau mahina a 17 mau makahiki, a hoʻokahi manawa i kēlā me kēia 4 mau pule no nā mākua. No ka hoʻomaʻamaʻa ʻana i ka osteomalacia i hoʻokomo ʻia e ka tumo, i nā keiki 2 a 17 mau makahiki, ua injected pinepine ʻia i kēlā me kēia 2 pule. No ka hoʻomaʻamaʻa ʻana i ka osteomalacia i hoʻokomo ʻia e ka tumo i nā mākua, ua injected mau ia i kēlā me kēia 4 mau pule a i ka hoʻonui ʻia ʻana o ka mahele hiki ke ʻimi ʻia i kēlā me kēia 2 mau pule. E hoʻokomo kāu kauka a kahu hānai paha i ka lāʻau i kou lima luna, ka ʻūhā o luna, ka ʻūlū, a i ʻole ka ʻōpū, a hoʻohana i kahi pūnaewele ʻokoʻa i kēlā me kēia manawa.

E haʻi i kāu kauka inā e lawe nei ʻoe i nā mea kōkua phosphate a i ʻole kekahi mau huaora D e like me ka calcitriol (Rocaltrol) a i ʻole paricalcitol (Zemplar). Pono ʻoe e hōʻoki i ka lawe ʻana i kēia mau pule he 1 ma mua o kou hoʻomaka ʻana i ka lāʻau.

Hiki i kāu kauka ke hoʻonui i kāu lāʻau (ʻaʻole i ʻoi aku ma mua o hoʻokahi manawa i kēlā me kēia 4 pule), a i ʻole lele i kahi lāʻau, e like me nā hopena o kāu hōʻike lab.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka hoʻohana ʻana i ka inikū burosumab-twza,

• e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka burosumab-twza, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka inikū burosumab-twza. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻai, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā loaʻa ʻoe i ka maʻi puʻuwai. E haʻi paha kāu kauka iā ʻoe mai hoʻohana i ka inikua burosumab-twza.
• E haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha iā ʻoe kahi maʻi maʻi wāwae hoʻomaha ʻole (RLS; kahi ʻano e hōʻoluʻolu ʻole i nā wāwae a me ka makemake nui e hoʻoneʻe i nā wāwae, keu hoʻi i ka pō a i ka wā e noho ai a moe paha i lalo.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka loaʻa ʻana o ka inikua burosumab-twza, e kāhea i kāu kauka.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā haʻalele ʻoe i kahi manawa e loaʻa ai kahi lāʻau, hana i kahi manawa hou i ka wā e hiki ai.

Burosumab-twza injection hiki ke hopena i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻeha poʻo
• ka luaʻi
• fiva
• ʻeha ma nā lima, nā wāwae, a i ʻole ke kua
• ʻeha mākala
• kōpaʻa
• ʻūpā

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea i kāu kauka:

• ʻulaʻula, ʻūlū, hives, ʻume, ʻōhū, ʻeha a ʻeha paha ma kahi kokoke a ma kahi paha i ʻāpono ʻia ai ka lāʻau.
• ʻehu a hives paha
• hōʻoluʻolu i nā wāwae; koi ikaika e hoʻoneʻe i nā wāwae, keu hoʻi i ka pō a ke noho a moe paha i lalo

Burosumab-twza injection hiki ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab a ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino i ka inikua burosumab-twza.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Crysvita^®